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4 results on '"López-Fuster, María J."'

1. R2d2Drives Selfish Sweeps in the House Mouse

Author

Didion, John P., primary, Morgan, Andrew P., additional, Yadgary, Liran, additional, Bell, Timothy A., additional, McMullan, Rachel C., additional, Ortiz de Solorzano, Lydia, additional, Britton-Davidian, Janice, additional, Bult, Carol J., additional, Campbell, Karl J., additional, Castiglia, Riccardo, additional, Ching, Yung-Hao, additional, Chunco, Amanda J., additional, Crowley, James J., additional, Chesler, Elissa J., additional, Förster, Daniel W., additional, French, John E., additional, Gabriel, Sofia I., additional, Gatti, Daniel M., additional, Garland, Theodore, additional, Giagia-Athanasopoulou, Eva B., additional, Giménez, Mabel D., additional, Grize, Sofia A., additional, Gündüz, İslam, additional, Holmes, Andrew, additional, Hauffe, Heidi C., additional, Herman, Jeremy S., additional, Holt, James M., additional, Hua, Kunjie, additional, Jolley, Wesley J., additional, Lindholm, Anna K., additional, López-Fuster, María J., additional, Mitsainas, George, additional, da Luz Mathias, Maria, additional, McMillan, Leonard, additional, Ramalhinho, Maria da Graça Morgado, additional, Rehermann, Barbara, additional, Rosshart, Stephan P., additional, Searle, Jeremy B., additional, Shiao, Meng-Shin, additional, Solano, Emanuela, additional, Svenson, Karen L., additional, Thomas-Laemont, Patricia, additional, Threadgill, David W., additional, Ventura, Jacint, additional, Weinstock, George M., additional, Pomp, Daniel, additional, Churchill, Gary A., additional, and Pardo-Manuel de Villena, Fernando, additional

Published
2016
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2. R2d2 drives selfish sweeps in the house mouse

Author

Didion, John P, primary, Morgan, Andrew Parker, additional, Yadgary, Liran, additional, Bell, Timothy A, additional, McMullan, Rachel Clara, additional, Ortiz de Solorzano, Lydia, additional, Britton-Davidian, Janice, additional, Bult, Carol J, additional, Campbell, Karl J, additional, Castiglia, Riccardo, additional, Ching, Yung-Hao, additional, Chunco, Amanda J, additional, Crowley, James J, additional, Chesler, Elissa J, additional, French, John E, additional, Gabriel, Sofia I, additional, Gatti, Daniel M, additional, Garland, Theodore, additional, Giagia-Athanasopoulou, Eva B, additional, Giménez, Mabel D, additional, Grize, Sofia A, additional, Gündüz, İslam, additional, Holmes, Andrew, additional, Hauffe, Heidi C, additional, Herman, Jeremy S, additional, Holt, James M, additional, Hua, Kunji, additional, Jolley, Wesley J, additional, Lindholm, Anna K, additional, López-Fuster, María J, additional, Mitsainas, George, additional, Mathias, Maria, additional, McMillan, Leonard, additional, Ramalhinho, M Graça, additional, Rehermann, Barbara, additional, Rosshart, Stephan P, additional, Searle, Jeremy B, additional, Shiao, Meng-Shin, additional, Solano, Emanuela, additional, Svenson, Karen L, additional, Thomas-Laemont, Pat, additional, Threadgill, David W, additional, Ventura Queija, Jacint, additional, Weinstock, George M, additional, Pomp, Daniel, additional, Churchill, Gary A, additional, and Pardo-Manuel de Villena, Fernando, additional

Published
2015
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3. R2d2 Drives Selfish Sweeps in the House Mouse

Author

Searle, Jeremy B., Didion, John P., Pomp, Daniel, Solano, Emanuela, López-Fuster, María J., Ventura, Jacint, Ramalhinho, Maria Da Graça Morgado, Churchill, Gary A., Morgan, Andrew P., McMullan, Rachel C., Giménez, Mabel D., Ching, Yung-Hao, Garland, Theodore, Castiglia, Riccardo, Bult, Carol J., Gündüz, Islam, Bell, Timothy A., Grize, Sofia A., Chesler, Elissa J., Lindholm, Anna K., Weinstock, George M., Gatti, Daniel M., Hauffe, Heidi C., Förster, Daniel W., French, John E., Da Luz Mathias, Maria, Holmes, Andrew, Giagia-Athanasopoulou, Eva B., Mitsainas, George, De Solorzano, Lydia Ortiz, Rehermann, Barbara, Rosshart, Stephan P., De Villena, Fernando Pardo-Manuel, Chunco, Amanda J., Britton-Davidian, Janice, Threadgill, David W., Svenson, Karen L., Holt, James M., Gabriel, Sofia I., Shiao, Meng-Shin, Crowley, James J., Campbell, Karl J., Hua, Kunjie, McMillan, Leonard, Jolley, Wesley J., Herman, Jeremy S., Yadgary, Liran, and Thomas-Laemont, Patricia

Subjects
2. Zero hunger
Abstract

A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether “selfish” genes are capable of fixation—thereby leaving signatures identical to classical selective sweeps—despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2HC) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2HC rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2HC is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution.

4. R2d2 Drives Selfish Sweeps in the House Mouse.

Author

Didion JP, Morgan AP, Yadgary L, Bell TA, McMullan RC, Ortiz de Solorzano L, Britton-Davidian J, Bult CJ, Campbell KJ, Castiglia R, Ching YH, Chunco AJ, Crowley JJ, Chesler EJ, Förster DW, French JE, Gabriel SI, Gatti DM, Garland T Jr, Giagia-Athanasopoulou EB, Giménez MD, Grize SA, Gündüz İ, Holmes A, Hauffe HC, Herman JS, Holt JM, Hua K, Jolley WJ, Lindholm AK, López-Fuster MJ, Mitsainas G, da Luz Mathias M, McMillan L, Ramalhinho Mda G, Rehermann B, Rosshart SP, Searle JB, Shiao MS, Solano E, Svenson KL, Thomas-Laemont P, Threadgill DW, Ventura J, Weinstock GM, Pomp D, Churchill GA, and Pardo-Manuel de Villena F

Subjects
Adaptation, Physiological genetics, Alleles, Animals, Biological Evolution, DNA Copy Number Variations genetics, Evolution, Molecular, Female, Genetic Variation, Genetics, Population, Male, Mice, Models, Genetic, Mutation, Selection, Genetic, Nuclear Proteins genetics, RNA-Binding Proteins genetics, Repetitive Sequences, Nucleic Acid
Abstract

A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the pattern and distribution of allelic diversity in a population. Population-level sequencing data have enabled discoveries of selective sweeps associated with genes involved in recent adaptations in many species. In contrast, much debate but little evidence addresses whether "selfish" genes are capable of fixation-thereby leaving signatures identical to classical selective sweeps-despite being neutral or deleterious to organismal fitness. We previously described R2d2, a large copy-number variant that causes nonrandom segregation of mouse Chromosome 2 in females due to meiotic drive. Here we show population-genetic data consistent with a selfish sweep driven by alleles of R2d2 with high copy number (R2d2(HC)) in natural populations. We replicate this finding in multiple closed breeding populations from six outbred backgrounds segregating for R2d2 alleles. We find that R2d2(HC) rapidly increases in frequency, and in most cases becomes fixed in significantly fewer generations than can be explained by genetic drift. R2d2(HC) is also associated with significantly reduced litter sizes in heterozygous mothers, making it a true selfish allele. Our data provide direct evidence of populations actively undergoing selfish sweeps, and demonstrate that meiotic drive can rapidly alter the genomic landscape in favor of mutations with neutral or even negative effects on overall Darwinian fitness. Further study will reveal the incidence of selfish sweeps, and will elucidate the relative contributions of selfish genes, adaptation and genetic drift to evolution., (© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)

Published
2016
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