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15 results on '"López-Cuevas, Rogelio"'

7. Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer’s type

Author

Martino Adami, Pamela V, primary, Orellana, Adelina, additional, García, Pablo, additional, Kleineidam, Luca, additional, Alarcón-Martín, Emilio, additional, Montrreal, Laura, additional, Aguilera, Nuria, additional, Espinosa, Ana, additional, Abdelnour, Carla, additional, Rosende-Roca, Maitee, additional, Pablo Tartari, Juan, additional, Vargas, Liliana, additional, Mauleón, Ana, additional, Esteban-De Antonio, Ester, additional, López-Cuevas, Rogelio, additional, Dalmasso, Maria Carolina, additional, Campos Martin, Rafael, additional, Parveen, Kayenat, additional, Andrade Fuentes, Victor M, additional, Amin, Najaf, additional, Ahmad, Shahzad, additional, Ikram, M Arfan, additional, Lewczuk, Piotr, additional, Kornhuber, Johannes, additional, Peters, Oliver, additional, Frölich, Lutz, additional, Rüther, Eckart, additional, Wiltfang, Jens, additional, Tarraga, Lluis, additional, Boada, Merce, additional, Maier, Wolfgang, additional, de Rojas, Itziar, additional, Cano, Amanda, additional, Sanabria, Angela, additional, Alegret, Montserrat, additional, Hernández, Isabel, additional, Marquié, Marta, additional, Valero, Sergi, additional, van Duijn, Cornelia M, additional, Wagner, Michael, additional, Jessen, Frank, additional, Schneider, Anja, additional, Sáez Goñi, María Eugenia, additional, González Pérez, Antonio, additional, Ruiz, Agustín, additional, and Ramírez, Alfredo, additional

Published
2022
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8. Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment

Author

Roberto, Natalia, primary, Portella, Maria J., additional, Marquié, Marta, additional, Alegret, Montserrat, additional, Hernández, Isabel, additional, Mauleón, Ana, additional, Rosende-Roca, Maitee, additional, Abdelnour, Carla, additional, Esteban de Antonio, Ester, additional, Tartari, Juan P., additional, Vargas, Liliana, additional, López-Cuevas, Rogelio, additional, Bojaryn, Urszula, additional, Espinosa, Ana, additional, Ortega, Gemma, additional, Pérez-Cordón, Alba, additional, Sanabria, Ángela, additional, Orellana, Adelina, additional, de Rojas, Itziar, additional, Moreno-Grau, Sonia, additional, Montrreal, Laura, additional, Alarcón-Martín, Emilio, additional, Ruíz, Agustín, additional, Tárraga, Lluís, additional, Boada, Mercè, additional, and Valero, Sergi, additional

Published
2021
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9. Metabolic syndrome impact on cognitive composites domain scores and on white matter hyperintensities in subjective cognitive decline: The FACEHBI Cohort

Author

Ortega, Gemma, primary, Espinosa, Ana, additional, Alegret, Montserrat, additional, Monté‐Rubio, Gemma, additional, Sotolongo‐Grau, Oscar, additional, Sanabria, Angela, additional, Tartari, Juan Pablo, additional, Rodriguez‐Gomez, Octavio, additional, Marquié, Marta, additional, Vivas, Assumpta, additional, Gómez‐Chiari, M, additional, Alarcón‐Martín, Emilio, additional, Pérez‐Cordón, Alba, additional, Roberto, Natalia, additional, Hernandez, Isabel, additional, Rosende‐Roca, Maitee, additional, Vargas, Liliana, additional, Mauleon, Ana, additional, Abdelnour, Carla, additional, Antonio, Ester Esteban‐De, additional, López‐Cuevas, Rogelio, additional, Alonso‐Lana, S, additional, Moreno‐Grau, Sonia, additional, de Rojas, Itziar, additional, Orellana, Adelina, additional, Montrreal, Laura, additional, Tarraga, Lluis, additional, Ruiz, Agustin, additional, Boada, Mercè, additional, and Valero, Sergi, additional

Published
2021
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10. From Face-to-Face to Home-to-Home: Validity of a Teleneuropsychological Battery

Author

Alegret, Montserrat, primary, Espinosa, Ana, additional, Ortega, Gemma, additional, Pérez-Cordón, Alba, additional, Sanabria, Ángela, additional, Hernández, Isabel, additional, Marquié, Marta, additional, Rosende-Roca, Maitée, additional, Mauleón, Ana, additional, Abdelnour, Carla, additional, Vargas, Liliana, additional, de Antonio, Ester Esteban, additional, López-Cuevas, Rogelio, additional, Tartari, Juan Pablo, additional, Alarcón-Martín, Emilio, additional, Tárraga, Lluís, additional, Ruiz, Agustín, additional, Boada, Mercè, additional, and Valero, Sergi, additional

Published
2021
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11. Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type.

Author

Adami, Pamela V Martino, Orellana, Adelina, García, Pablo, Kleineidam, Luca, Alarcón-Martín, Emilio, Montrreal, Laura, Aguilera, Nuria, Espinosa, Ana, Abdelnour, Carla, Rosende-Roca, Maitee, Tartari, Juan Pablo, Vargas, Liliana, Mauleón, Ana, Antonio, Ester Esteban-De, López-Cuevas, Rogelio, Dalmasso, Maria Carolina, Martin, Rafael Campos, Parveen, Kayenat, Fuentes, Victor M Andrade, and Amin, Najaf

Subjects
DISEASE progression, RESEARCH, ALZHEIMER'S disease, NERVE tissue proteins, RESEARCH methodology, PROTEOLYTIC enzymes, EVALUATION research, COMPARATIVE studies, PSYCHOLOGICAL tests, PEPTIDES, LONGITUDINAL method
Abstract

Alzheimer's disease has a long asymptomatic phase that offers a substantial time window for intervention. Using this window of opportunity will require early diagnostic and prognostic biomarkers to detect Alzheimer's disease pathology at predementia stages, thus allowing identification of patients who will most probably progress to dementia of the Alzheimer's type and benefit from specific disease-modifying therapies. Consequently, we searched for CSF proteins associated with disease progression along with the clinical disease staging. We measured the levels of 184 proteins in CSF samples from 556 subjective cognitive decline and mild cognitive impairment patients from three independent memory clinic longitudinal studies (Spanish ACE, n = 410; German DCN, n = 93; German Mannheim, n = 53). We evaluated the association between protein levels and clinical stage, and the effect of protein levels on the progression from mild cognitive impairment to dementia of the Alzheimer's type. Mild cognitive impairment subjects with increased CSF level of matrix metalloproteinase 10 (MMP-10) showed a higher probability of progressing to dementia of the Alzheimer's type and a faster cognitive decline. CSF MMP-10 increased the prediction accuracy of CSF amyloid-β 42 (Aβ42), phospho-tau 181 (P-tau181) and total tau (T-tau) for conversion to dementia of the Alzheimer's type. Including MMP-10 to the [A/T/(N)] scheme improved considerably the prognostic value in mild cognitive impairment patients with abnormal Aβ42, but normal P-tau181 and T-tau, and in mild cognitive impairment patients with abnormal Aβ42, P-tau181 and T-tau. MMP-10 was correlated with age in subjects with normal Aβ42, P-tau181 and T-tau levels. Our findings support the use of CSF MMP-10 as a prognostic marker for dementia of the Alzheimer's type and its inclusion in the [A/T/(N)] scheme to incorporate pathologic aspects beyond amyloid and tau. CSF level of MMP-10 may reflect ageing and neuroinflammation. [ABSTRACT FROM AUTHOR]

Published
2022
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