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2. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Martínez de Soto, Lucía, Rodríguez Mariblanca, Amelia, Díaz García, Lucía, Ramírez García, Elena, Seco Meseguer, Enrique, Stewart Balbás, Stefan Mark, Marín Candón, Alicia, García García, Irene, Urroz Elizalde, Mikel, Monserrat Villatoro, Jaime, de la Rosa, Paula, Sanz García, Marta, López Crespo, Cristina, Mauleón Martínez, Vega, de Madariaga Castell, Raquel, Vitón Vara, Laura, García Rodríguez, Julio, Buño, Antonio, López Granados, Eduardo, Cámara, Carmen, Rey Cuevas, Esther, Ayllon García, Pilar, Jiménez González, María, Hernández Rubio, Victoria, Moraga Alapont, Paloma, Sánchez, Amparo, Prieto, Rocío, Llorente Gómez, Silvia, Miragall Roig, Cristina, Aparicio Marlasca, Marina, de la Calle, Fernando, Arsuaga, Marta, Duque, Blanca, Meijide, Susana, García de Vicuña, Aitor, Santorcuato, Ana, Expósito, Iraide, de Benito, Sara, Andia, Joseba, Castillo, Cristina, Irurzun, Esther, Camino, Jesús, Temprano, Mikel, Goikoetxea, Josune, Bustinza, Alazne, Larrea, Maialen, Gallego, Mikel, García-Vázquez, Dolores, de la Hoz, Ana Belén, Pérez-Nanclares, Gustavo, Pérez-Guzmán, Estíbaliz, Idoyaga, Eneko, Lamela, Adriana, Oteo, Jesús, Castillo de la Osa, María, Hernández Gutiérrez, Lourdes, Andrés Galván, María Elena, Calonge, Esther, Bermejo, Mercedes, de la Torre-Tarazona, Erick Humberto, Cascajero, Almudena, Fedele, Giovanni, Perea, Concepción, Cervera, Isabel, Bodega-Mayor, Irene, Montes-Casado, María, Portolés, Pilar, Baranda, Jana, Granés, Laura, Lazaar, Sulayman, Herranz, Sara, Mellado, María Eugènia, Tortajada, Marta, Malet, Montserrat, Quesada, Sebastiana, Vilella, Anna, Llupià, Anna, Olivé, Victoria, Trilla, Antoni, Gómez, Begoña, González, Elisenda, Romero, Sheila, Gámez, Francisco Javier, Casals, Cristina, Burunat, Laura, Castelló, Juan José, Fernández, Patricia, Bedini, Josep Lluís, Vila, Jordi, Aguilar, Carla, Altadill, Carmen, Armadans, Lluis, Borras-Bermejo, Blanca, Calonge, Julia, Camacho, Lina, Feliu, Anna, Gili, Gisela, Llorente, Cesar, Martínez-Gómez, Xavier, Otero-Romero, Susana, Palacio, Esther, Parés, Oleguer, Pinós, Laia, Plaza, Aitana, Riera-Arnau, Judit, Rodrigo-Pendás, José Angel, Sans, Carla, Santos, José, Torres, Gloria, Torrens, Margarita, Uriona, Sonia, Ballarin Alins, Elena, Pérez Esquirol, Eulàlia, Vendrell Bosch, Lourdes, Laredo Velasco, Leonor, Uribe López, Diana, González Rojano, Esperanza, Sánchez-Craviotto, Manuel, Rivas Paterna, Ana Belén, Hernán-Gómez, Teresa Iglesias, Rodríguez Galán, Natalia, Gil Marín, José Antonio, Álvarez-Morales, Verónica, Navalpotro, Ana Belén, Jiménez-Santamaría, M Dolores, Cardós, M Carmen, Hermoso, Elena, García-Arenillas, Mar, Pérez Macías, Natalia, Domingo Fernández, Alexandra, López Picado, Amanda, Quiñones, Jorge Mario, Deidda, Nicoletta, García-Franco, Ana, Torvisco, José María, Borobia, Alberto M, Carcas, Antonio J, Pérez-Olmeda, Mayte, Castaño, Luis, Bertran, María Jesús, García-Pérez, Javier, Campins, Magdalena, Portolés, Antonio, González-Pérez, María, García Morales, María Teresa, Arana-Arri, Eunate, Aldea, Marta, Díez-Fuertes, Francisco, Fuentes, Inmaculada, Ascaso, Ana, Lora, David, Imaz-Ayo, Natale, Barón-Mira, Lourdes E, Agustí, Antonia, Pérez-Ingidua, Carla, Gómez de la Cámara, Agustín, Arribas, José Ramón, Ochando, Jordi, Alcamí, José, Belda-Iniesta, Cristóbal, and Frías, Jesús

Published
2021
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3. Socio-Demographic Health Determinants Are Associated with Poor Prognosis in Spanish Patients Hospitalized with COVID-19

Author

Martín-Sánchez, F. Javier, Valls Carbó, Adrián, Miró, Òscar, Llorens, Pere, Jiménez, Sònia, Piñera, Pascual, Burillo-Putze, Guillermo, Martín, Alfonso, García-Lamberechts, Jorge E., Jacob, Javier, Alquézar, Aitor, Martínez-Valero, Carmen, Miranda, Juan de D., López Picado, Amanda, Arrebola, Juan Pedro, López, Marta Esteban, Parviainen, Annika, González del Castillo, Juan, Miró, Oscar, Jimenez, Sonia, Ferreras Amez, José María, Rubio Díaz, Rafael, Gamazo del Rio, Julio Javier, Alonso, Héctor, Herrero, Pablo, Ruiz de Lobera, Noemí, Ibero, Carlos, Mayan, Plácido, Peinado, Rosario, Navarro Bustos, Carmen, Manzanares, Jesús Álvarez, Román, Francisco, Piñera, Pascual, Burillo, Guillermo, Jacob, Javier, and Bibiano, Carlos

Published
2021
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4. Project for the education and diagnosis of Gaucher disease and acid sphingomyelinase deficiency (PREDIGA-2)

Author

Amador, Agustin Pijierro, González, Eukene Gainza, Gómez, María Camprodón, García, Mª. Luisa Pérez, Lorenzo, Álvaro, Canal, Cristina Fernández, Canales, Elena Arranz, Marín, Javier López, Almeijeras, Álvaro Hermida, Lopez-Picado, Amanda, Rivera, Susana, Arcila, Tatiana Bohorquez, Miranda, David Puertas, and Villaseca, Berta Moyano

Published
2025
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5. Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department

Author

Martín-Sánchez, F. Javier, del Toro, Enrique, Cardassay, Eduardo, Valls Carbó, Adrián, Cuesta, Federico, Vigara, Marta, Gil, Pedro, López Picado, Amanda López, Martínez Valero, Carmen, Miranda, Juande D., Lopez-Ayala, Pedro, Chaparro, David, Cozar López, Gabriel, del Mar Suárez-Cadenas, María, Jerez Fernández, Pablo, Angós, Beatriz, Díaz del Arco, Cristina, Rodríguez Adrada, Esther, Montalvo Moraleda, María Teresa, Espejo Paeres, Carolina, Fernández Alonso, Cesáreo, Elvira, Carlos, Chacón, Ana, García Briñón, Miguel Ángel, Fernández Rueda, José Luis, Ortega, Luis, Fernández Pérez, Cristina, González Armengol, Juan Jorge, and González del Castillo, Juan

Published
2020
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7. Ultrarapid Insulin Use Can Reduce Postprandial Hyperglycemia and Late Hypoglycemia, Even in Delayed Insulin Injections: A Connected Insulin Cap-Based Real-World Study

Author

Gómez-Peralta, Fernando, primary, Valledor, Xoan, additional, López-Picado, Amanda, additional, Abreu, Cristina, additional, Fernández-Rubio, Elsa, additional, Cotovad, Laura, additional, Pujante, Pedro, additional, García-Fernández, Elena, additional, Azriel, Sharona, additional, Corcoy, Rosa, additional, Pérez-González, Jesús, additional, and Ruiz-Valdepeñas, Luis, additional

Published
2023
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8. Short-course antibiotic regimen compared to conventional antibiotic treatment for gram-positive cocci infective endocarditis: randomized clinical trial (SATIE)

Author

Olmos, Carmen, Vilacosta, Isidre, López, Javier, Sáez, Carmen, Anguita, Manuel, García-Granja, Pablo Elpidio, Sarriá, Cristina, Silva, Jacobo, Álvarez-Álvarez, Belén, Martínez-Monzonis, María Amparo, Castillo, Juan Carlos, Seijas, José, López-Picado, Amanda, Peral, Vicente, Maroto, Luis, and San Román, J. Alberto

Published
2020
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15. Efficacy, Safety and Cost-Effectiveness of Methotrexate, Adalimumab or Their Combination in Non-infectious Non-anterior Uveitis: A Protocol for a Multicentre, Randomised, Parallel Three Arms, Active-Controlled, Phase III Open Label With Blinded Outcome Assessment Study

Author

Rivas, Ana Belén, López-Picado, Amanda, Calamia, Valentina, Carreño, Ester, Cocho, Lidia, Cordero-Coma, Miguel, Fonollosa, Alex, Hernández, Félix M. Francisco, García-Aparicio, Ángel, García-González, Javier, Mondéjar, José Juan, Lojo-Oliveira, Leticia, Martínez-Costa, Llucí, Muñoz, Santiago, Peiteado, Diana, Pinto, José Antonio, Rodríguez-Lozano, Beatriz, Pato, Esperanza, Díaz-Valle, David, Molina, Elena, Tebar, Luis Alberto, Rodríguez-Rodríguez, Luis, CoTHEIA Study Group, Rivas, Ana Belén, López-Picado, Amanda, Calamia, Valentina, Carreño, Ester, Cocho, Lidia, Cordero-Coma, Miguel, Fonollosa, Alex, Hernández, Félix M. Francisco, García-Aparicio, Ángel, García-González, Javier, Mondéjar, José Juan, Lojo-Oliveira, Leticia, Martínez-Costa, Llucí, Muñoz, Santiago, Peiteado, Diana, Pinto, José Antonio, Rodríguez-Lozano, Beatriz, Pato, Esperanza, Díaz-Valle, David, Molina, Elena, Tebar, Luis Alberto, Rodríguez-Rodríguez, Luis, and CoTHEIA Study Group

Abstract

[Abstract] Introduction: Non-infectious uveitis include a heterogeneous group of sight-threatening and incapacitating conditions. Their correct management sometimes requires the use of immunosuppressive drugs (ISDs), prescribed in monotherapy or in combination. Several observational studies showed that the use of ISDs in combination could be more effective than and as safe as their use in monotherapy. However, a direct comparison between these two treatment strategies has not been carried out yet. Methods and analysis: The Combination THerapy with mEthotrexate and adalImumAb for uveitis (CoTHEIA) study is a phase III, multicentre, prospective, randomised, single-blinded with masked outcome assessment, parallel three arms with 1:1:1 allocation, active-controlled, superiority study design, comparing the efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis. We aim to recruit 192 subjects. The duration of the treatment and follow-up will last up to 52 weeks, plus 70 days follow-up with no treatment. The complete and maintained resolution of the ocular inflammation will be assessed by masked evaluators (primary outcome). In addition to other secondary measurements of efficacy (quality of life, visual acuity and costs) and safety, we will identify subjects’ subgroups with different treatment responses by developing prediction models based on machine learning techniques using genetic and proteomic biomarkers. Ethics and dissemination: The protocol, annexes and informed consent forms were approved by the Reference Clinical Research Ethic Committee at the Hospital Clínico San Carlos (Madrid, Spain) and the Spanish Agency for Medicines and Health Products. We will elaborate a dissemination plan including production of materials adapted to several formats to communicate the clinical trial progress and findings to a broad group of stakeholders. The promoter will be the only access to the participant-leve

Published
2022

16. Preoperative psychological profile of women with increased risk of breast cancer

Author

Luque Suárez, Sofía, Olivares Crespo, María Eugenia, Olivera Pérez-Frade, Helena, Brenes Sánchez, Juana María, López Picado, Amanda, de la Puente Yagüe, Miriam, Ruiz Rodríguez, Jorge, González Palomares, Blanca, Herrera de la Muela, María, Luque Suárez, Sofía, Olivares Crespo, María Eugenia, Olivera Pérez-Frade, Helena, Brenes Sánchez, Juana María, López Picado, Amanda, de la Puente Yagüe, Miriam, Ruiz Rodríguez, Jorge, González Palomares, Blanca, and Herrera de la Muela, María

Abstract

Aim: analyze depressive and anxiety symptomatology, body image and quality of life in a group of women with genetic vulnerability to breast cancer who were going to undergo a riskreducing mastectomy. Method:184 women participated in this study, all of whom had an increased risk of breast cancer, either because they were BRCA1/2 mutation carriers or because they had several affected relatives. The psychological instruments used were: Hospital Anxiety and Depression Scale, Body Image Scale, European Organization for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 and BR23. Results: The results of this study showed that the participants presented clinical anxiety symptomatology and subclinical depressive symptomatology. However, all the sample were at normative levels in body image and quality of life. Participants with previous diagnosis of cancer showed, higher dissatisfaction with their body image, lower levels on the scales of physical, and cognitive and global functioning on quality of life, as well as higher fatigue, more general pain also in the breast and in the arm compared to women without diagnosis. Conclusions: BRCA1/2 non-mutation carriers showed more symptomatology in the breast and in the arm fatigue than BRCA1/2 mutation carriers. BRCA1/2 mutation carriers had more economic difficulties than non-carriers. It is highly recommended a psychological intervention before a risk-reducing surgery., Objetivo: analizar los niveles de sintomatología ansiosa y depresiva, imagen corporal y calidad de vida en un grupo de mujeres con vulnerabilidad genética de cáncer de mama que se iban a someter a una mastectomía reductora de riesgo. Método: 184 mujeres participaron en este estudio, todas ellas tenían riesgo aumentado de cáncer de mama, bien por ser portadoras de una mutación BRCA1/2 o por agregación familiar. Los instrumentos utilizados fueron: Escala de Ansiedad y Depresión Hospitalaria, Escala de Imagen Corporal, European Organisation for Research and Treatment of Cancer calidad de vida oncológica C30 y BR23. Resultados: Los resultados de este estudio mostraron que las participantes presentaban niveles clínicos en sintomatología ansiosa y subclínicos en sintomatología depresiva. Sin embargo, se encontraban en niveles normativos en imagen corporal y calidad de vida. Las participantes con antecedentes oncológicos manifestaban, mayor insatisfacción con la imagen corporal, niveles inferiores en las escalas de funcionamiento físico, cognitivo y global de la calidad de vida, así como mayor fatiga, dolor general, en el brazo y en la mama en comparación con las mujeres sin diagnósticos previos. Conclusiones: Las mujeres sin mutación poseían mayor sintomatología en la mama y en el brazo que las mujeres con mutación, las cuales presentaban más dificultades económicas que las mujeres no portadoras. Evidenciando la necesidad de realizar una intervención psicológica antes de la cirugía especialmente en este colectivo.

Published
2022

17. Procalcitonin concentration in the emergency department predicts 30-day mortality in COVID-19 better than the lymphocyte count, the neutrophil-tolymphocyte ratio, or the C-reactive protein level

Author

López-Ayala, Pedro, Alcaraz-Serna, Ana, Valls Carbó, Adrián, Cuadrado Cenzual, Mª Ángeles, Torrejón Martínez, María José, López Picado, Amanda, Martínez Valero, Carmen, Miranda, Juande D., Díaz Del Arco, Cristina, Cozar López, Gabriel, Suárez-Cadenas, María Del Mar, Jerez Fernández, Pablo, Angós, Beatriz, Rodríguez Adrada, Esther, Cardassay, Eduardo, Del Toro, Enrique, Chaparro, David, Montalvo Moraleda, María Teresa, Espejo Paeres, Carolina, García Briñón, Miguel Ángel, Hernández Martín-Romo, Víctor, Ortega, Luis, Fernández Pérez, Cristina, Martínez-Novillo, Mercedes, González Armengol, Juan Jorge, González Del Castillo, Juan, Mueller, Christian E., Martín-Sánchez, F. Javier, and IdIssc-Covid-Taskforce

Published
2022
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20. Effect of Obesity and Roux-En-Y Gastric Surgery on Omeprazole Pharmacokinetics

Author

Portolés-Pérez, Antonio, primary, Paterna, Ana Belén Rivas, additional, Sánchez Pernaute, Andrés, additional, Torres García, Antonio José, additional, Moreno Lopera, Carmen, additional, Chicharro, Luis M., additional, Bandrés, Fernando, additional, López-Picado, Amanda, additional, Rubio, Miguel A., additional, and Castrillón, Emilio Vargas, additional

Published
2022
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21. Evaluation Of Pharyngeal Lidocaine Anesthesia For Esophagogastroduodenoscopy: A Double Blind Randomized Control Trial

Author

Martín‐Marcos, Irene, primary, Fernández‐Morte, Nuria, additional, Balsategui‐Martín, María, additional, Ortiz‐Cantero, Alexandra, additional, Bermúdez‐Ampudia, Cristina, additional, López‐Picado, Amanda, additional, Pérez‐Vaquero, Pilar, additional, Salvador‐Pérez, Marta, additional, and Cristóbal‐Domínguez, Estíbaliz, additional

Published
2021
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22. Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial

Author

Martín Sánchez, Francisco Javier, Parra Esquivel, Patricia, Llopis Garcia, Guillermo, Gonzalez del Castillo, Juan, Rodriguez Adrada, Esther, Espinosa, Begoña, López Diez, Maria Pilar, Romero Pareja, Rodolfo, Rizzi Bordigoni, Miguel Alberto, Pérez-Durá, Maria José, Bibiano, Carlos, Ferrer, Carles, Aguiló, Sira, Martín Mojarro, Enrique, Aguirre Tejedo, Alfons, Piñera, Pascual, López-Picado, Amanda, Llorens, Pere, Jacob, Javier, Gil, Víctor, Herrero Puente, Pablo, Fernandez Pérez, Cristina, Gil, Pedro, Calvo, Elpidio, Rossello, Xavier, Bueno, Hector, Burillo Putze, Guillermo, and Miró i Andreu, Òscar

Subjects
Aged, 80 and over, Heart Failure, Male, Acute heart failure., Aged., Anciano., Emergency department., Fragilidad., Frail elderly., Insuficiencia cardiaca aguda., Servicio de urgencias, Emergency department, Frail Elderly, Acute heart failure, Heart failure, Insuficiència cardíaca, Frail elderly, Persones grans, Patient Discharge, Serveis d'urgències hospitalàries, Acute Disease, Hospital emergency services, Humans, Female, Older people, Emergency Service, Hospital, Aged
Abstract

To study the effect of high-risk criteria on 30-day outcomes in frail older patients with acute heart failure (AHF) discharged from an emergency department (ED) or an ED's observation and short-stay areas.Secondary analysis of discharge records in the Older AHF Key Data registry. We selected frail patients (aged70 years) discharged with AHF from EDs. Risk factors were categorized as modifiable or nonmodifiable. The outcomes were a composite endpoint for a cardiovascular event (revisits for AHF, hospitalization for AHF, or cardiovascular death) and the number of days alive out-of-hospital (DAOH) within 30 days of discharge.We included 380 patients with a mean (SD) age of 86 (5.5) years (61.2% women). Modifiable risk factors were identified in 65.1%, nonmodifiable ones in 47.8%, and both types in 81.6%. The 30-day cardiovascular composite endpoint occurred in 83 patients (21.8%). The mean 30-day DAOH observed was 27.6 (6.1) days. Highrisk factors were present more often in patients who developed the cardiovascular event composite endpoint: the rates for patients with modifiable, nonmodifiable, or both types of risk were, respectively, as follows in comparison with patients not at high risk: 25.0% vs 17.2%, P = .092; 27.6% vs 16.7%, P = .010; and 24.7% vs 15.2%, P = .098). The 30-day DAOH outcome was also lower for at-risk patients, according to type of risk factor present: modifiable, 26.9 (7.0) vs 28.4 (4.4) days, P = .011; nonmodifiable, 27.1 (7.0) vs 28.0 (5.0) days, P = .127; and both, 27.1 (6.7) vs 28.8 (3.4) days, P = .005). After multivariate analysis, modifiable risk remained independently associated with fewer days alive (adjusted absolute difference in 30-day DAOH, -1.3 days (95% CI, -2.7 to -0.1 days). Nonmodifiable factors were associated with increased risk for the 30-day cardiovascular composite endpoint (adjusted absolute difference, 10.4%; 95% CI, -2.1% to 18.7%).Risk factors are common in frail elderly patients with AHF discharged home from hospital ED areas. Their presence is associated with a worse 30-day prognosis.Estudiar el efecto a 30 días de los criterios de alto riesgo (CAR) en los mayores frágiles con insuficiencia cardiaca aguda (ICA) dados de alta desde urgencias o unidades vinculadas (URG_UV).Análisis secundario del registro OAK-Discharge. Se seleccionaron pacientes frágiles 70 años con ICA dados de alta desde URG_UV. Los CAR se clasificaron en modificables (CAR_M) y no modificables (CAR_NM). Las variables de resultado fueron la compuesta cardiovascular (VC_CV) (revisita u hospitalización por ICA o mortalidad cardiovascular) y días vivos fuera del hospital (DVFH) a 30 días del alta.Se incluyeron 380 pacientes con una edad media de 86 (DE 5,5) años, 61,2% mujeres. Un 65,1% tuvo CAR_M, 47,8% CAR_NM y 81,6% ambos. Ochenta y tres pacientes (21,8%) presentaron la VC_CV a 30 días. La media de DVFH a 30 días fue de 27,6 (DE 6,1) días. La presencia de CAR modificable, no modificable o ambos, se asoció más frecuentemente a la VC_CV a 30 días (25,0% vs 17,2%, p = 0,092; 27,6% vs 16,7%, p = 0,010; 24,7% vs 15,2%, p = 0,098) y a menos DVFH a 30 días [26,9 (7,0) vs 28,4 (4,4), p = 0,011; 27,1 (7,0) vs 28,0 (5,0), p = 0,127; 27,1 (6,7) vs 28,8 (3,4), p = 0,005], respectivamente. Tras el análisis multivariante, los CAR_M se asociaron de forma independiente con menos DVFH a 30 días (diferencia absoluta ajustada –1,3 días; IC 95% –2,7 a –0,1) y los CAR_NM con más eventos en la VC_CV a 30 días (diferencia absoluta ajustada 10,4%; IC 95% 2,1% a 18,7%).Los CAR son frecuentes en los mayores frágiles con ICA dados de alta desde URG_UV y su presencia se asocia a peores resultados a 30 días tras alta.

Published
2021

23. Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial

Author

Borobia, Alberto M, primary, Carcas, Antonio J, additional, Pérez-Olmeda, Mayte, additional, Castaño, Luis, additional, Bertran, María Jesús, additional, García-Pérez, Javier, additional, Campins, Magdalena, additional, Portolés, Antonio, additional, González-Pérez, María, additional, García Morales, María Teresa, additional, Arana-Arri, Eunate, additional, Aldea, Marta, additional, Díez-Fuertes, Francisco, additional, Fuentes, Inmaculada, additional, Ascaso, Ana, additional, Lora, David, additional, Imaz-Ayo, Natale, additional, Barón-Mira, Lourdes E, additional, Agustí, Antonia, additional, Pérez-Ingidua, Carla, additional, Gómez de la Cámara, Agustín, additional, Arribas, José Ramón, additional, Ochando, Jordi, additional, Alcamí, José, additional, Belda-Iniesta, Cristóbal, additional, Frías, Jesús, additional, Martínez de Soto, Lucía, additional, Rodríguez Mariblanca, Amelia, additional, Díaz García, Lucía, additional, Ramírez García, Elena, additional, Seco Meseguer, Enrique, additional, Stewart Balbás, Stefan Mark, additional, Marín Candón, Alicia, additional, García García, Irene, additional, Urroz Elizalde, Mikel, additional, Monserrat Villatoro, Jaime, additional, de la Rosa, Paula, additional, Sanz García, Marta, additional, López Crespo, Cristina, additional, Mauleón Martínez, Vega, additional, de Madariaga Castell, Raquel, additional, Vitón Vara, Laura, additional, García Rodríguez, Julio, additional, Buño, Antonio, additional, López Granados, Eduardo, additional, Cámara, Carmen, additional, Rey Cuevas, Esther, additional, Ayllon García, Pilar, additional, Jiménez González, María, additional, Hernández Rubio, Victoria, additional, Moraga Alapont, Paloma, additional, Sánchez, Amparo, additional, Prieto, Rocío, additional, Llorente Gómez, Silvia, additional, Miragall Roig, Cristina, additional, Aparicio Marlasca, Marina, additional, de la Calle, Fernando, additional, Arsuaga, Marta, additional, Duque, Blanca, additional, Meijide, Susana, additional, García de Vicuña, Aitor, additional, Santorcuato, Ana, additional, Expósito, Iraide, additional, de Benito, Sara, additional, Andia, Joseba, additional, Castillo, Cristina, additional, Irurzun, Esther, additional, Camino, Jesús, additional, Temprano, Mikel, additional, Goikoetxea, Josune, additional, Bustinza, Alazne, additional, Larrea, Maialen, additional, Gallego, Mikel, additional, García-Vázquez, Dolores, additional, de la Hoz, Ana Belén, additional, Pérez-Nanclares, Gustavo, additional, Pérez-Guzmán, Estíbaliz, additional, Idoyaga, Eneko, additional, Lamela, Adriana, additional, Oteo, Jesús, additional, Castillo de la Osa, María, additional, Hernández Gutiérrez, Lourdes, additional, Andrés Galván, María Elena, additional, Calonge, Esther, additional, Bermejo, Mercedes, additional, de la Torre-Tarazona, Erick Humberto, additional, Cascajero, Almudena, additional, Fedele, Giovanni, additional, Perea, Concepción, additional, Cervera, Isabel, additional, Bodega-Mayor, Irene, additional, Montes-Casado, María, additional, Portolés, Pilar, additional, Baranda, Jana, additional, Granés, Laura, additional, Lazaar, Sulayman, additional, Herranz, Sara, additional, Mellado, María Eugènia, additional, Tortajada, Marta, additional, Malet, Montserrat, additional, Quesada, Sebastiana, additional, Vilella, Anna, additional, Llupià, Anna, additional, Olivé, Victoria, additional, Trilla, Antoni, additional, Gómez, Begoña, additional, González, Elisenda, additional, Romero, Sheila, additional, Gámez, Francisco Javier, additional, Casals, Cristina, additional, Burunat, Laura, additional, Castelló, Juan José, additional, Fernández, Patricia, additional, Bedini, Josep Lluís, additional, Vila, Jordi, additional, Aguilar, Carla, additional, Altadill, Carmen, additional, Armadans, Lluis, additional, Borras-Bermejo, Blanca, additional, Calonge, Julia, additional, Camacho, Lina, additional, Feliu, Anna, additional, Gili, Gisela, additional, Llorente, Cesar, additional, Martínez-Gómez, Xavier, additional, Otero-Romero, Susana, additional, Palacio, Esther, additional, Parés, Oleguer, additional, Pinós, Laia, additional, Plaza, Aitana, additional, Riera-Arnau, Judit, additional, Rodrigo-Pendás, José Angel, additional, Sans, Carla, additional, Santos, José, additional, Torres, Gloria, additional, Torrens, Margarita, additional, Uriona, Sonia, additional, Ballarin Alins, Elena, additional, Pérez Esquirol, Eulàlia, additional, Vendrell Bosch, Lourdes, additional, Laredo Velasco, Leonor, additional, Uribe López, Diana, additional, González Rojano, Esperanza, additional, Sánchez-Craviotto, Manuel, additional, Rivas Paterna, Ana Belén, additional, Hernán-Gómez, Teresa Iglesias, additional, Rodríguez Galán, Natalia, additional, Gil Marín, José Antonio, additional, Álvarez-Morales, Verónica, additional, Navalpotro, Ana Belén, additional, Jiménez-Santamaría, M Dolores, additional, Cardós, M Carmen, additional, Hermoso, Elena, additional, García-Arenillas, Mar, additional, Pérez Macías, Natalia, additional, Domingo Fernández, Alexandra, additional, López Picado, Amanda, additional, Quiñones, Jorge Mario, additional, Deidda, Nicoletta, additional, García-Franco, Ana, additional, and Torvisco, José María, additional

Published
2021
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24. Clinical Characteristics, Treatment Approach and Long-Term Outcomes of 678 Patients with Symptomatic Waldenstrom's Macroglobulinemia: Comprehensive Insights from a Spanish Registry of IgM Gammapathies

Author

Askari, Elham, Moreno, David F., Escalante, Fernando, Domingo-González, Amalia, Heredia, Angela, Bermúdez, Arancha, Canales, Miguel, Herraiz, Mario Arnao, Alcala Peña, Maria Magdalena, Saus Carreres, Ana, Ríos Rull, Pablo, Casanova, María, Gironella, Mercedes, Ribas Garcia, Paz, De La Rubia, Javier, Navarro, Belén, Blanchard, María-Jesús, Motlló, Cristina, García Sánchez, Ricarda, Taboada Alameda, Francisco, Garcia, Antonio, Abella, Eugenio, Alvarez Rivas, Miguel Angel, Bargay, Joan, Sabater, Laura Abril, Lopez Picado, Amanda, Fernández de Larrea, Carlos, and Garcia-Sanz, Ramon

Published
2023
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25. Socio-Demographic Health Determinants Are Associated with Poor Prognosis in Spanish Patients Hospitalized with COVID-19

Author

Ministerio de Economía y Competitividad (España), Martín-Sánchez, F. Javier, Valls Carbó, Adrián, Miró, Oscar, Llorens, Pere, Jiménez, Sonia, Piñera, Pascual, Burillo-Putze, Guillermo, Martín, Alfonso, García-Lamberechts, Jorge E., Jacob, Javier, Alquézar, Aitor, Martínez-Valero, Carmen, Miranda, Juan de D., López Picado, Amanda, Arrebola, Juan Pedro, Esteban López, Marta, Parviainen, Annika, González del Castillo, Juan, Ferreras Amez, José María, Rubio Díaz, Rafael, Gamazo del Rio, Julio Javier, Alonso, Héctor, Herrero-Gómez, P., Ruiz de Lobera, Noemí, Ibero, Carlos, Mayan, Plácido, Peinado, Rosario, Navarro Bustos, Carmen, Álvarez Manzanares, Jesús, Román, Francisco, Bibiano, Carlos, Ministerio de Economía y Competitividad (España), Martín-Sánchez, F. Javier, Valls Carbó, Adrián, Miró, Oscar, Llorens, Pere, Jiménez, Sonia, Piñera, Pascual, Burillo-Putze, Guillermo, Martín, Alfonso, García-Lamberechts, Jorge E., Jacob, Javier, Alquézar, Aitor, Martínez-Valero, Carmen, Miranda, Juan de D., López Picado, Amanda, Arrebola, Juan Pedro, Esteban López, Marta, Parviainen, Annika, González del Castillo, Juan, Ferreras Amez, José María, Rubio Díaz, Rafael, Gamazo del Rio, Julio Javier, Alonso, Héctor, Herrero-Gómez, P., Ruiz de Lobera, Noemí, Ibero, Carlos, Mayan, Plácido, Peinado, Rosario, Navarro Bustos, Carmen, Álvarez Manzanares, Jesús, Román, Francisco, and Bibiano, Carlos

Abstract

Introduction Social vulnerability is a known determinant of health in respiratory diseases. Our aim was to identify whether there are socio-demographic factors among COVID-19 patients hospitalized in Spain and their potential impact on health outcomes during the hospitalization. Methods A multicentric retrospective case series study based on administrative databases that included all COVID-19 cases admitted in 19 Spanish hospitals from 1 March to 15 April 2020. Socio-demographic data were collected. Outcomes were critical care admission and in-hospital mortality. Results We included 10,110 COVID-19 patients admitted to 18 Spanish hospitals (median age 68 (IQR 54–80) years old; 44.5% female; 14.8% were not born in Spain). Among these, 779 (7.7%) cases were admitted to critical care units and 1678 (16.6%) patients died during the hospitalization. Age, male gender, being immigrant, and low hospital saturation were independently associated with being admitted to an intensive care unit. Age, male gender, being immigrant, percentile of average per capita income, and hospital experience were independently associated with in-hospital mortality. Conclusions Social determinants such as residence in low-income areas and being born in Latin American countries were associated with increased odds of being admitted to an intensive care unit and of in-hospital mortality. There was considerable variation in outcomes between different Spanish centers.

Published
2021

27. Evaluation of pharyngeal lidocaine anesthesia for esophagogastroduodenoscopy: Double‐blind randomized control trial.

Author

Martín‐Marcos, Irene, Fernández‐Morte, Nuria, Balsategui‐Martín, María, Ortiz‐Cantero, Alexandra, Bermúdez‐Ampudia, Cristina, López‐Picado, Amanda, Pérez‐Vaquero, Pilar, Salvador‐Pérez, Marta, and Cristóbal‐Domínguez, Estíbaliz

Subjects
LIDOCAINE, DIGESTIVE system endoscopic surgery, CLINICAL trials, ANESTHESIA, LOCAL anesthesia
Abstract

Objectives: The aim of this study was to assess whether the use of topical pharyngeal anesthesia improves endoscopist‐ and patient‐reported tolerance and satisfaction, the total dose of propofol used and the rate of adverse effects associated with this procedure. Methods: This double‐blind randomized clinical trial was conducted in patients undergoing elective oesophagogastroduodenoscopy, who met the inclusion criteria. Patients were randomly assigned to receive five squirts of lidocaine 10% spray (50 mg, n = 268) or placebo (n = 271) 3 min before starting the procedure or sedation. The main outcome measures were patient‐ and endoscopist‐reported tolerance, and additionally, satisfaction with the procedure, adverse events and supplementary propofol used. Results: In the lidocaine group, it was twice (odds ratio [OR] 2.136, 95% confidence interval [CI] 1.228–3.715) or three times (OR 3.311, 95% CI 1.623–6.757) more likely that the endoscopist rated the procedure as well tolerated and easy to intubate than as well tolerated but the patient difficult to intubate or as poorly tolerated, respectively. Further, in these patients, less propofol was used (80 vs. 100 mg, P = 0.001). Controls were more likely to cough during the intubation (OR 2.172, 95% CI 1.378–3.423) and the procedure (OR 1.989, 95% CI 1.325–2.984), as well as more likely to retch (OR 3.582, 95% CI 1.667–7.7). Conclusions: Topical lidocaine may improve the procedure as rated by the endoscopist, as well as reduce the requirement for propofol and rate of adverse events such as retching and coughing. No adverse events associated with lidocaine administration were observed. ClinicalTrials registration no. NCT02733471. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Procalcitonina es superior a recuento linfocitario, índice neutrófilo/linfocito y proteína C reactiva para la predicción de mortalidad a 30 días de pacientes con COVID-19 en el servicio de urgencias.

Author

López-Ayala, Pedro, Alcaraz-Serna, Ana, Valls Carbó, Adrián, Cuadrado Cenzual, Mª Ángeles, Torrejón Martínez, María José, López Picado, Amanda, Martínez Valero, Carmen, Miranda, Juande D., Díaz del Arco, Cristina, Cozar López, Gabriel, Suárez-Cadenas, María del Mar, Jerez Fernández, Pablo, Angós, Beatriz, Rodríguez Adrada, Esther, Cardassay, Eduardo, del Toro, Enrique, Chaparro, David, Montalvo Moraleda, María Teresa, Espejo Paeres, Carolina, and García Briñón, Miguel Ángel

Published
2022

29. Resultados a 30 días en los pacientes mayores frágiles con insuficiencia cardiaca aguda dados de alta desde urgencias o sus unidades vinculadas que cumplen los criterios de alto riesgo del estudio DEED FRAIL-AHF.

Author

Martín-Sánchez, Francisco Javier, Parra Esquivel, Patricia, Llopis García, Guillermo, González del Castillo, Juan, Rodríguez Adrada, Esther, Espinosa, Begoña, López Díez, María Pilar, Romero Pareja, Rodolfo, Rizzi Bordigoni, Miguel Alberto, Pérez-Durá, María José, Bibiano, Carlos, Ferrer, Carles, Aguiló, Sira, Mojarro, Enrique Martín, Aguirre, Alfons, Piñera, Pascual, López-Picado, Amanda, Llorens, Pere, Jacob, Javier, and Gil, Víctor

Published
2021

30. Categorías diagnósticas y resultados a corto plazo en los pacientes con sospecha de COVID-19 atendidos en un servicio de urgencias.

Author

Martín-Sánchez, F. Javier, González del Castillo, Juan, Carbó, Adrián Valls, López Picado, Amanda, Martínez-Valero, Carmen, Miranda, Juande D., Chacón, Ana, López-Ayala, Pedro, Chaparro, David, Cozar López, Gabriel, del Mar Suárez-Cadenas, María, Jerez Fernández, Pablo, del Toro, Enrique, Cardassay, Eduardo, Angós, Beatriz, Díaz del Arco, Cristina, Rodríguez Adrada, Esther, Montalvo Moraleda, María Teresa, Espejo Paeres, Carolina, and Elvira, Carlos

Published
2020

31. Impact of Spanish Public Health Measures on Emergency Visits and COVID- 19 diagnosed cases during the pandemic in Madrid.

Author

Javier Martín-Sánchez, Francisco, Valls Carbó, Adrián, López Picado, Amanda, Martínez-Valero, Carmen, Miranda, Juande D., Leal Pozuleo, José María, and González del Castillo, Juan

Subjects
COVID-19 pandemic, PUBLIC health, POLYMERASE chain reaction, EPIDEMIOLOGY
Abstract

Copyright of Revista Española de Quimioterapia is the property of Sociedad Espanola de Quimioterapia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020
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32. Validación de una regla de predicción clínica para la discriminación desde atención primaria del Síndrome de Apneas e Hipopneas durante el sueño (SAHS) de bajo (IAH<15) y alto (IAH>30) riesgo

Author

López Picado, Amanda and Abecia Inchaurregui, Luis Carlos

Subjects
salud pública, public health, epidemiology, pharmacology, farmacología, epidemiología
Abstract

209 p., ANTECEDENTES Y OBJETIVO: El SAHS es una enfermedad prevalente para la cual existen reglas de predicción clínica (RCP) pero de difícil aplicabilidad en atención primaria (AP). Este estudio plantea la derivación y validación de una RCP para su manejo utilizando mediciones sencillas disponibles en AP.MATERIAL Y METODOS: Estudio prospectivo realizado en los centros de salud del área de influencia de 3 hospitales. Se incluyeron pacientes entre 18 y 70 años que acudían a consulta por cualquier motivo y tenían al menos uno síntomas guía del SAHS, tras recoger la información fueron remitidos a la unidad de sueño donde se decidía la instauración o no de tratamiento.Se construyó un modelo logístico multivariante con una submuestra y se validó la RPC con el resto de la muestra. RESULTADOS:352 pacientes conformaron la muestra de derivación y 260 la de validación. La RPC constaba de 4 factores (hipertensión arterial, edad, IMC y sexo). El punto de corte que optimiza el área bajo la curva es ¿2,5 puntos ¿AUC=0,78; sensibilidad=86%; especificidad=54%; VPP=45%; VPN=90%. Con ese punto de corte, las propiedades en la submuestra de validación son: AUC=0,68; sensibilidad=81%; especificidad=43%; VPP=61%; VPN=68%.CONCLUSIONES: Como otras casos, la especificidad es baja, por lo que se derivan personas sanas. Sin embargo, un resultado negativo descarta la enfermedad en la mayoría de los casos.

Published
2017

33. El cuerpo como objeto de deseo en obesos mórbidos con antecedentes de abuso sexual

Author

Mazagatos, Begoña, Ingles-Borda, Sandra, and López-Picado, Amanda

Subjects
abusos sexuales, body image, obesidad mórbida, sexual abuse, imagen corporal, morbid obesity
Abstract

Introducción: La imagen corporal del obeso mórbido puede ser usada como factor de protección frente a la sexualidad. Se ha hipotetizado que los sujetos con antecedentes de abuso sexual serían más proclives a utilizar la obesidad mórbida en este sentido. Acercarnos a la verificación de esta hipótesis en una muestra de 398 pacientes con obesidad mórbida que solicitan intervención de cirugía bariátrica. Método: Entrevista semiestructurada con recogida sistemática de datos, de los abusos sufridos y de las vivencias y repercusiones de la obesidad en las relaciones sexuales de los pacientes. Resultados: la mayoría de los pacientes entrevistados con antecedentes de abusos sexuales eran mujeres (n=39; 88,6%). Los pacientes con antecedentes de abusos sexuales presentaban una comorbilidad psiquiátrica mayor y menor autoestima (2.60 OR (1,32-5,13)) aunque la obesidad no representaba un problema en sus relaciones sexuales 1.52 (0,71-3,24)). Conclusión: La utilización de la imagen corporal del obeso como barrera de protección ante la sexualidad no requiere del antecedente de abuso sexual. Background: Morbid obesity may use their body image in order to avoid attracting erotic attention. Some authors have suggest that people who have been sexually abused are likely to used their body image in that way. We try to attempt to verify this hypothesis in a sample of 398 morbidly obese patients who requested bariatric surgery. Method: A semi-structured interview with systematic collection of information regarding the abuse suffered and the experiences and repercussions of obesity on the patients' sexual relations. Results: The majority of patients interviewed with a history of abuse were women (n=39; 88.6%). Patients with a history of sexual abuse presented higher psychiatric comorbidity and lower self-esteem (2.60 (1.32-5.13)), although the belief and convictions of interference of their body image in their sexuality was similar to those who had not suffered sexual abuse (1.52 (0.71-3.24)). Conclusion: The use of an obese subject's body image as a protective barrier against sexuality does not require a history of sexual abuse.

Published
2015

34. Validación de una regla de predicción clínica para la discriminación desde atención primaria del Síndrome de Apneas e Hipopneas durante el sueño (SAHS) de bajo (IAH<15) y alto (IAH>30) riesgo

Author

Abecia Inchaurregui, Luis Carlos, Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, López Picado, Amanda, Abecia Inchaurregui, Luis Carlos, Medicina preventiva y salud pública, Prebentzio medikuntza eta osasun publikoa, and López Picado, Amanda

Abstract

209 p., ANTECEDENTES Y OBJETIVO: El SAHS es una enfermedad prevalente para la cual existen reglas de predicción clínica (RCP) pero de difícil aplicabilidad en atención primaria (AP). Este estudio plantea la derivación y validación de una RCP para su manejo utilizando mediciones sencillas disponibles en AP.MATERIAL Y METODOS: Estudio prospectivo realizado en los centros de salud del área de influencia de 3 hospitales. Se incluyeron pacientes entre 18 y 70 años que acudían a consulta por cualquier motivo y tenían al menos uno síntomas guía del SAHS, tras recoger la información fueron remitidos a la unidad de sueño donde se decidía la instauración o no de tratamiento.Se construyó un modelo logístico multivariante con una submuestra y se validó la RPC con el resto de la muestra. RESULTADOS:352 pacientes conformaron la muestra de derivación y 260 la de validación. La RPC constaba de 4 factores (hipertensión arterial, edad, IMC y sexo). El punto de corte que optimiza el área bajo la curva es ¿2,5 puntos ¿AUC=0,78; sensibilidad=86%; especificidad=54%; VPP=45%; VPN=90%. Con ese punto de corte, las propiedades en la submuestra de validación son: AUC=0,68; sensibilidad=81%; especificidad=43%; VPP=61%; VPN=68%.CONCLUSIONES: Como otras casos, la especificidad es baja, por lo que se derivan personas sanas. Sin embargo, un resultado negativo descarta la enfermedad en la mayoría de los casos.

Published
2017

36. Planificación del alta desde urgencias para reducir eventos adversos a 30 días en pacientes mayores frágiles con insuficiencia cardiaca aguda: diseño y justificación del ensayo clínico DEED FRAIL-AHF.

Author

Martín-Sánchez, Francisco Javier, García, Guillermo Llopis, Llorens, Pere, Jacob, Javier, Herrero, Pablo, Gil, Víctor, Pastor, Antoni Juan, López-Picado, Amanda, Ferrer, Manuel Fuentes, Rosselló, Xavier, Gil, Pedro, Villanueva, Pablo Díez, Calvo, Elpidio, Bailón, Manuel Méndez, Cuesta-Triana, Federico, González Armengol, Juan Jorge, del Castillo, Juan González, Runtkle, Isabelle, Vidán, Ma. Teresa, and Comín-Colet, Josep

Published
2019

37. Fitoterapia como coadyuvante en el tratamiento de la obesidad

Author

López-Regueiro, Sofía, Ramos Sáiz, Eva María, López-Picado, Amanda, Burgos-Alonso, Natalia, and Arana-Salaberría, Ainara

Subjects
Fitoterapia, obesidad, tratamiento, fucus, garcinia, diuréticos, té, plantago, glucomanano, opuntia
Abstract

La obesidad es uno de los problemas de salud más importantes a nivel mundial debido a su relación con numerosas patologías como la diabetes mellitus tipo 2, la hipertensión y el aumento importante en el riesgo cardiovascular. La base del tratamiento es la dieta y el ejercicio físico, pero en muchos casos no es sufi ciente y es necesario combinarlo con tratamiento farmacológico. Recientemente se ha retirado sibutramina del mercado por lo que sólo se dispone de orlistat, que no está exento de contraindicaciones y efectos secundarios. Ante esta situación, se ha vuelto a retomar el tratamiento fi toterápico, aunque, en muchas ocasiones, con numerosas dudas. Esta revisión pretende aportar la información necesaria sobre las principales plantas utilizadas en este tratamiento.

Published
2013

39. Dispensación de medicamentos hipolipemiantes en seis oficinas de farmacia de Vizcaya

Author

Burgos-Alonso, Natalia, López-Picado, Amanda, and Abecia Inchaurregui, Luis Carlos

Subjects
Hipolipemiantes, dispensación, encuesta
Abstract

Las enfermedades cardiovasculares (ECV) son la primera causa de muerte en nuestro país, provocando en torno al 40% del total de fallecimientos1. El mantenimiento de las tasas de colesterolemia en valores normales se asocia en términos generales a una disminución de la incidencia y mortalidad por cardiopatía isquémica y ECV2. El control del colesterol plasmático se ha convertido en una medida preventiva de primer orden para la cual, además de la elección de una dieta adecuada y hábitos de vida saludables, como no fumar o practicar ejercicio físico, se cuenta con un grupo específico de medicamentos: los hipolipemiantes. Estos fármacos son útiles en la prevención y tratamiento de las enfermedades cardiovasculares, constituyendo el grupo de fármacos que más coste supone al Sistema Nacional de Salud. Su prescripción ha sufrido un aumento importante en los últimos años debido probablemente al sobrepeso, sedentarismo y aumento de la esperanza de vida en los países industrializados. El objetivo de nuestro estudio ha sido conocer las características del consumo de fármacos hipolipemiantes mediante encuestas a los pacientes en seis farmacias comunitarias en la provincia de Vizcaya.

Published
2011

42. Intervención farmacéutica en gestante: Derivación al médico para modificar la posición del feto

Author

Pérez-Francisco, Inés, López-Picado, Amanda, Burgos-Alonso, Natalia, Guerra Merino, Sandra, and Muñoz Hernández, Henar

Subjects
Indicación farmacéutica, versión externa, cesárea, dolor
Abstract

Se presenta en la farmacia una paciente habitual cuyo primer embarazo hemos seguido desde el principio. Durante los meses de gestación, la mujer no ha sufrido ningún problema importante, pero nos comenta que en la última ecografía el ginecólogo le ha informado que el feto se encuentra de nalgas y que es posible que le tengan que realizar una cesárea. La gestante se encuentra asustada ya que desea tener un parto natural por vía vaginal y nos pregunta si existe alguna técnica que ayude a colocar el feto, evitando la cesárea.

Published
2010

44. Inducción con propofol: infusión controlada por objetivo o manual. Un estudio observacional.

Author

Laso, Lourdes Ferreira, López-Picado, Amanda, de la Fuente, Erika Olea, Murua, Ana Mendiguren, Sánchez-Castro, Clara, Ruilope, Lorena Pipaon, and Valero-Martínez, César

Abstract

Copyright of Colombian Journal of Anesthesiology / Revista Colombiana de Anestesiología is the property of Sociedad Colombiana de Anestesiologia y Reanimacion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2016
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46. Tratamiento de la neumonía adquirida en la comunidad en hospitalización a domicilio: resultado clínico en casos con diferente nivel de gravedad

Author

Regalado de Los Cobos, José, primary, Aizpuru Barandiaran, Felipe, additional, Oceja Barrutieta, Esther, additional, de Juan Rodríguez, María, additional, Apraiz Ruiz, Leire, additional, Altuna Basurto, Elena, additional, Gomez Rodríguez de Mendarozqueta, Montserrat, additional, López-Picado, Amanda, additional, and Cia Ruiz, Juan Miguel, additional

Published
2010
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48. Desprendimiento de placenta como complicación de la versión cefálica externa: a propósito de un caso.

Author

Muñoz, Henar, López-Picado, Amanda, and Guerra, Sandra

Subjects
CASE studies, ABRUPTIO placentae, PREGNANCY, INFANTS, BREECH delivery
Abstract

Copyright of Matronas Profesion is the property of Ediciones Mayo and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011

49. Procalcitonin concentration in the emergency department predicts 30-day mortality in COVID-19 better than the lymphocyte count, the neutrophil-tolymphocyte ratio, or the C-reactive protein level.

Author

López-Ayala P, Alcaraz-Serna A, Valls Carbó A, Cuadrado Cenzual MÁ, Torrejón Martínez MJ, López Picado A, Martínez Valero C, Miranda JD, Díaz Del Arco C, Cozar López G, Suárez-Cadenas MDM, Jerez Fernández P, Angós B, Rodríguez Adrada E, Cardassay E, Del Toro E, Chaparro D, Montalvo Moraleda MT, Espejo Paeres C, García Briñón MÁ, Hernández Martín-Romo V, Ortega L, Fernández Pérez C, Martínez-Novillo M, González Armengol JJ, González Del Castillo J, Mueller CE, and Martín-Sánchez FJ

Subjects
Aged, C-Reactive Protein analysis, Calcitonin, Emergency Service, Hospital, Humans, Lymphocyte Count, Male, Middle Aged, Neutrophils chemistry, Retrospective Studies, COVID-19 diagnosis, Procalcitonin
Abstract

Objectives: Although many demographic and clinical predictors of mortality have been studied in relation to COVID-19, little has been reported about the prognostic utility of inflammatory biomarkers., Material and Methods: Retrospective cohort study. All patients with laboratory-confirmed COVID-19 treated in a hospital emergency department were included consecutively if baseline measurements of the following biomarkers were on record: lymphocyte counts, neutrophil-to-lymphocyte ratio NRL, and C-reactive protein (CRP) and procalcitonin (PCT) levels. We analyzed associations between the biomarkers and all-cause 30-day mortality using Cox regression models and dose-response curves., Results: We included 896 patients, 151 (17%) of whom died within 30 days. The median (interquartile range) age was 63 (51-78) years, and 494 (55%) were men. NLR, CRP and PCT levels at ED presentation were higher, while lymphocyte counts were lower, in patients who died compared to those who survived (P .001). The areas under the receiver operating characteristic curves revealed the PCT concentration (0.79; 95% CI, 0.75-0.83) to be a better predictor of 30-day mortality than the lymphocyte count (0.70; 95% CI, 0.65-0.74; P .001), the NLR (0.74; 95% CI, 0.69-0.78; P = .03), or the CRP level (0.72; 95% CI, 0.68-0.76; P .001). The proposed PCT concentration decision points for use in emergency department case management were 0.06 ng/L (negative) and 0.72 ng/L (positive). These cutoffs helped classify risk in 357 patients (40%). Multivariable analysis demonstrated that the PCT concentration had the strongest association with mortality., Conclusion: PCT concentration in the emergency department predicts all-cause 30-day mortality in patients with COVID-19 better than other inflammatory biomarkers.

Published
2022

50. Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial.

Author

Martín-Sánchez FJ, Parra Esquivel P, Llopis García G, González Del Castillo J, Rodríguez Adrada E, Espinosa B, López Díez MP, Romero Pareja R, Rizzi Bordigoni MA, Pérez-Durá MJ, Bibiano C, Ferrer C, Aguiló S, Martín Mojarro E, Aguirre A, Piñera P, López-Picado A, Llorens P, Jacob J, Gil V, Herrero P, Fernández Pérez C, Gil P, Calvo E, Rosselló X, Bueno H, Burillo G, and Miró Ò

Subjects
Acute Disease, Aged, Aged, 80 and over, Emergency Service, Hospital, Female, Frail Elderly, Humans, Male, Heart Failure epidemiology, Patient Discharge
Abstract

Objectives: To study the effect of high-risk criteria on 30-day outcomes in frail older patients with acute heart failure (AHF) discharged from an emergency department (ED) or an ED's observation and short-stay areas., Material and Methods: Secondary analysis of discharge records in the Older AHF Key Data registry. We selected frail patients (aged > 70 years) discharged with AHF from EDs. Risk factors were categorized as modifiable or nonmodifiable. The outcomes were a composite endpoint for a cardiovascular event (revisits for AHF, hospitalization for AHF, or cardiovascular death) and the number of days alive out-of-hospital (DAOH) within 30 days of discharge., Results: We included 380 patients with a mean (SD) age of 86 (5.5) years (61.2% women). Modifiable risk factors were identified in 65.1%, nonmodifiable ones in 47.8%, and both types in 81.6%. The 30-day cardiovascular composite endpoint occurred in 83 patients (21.8%). The mean 30-day DAOH observed was 27.6 (6.1) days. Highrisk factors were present more often in patients who developed the cardiovascular event composite endpoint: the rates for patients with modifiable, nonmodifiable, or both types of risk were, respectively, as follows in comparison with patients not at high risk: 25.0% vs 17.2%, P = .092; 27.6% vs 16.7%, P = .010; and 24.7% vs 15.2%, P = .098). The 30-day DAOH outcome was also lower for at-risk patients, according to type of risk factor present: modifiable, 26.9 (7.0) vs 28.4 (4.4) days, P = .011; nonmodifiable, 27.1 (7.0) vs 28.0 (5.0) days, P = .127; and both, 27.1 (6.7) vs 28.8 (3.4) days, P = .005). After multivariate analysis, modifiable risk remained independently associated with fewer days alive (adjusted absolute difference in 30-day DAOH, -1.3 days (95% CI, -2.7 to -0.1 days). Nonmodifiable factors were associated with increased risk for the 30-day cardiovascular composite endpoint (adjusted absolute difference, 10.4%; 95% CI, -2.1% to 18.7%)., Conclusion: Risk factors are common in frail elderly patients with AHF discharged home from hospital ED areas. Their presence is associated with a worse 30-day prognosis.

Published
2021

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