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1. A case–control study of the clinical and economic impact of infections caused by Carbapenemase-producing Enterobacterales (CPE)

Author: López Montesinos, Inmaculada, Carot-Coll, Aina, Montero, Maria Milagro, Sorli Redó, Luisa, Siverio-Parès, Ana, Esteban-Cucó, Sandra, Durán, Xavier, Gomez-Zorrilla, Silvia, and Horcajada, Juan Pablo
Published: 2024
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2. Safety and efficacy of favipiravir in COVID-19 patients with pneumonia. A randomized, double-blind, placebo-controlled study (FAVID)

Author: Horcajada, Juan P., Aldonza, Rebeca, Real, Mónica, Castañeda-Espinosa, Silvia, Sendra, Elena, Gomez-Junyent, Joan, López-Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Briansó, Silvia, Duran-Taberna, Montserrat, Fernández, Andrés, Tarragó, Cristina, and Auguet-Quintillá, Teresa
Published: 2024
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3. Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Author: Sahner, David, Tierney, John, Vogel, Susan E., Herpin, Betsey R., Smolskis, Mary C., McKay, Laura A., Cahill, Kelly, Crew, Page, Sardana, Ratna, Raim, Sharon Segal, Hensely, Lisa, Lorenzo, Johsua, Mock, Rebecca, Zuckerman, Judith, Atri, Negin, Miller, Mark, Vallee, David, Chung, Lucy, Kang, Nayon, Barrett, Kevin, Adam, Stacey J., Read, Sarah, Draghia-Akli, Ruxandra, Currier, Judy, Hughes, Eric, Harrigan, Rachel H., Amos, Laura, Carlsen, Amy, Carter, Anita, Collins, Gary, Davis, Bionca, Denning, Eileen, DuChene, Alain, Eckroth, Kate, Engen, Nicole, Frase, Alex, Gandits, Greg, Grund, Birgit, Harrison, Merrie, Hurlbut, Nancy, Kaiser, Payton, Koopmeiners, Joseph, Larson, Gregg, Meger, Sue, Mistry, Shweta Sharma, Murray, Thomas, Nelson, Ray, Quan, Kien, Quan, Siu Fun, Reilly, Cavan, Siegel, Lianne, Thompson, Greg, Vock, David, Walski, Jamie, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, O'Sullivan, Karen, Marks, Mary E., Accardi, Evan, Kinzel, Emily, Burris, Sarah, Bedoya, Gabriela, Gupta, Lola, Overbey, Jessica R., Santos, Milerva, Gillinov, Marc A., Miller, Marissa A., Taddei-Peters, Wendy C., Fenton, Kathleen, Sandkovsky, Uriel, Gottlieb, Robert L., Mack, Michael, Berhe, Mezgebe, Haley, Clinton, Dishner, Emma, Bettacchi, Christopher, Golden, Kevin, Duhaime, Erin, Ryan, Madison, Tallmadge, Catherine, Estrada, Lorie, Jones, Felecia, Villa, Samatha, Wang, Samatha, Robert, Raven, Coleman, Tanquinisha, Clariday, Laura, Baker, Rebecca, Hurutado-Rodriguez, Mariana, Iram, Nazia, Fresnedo, Michelle, Davis, Allyson, Leonard, Kiara, Ramierez, Noelia, Thammavong, Jon, Duque, Krizia, Turner, Emma, Fisher, Tammy, Robinson, Dianna, Ransom, Desirae, Maldonado, Nicholas, Lusk, Erica, Killian, Aaron, Palacious, Adriana, Solis, Edilia, Jerrow, Janet, Watts, Matthew, Whitacre, Heather, Cothran, Elizabeth, Smith, Peter K., Barkauskas, Christina E., Vekstein, Andrew M., Ko, Emily R., Dreyer, Grace R., Stafford, Neil, Brooks, Megan, Der, Tatyana, Witte, Marie, Gamarallage, Ruwan, Franzone, John, Ivey, Noel, Lumsden, Rebecca H., Mosaly, Nilima, Mourad, Ahmaad, Holland, Thomas L., Motta, Mary, Lane, Kathleen, McGowan, Lauren M., Stout, Jennifer, Aloor, Heather, Bragg, Kennesha M., Toledo, Barvina, McLendon-Arvik, Beth, Bussadori, Barbara, Hollister, Beth A., Griffin, Michelle, Giangiacomo, Dana M., Rodriguez, Vicente, Bokhart, Gordon, Eichman, Sharon M., Parrino, Patrick E., Spindel, Stephen, Bansal, Aditya, Baumgarten, Katherine, Hand, Johnathan, Vonderhaar, Derek, Nossaman, Bobby, Sylvia Laudun, Ames, DeAnna, Broussard, Shane, Hernandez, Nilmo, Isaac, Geralyn, Dinh, Huan, Zheng, Yiling, Tran, Sonny, McDaniel, Hunter, Crovetto, Nicolle, Perin, Emerson, Costello, Briana, Manian, Prasad, Sohail, M. Rizwan, Postalian, Alexander, Hinsu, Punit, Watson, Carolyn, Chen, James, Fink, Melyssa, Sturgis, Lydia, Walker, Kim, Mahon, Kim, Parenti, Jennifer, Kappenman, Casey, Knight, Aryn, Sturek, Jeffrey M., Barros, Andrew, Enfield, Kyle B., Kadl, Alexandra, Green, China J., Simon, Rachel M., Fox, Ashley, Thornton, Kara, Adams, Amy, Badhwar, Vinay, Sharma, Sunil, Peppers, Briana, McCarthy, Paul, Krupica, Troy, Sarwari, Arif, Reece, Rebecca, Fornaresico, Lisa, Glaze, Chad, Evans, Raquel, Di, Fang, Carlson, Shawn, Aucremanne, Tanja, Tennant, Connie, Sutton, Lisa Giblin, Buterbaugh, Sabrina, Williams, Roger, Bunner, Robin, Traverse, Jay H., Rhame, Frank, Huelster, Joshua, Kethireddy, Rajesh, Davies, Irena, Salamanca, Julianne, Majeski, Christine, Skelton, Paige, Zarambo, Maria, Sarafolean, Andrea, Bowdish, Michael E., Borok, Zea, Wald-Dickler, Noah, Hutcheon, Douglass, Towfighi, Amytis, Lee, Mary, Lewis, Meghan R., Spellberg, Brad, Sher, Linda, Sharma, Aniket, Olds, Anna P., Justino, Chris, Loxano, Edward, Romero, Chris, Leong, Janet, Rodina, Valentina, Quesada, Christine, Hamilton, Luke, Escobar, Jose, Leshnower, Brad, Bender, William, Sharifpour, Milad, Miller, Jeffrey, Farrington, Woodrow, Baio, Kim T., McBride, Mary, Fielding, Michele, Mathewson, Sonya, Porte, Kristina, Maton, Missy, Ponder, Chari, Haley, Elisabeth, Spainhour, Christine, Rogers, Susan, Tyler, Derrick, Madathil, Ronson J., Rabin, Joseph, Levine, Andrea, Saharia, Kapil, Tabatabai, Ali, Lau, Christine, Gammie, James S., Peguero, Maya-Loren, McKernan, Kimberly, Audette, Mathew, Fleischmann, Emily, Akbari, Kreshta, Lee, Myounghee, Chi, Andrew, Salehi, Hanna, Pariser, Alan, Nyguyen, Phuong Tran, Moore, Jessica, Gee, Adrienne, Vincent, Shelika, Zuckerman, Richard A., Iribarne, Alexander, Metzler, Sara, Shipman, Samantha, Johnson, Haley, Newton, Crystallee, Parr, Doug, Miller, Leslie, Schelle, Beth, McLean, Sherry, Rothbaum, Howard R., Alvarez, Michael S., Kalan, Shivam P., Germann, Heather H., Hendershot, Jennifer, Moroney, Karen, Herring, Karen, Cook, Sharri, Paul, Pam, Walker-Ignasiak, Rebecca, North, Crystal, Oldmixon, Cathryn, Ringwood, Nancy, Muzikansky, Ariela, Morse, Richard, Fitzgerald, Laura, Morin, Haley D., Brower, Roy G., Reineck, Lora A., Bienstock, Karen, Steingrub, Jay H., Hou, Peter K., Steingrub, Jay S., Tidswell, Mark A., Kozikowski, Lori-Ann, Kardos, Cynthia, DeSouza, Leslie, Romain, Sarah, Thornton-Thompson, Sherell, Talmor, Daniel, Shapiro, Nathan, Andromidas, Konstantinos, Banner-Goodspeed, Valerie, Bolstad, Michael, Boyle, Katherine L., Cabrera, Payton, deVilla, Arnaldo, Ellis, Joshua C., Grafals, Ana, Hayes, Sharon, Higgins, Conor, Kurt, Lisa, Kurtzman, Nicholas, Redman, Kimberly, Rosseto, Elinita, Scaffidi, Douglas, Filbin, Michael R., Hibbert, Kathryn A., Parry, Blair, Margolin, Justin, Hillis, Brooklynn, Hamer, Rhonda, Brait, Kelsey, Beakes, Caroline, McKaig, Brenna, Kugener, Eleonore, Jones, Alan E., Galbraith, James, Nandi, Utsav, Peacock, Rebekah, Hendey, Gregory, Kangelaris, Kirsten, Ashktorab, Kimia, Gropper, Rachel, Agrawal, Anika, Yee, Kimberley J., Jauregui, Alejandra E., Zhuo, Hanjing, Almasri, Eyad, Fayed, Mohamed, Hubel, Kinsley A., Hughes, Alyssa R., Garcia, Rebekah L., Lim, George W., Chang, Steven Y., Lin, Michael Y., Vargas, Julia, Sihota, Hena, Beutler, Rebecca, Agarwal, Trisha, Wilson, Jennifer G., Vojnik, Rosemary, Perez, Cynthia, McDowell, Jordan H., Roque, Jonasel, Wang, Henry, Huebinger, Ryan M., Patel, Bela, Vidales, Elizabeth, Albertson, Timothy, Hardy, Erin, Harper, Richart, Moss, Marc A., Baduashvili, Amiran, Chauhan, Lakshmi, Douin, David J., Martinez, Flora, Finck, Lani L., Bastman, Jill, Howell, Michelle, Higgins, Carrie, McKeehan, Jeffrey, Finigan, Jay, Stubenrauch, Peter, Janssen, William J., Griesmer, Christine, VerBurg, Olivia, Hyzy, Robert C., Park, Pauline K., Nelson, Kristine, McSparron, Jake I., Co, Ivan N., Wang, Bonnie R., Jimenez, Jose, Olbrich, Norman, McDonough, Kelli, Jia, Shijing, Hanna, Sinan, Gong, Michelle N., Richardson, Lynne D., Nair, Rahul, Lopez, Brenda, Amosu, Omowunmi, Offor, Obiageli, Tzehaie, Hiwet, Nkemdirim, William, Boujid, Sabah, Mosier, Jarrod M., Hypes, Cameron, Campbell, Elizabeth Salvagio, Bixby, Billie, Gilson, Boris, Lopez, Anitza, Bime, Christian, Parthasarathy, Sairam, Cano, Ariana M., Hite, R. Duncan, Terndrup, Thomas E., Wiedemann, Herbert P., Hudock, Kristin, Tanzeem, Hammad, More, Harshada, Martinkovic, Jamie, Sellers, Susan, Houston, Judy, Burns, Mary, Kiran, Simra, Roads, Tammy, Kennedy, Sarah, Duggal, Abhijit, Thiruchelvam, Nirosshan, Ashok, Kiran, King, Alexander H., Mehkri, Omar, Dugar, Siddharth, Sahoo, Debasis, Yealy, Donald M., Angus, Derek C., Weissman, Alexandra J., Vita, Tina M., Berryman, Emily, Hough, Catherine L., Khan, Akram, Krol, Olivia F., Mills, Emmanuel, Kinjal, Mistry, Briceno, Genesis, Reddy, Raju, Hubel, Kinsley, Jouzestani, Milad K., McDougal, Madeline, Deshmukh, Rupali, Johnston, Nicholas J., Robinson, Bryce H., Gundel, Staphanie J., Katsandres, Sarah C., Chen, Peter, Torbati, Sam S., Parimon, Tanyalak, Caudill, Antonina, Mattison, Brittany, Jackman, Susan E., Chen, Po-En, Bayoumi, Emad, Ojukwu, Cristabelle, Fine, Devin, Weissberg, Gwendolyn, Isip, Katherine, Choi-Kuaea, Yunhee, Mehdikhani, Shaunt, Dar, Tahir B., Fleury Augustin, Nsole Biteghe, Tran, Dana, Dukov, Jennifer Emilow, Matusov, Yuri, Choe, June, Hindoyan, Niree A., Wynter, Timothy, Pascual, Ethan, Clapham, Gregg J., Herrera, Lisa, Caudill, Antonia, O’Mahony, D. Shane, Nyatsatsang, Sonam T., Wilson, David M., Wallick, Julie A., Duven, Alexandria M., Fletcher, Dakota D., Miller, Chadwick, Files, D. Clark, Gibbs, Kevin W., Flores, Lori S., LaRose, Mary E., Landreth, Leigha D., Palacios, D. Rafael, Parks, Lisa, Hicks, Madeline, Goodwin, Andrew J., Kilb, Edward F., Lematty, Caitlan T., Patti, Kerilyn, Grady, Abigail, Rasberry, April, Morris, Peter E., Sturgill, Jamie L., Cassity, Evan P., Dhar, Sanjay, Montgomery-Yates, Ashley A., Pasha, Sarah N., Mayer, Kirby P., Pharm.D., Brittany Bissel, Trott, Terren, Rehman, Shahnaz, de Wit, Marjolein, Mason, Jessica, Bledsoe, Joseph, Knowlton, Kirk U., Brown, Samuel, Lanspa, Michael, Leither, Lindsey, Pelton, Ithan, Armbruster, Brent P., Montgomery, Quinn, Kumar, Naresh, Fergus, Melissa, Imel, Karah, Palmer, Ghazal, Webb, Brandon, Klippel, Carolyn, Jensen, Hannah, Duckworth, Sarah, Gray, Andrew, Burke, Tyler, Knox, Dan, Lumpkin, Jenna, Aston, Valerie T., Applegate, Darrin, Serezlic, Erna, Brown, Katie, Merril, Mardee, Harris, Estelle S., Middleton, Elizabeth A., Barrios, Macy A.G., Greer, Jorden, Schmidt, Amber D., Webb, Melissa K., Paine, Roert, Callahan, Sean J., Waddoups, Lindsey J., Yamane, Misty B., Self, Wesley H., Rice, Todd W., Casey, Jonathan D., Johnson, Jakea, Gray, Christopher, Hays, Margaret, Roth, Megan, Menon, Vidya, Kasubhai, Moiz, Pillai, Anjana, Daniel, Jean, Sittler, Daniel, Kanna, Balavenkatesh, Jilani, Nargis, Amaro, Francisco, Santana, Jessica, Lyakovestsky, Aleksandr, Madhoun, Issa, Desroches, Louis Marie, Amadon, Nicole, Bahr, Alaa, Ezzat, Imaan, Guerrero, Maryanne, Padilla, Joane, Fullmer, Jessie, Singh, Inderpreet, Ali Shah, Syed Hamad, Narang, Rajeev, Mock, Polly, Shadle, Melissa, Hernandez, Brenda, Welch, Kevin, Payne, Andrea, Ertl, Gabriela, Canario, Daniel, Barrientos, Isabel, Goss, Danielle, DeVries, Mattie, Folowosele, Ibidolapo, Garner, Dorothy, Gomez, Mariana, Price, Justin, Bansal, Ekta, Wong, Jim, Faulhaber, Jason, Fazili, Tasaduq, Yeary, Brian, Ndolo, Ruth, Bryant, Christina, Smigeil, Bridgette, Robinson, Philip, Najjar, Rana, Jones, Patrice, Nguyen, Julie, Chin, Christina, Taha, Hassan, Najm, Salah, Smith, Christopher, Moore, Jason, Nassar, Talal, Gallinger, Nick, Christian, Amy, Mauer, D’Amber, Phipps, Ashley, Waters, Michael, Zepeda, Karla, Coslet, Jordan, Landazuri, Rosalynn, Pineda, Jacob, Uribe, Nicole, Garcia, Jose Ruiz, Barbabosa, Cecilia, Sandler, Kaitlyn, Overcash, J. Scott, Marquez, Adrienna, Chu, Hanh, Lee, Kia, Quillin, Kimberly, Garcia, Andrea, Lew, Pauline, Rogers, Ralph, Shehadeh, Fadi, Mylona, Evangelia K., Kaczynski, Matthew, Tran, Quynh-Lam, Benitez, Gregorio, Mishra, Biswajit, Felix, Lewis Oscar, Vafea, Maria Tsikala, Atalla, Eleftheria, Davies, Robin, Hedili, Salma, Monkeberg, Maria Andrea, Tabler, Sandra, Harrington, Britt, Meegada, Sreenath, Koripalli, Venkata Sandeep, Muddana, Prithvi, Jain, Lakshay, Undavalli, Chaitanya, Kavya, Parasa, Ibiwoye, Mofoluwaso, Akilo, Hameed, Lovette, Bryce D., Wylie, Jamie-Crystal, Smith, Diana M., Poon, Kenneth, Eckardt, Paula, Heysu, Rubio-Gomez, Sundararaman, Nithya, Alaby, Doris, Sareli, Candice, Sánchez, Adriana, Popielski, Laura, Kambo, Amy, Viens, Kimberley, Turner, Melissa, Vjecha, Michael J., Weintrob, Amy, Brar, Indira, Markowitz, Norman, Pastor, Erika, Corpuz, Roweena, Alangaden, George, McKinnon, John, Ramesh, Mayur, Herc, Erica, Yared, Nicholas, Lanfranco, Odaliz Abreu, Rivers, Emanuel, Swiderek, Jennifer, Gupta, Ariella Hodari, Pabla, Pardeep, Eliya, Sonia, Jazrawi, Jehan, Delor, Jeremy, Desai, Mona, Cook, Aaron, Jaehne, Anja Kathrina, Gill, Jasreen Kaur, Renaud, Sheri, Sarveswaran, Siva, Gardner, Edward, Scott, James, Bianchini, Monica, Melvin, Casey, Kim, Gina, Wyles, David, Kamis, Kevin, Miller, Rachel, Douglas, Ivor, Haukoos, Jason, Hicks, Carrie, Lazarte, Susana, Marines-Price, Rubria, Osuji, Alice, Agbor Agbor, Barbine Tchamba, Petersen, Tianna, Kamel, Dena, Hansen, Laura, Garcia, Angie, Cha, Christine, Mozaffari, Azadeh, Hernandez, Rosa, Cutrell, James, Kim, Mina, DellaValle, Natalie, Gonzales, Sonia, Somboonwit, Charurut, Oxner, Asa, Guerra, Lucy, Hayes, Michael, Nguyen, Thi, Tran, Thanh, Pinto, Avenette, Hatlen, Timothy, Anderson, Betty, Zepeda-Gutierrez, Ana, Martin, Dannae, Temblador, Cindi, Cuenca, Avon, Tanoviceanu, Roxanne, Prieto, Martha, Guerrero, Mario, Daar, Eric, Correa, Ramiro, Hartnell, Gabe, Wortmann, Glenn, Doshi, Saumil, Moriarty, Theresa, Gonzales, Melissa, Garman, Kristin, Baker, Jason V., Frosch, Anne, Goldsmith, Rachael, Driver, Brian, Frank, Christine, Leviton, Tzivia, Prekker, Matthew, Jibrell, Hodan, Lo, Melanie, Klaphake, Jonathan, Mackedanz, Shari, Ngo, Linh, Garcia-Myers, Kelly, Kunisaki, Ken M., Wendt, Chris, Melzer, Anne, Wetherbee, Erin, Drekonja, Dimitri, Pragman, Alexa, Hamel, Aimee, Thielen, Abbie, Hassler, Miranda, Walquist, Mary, Augenbraun, Michael, George, Jensen, Demeo, Lynette, Mishko, Motria, Thomas, Lorraine, Tatem, Luis, Dehovitz, Jack, Abassi, Mahsa, Leuck, Anne-Marie, Rao, Via, Pullen, Matthew, Luke, Darlette, LaBar, Derek, Christiansen, Theresa, Howard, Diondra, Biswas, Kousick, Harrington, Cristin, Garcia, Amanda, Bremer, Tammy, Burke, Tara, Koker, Brittany, Davis-Karim, Anne, Pittman, David, Vasudeva, Shikha S., Johnstone, Jaylynn R., Agnetti, Kate, Davis, Ruby, Trautner, Barbara, Hines-Munson, Casey, Van, John, Dillon, Laura, Wang, Yiqun, Nagy-Agren, Stephanie, Vasudeva, Shikha, Ochalek, Tracy, Caldwell, Erin, Humerickhouse, Edward, Boone, David, McGraw, William, Looney, David J., Mehta, Sanjay R., Johns, Scott Thompson, St. John, Melissa, Raceles, Jacqueline, Sear, Emily, Funk, Stephen, Cesarini, Rosa, Fang, Michelle, Nicalo, Keith, Drake, Wonder, Jones, Beatrice, Holtman, Teresa, Nguyen, Hien H., Maniar, Archana, Johnson, Eric A., Nguyen, Lam, Tran, Michelle T., Barrett, Thomas W., Johnston, Tera, Huggins, John T., Beiko, Tatsiana Y., Hughes, Heather Y., McManigle, William C., Tanner, Nichole T., Washburn, Ronald G., Ardelt, Magdalena, Tuohy, Patricia A., Mixson, Jennifer L., Hinton, Charles G., Thornley, Nicola, Allen, Heather, Elam, Shannon, Boatman, Barry, Baber, Brittany J., Ryant, Rudell, Roller, Brentin, Nguyen, Chinh, Mikail, Amani Morgan, Research, Marivic Hansen, Lichtenberger, Paola, Baracco, Gio, Ramos, Carol, Bjork, Lauren, Sueiro, Melyssa, Tien, Phyllis, Freasier, Heather, Buck, Theresa, Nekach, Hafida, Holodniy, Mark, Chary, Aarthi, Lu, Kan, Peters, Theresa, Lopez, Jessica, Tan, Susanna Yu, Lee, Robert H., Asghar, Aliya, Karyn Isip, Tasadduq Karim, Le, Katherine, Nguyen, Thao, Wong, Shinn, Raben, Dorthe, Murray, Daniel D., Jensen, Tomas O., Peters, Lars, Aagaard, Bitten, Nielsen, Charlotte B., Krapp, Katharina, Nykjær, Bente Rosdahl, Olsson, Christina, Kanne, Katja Lisa, Grevsen, Anne Louise, Joensen, Zillah Maria, Bruun, Tina, Bojesen, Ane, Woldbye, Frederik, Normand, Nick E., Esman, Frederik V.L., Benfield, Thomas, Clausen, Clara Lundetoft, Hovmand, Nichlas, Israelsen, Simone Bastrup, Iversen, Katrine, Leding, Caecilie, Pedersen, Karen Brorup, Thorlacius-Ussing, Louise, Tinggaard, Michaela, Tingsgard, Sandra, Krohn-Dehli, Louise, Pedersen, Dorthe, Villadsen, Signe, Staehr Jensen, Jens-Ulrik, Overgaard, Rikke, Rastoder, Ema, Heerfordt, Christian, Hedsund, Caroline, Ronn, Christian Phillip, Kamstrup, Peter Thobias, Hogsberg, Dorthe Sandbaek, Bergsoe, Christina, Søborg, Christian, Hissabu, Nuria M.S., Arp, Bodil C., Ostergaard, Lars, Staerke, Nina Breinholt, Yehdego, Yordanos, Sondergaard, Ane, Johansen, Isik S., Pedersen, Andreas Arnholdt, Knudtzen, Fredrikke C., Larsen, Lykke, Hertz, Mathias A., Fabricius, Thilde, Holden, Inge K., Lindvig, Susan O., Helleberg, Marie, Gerstoft, Jan, Kirk, Ole, Jensen, Tomas Ostergaard, Madsen, Birgitte Lindegaard, Pedersen, Thomas Ingemann, Harboe, Zitta Barrella, Roge, Birgit Thorup, Hansen, Thomas Michael, Glesner, Matilde Kanstrup, Lofberg, Sandra Valborg, Nielsen, Ariella Denize, Leicht von Huth, Sebastian, Nielsen, Henrik, Thisted, Rikke Krog, Petersen, Kristine Toft, Juhl, Maria Ruwald, Podlekareva, Daria, Johnsen, Stine, Andreassen, Helle Frost, Pedersen, Lars, Clara Ellinor Lindnér, Cecilia Ebba, Wiese, Lothar, Knudsen, Lene Surland, Skrøder Nytofte, Nikolaj Julian, Havmøller, Signe Ravn, Expósito, Maria, Badillo, José, Martínez, Ana, Abad, Elena, Chamorro, Ana, Figuerola, Ariadna, Mateu, Lourdes, España, Sergio, Lucero, Maria Constanza, Santos, José Ramón, Lladós, Gemma, Lopez, Cristina, Carabias, Lydia, Molina-Morant, Daniel, Loste, Cora, Bracke, Carmen, Siles, Adrian, Fernández-Cruz, Eduardo, Di Natale, Marisa, Padure, Sergiu, Gomez, Jimena, Ausin, Cristina, Cervilla, Eva, Balastegui, Héctor, Sainz, Carmen Rodríguez, Lopez, Paco, Carbone, Javier, Escobar, Mariam, Balerdi, Leire, Legarda, Almudena, Roldan, Montserrat, Letona, Laura, Muñoz, José, Camprubí, Daniel, Arribas, Jose R., Sánchez, Rocio Montejano, Díaz-Pollán, Beatriz, Stewart, Stefan Mark, Garcia, Irene, Borobia, Alberto, Mora-Rillo, Marta, Estrada, Vicente, Cabello, Noemi, Nuñez-Orantos, M.J., Sagastagoitia, I., Homen, J.R., Orviz, E., Montalvá, Adrián Sánchez, Espinosa-Pereiro, Juan, Bosch-Nicolau, Pau, Salvador, Fernando, Burgos, Joaquin, Morales-Rull, Jose Luis, Moreno Pena, Anna Maria, Acosta, Cristina, Solé-Felip, Cristina, Horcajada, Juan P., Sendra, Elena, Castañeda, Silvia, López-Montesinos, Inmaculada, Gómez-Junyent, Joan, Gonzáles, Carlota Gudiol, Cuervo, Guilermo, Pujol, Miquel, Carratalà, Jordi, Videla, Sebastià, Günthard, Huldrych, Braun, Dominique L., West, Emily, M’Rabeth-Bensalah, Khadija, Eichinger, Mareile L., Grüttner-Durmaz, Manuela, Grube, Christina, Zink, Veronika, pharmacist, Goes pharmacist, Josefine, Fätkenheuer, Gerd, Malin, Jakob J., Tsertsvadze, Tengiz, Abutidze, Akaki, Chkhartishvili, Nikoloz, Metchurtchlishvili, Revaz, Endeladze, Marina, Paciorek, Marcin, Bursa, Dominik, Krogulec, Dominika, Pulik, Piotr, Ignatowska, Anna, Horban, Andrzej, Bakowska, Elzbieta, Kowaska, Justyna, Bednarska, Agnieszka, Jurek, Natalia, Skrzat-Klapaczynska, Agata, Bienkowski, Carlo, Hackiewicz, Malgorzata, Makowiecki, Michal, Platowski, Antoni, Fishchuk, Roman, Kobrynska, Olena, Levandovska, Khrystyna, Kirieieva, Ivanna, Kuziuk, Mykhailo, Naucler, Pontus, Perlhamre, Emma, Mazouch, Lotta, Kelleher, Anthony, Polizzotto, Mark, Carey, Catherine, Chang, Christina C., Hough, Sally, Virachit, Sophie, Davidson, Sarah, Bice, Daniel J., Ognenovska, Katherine, Cabrera, Gesalit, Flynn, Ruth, Young, Barnaby E., Chia, Po Ying, Lee, Tau Hong, Lin, Ray J., Lye, David C., Ong, Sean W.X., Puah, Ser Hon, Yeo, Tsin Wen, Diong, Shiau Hui, Ongko, Juwinda, Yeo, He Ping, Eriobu, Nnakelu, Kwaghe, Vivian, Zaiyad, Habib, Idoko, Godwin, Uche, Blessing, Selvamuthu, Poongulali, Kumarasamy, Nagalingeswaran, Beulah, Faith Ester, Govindarajan, Narayan, Mariyappan, Kowsalya, Losso, Marcelo H., Abela, Cecilia, Moretto, Renzo, Belloc, Carlos G., Ludueña, Jael, Amar, Josefina, Toibaro, Javier, Macias, Laura Moreno, Fernandez, Lucia, Frare, Pablo S., Chaio, Sebastian R., Pachioli, Valeria, Timpano, Stella M., Sanchez, Marisa del Lujan, de Paz Sierra, Mariana, Stanek, Vanina, Belloso, Waldo, Cilenti, Flavia L., Valentini, Ricardo N., Stryjewski, Martin E., Locatelli, Nicolas, Soler Riera, Maria C., Salgado, Clara, Baeck, Ines M., Di Castelnuovo, Valentina, Zarza, Stella M., Hudson, Fleur, Parmar, Mahesh K.B., Goodman, Anna L., Dphil, Badrock, Jonathan, Gregory, Adam, Goodall, Katharine, Harris, Nicola, Wyncoll, James, Bhagani, S., Rodger, A., Luntiel, A., Patterson, C., Morales, J., Witele, E., Preston, A.-M., Nandani, A., Price, D.A., Hanrath, Aiden, Nell, Jeremy, Patel, Bijal, Hays, Carole, Jones, Geraldine, Davidson, Jade, Bawa, T., Mathews, M., Mazzella, A., Bisnauthsing, K., Aguilar-Jimenez, L., Borchini, F., Hammett, S., Touloumi, Giota, Pantazis, Nikos, Gioukari, Vicky, Souliou, Tania, Antoniadou, A., Protopapas, K., Kavatha, D., Grigoropoulou, S., Oikonomopoulo, C., Moschopoulos, C., Koulouris, N.G., Tzimopoulos, K., Koromilias, A., Argyraki, K., Lourida, P., Bakakos, P., Kalomenidis, I., Vlachakos, V., Barmparessou, Z., Balis, E., Zakynthinos, S., Sigala, I., Gianniou, N., Dima, E., Magkouta, S., Synolaki, E., Konstanta, S., Vlachou, M., Stathopoulou, P., Panagopoulos, P., Petrakis, V., Papazoglou, D., Tompaidou, E., Isaakidou, E., Poulakou, G., Rapti, V., Leontis, K., Nitsotolis, T., Athanasiou, K., Syrigos, K., Kyriakoulis, K., Trontzas, I., Arfara-Melanini, M., Kolonis, V., Kityo, Cissy, Mugerwa, Henry, Kiweewa, Francis, Kimuli, Ivan, Lukaakome, Joseph, Nsereko, Christoher, Lubega, Gloria, Kibirige, Moses, Nakahima, William, Wangi, Deus, Aguti, Evelyne, Generous, Lilian, Massa, Rosemary, Nalaki, Margaret, Magala, Felix, Nabaggala, Phiona Kaweesi, Kidega, Robert, Faith, Oryem Daizy, Florence, Apio, Emmanuel, Ocung, Beacham, Mugoonyi Paul, Geoffrey, Amone, Nakiboneka, Dridah, Apiyo, Paska, Kirenga, Bruce, Atukunda, Angella, Muttamba, Winters, Remmy, Kyeyume, Segawa, Ivan, Pheona, Nsubuga, Kigere, David, Mbabazi, Queen Lailah, Boersalino, Ledra, Nyakoolo, Grace, Fred, Aniongo, Alupo, Alice, Ebong, Doryn, Monday, Edson, Nalubwama, Ritah Norah, Kainja, Milton, Ambrose, Munu, Kwehayo, Vanon, Nalubega, Mary Grace, Ongoli, Augustine, Obbo, Stephen, Sebudde, Nicholus, Alaba, Jeniffer, Magombe, Geoffrey, Tino, Harriet, Obonya, Emmanuel, Lutaakome, Joseph, Kitonsa, Jonathan, Onyango, Martin, Naboth, Tukamwesiga, Naluyinda, Hadijah, Nanyunja, Regina, Irene, Muttiibwa, Jane, Biira, Wimfred, Kyobejja, Leonard, Ssemazzi, Deus, Tkiinomuhisha, Babra, Namasaba, Taire, Paul, Nabankema, Evelyn, Ogavu, Joseph, Mugerwa, Oscar, Okoth, Ivan, Mwebaze, Raymond, Mugabi, Timothy, Makhoba, Anthony, Arikiriza, Phiona, Theresa, Nabuuma, Nakayima, Hope, Frank, Kisuule, Ramgi, Patrícia, Pereira, Kássia, Osinusi, Anu, Cao, Huyen, Klekotka, Paul, Price, Karen, Nirula, Ajay, Osei, Suzette, Tipple, Craig, Wills, Angela, Peppercorn, Amanda, Watson, Helen, Gupta, Rajesh, Alexander, Elizabeth, Mogalian, Erik, Lin, Leo, Ding, Xiao, Margolis, David, Yan, Li, Girardet, Jean-Luc, Ma, Ji, Hong, Zhi, Zhu, Quing, Seegobin, Seth, Gibbs, Michael, Latchman, Mickel, Hasior, Katarzyna, Bouquet, Jerome, Wei, Jianxin, Streicher, Katie, Schmelzer, Albert, Brooks, Dennis, Butcher, Jonny, Tonev, Dimitar, Arbetter, Douglas, Damstetter, Philippe, Legenne, Philippe, Stumpp, Michael, Goncalves, Susana, Ramanathan, Krishnan, Chandra, Richa, Baseler, Beth, Teitelbaum, Marc, Schechner, Adam, Holley, H. Preston, Jankelevich, Shirley, Becker, Nancy, Dolney, Suzanne, Hissey, Debbie, Simpson, Shelly, Kim, Mi Ha, Beeler, Joy, Harmon, Liam, Asomah, Mabel, Jato, Yvonne, Stottlemyer, April, Tang, Olivia, Vanderpuye, Sharon, Yeon, Lindsey, Buehn, Molly, Eccard-Koons, Vanessa, Frary, Sadie, MacDonald, Leah, Cash, Jennifer, Hoopengardner, Lisa, Linton, Jessica, Schaffhauser, Marylu, Nelson, Michaela, Spinelli-Nadzam, Mary, Proffitt, Calvin, Lee, Christopher, Engel, Theresa, Fontaine, Laura, Osborne, C.K., Hohn, Matt, Galcik, Michael, Thompson, DeeDee, Kopka, Stacey, Shelley, Denise M., Mendez, Gregg, Brown, Shawn, Albert, Sara, Balde, Abby, Baracz, Michelle, Bielica, Mona, Billouin-Frazier, Shere, Choudary, Jay, Dixon, Mary, Eyler, Carolyn, Frye, Leanne, Gertz, Jensen, Giebeig, Lisa, Gulati, Neelam, Hankinson, Liz, Hogarty, Debi, Huber, Lynda, Krauss, Gary, Lake, Eileen, Manandhar, Meryan, Rudzinski, Erin, Sandrus, Jen, Suders, Connie, Natarajan, Ven, Rupert, Adam W., Baseler, Michael, Lynam, Danielle, Imamichi, Tom, Laverdure, Sylvain, McCormack, Ashley, Paudel, Sharada, Cook, Kyndal, Haupt, Kendra, Khan, Ayub, Hazen, Allison, Badralmaa, Yunden, Smith, Kenneth, Patel, Bhakti, Kubernac, Amanda, Kubernac, Robert, Hoover, Marie L., Solomon, Courtney, Rashid, Marium, Murphy, Joseph, Brown, Craig, DuChateau, Nadine, Ellis, Sadie, Flosi, Adam, Fox, Lisa, Johnson, Les, Nelson, Rich, Stojanovic, Jelena, Treagus, Amy, Wenner, Christine, Williams, Richard, Jensen, Tomas O, Murray, Thomas A, Grandits, Greg A, Jain, Mamta K, Shaw-Saliba, Kathryn, Matthay, Michael A, Baker, Jason V, Dewar, Robin L, Goodman, Anna L, Hatlen, Timothy J, Highbarger, Helene C, Lallemand, Perrine, Leshnower, Bradley G, Looney, David, Moschopoulos, Charalampos D, Murray, Daniel D, Mylonakis, Eleftherios, Rehman, M Tauseef, Rupert, Adam, Stevens, Randy, Turville, Stuart, Wick, Katherine, Lundgren, Jens, and Ko, Emily R
Published: 2024
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4. Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study

Author: López Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Palacios-Baena, Zaira Raquel, Prim, Nuria, Echeverria-Esnal, Daniel, Gracia, María Pilar, Montero, María Milagro, Durán-Jordà, Xavier, Sendra, Elena, Sorli, Luisa, Guerri-Fernandez, Roberto, Padilla, Eduardo, Grau, Santiago, and Horcajada, Juan Pablo
Published: 2022
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5. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author: Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Díaz Menéndez, Marta, de la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, Pérez Valero, Ignacio, de Miguel Buckley, Rosa, Cadiñaños Loidi, Julen, Diaz Pollan, Beatriz, Martín Carbonero, Luz, Ramos Ramos, Juan Carlos, Loeches Yagüe, Belén, Montejano Sánchez, Rocío, González García, Juan, García Rodríguez, Julio, Berenguer, Juan, Ramírez, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Pinilla, Blanca, López, Juan Carlos, Such Diaz, Ana, Álvaro Alonso, Elena, Torres Macho, Juan, Cuevas Tascon, Guillermo, Jiménez González de Buitrago, Eva, Brañas Baztán, Fátima, Valencia de la Rosa, Jorge, Pérez Butragueño, Mario, Fernández Jiménez, Inés, Muñiz Nicolás, Gemma, Sepúlveda Berrocal, Antonia, Gato Díez, Alberto, Toledano Sierra, María Pilar, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Fernández Romero, Isidoro, Peláez Ballesta, Cristina, Guirado Torrecillas, María Isabel, Goikoetxea Agirre, Josune, Bereciartua Bastarrica, Elena, Guio Carrión, Laura, Rodríguez Álvarez, Regino, Ibarrola Hierro, Marta, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Román Soto, Sergio, Kallouchi, Mohamed, Domínguez Vicent, Juan Ramón, Silvariño Fernández, Rafae, Ugalde Espiñeira, Jon, Sanjuan López, Ainhoa, García Martínez, Silvia, Temprano Gogenola, Mikel, Asensi, Víctor, Suárez, Silvia, Suárez, Lucia, Yllera, Carmen, Rivas-Carmenado, María, Romero-Palacios, Alberto, Ruiz Aragón, Jesús, Jiménez Aguilar, Patricia, Fernández Ávila, Ma Luisa, Castilla Ortiz, Rosario, Alende Castro, Vanesa, Pérez García, Cristina, Fernández Morales, Marta, Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María, Gómez-Junyent, Joan, Villar-García, Judit, López-Montesinos, Inmaculada, Arrieta-Aldea, Itziar, Rial-Villavecchia, Abora, García Vázquez, Elisa, Roura Piloto, Aychel Elena, Moral Escudero, Encarnación, Hernández Torres, Alicia, Albendín Iglesias, Helena, Vinuesa García, David, Martínez Montes, Clara, De la Hera Fernández, Francisco Javier, Anguita Santos, Francisco, Ruiz Sancho, Andrés, Díaz de Brito Fernández, Vicens, Sanmarti Vilamala, Montserrat, España Cueto, Sergio, Molina Morant, Daniel, González-Cuevas, Araceli, Chara Cervantes, Joel Elías, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Angerri Nadal, Mònica, De Genover Gil, Ariadna, Patera, Eleni, Godoy Lorenzo, Rita, Zioga, Evangelia Anna María, Isern Fernández, Virginia, Sabbagh Fajardo, Carlos Enrique, Ferrer Ribera, Ana, Bea Serrano, Carlos, Oltra Sempere, Rosa, Vela Bernal, Sara, Albiol Viñals, Paloma, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, Fiorante, Silvana, Pérez Pinto, Sergio, de la Vega, Alexandra, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Giménez, Teresa, Calvo, Jorge, Meije Castillo, Yolanda, Duarte Borges, Alejandra, Pareja Coca, Júlia, Clemente Presas, Mercedes, Sanz Salvador, Xavier, Pérez Rodríguez, Ma Teresa, Sousa, Adrián, Pérez González, Alexandre, Longueira, Rebeca, Araujo, Alejandro, Alonso Martínez, Blanca, García Escudero, Laura, Lidia Kamel Rey, Sara, Roa Alonso, David, Avilés Parra, Juan Pablo, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Raich Montiu, Laia, Souto Higueras, Jessica, Gálvez Bobadilla, Manuel Alejandro, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Velasco Fuentes, Sara, García Pereña, Laura, Lluna Carrascosa, Alfonso, Gilaberte Reyzábal, Sergio, Liébana Gómez, Mónica, Salillas Hernando, Juan, Serrano Martínez, Alberto, Torralba González de Suso, Miguel, Martínez Martín, Patricia, Rábago Lorite, Isabel, González-Ruano Pérez, Patricia, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Martín Plata, Andrea, Santana Báez, Sergio Manuel, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Robaina Bordón, José María, Vílchez Rueda, Helem Haydeé, Riera Jaume, Melchor, Mut Ramon, Gemma, Gavalda Manso, Meritxell, Planas Bibiloni, Lluis, Castelo Corral, Laura, Ramos Merino, Lucía, Sánchez Vidal, Efrén, Rodríguez Mayo, María, Míguez Rey, Enrique, García de Lomas Guerrero, José M., De la Torre Lima, Javier, Correa Ruiz, Ana, Fernández Sánchez, Fernando, Jiménez-García, Nicolás, Sierra-Monzón, José Luis, Gracia-Tello, Borja, Hernández-Bonaga, María, Pellejero, Galadriel, Asín-Corrochano, Marta, Boix Palop, Lucia, Calbo, Esther, Badía, Cristina, Dietl, Beatriz, Lucía, Gómez, Domínguez-Castellano, Ángel, Ríos-Villegas, María José, del Toro, María D., Palacios Baena, Zaira R., Salamanca-Rivera, Elena, Marín, Elena, Almadana, Virginia, Pérez-Galera, Salvador, González-Iglesias, Luisa, Abelenda-Alonso, Gabriela, Álvarez-Pouso, Claudia, Escrihuela, Francesc, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Salvert Lletí, Miguel, Gil Sánchez, Ricardo, Jiménez Escrig, Marta, Parra Gómez, Laura, Tasias Pitarch, Mariona, Navarro Vilasaró, Marta, Machado Sicilia, María Luisa, Gomila Grange, Aina, Calzado Isbert, Sonia, Carrasco Antón, Nerea, Petkova-Saiz, Elizabet, Cabello Úbeda, Alfonso, Górgolas Hernández-Mora, Miguel, Sánchez-Pernaute, Olga, Dueñas Gutiérrez, Carlos, Martin Guerra, Javier, Castrodeza Sanz, José Javier, Fernández Espinilla, Virginia, Rodríguez Fernández, Laura, González-Moreno, Juan, Villoslada Gelabert, Aroa, Ribot Sanso, María Antonia, Fernández-Baca, María Victoria, Hernández Milian, Almudena, Morán Rodríguez, Miguel Ángel, Ortiz de Zárate Ibarra, Zuriñe, Portu Zapirain, José Joaquin, Saez de Adana Arroniz, Ester, Gainzarain Arana, Juan Carlos, Meca Birlanga, Olga, del Amor Espín, Ma Jesús, Viqueira González, Montserrat, García García, Josefina, Martínez Madrid, Onofre, Bernal Morell, Enrique, Alcaraz, Antonia, Muñoz, Ángeles, Pina, Ignacio, de la Rosa, Vicente, Caínzos Romero, Tamara, Sánchez Trigo, Sabela, Mariño Callejo, Ana Isabel, Álvarez Díaz, Hortensia, Valcarce Pardeiro, Nieves, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, García Villalba, Eva Pilar, Aguayo Jiménez, Carmen, Ruíz Campuzano, María, Naranjo Velasco, Virginia, Santos Peña, Marta, Mora Delgado, Juan, Sevilla Moreno, Israel, Lojo Cruz, Cristina, Kortajarena Urkola, Xabier, Iribarren Loyarte, José Antonio, Bustinduy Odriozola, María Jesús, Ibarguren Pinilla, Maialen, Álvarez Rodríguez, Ignacio, Martínez Marcos, Francisco Javier, Rodríguez Gómez, Francisco Javier, Asschert Agüero, Isabel, Muñoz Beamud, Francisco, Ruiz Reina, Antonio José, Llenas-García, Jara, González-Cuello, Inmaculada, Hellín-Valiente, Elena, Martínez Birlanga, Esther, Tafalla Torres, José Manuel, Calderón Parra, Jorge, Escudero López, Gabriela, Gutiérrez Martín, Isabel, Andrés Eisenhofer, Ane, García Prieto, Sonia, Álvarez Franco, Raquel, Roger Zapata, Daniel, Martínez Cifre, Blanca, Aranda Rife, Elena, Martín Rubio, Irene, Barbosa Ventura, André, Garrido, Javier, Gonzalo, Concepción, Piñero, Iván, de la Cruz Felipe, Nieves, Talavera García, Eva, Lamata Subero, Marta, Mendoza Roy, Paula, García de Carlos, María Soledad, Lajusticia Aisa, Justo, Arteche Eguizabal, Lorea, Urrutia Losada, Ainhoa, Domingo Echaburu, Saioa, Cuadros Tito, Pedro Ángel, Orbe Narváez, Gurutz, Liébana Martos, Ma del Carmen, Roldán Fontana, Carolina, Herrero Rodríguez, Carmen, Duro Ruiz, Gaspar, Pérez Parra, Santiago, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Alberich Conesa, Ana, Bladé Vidal, Lourdes, Merchante Gutiérrez, Nicolás, León Jiménez, Eva, Espíndola Gómez, Reinaldo, Erostarbe Gallardo, María, Martínez Pérez-Crespo, Pedro, Cisneros, José Miguel, Aguilar-Guisado, Manuela, Aldabó, Teresa, Bueno, Claudio, Cordero-Matía, Elisa, Escoresca, Ana, Infante, Carmen, Guillermo, Martín, Salto, Sonsoles, Gioia, Francesca, Vizcarra, Pilar, Fortún Abete, Jesús, Martín Dávila, Pilar, Moreno Guillén, Santiago, Oteo Revuelta, José A., García-García, Concepción, Santibañez Sáenz, Paula, Cervera Acedo, Cristina, Azcona Gutiérrez, José M., Reguera Iglesias, José María, Plata Ciezar, Antonio, Valiente de Santis, Lucia, Sobrino Diaz, Beatriz, Ruiz Mesa, Juan Diego, Rodríguez-Baño, Jesús, Pachón, Jerónimo, Carratalà, Jordi, Ryan, Pablo, Jarrín, Inmaculada, Yllescas, María, and Arribas, José Ramón
Published: 2021
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6. Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant Pseudomonas aeruginosa

Author: Sorlí, Luisa, primary, Luque, Sonia, additional, Li, Jian, additional, Benítez-Cano, Adela, additional, Fernández, Xenia, additional, Prim, Nuria, additional, Vega, Victoria, additional, Gómez-Junyent, Joan, additional, López-Montesinos, Inmaculada, additional, Gómez-Zorrilla, Silvia, additional, Montero, M. Milagro, additional, Grau, Santiago, additional, and Horcajada, Juan Pablo, additional
Published: 2023
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7. Resistant Hyponatremia Secondary to the Syndrome of Inappropriate Antidiuretic Hormone Secretion Associated with Thymic Neuroblastoma

Author: Aramburu-Bodas, Óscar, Salamanca-Bautista, Prado, Scocco, Serena, Congregado-Loscertales, Miguel, Fernández-Díaz, Marta, Cano-Guzmán, María, López-Montesinos, Inmaculada, Ríos-Martín, Juan José, and Runkle, Isabelle
Published: 2016
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8. Comparative Analysis of Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae

Author: Sendra, Elena, primary, López Montesinos, Inmaculada, additional, Rodriguez-Alarcón, Alicia, additional, Du, Juan, additional, Siverio-Parés, Ana, additional, Arenas-Miras, Mar, additional, Cañas-Ruano, Esperanza, additional, Prim, Nuria, additional, Durán-Jordà, Xavier, additional, Blasco-Hernando, Fabiola, additional, García-Alzorriz, Enric, additional, Cots, Francesc, additional, Ferrández, Olivia, additional, and Gómez-Zorrilla, Silvia, additional
Published: 2022
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9. Antibiotic desensitization as a potential tool in antimicrobial stewardship programs: retrospective data analysis and systematic literature review

Author: Rodríguez-Alarcón, Alicia, primary, Barceló-Vidal, Jaime, additional, Echeverría-Esnal, Daniel, additional, Sorli, Luisa, additional, Güerri-Fernández, Roberto, additional, Ramis Fernández, Sofía Martina, additional, Benitez-Cano, Adela, additional, Sendra, Elena, additional, López Montesinos, Inmaculada, additional, Membrilla-Fernández, Estela, additional, Ferrández, Olivia, additional, Adalia, Ramón, additional, Horcajada, Juan Pablo, additional, Escolano, Fernando, additional, Gómez-Zorrilla, Silvia, additional, and Grau, Santiago, additional
Published: 2022
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10. Liver stiffness predicts variceal bleeding in HIV/HCV-coinfected patients with compensated cirrhosis

Author: Merchante, Nicolás, Rivero-Juárez, Antonio, Téllez, Francisco, Merino, Dolores, Ríos-Villegas, Maria José, Ojeda-Burgos, Guillermo, Omar, Mohamed, Macías, Juan, Rivero, Antonio, Pérez-Pérez, Monserrat, Raffo, Miguel, López-Montesinos, Inmaculada, Márquez-Solero, Manuel, Gómez-Vidal, Maria Amparo, and Pineda, Juan A.
Published: 2017
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11. Comparison of Ceftolozane/Tazobactam Infusion Regimens in a Hollow-Fiber Infection Model against Extensively Drug-Resistant Pseudomonas aeruginosa Isolates

Author: Montero, María Milagro, primary, Domene-Ochoa, Sandra, additional, López-Causapé, Carla, additional, López-Montesinos, Inmaculada, additional, Luque, Sonia, additional, Sorlí, Luisa, additional, Campillo, Núria, additional, Padilla, Eduardo, additional, Prim, Núria, additional, Ferrer Alapont, Lorena, additional, Grau, Santiago, additional, Oliver, Antonio, additional, and Horcajada, Juan P., additional
Published: 2022
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12. Severe COVID-19 pneumonia in Good syndrome with a favorable outcome

Author: Cos Esquius, Maria Lourdes, López Montesinos, Inmaculada, Gimeno Martinez, Ramón, Eguía Núñez, Jorge, Caballero-Rabasco, M. Araceli, Sánchez González, Blanca, López García, Alicia, and Mellibovsky, Leonardo
Published: 2022
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13. Aminoglycoside or Polymyxin Monotherapy for Treating Complicated Urinary Tract Infections Caused by Extensively Drug-Resistant Pseudomonas aeruginosa: A Propensity Score-Adjusted and Matched Cohort Study

Author: Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, López-Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Palacios-Baena, Zaira Raquel, Prim, Nuria, Echeverría-Esnal, Daniel, Gracia, María Pilar, Montero, Milagros, Durán-Jordà, Xavier, Sendra, Elena, Sorlí, Luisa, Guerri-Fernández, Roberto, Padilla, Eduardo, Grau, Santiago, Horcajada, Juan Pablo, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica, López-Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Palacios-Baena, Zaira Raquel, Prim, Nuria, Echeverría-Esnal, Daniel, Gracia, María Pilar, Montero, Milagros, Durán-Jordà, Xavier, Sendra, Elena, Sorlí, Luisa, Guerri-Fernández, Roberto, Padilla, Eduardo, Grau, Santiago, and Horcajada, Juan Pablo
Abstract: [Introduction] Extensively drug-resistant (XDR) Pseudomonas aeruginosa (PA) infections are difficult to treat. We aimed to compare aminoglycosides or polymyxin monotherapy versus other antibiotic regimens (carbapenems, aztreonam, ceftazidime, cefepime, ceftolozane-tazobactam, or ceftazidime-avibactam) in complicated urinary tract infections (cUTI) caused by XDR-PA., [Methods] Study performed at a tertiary-care hospital from 2010 to 2019. All consecutive adult patients with XDR-PA urine cultures and diagnosed with cUTI were retrospectively reviewed. XDR phenotype was defined according to Magiorakos et al. A propensity score was used as a covariate in multivariate analyses and for matching. Primary outcome was early clinical failure and at end of treatment (EOT). Main secondary outcomes were 30- and 90-day mortality, microbiological clearance, and antibiotic-related side effects., [Results] Of the 465 episodes screened, 101 were included, 48% were treated with aminoglycoside or colistin monotherapy. Most XDR-PA were susceptible to colistin (100%) and amikacin (43%). Patients treated with antibiotic regimens other than aminoglycosides or polymyxin monotherapy were more likely to have hematologic malignancy (p < 0.001), higher SOFA score (p = 0.048), and bacteremia (p = 0.003). In multivariate models adjusted by propensity score, aminoglycoside or colistin monotherapy was not associated with worse outcomes. After propensity score matching, 28 episodes in each treatment group were matched. Adjusted ORs (95% CI) for early clinical failure and at EOT with aminoglycosides or polymyxin monotherapy were 0.53 (0.18–1.58) and 1.29 (0.34–4.83), respectively. Aminoglycoside or colistin monotherapy was not associated with higher 30-day (HR 0.93, 95% CI 0.17–5.08) or 90-day mortality (HR 0.68, 95% CI 0.20–2.31), nor with absence of microbiological clearance (OR 0.72, 95% CI 0.33–1.58). No statistically significant differences were found in terms of nephrotoxicity. Clostridioides difficile infection was observed only in the “other antibiotic regimens” group (n = 6, 11.3%)., [Conclusions] Aminoglycosides or polymyxin monotherapy showed good efficacy and safety profile in treating cUTI caused by XDR-PA. These results may be useful for antibiotic stewardship activities.
Published: 2022

14. Application of an adaptable multimodal machine learning approach to predict COVID-19 outcomes for hospital resource management

Author: Gómez-Zorrilla, Silvia, primary, López-Montesinos, Inmaculada, additional, Pérez, Eva, additional, Pomés, Pau, additional, Sorli, Maria Luisa, additional, Güerri-Fernández, Robert, additional, Grau, Santiago, additional, Márquez, Albert, additional, Martínez-Roldán, Jordi, additional, Principe, Alessandro, additional, and Horcajada, Juan P., additional
Published: 2022
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15. Comparison of hospitalized COVID-19 and influenza patients requiring supplemental oxygen in a cohort study: clinical impact and resource consumption

Author: López Montesinos, Inmaculada, Arrieta Aldea, Itziar, Dicastillo, Aitor, Zuccarino, Flavio, Sorli Redó, M. Luisa, Güerri Fernández, Roberto, Arnau-Barrés, Isabel, Milagro Montero, Maria, Siverio-Parès, Ana, Duran Jordà, Xavier, 1974, Arenas-Miras, María Del Mar, Brasé Arnau, Ariadna, Cañas-Ruano, Esperanza, Castañeda, Silvia, Kamber, Ignacio Domingo, Gómez Junyent, Joan, Pelegrín, Iván, Sánchez Martínez, Francisca, Sendra, Elena, Suaya Leiro, Lucía, Villar García, Judit, Nogués Solan, Francesc Xavier, Grau Cerrato, Santiago, Knobel Freud, Hernando, Gómez-Zorrilla, Silvia, Horcajada Gallego, Juan Pablo, and COVID-MAR Group
Subjects: Flu, Pandemic, COVID-19, Resource consumption, Mortality, Hospital costs
Abstract: Data de publicació electrònica: 20-04-2022 Background: To compare clinical characteristics, outcomes, and resource consumption of patients with COVID-19 and seasonal influenza requiring supplemental oxygen. Methods: Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted due to seasonal influenza between 2017 and 2019, or with COVID-19 between March and May 2020 requiring supplemental oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality and hospitalization costs. Attempted sample size to detect an 11% difference in mortality was 187 patients per group. Results: COVID-19 cases were younger (median years, 67 (IQR 54-78) vs 76 (IQR 64-83); p < 0.001) and more frequently overweight whereas influenza cases had more hypertension, immunosuppression, and chronic heart, respiratory and renal disease. Compared to influenza, COVID-19 cases had more pneumonia (98% vs 60%
Published: 2022

16. Comparative Analysis of Dalbavancin versus Other Antimicrobial Options for Gram-Positive Cocci Infections: Effectiveness, Hospital Stay and Mortality

Author: Horcajada Gallego, Juan Pablo, de Pablo-Miró, Mar, Pujol-Ruiz¸ Sergi, Iftimie, Simona, Arenas-Miras, María Del Mar, López Montesinos, Inmaculada, Duran Jordà, Xavier, 1974, Anglès, Albert, and Grau Cerrato, Santiago
Subjects: Microbiology (medical), medicine.medical_specialty, medicine.drug_class, Antibiotics, multidrug-resistant gram-positive cocci, methicillin-resistant Staphylococci, effectiveness, RM1-950, Biochemistry, Microbiology, Article, chemistry.chemical_compound, Internal medicine, medicine, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Methicillin-resistant staphylococci, Adverse effect, gram-positive, business.industry, Dalbavancin, Antimicrobial, mortality, hospital stay, Infectious Diseases, chemistry, Ambulatory, Linezolid, Vancomycin, Therapeutics. Pharmacology, Daptomycin, business, dalbavancin, medicine.drug
Abstract: Dalbavancin is a new antibiotic that is effective against Gram-positive microorganisms, including methicillin-resistant Staphylococci, and offers the possibility of administering intravenous therapy once weekly in an ambulatory setting. We conducted a multicenter observational case-control study, comparing all patients who received dalbavancin (cases) with hospitalized patients who were treated instead with daptomycin, linezolid or vancomycin (controls), based on clinical diagnosis, main microorganism involved, and age. The primary outcome was the length of hospital stay after starting the study antimicrobial. Secondary outcomes were 7-day and 30-day efficacy, 30-day mortality, 90-day recurrence, 90-day and 6-month hospitalization, presence of adverse events and healthcare-associated infections, 161 patients (44 cases and 117 controls) were included. Bivariate analysis showed that dalbavancin reduced the total length of hospital stay (p &lt, 0.001), with fewer 90-day recurrences (p = 0.005), 6-month hospitalizations related to the same infection (p = 0.004) and non-related hospitalizations (p = 0.035). Multivariate analyses showed that length of hospital stay was significantly shorter in patients treated with dalbavancin (−12.05 days 95% CI [−17.00, −7.11], p &lt, 0.001), and 30-day efficacy was higher in the dalbavancin group (OR 2.62 95% CI [1.07, 6.37], p = 0.034). Although sample size of the study may be a limitation, we can conclude that Dalbavancin is a useful antimicrobial drug against Gram-positive infections, including multidrug-resistant pathogens, and allows for a remarkable reduction in length of hospital stay with greater 30-day efficacy.
Published: 2021

17. Acute-to-Chronic Glycemic Ratio as a Predictor of COVID-19 Severity and Mortality

Author: Ramon, Jordi, primary, Llauradó, Gemma, additional, Güerri, Roberto, additional, Climent, Elisenda, additional, Ballesta, Silvia, additional, Benaiges, David, additional, López-Montesinos, Inmaculada, additional, Navarro, Humberto, additional, Fernández, Natalia, additional, Carrera, Maria José, additional, Mauricio, Dídac, additional, Flores-Le Roux, Juana A., additional, and Chillarón, Juan-José, additional
Published: 2021
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18. Severe Hypoalbuminemia at Admission Is Strongly Associated with Worse Prognosis in Older Adults with SARS-CoV-2 Infection

Author: Arnau-Barrés, Isabel, primary, Pascual-Dapena, Ana, additional, López-Montesinos, Inmaculada, additional, Gómez-Zorrilla, Silvia, additional, Sorlí, Luisa, additional, Herrero, Marta, additional, Nogués, Xavier, additional, Navarro-Valls, Claudia, additional, Ibarra, Beatriz, additional, Canchucaja, Lizzeth, additional, da Costa Venancio, Elizabeth, additional, Blasco-Hernando, Fabiola, additional, Cruz, Juany, additional, Vázquez, Olga, additional, Miralles, Ramón, additional, García-Giralt, Natalia, additional, and Güerri-Fernández, Robert, additional
Published: 2021
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19. Comparative Analysis of Dalbavancin versus Other Antimicrobial Options for Gram-Positive Cocci Infections: Effectiveness, Hospital Stay and Mortality

Author: de Pablo-Miró, Mar, primary, Pujol-Ruiz, Sergi, additional, Iftimie, Simona, additional, Arenas-Miras, María del Mar, additional, López-Montesinos, Inmaculada, additional, Duran-Jordà, Xavier, additional, Anglès, Albert, additional, Grau, Santiago, additional, and Horcajada, Juan P., additional
Published: 2021
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20. Time-Kill Evaluation of Antibiotic Combinations Containing Ceftazidime-Avibactam against Extensively Drug-Resistant Pseudomonas aeruginosa and Their Potential Role against Ceftazidime-Avibactam-Resistant Isolates

Author: Montero, María M., primary, Domene Ochoa, Sandra, additional, López-Causapé, Carla, additional, Luque, Sonia, additional, Sorlí, Luisa, additional, Campillo, Núria, additional, López Montesinos, Inmaculada, additional, Padilla, Eduardo, additional, Prim, Núria, additional, Angulo-Brunet, Ariadna, additional, Grau, Santiago, additional, Oliver, Antonio, additional, and Horcajada, Juan P., additional
Published: 2021
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21. Prevalence and Prognostic Value of Myocardial Injury in the Initial Presentation of SARS-CoV-2 Infection among Older Adults

Author: Arnau-Barrés, Isabel, primary, Pascual-Dapena, Ana, additional, López-Montesinos, Inmaculada, additional, Gómez-Zorrilla, Silvia, additional, Sorlí, Luisa, additional, Herrero, Marta, additional, Nogués, Xavier, additional, Montero, Mila, additional, Vázquez, Olga, additional, García-Giralt, Natalia, additional, Miralles, Ramón, additional, and Güerri-Fernández, Robert, additional
Published: 2021
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22. A Large Multicenter Prospective Study of Community-Onset Healthcare Associated Bacteremic Urinary Tract Infections in the Era of Multidrug Resistance: Even Worse than Hospital Acquired Infections?

Author: Gómez-Zorrilla, Silvia, Becerra-Aparicio, Federico, López Montesinos, Inmaculada, Ruiz de Gopegui, Enrique, Grau, Inmaculada, Pintado, Vicente, Padilla, Belén, Benito, Natividad, Boix-Palop, Lucía, Fariñas, Maria Carmen, Peñaranda, María, Gamallo, Maria Rocío, Martinez, Jose Antonio, Morte-Romea, Elena, Del Pozo, Jose Luis, Durán-Jordá, Xavier, Díaz-Regañón, Jazmin, López-Mendoza, Diego, Cantón, Rafael, Oliver, Antonio, Ruiz-Garbajosa, Patricia, Horcajada, Juan Pablo, Siverio, Ana, Gijón, Desiré, Merino, Irene, López-Causapé, Carla, Sabé, Nuria, Shaw, Evelyn, Berbel, Dámaris, Tubau Quintano, Fe, Sánchez Carrillo, Carlos, Cercenado, Emilia, Sendra, Elena, Rubio, Verónica, Rivera, Alba, Calvo, Esther, Badía, Cristina, Xercavins, Mariona, de Malet, Ana, Canoura-Fernández, Luis, Salvo, Soledad, Paño-Pardo, Jose Ramón, Carmona-Torre, Francisco, and Universidad de Cantabria
Subjects: Microbiology (medical), medicine.medical_specialty, Hospital-acquired infections, business.industry, medicine.drug_class, Proportional hazards model, Urinary system, Antibiotics, Logistic regression, medicine.disease, Urinary tract infections, Multiple drug resistance, Infectious Diseases, Multidrug resistant, Bacteremia, Internal medicine, Medicine, Bloodstream infections, business, Prospective cohort study, Community-onset healthcare-associated infections, Cohort study, Original Research
Abstract: Introduction: Healthcare-associated (HCA) infections represent a growing public health problem. The aim of this study was to compare community-onset healthcare associated (CO-HCA) bacteremic urinary tract infections (BUTI) and hospital-acquired (HA)-BUTI with special focus on multidrug resistances (MDR) and outcomes. Methods: ITUBRAS-project is a prospective multicenter cohort study of patients with HCA-BUTI. All consecutive hospitalized adult patients with CO-HCA-BUTI or HA-BUTI episode were included in the study. Exclusion criteria were: patients \ 18 years old, non-hospitalized patients, bacteremia from another source or primary bacteremia, non-healthcare related infections and infections caused by unusual pathogens of the urinary tract. Th main outcome variable was 30-day all-cause mortality with day 1 as the first day of positive blood culture. Logistic regression was used to analyze factors associated with clinical cure at hospital discharge and with receiving inappropriate initial antibiotic treatment. Cox regression was used to evaluate 30-day all-cause mortality. Results: Four hundred forty-three episodes were included, 223 CO-HCA-BUTI. Patients with CO-HCA-BUTI were older (p \ 0.001) and had more underlying diseases (p = 0.029) than those with HA-BUTI. The severity of the acute illness (Pitt score) was also higher in CO-HCABUTI (p = 0.026). Overall, a very high rate of MDR profiles (271/443, 61.2%) was observed, with no statistical differences between groups. In multivariable analysis, inadequate empirical treatment was associated with MDR profile (aOR 3.35; 95% CI 1.77?6.35), Pseudomonas aeruginosa (aOR 2.86; 95% CI 1.27?6.44) and Charlson index (aOR 1.11; 95% CI 1.01?1.23). Mortality was not associated with the site of acquisition of the infection or the presence of MDR profile. However, in the logistic regression analyses patients with CO-HCA-BUTI (aOR 0.61; 95% CI 0.40?0.93) were less likely to present clinical cure. Conclusion: The rate of MDR infections was worryingly high in our study. No differences in MDR rates were found between CO-HCA-BUTI and HA-BUTI, in the probability of receiving inappropriate empirical treatment or in 30-day mortality. However, CO-HCA-BUTIs were associated with worse clinical cure. Funding. This study and the journal’s Rapid Service Fee are sponsored and funded by MSD Spain. The study was also supported by Plan Nacional de I+D+i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Economía, Industria y Competitividad, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0004, RD16/ 0016/0005, RD16/0016/0007, RD16/0016/0010, RD16/0016/0011 and RD16/0016/0015), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (ERDF), Operative program Intelligent Growth 2014–2020.
Published: 2021

23. COVID19 Outcome Prediction: Differences Between Raw Laboratory and Human Pre-Processed Data

Author: Principe, Alessandro, primary, Gómez-Zorrilla, Silvia, additional, López-Montesinos, Inmaculada, additional, Pérez-Almengor, Eva, additional, Pomés-Arnau, Pau, additional, Sorli, María, additional, Güerri-Fernández, Robert, additional, Grau, Santiago, additional, Márquez, Albert, additional, Martínez-Roldán, Jordi, additional, and Horcajada, Juan, additional
Published: 2021
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24. Impact of a Nosocomial COVID-19 Outbreak on a Non-COVID-19 Nephrology Ward during the First Wave of the Pandemic in Spain

Author: Montero, María Milagro, primary, Hidalgo López, Carlota, additional, López Montesinos, Inmaculada, additional, Sorli, Luisa, additional, Barrufet Gonzalez, Cristina, additional, Villar-García, Judith, additional, Güerri-Fernández, Roberto, additional, Herranz, Milagros, additional, Crespo, Marta, additional, Arenas Jiménez, María Dolores, additional, Pascual, Julio, additional, González Juanes, Cristina, additional, and Horcajada, Juan P., additional
Published: 2021
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25. Severe hypoalbuminemia at admission is strongly associated with worse prognosis in older adults with sars-cov-2 infection

Author: Arnau-Barrés, Isabel, Pascual-Dapena, Ana, López-Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Sorlí, Luisa, Herrero, Marta, Nogués Solán, Xavier, Navarro-Valls, Claudia, Ibarra, Beatriz, Canchucaja, Lizzeth, da Costa Venancio, Elizabeth, Blasco-Hernando, Fabiola, Cruz, Juany, Vázquez, Olga, Miralles, Ramón, Garcia-Giralt, Natalia, Güerri-Fernández, Robert, Arnau-Barrés, Isabel, Pascual-Dapena, Ana, López-Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Sorlí, Luisa, Herrero, Marta, Nogués Solán, Xavier, Navarro-Valls, Claudia, Ibarra, Beatriz, Canchucaja, Lizzeth, da Costa Venancio, Elizabeth, Blasco-Hernando, Fabiola, Cruz, Juany, Vázquez, Olga, Miralles, Ramón, Garcia-Giralt, Natalia, and Güerri-Fernández, Robert
Abstract: Serum albumin levels have been associated with prognosis in several conditions among older adults. The aim of this study is to assess the prognostic value in mortality of serum albumin in older adults with SARS-CoV-2 infection. Methods. Cohort observational study with consecu-tive older-adults (≥65 years old), with confirmed SARS-CoV-2 infection admitted to a university hospital between March-May 2020. A logistic regression model was fitted to assess the impact of albumin levels on in-hospital mortality adjusted by potential confounders. Results. Among a total of 840 patients admitted to the hospital, 405 (48%) were older adults with a total of 92 deaths (23%) among them. Those who died were older, had more comorbidities, higher inflammation status and lower levels of serum albumin at admission [3.10 g/dL (0.51) vs. 3.45 g/dL (0.45); p < 0.01. Serum albumin levels at admission were negatively correlated with inflammatory markers such as C-Reactive protein (Pearson Coeff −0.4634; p < 0.001) or IL-6 (Pearson's Coeff −0.244; p = 0.006) at admission but also to other clinical outcomes such time to clinical stability (Pearson's Coeff −0.259; p < 0.001). Severe hypoalbuminemia associated with increased risk of mortality was defined as ≤3 g/dL at admission according to the AUC/ROC analysis (0.72 95%CI 0.63-0.81) In a multivariate logistic regression model adjusting by age, inflammation, comorbidities and severity at admission severe hypoalbuminemia was a strong predictor of in-hospital mortality (OR 2.18 95% CI 1.03-4.62; p = 0.039). Conclusion. Severe hypoalbuminemia with ≤3 g/dL is an independent risk factor for mortality among older adults with SARS-CoV-2 infection. There is a consistent correlation between albumin levels and inflammatory biomarkers. Further studies are needed to determine whether the supplementation of albumin as coadjuvant treatment will have a positive impact on the prognosis of this infection.
Published: 2021

26. Sustained virological response to direct-acting antiviral regimens reduces the risk of hepatocellular carcinoma in HIV/HCV-coinfected patients with cirrhosis

Author: Merchante, Nicolás, Rivero-Juárez, Antonio, Téllez, Francisco, Merino, Dolores, Ríos-Villegas, María J, Villalobos, Marina, Omar, Mohamed, Rincón, Pilar, Rivero, Antonio, Pérez-Pérez, Montserrat, Raffo, Miguel, López-Montesinos, Inmaculada, Palacios, Rosario, Gómez-Vidal, María A, Macías, Juan, Pineda, Juan A, Members of the HEPAVIR-Cirrhosis Study Group, Junta de Andalucía, Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, and European Commission
Subjects: Adult, Liver Cirrhosis, Male, Microbiology (medical), medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, Sustained Virologic Response, HIV Infections, Lower risk, Antiviral Agents, Risk Assessment, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Medicine, Pharmacology (medical), Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Pharmacology, Antiinfective agent, Coinfection, business.industry, Incidence, virus diseases, Hepatitis C, Hepatitis C, Chronic, Middle Aged, medicine.disease, digestive system diseases, Regimen, Infectious Diseases, Hepatocellular carcinoma, Cohort, Female, 030211 gastroenterology & hepatology, business, Follow-Up Studies
Abstract: HEPAVIR-Cirrhosis Study Group., [Objectives] To assess the impact of all-oral direct-acting antiviral agent (DAA) regimens on the risk of hepatocellular carcinoma (HCC) in HIV/HCV-coinfected patients with cirrhosis., [Methods] This was a multicentre prospective cohort study recruiting HIV/HCV-coinfected patients with a new diagnosis of compensated cirrhosis. Patients were followed up until HCC, death or the censoring date (March 2017). The primary endpoint was the emergence of HCC. The incidence rate (IR) (95% CI) of HCC in different groups was computed. Time-to-event analyses were performed to identify predictors of HCC emergence., [Results] The study included 495 HIV/HCV-coinfected patients with cirrhosis. After a median (IQR) follow-up of 59 (27–84) months, 22 (4.4%; 95% CI 2.6–6.3) patients developed an HCC. The IR (95% CI) of HCC was 0.93 (0.06–1.42) per 100 person-years (PY). Three hundred and three (61%) patients achieved sustained virological response (SVR) during follow-up, 79 after interferon (IFN)-based regimens and 224 after an all-oral DAA regimen. The IR (95% CI) of HCC after all-oral DAA was 0.35 (0.14–0.85) per 100 PY whereas it was 1.79 (1.11–2.88) per 100 PY in the remaining cohort (P = 0.0005). When only patients with SVR were considered, the IR (95% CI) of HCC after all-oral DAA was 0.32 (0.12–0.86) whereas it was 0 per 100 PY among those with SVR after IFN-based therapies (P = 0.27). Achieving SVR with an all-oral DAA regimen during follow-up was independently associated with a lower risk of HCC emergence (subhazard ratio 0.264; 95% CI 0.070–0.991; P = 0.049)., [Conclusions] SVR with all-oral DAA regimens reduces the risk of HCC in HIV/HCV-coinfected patients with compensated cirrhosis., This study was supported by grants from the Consejería de Salud de la Junta de Andalucía (PI-0014/2014), the Servicio Andaluz de Salud (grant number SAS/111239) and the Fondo de Investigaciones Sanitarias ISCIII (grant number PI13/01621 and PI16/01443). J. A. P. is the recipient of an intensification grant from the Instituto de Salud Carlos III (grant number Programa-I3SNS). In addition, this work has been partially funded by the Spanish AIDS Research Network RD16/0025/0010 as part of the Plan Nacional R + D+I and cofinanced by ISCIII Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER).
Published: 2018
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27. Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection

Author: Vogel-González, Marina, primary, Talló-Parra, Marc, additional, Herrera-Fernández, Víctor, additional, Pérez-Vilaró, Gemma, additional, Chillón, Miguel, additional, Nogués, Xavier, additional, Gómez-Zorrilla, Silvia, additional, López-Montesinos, Inmaculada, additional, Arnau-Barrés, Isabel, additional, Sorli-Redó, Maria Luisa, additional, Horcajada, Juan Pablo, additional, García-Giralt, Natalia, additional, Pascual, Julio, additional, Díez, Juana, additional, Vicente, Rubén, additional, and Güerri-Fernández, Robert, additional
Published: 2021
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28. Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Author: Rodríguez-Baño, Jesús, primary, Pachón, Jerónimo, additional, Carratalà, Jordi, additional, Ryan, Pablo, additional, Jarrín, Inmaculada, additional, Yllescas, María, additional, Arribas, José Ramón, additional, Berenguer, Juan, additional, Aznar Muñoz, Esther, additional, Gil Divasson, Pedro, additional, González Muñiz, Patricia, additional, Muñoz Aguirre, Clara, additional, Díaz Menéndez, Marta, additional, de la Calle Prieto, Fernando, additional, Arsuaga Vicente, Marta, additional, Trigo Esteban, Elena, additional, Pérez Valero, Ignacio, additional, de Miguel Buckley, Rosa, additional, Cadiñaños Loidi, Julen, additional, Diaz Pollan, Beatriz, additional, Martín Carbonero, Luz, additional, Ramos Ramos, Juan Carlos, additional, Loeches Yagüe, Belén, additional, Montejano Sánchez, Rocío, additional, González García, Juan, additional, García Rodríguez, Julio, additional, Ramírez, Margarita, additional, Gutiérrez, Isabel, additional, Tejerina, Francisco, additional, Aldámiz-Echevarría, Teresa, additional, Díez, Cristina, additional, Fanciulli, Chiara, additional, Pérez-Latorre, Leire, additional, Pinilla, Blanca, additional, López, Juan Carlos, additional, Such Diaz, Ana, additional, Álvaro Alonso, Elena, additional, Torres Macho, Juan, additional, Cuevas Tascon, Guillermo, additional, Jiménez González de Buitrago, Eva, additional, Brañas Baztán, Fátima, additional, Valencia de la Rosa, Jorge, additional, Pérez Butragueño, Mario, additional, Fernández Jiménez, Inés, additional, Muñiz Nicolás, Gemma, additional, Sepúlveda Berrocal, Antonia, additional, Gato Díez, Alberto, additional, Toledano Sierra, María Pilar, additional, García Butenegro, María Paz, additional, Peláez Ballesta, Ana Isabel, additional, Morcillo Rodríguez, Elena, additional, Fernández Romero, Isidoro, additional, Peláez Ballesta, Cristina, additional, Guirado Torrecillas, María Isabel, additional, Goikoetxea Agirre, Josune, additional, Bereciartua Bastarrica, Elena, additional, Guio Carrión, Laura, additional, Rodríguez Álvarez, Regino, additional, Ibarrola Hierro, Marta, additional, Pérez Hernández, Isabel A., additional, Pérez Zapata, Inés, additional, Román Soto, Sergio, additional, Kallouchi, Mohamed, additional, Domínguez Vicent, Juan Ramón, additional, Silvariño Fernández, Rafae, additional, Ugalde Espiñeira, Jon, additional, Sanjuan López, Ainhoa, additional, García Martínez, Silvia, additional, Temprano Gogenola, Mikel, additional, Asensi, Víctor, additional, Suárez, Silvia, additional, Suárez, Lucia, additional, Yllera, Carmen, additional, Rivas-Carmenado, María, additional, Romero-Palacios, Alberto, additional, Ruiz Aragón, Jesús, additional, Jiménez Aguilar, Patricia, additional, Fernández Ávila, Ma Luisa, additional, Castilla Ortiz, Rosario, additional, Alende Castro, Vanesa, additional, Pérez García, Cristina, additional, Fernández Morales, Marta, additional, Valle Feijoo Begoña Rodríguez Ferreira, María Lorena María, additional, Gómez-Junyent, Joan, additional, Villar-García, Judit, additional, López-Montesinos, Inmaculada, additional, Arrieta-Aldea, Itziar, additional, Rial-Villavecchia, Abora, additional, García Vázquez, Elisa, additional, Roura Piloto, Aychel Elena, additional, Moral Escudero, Encarnación, additional, Hernández Torres, Alicia, additional, Albendín Iglesias, Helena, additional, Vinuesa García, David, additional, Martínez Montes, Clara, additional, De la Hera Fernández, Francisco Javier, additional, Anguita Santos, Francisco, additional, Ruiz Sancho, Andrés, additional, Díaz de Brito Fernández, Vicens, additional, Sanmarti Vilamala, Montserrat, additional, España Cueto, Sergio, additional, Molina Morant, Daniel, additional, González-Cuevas, Araceli, additional, Chara Cervantes, Joel Elías, additional, Policarpo Torres, Guillem, additional, Ortega Montoliu, Meritxell, additional, Angerri Nadal, Mònica, additional, De Genover Gil, Ariadna, additional, Patera, Eleni, additional, Godoy Lorenzo, Rita, additional, Zioga, Evangelia Anna María, additional, Isern Fernández, Virginia, additional, Sabbagh Fajardo, Carlos Enrique, additional, Ferrer Ribera, Ana, additional, Bea Serrano, Carlos, additional, Oltra Sempere, Rosa, additional, Vela Bernal, Sara, additional, Albiol Viñals, Paloma, additional, Pedromingo Kus, Miguel, additional, Garcinuño, María Ángeles, additional, Fiorante, Silvana, additional, Pérez Pinto, Sergio, additional, de la Vega, Alexandra, additional, Fariñas Álvarez, María Carmen, additional, González Rico, Claudia, additional, Arnaiz de las Revillas, Francisco, additional, Giménez, Teresa, additional, Calvo, Jorge, additional, Meije Castillo, Yolanda, additional, Duarte Borges, Alejandra, additional, Pareja Coca, Júlia, additional, Clemente Presas, Mercedes, additional, Sanz Salvador, Xavier, additional, Pérez Rodríguez, Ma Teresa, additional, Sousa, Adrián, additional, Pérez González, Alexandre, additional, Longueira, Rebeca, additional, Araujo, Alejandro, additional, Alonso Martínez, Blanca, additional, García Escudero, Laura, additional, Lidia Kamel Rey, Sara, additional, Roa Alonso, David, additional, Avilés Parra, Juan Pablo, additional, Pelegrín Senent, Iván, additional, Rouco Esteves Marques, Rosana, additional, Raich Montiu, Laia, additional, Souto Higueras, Jessica, additional, Gálvez Bobadilla, Manuel Alejandro, additional, Parra Ruiz, Jorge, additional, Ramos Sesma, Violeta, additional, Velasco Fuentes, Sara, additional, García Pereña, Laura, additional, Lluna Carrascosa, Alfonso, additional, Gilaberte Reyzábal, Sergio, additional, Liébana Gómez, Mónica, additional, Salillas Hernando, Juan, additional, Serrano Martínez, Alberto, additional, Torralba González de Suso, Miguel, additional, Martínez Martín, Patricia, additional, Rábago Lorite, Isabel, additional, González-Ruano Pérez, Patricia, additional, Pérez-Monte Mínguez, Beatriz, additional, García Flores, Ángeles, additional, Comas Casanova, Pere, additional, Martín Plata, Andrea, additional, Santana Báez, Sergio Manuel, additional, Sanz Peláez, Oscar, additional, Mohamed Ramírez, Karim, additional, Robaina Bordón, José María, additional, Vílchez Rueda, Helem Haydeé, additional, Riera Jaume, Melchor, additional, Mut Ramon, Gemma, additional, Gavalda Manso, Meritxell, additional, Planas Bibiloni, Lluis, additional, Castelo Corral, Laura, additional, Ramos Merino, Lucía, additional, Sánchez Vidal, Efrén, additional, Rodríguez Mayo, María, additional, Míguez Rey, Enrique, additional, García de Lomas Guerrero, José M., additional, De la Torre Lima, Javier, additional, Correa Ruiz, Ana, additional, Fernández Sánchez, Fernando, additional, Jiménez-García, Nicolás, additional, Sierra-Monzón, José Luis, additional, Gracia-Tello, Borja, additional, Hernández-Bonaga, María, additional, Pellejero, Galadriel, additional, Asín-Corrochano, Marta, additional, Boix Palop, Lucia, additional, Calbo, Esther, additional, Badía, Cristina, additional, Dietl, Beatriz, additional, Lucía, Gómez, additional, Domínguez-Castellano, Ángel, additional, Ríos-Villegas, María José, additional, del Toro, María D., additional, Palacios Baena, Zaira R., additional, Salamanca-Rivera, Elena, additional, Marín, Elena, additional, Almadana, Virginia, additional, Pérez-Galera, Salvador, additional, González-Iglesias, Luisa, additional, Abelenda-Alonso, Gabriela, additional, Álvarez-Pouso, Claudia, additional, Escrihuela, Francesc, additional, Gudiol, Carlota, additional, Lorenzo-Esteller, Laia, additional, Niubó, Jordi, additional, Podzamczer, Daniel, additional, Pujol, Miquel, additional, Rombauts, Alexander, additional, Salvert Lletí, Miguel, additional, Gil Sánchez, Ricardo, additional, Jiménez Escrig, Marta, additional, Parra Gómez, Laura, additional, Tasias Pitarch, Mariona, additional, Navarro Vilasaró, Marta, additional, Machado Sicilia, María Luisa, additional, Gomila Grange, Aina, additional, Calzado Isbert, Sonia, additional, Carrasco Antón, Nerea, additional, Petkova-Saiz, Elizabet, additional, Cabello Úbeda, Alfonso, additional, Górgolas Hernández-Mora, Miguel, additional, Sánchez-Pernaute, Olga, additional, Dueñas Gutiérrez, Carlos, additional, Martin Guerra, Javier, additional, Castrodeza Sanz, José Javier, additional, Fernández Espinilla, Virginia, additional, Rodríguez Fernández, Laura, additional, González-Moreno, Juan, additional, Villoslada Gelabert, Aroa, additional, Ribot Sanso, María Antonia, additional, Fernández-Baca, María Victoria, additional, Hernández Milian, Almudena, additional, Morán Rodríguez, Miguel Ángel, additional, Ortiz de Zárate Ibarra, Zuriñe, additional, Portu Zapirain, José Joaquin, additional, Saez de Adana Arroniz, Ester, additional, Gainzarain Arana, Juan Carlos, additional, Meca Birlanga, Olga, additional, del Amor Espín, Ma Jesús, additional, Viqueira González, Montserrat, additional, García García, Josefina, additional, Martínez Madrid, Onofre, additional, Bernal Morell, Enrique, additional, Alcaraz, Antonia, additional, Muñoz, Ángeles, additional, Pina, Ignacio, additional, de la Rosa, Vicente, additional, Caínzos Romero, Tamara, additional, Sánchez Trigo, Sabela, additional, Mariño Callejo, Ana Isabel, additional, Álvarez Díaz, Hortensia, additional, Valcarce Pardeiro, Nieves, additional, Sánchez Serrano, Adriana, additional, Piñar Cabezos, Diana, additional, García Villalba, Eva Pilar, additional, Aguayo Jiménez, Carmen, additional, Ruíz Campuzano, María, additional, Naranjo Velasco, Virginia, additional, Santos Peña, Marta, additional, Mora Delgado, Juan, additional, Sevilla Moreno, Israel, additional, Lojo Cruz, Cristina, additional, Kortajarena Urkola, Xabier, additional, Iribarren Loyarte, José Antonio, additional, Bustinduy Odriozola, María Jesús, additional, Ibarguren Pinilla, Maialen, additional, Álvarez Rodríguez, Ignacio, additional, Martínez Marcos, Francisco Javier, additional, Rodríguez Gómez, Francisco Javier, additional, Asschert Agüero, Isabel, additional, Muñoz Beamud, Francisco, additional, Ruiz Reina, Antonio José, additional, Llenas-García, Jara, additional, González-Cuello, Inmaculada, additional, Hellín-Valiente, Elena, additional, Martínez Birlanga, Esther, additional, Tafalla Torres, José Manuel, additional, Calderón Parra, Jorge, additional, Escudero López, Gabriela, additional, Gutiérrez Martín, Isabel, additional, Andrés Eisenhofer, Ane, additional, García Prieto, Sonia, additional, Álvarez Franco, Raquel, additional, Roger Zapata, Daniel, additional, Martínez Cifre, Blanca, additional, Aranda Rife, Elena, additional, Martín Rubio, Irene, additional, Barbosa Ventura, André, additional, Garrido, Javier, additional, Gonzalo, Concepción, additional, Piñero, Iván, additional, de la Cruz Felipe, Nieves, additional, Talavera García, Eva, additional, Lamata Subero, Marta, additional, Mendoza Roy, Paula, additional, García de Carlos, María Soledad, additional, Lajusticia Aisa, Justo, additional, Arteche Eguizabal, Lorea, additional, Urrutia Losada, Ainhoa, additional, Domingo Echaburu, Saioa, additional, Cuadros Tito, Pedro Ángel, additional, Orbe Narváez, Gurutz, additional, Liébana Martos, Ma del Carmen, additional, Roldán Fontana, Carolina, additional, Herrero Rodríguez, Carmen, additional, Duro Ruiz, Gaspar, additional, Pérez Parra, Santiago, additional, Mera Fidalgo, Arantzazu, additional, Hortos Alsina, Miquel, additional, Alberich Conesa, Ana, additional, Bladé Vidal, Lourdes, additional, Merchante Gutiérrez, Nicolás, additional, León Jiménez, Eva, additional, Espíndola Gómez, Reinaldo, additional, Erostarbe Gallardo, María, additional, Martínez Pérez-Crespo, Pedro, additional, Cisneros, José Miguel, additional, Aguilar-Guisado, Manuela, additional, Aldabó, Teresa, additional, Bueno, Claudio, additional, Cordero-Matía, Elisa, additional, Escoresca, Ana, additional, Infante, Carmen, additional, Guillermo, Martín, additional, Salto, Sonsoles, additional, Gioia, Francesca, additional, Vizcarra, Pilar, additional, Fortún Abete, Jesús, additional, Martín Dávila, Pilar, additional, Moreno Guillén, Santiago, additional, Oteo Revuelta, José A., additional, García-García, Concepción, additional, Santibañez Sáenz, Paula, additional, Cervera Acedo, Cristina, additional, Azcona Gutiérrez, José M., additional, Reguera Iglesias, José María, additional, Plata Ciezar, Antonio, additional, Valiente de Santis, Lucia, additional, Sobrino Diaz, Beatriz, additional, and Ruiz Mesa, Juan Diego, additional
Published: 2021
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29. Low zinc levels at clinical admission associates with poor outcomes in COVID-19

Author: Vogel-González, Marina, primary, Talló-Parra, Marc, additional, Herrera-Fernández, Víctor, additional, Pérez-Vilaró, Gemma, additional, Chillón, Miguel, additional, Nogués, Xavier, additional, Gómez-Zorrilla, Silvia, additional, López-Montesinos, Inmaculada, additional, Villar, Judit, additional, Sorli-Redó, Maria Luisa, additional, Horcajada, Juan Pablo, additional, García-Giralt, Natalia, additional, Pascual, Julio, additional, Díez, Juana, additional, Vicente, Rubén, additional, and Güerri-Fernández, Robert, additional
Published: 2020
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30. Risk Factors for Mortality among Patients with Pseudomonas aeruginosa Bloodstream Infections: What Is the Influence of XDR Phenotype on Outcomes?

Author: Montero, María Milagro, primary, López Montesinos, Inmaculada, additional, Knobel, Hernando, additional, Molas, Ema, additional, Sorlí, Luisa, additional, Siverio-Parés, Ana, additional, Prim, Nuria, additional, Segura, Concepción, additional, Duran-Jordà, Xavier, additional, Grau, Santiago, additional, and Horcajada, Juan Pablo, additional
Published: 2020
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31. Risk Factors for Mortality among Patients with Pseudomonas aeruginosa Bloodstream Infections : what is the Influence of XDR Phenotype on Outcomes?

Author: Montero, María Milagro, López Montesinos, Inmaculada, Knobel Freud, Hernando, Molas, Ema, Sorlí, Luisa, Siverio Pares, Ana Cristina, Prim, Nuria, Segura, Concepción, Duran-Jordà, Xavier, Grau, Santiago, Horcajada, Juan Pablo, Montero, María Milagro, López Montesinos, Inmaculada, Knobel Freud, Hernando, Molas, Ema, Sorlí, Luisa, Siverio Pares, Ana Cristina, Prim, Nuria, Segura, Concepción, Duran-Jordà, Xavier, Grau, Santiago, and Horcajada, Juan Pablo
Abstract: This study aimed to assess the impact of extensively drug-resistant (XDR) phenotype on mortality in Pseudomonas aeruginosa bacteremia. A retrospective cohort study was performed in a tertiary hospital from January 2000 to December 2018. All consecutive prospectively recorded P. aeruginosa bacteremia in adult patients were assessed. In this study, 382 patients were included, of which 122 (31.9%) due to XDR P. aeruginosa. Independent factors associated with 14-day mortality were as follows: high-risk source of bacteremia (hazard ratio (HR) 3.07, 95% confidence interval (CI), 1.73-5.46), septic shock (HR 1.75, 95% CI, 1.12-2.75), and higher Pitt scores (one-point increments; HR 1.25, 95% CI, 1.12-1.38). Otherwise, the appropriateness of definitive antibiotic therapy was a protective factor (HR 0.39, 95% CI, 0.24-0.62). The same variables were also associated with 30-day mortality. XDR phenotype was not associated with 14- or 30-day mortality. In a subanalysis considering only high-risk source cases, combined antimicrobial therapy was independently associated with 14-day favorable outcome (HR 0.56, 95% CI, 0.33-0.93). In conclusion, XDR phenotype was not associated with poor prognosis in patients with P. aeruginosa bacteremia in our cohort. However, source of infection, clinical severity, and inappropriate definitive antibiotic therapy were risk factors for mortality. Combined antimicrobial therapy should be considered for high-risk sources.
Published: 2020

32. Acute-to-Chronic Glycemic Ratio as a Predictor of COVID-19 Severity and Mortality.

Author: Ramon, Jordi, Llauradó, Gemma, Güerri, Roberto, Climent, Elisenda, Ballesta, Silvia, Benaiges, David, López-Montesinos, Inmaculada, Navarro, Humberto, Fernández, Natalia, José Carrera, Maria, Mauricio, Dídac, Flores-Le Roux, Juana A., and Chillarón, Juan-José
Subjects: HYPERGLYCEMIA, TYPE 2 diabetes, COVID-19, INTENSIVE care units, HOSPITAL mortality, MORTALITY
Abstract: Objective: To evaluate the association between acute-to-chronic (A/C) glycemic ratio and mortality and severity outcomes for patients with type 2 diabetes (T2D) hospitalized with coronavirus disease 2019 (COVID-19).Research Design and Methods: A total of 91 patients were included. We measured glycemia at admission and estimated the average chronic glucose levels to calculate the A/C glycemic ratio. The primary outcome was a composite of in-hospital mortality, intensive care unit admission, and mechanical ventilation.Results: Thirty-five patients had a primary outcome event, presenting a significant association with the A/C glycemic ratio (hazard ratio [HR] 1.57 [95% CI 1.14-2.15], P = 0.005). In comparisons with the 2nd tertile, the 3rd tertile of the A/C glycemic ratio was associated with the primary outcome (HR 3.39 [95% CI 1.31-8.75], P = 0.012). In the multivariate analysis, after additional adjustment for age, sex, comorbidities, inflammatory markers, and corticosteroid therapy, the association for the 3rd tertile (HR 3.96 [95% CI 1.35-11.59], P = 0.012) remained significant.Conclusions: In patients with T2D hospitalized with COVID-19, the imbalance between acute glycemia at admission and chronic metabolic control is associated with worse prognosis. [ABSTRACT FROM AUTHOR]
Published: 2022
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33. Oral and intravenous fosfomycin in complicated urinary tract infections

Author: López Montesinos, Inmaculada and Horcajada Gallego, Juan Pablo
Subjects: Infeccions -- Tractament, Aparell urinari -- Infeccions -- Tractament, Urologia -- Malalties
Abstract: Urinary tract infections are one of the most common health problems and entail a high consumption of health system resources. Due to the increase in global antibiotic resistances in recent years, it is increasingly common to find uropathogens with multiple resistance mechanisms, including quinolone-resistant bacteria, broad-spectrum β-lactamase producers and carbapenemase producers. In this scenario, the role of fosfomycin has gained considerable importance, given its spectrum of activity against multidrug resistant microorganisms (Gram-positive and Gram-negative), becoming an attractive alternative therapy. Regarding the use of fosfomycin in complicated urinary tract infections, there is increasing clinical experience with patients with infections caused by multidrug resistant bacteria, those with recurrent urinary tract infection and special populations such as those with kidney transplants. Randomized comparative studies and series are underway, which will provide greater evidence. Nevertheless, more studies are needed to confirm the enormous potential of fosfomycin in complicated urinary tract infection in the era of multiresistance.
Published: 2019

34. Sustained virological response to direct-acting antiviral regimens reduces the risk of hepatocellular carcinoma in HIV/HCV-coinfected patients with cirrhosis

Author: Junta de Andalucía, Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, European Commission, Merchante, Nicolás, Rivero-Juárez, Antonio, Téllez, Francisco, Merino, Dolores, Ríos-Villegas, María José, Villalobos, Marina, Omar, Mohamed, Rincón, Pilar, Rivero, Antonio, Pérez-Pérez, Monserrat, Raffo, Miguel, López-Montesinos, Inmaculada, Palacios, Rosario, Gómez-Vidal, María Amparo, Macías Sánchez, Juan, Pineda, Juan A., Junta de Andalucía, Instituto de Salud Carlos III, Red Española de Investigación en Patología Infecciosa, European Commission, Merchante, Nicolás, Rivero-Juárez, Antonio, Téllez, Francisco, Merino, Dolores, Ríos-Villegas, María José, Villalobos, Marina, Omar, Mohamed, Rincón, Pilar, Rivero, Antonio, Pérez-Pérez, Monserrat, Raffo, Miguel, López-Montesinos, Inmaculada, Palacios, Rosario, Gómez-Vidal, María Amparo, Macías Sánchez, Juan, and Pineda, Juan A.
Abstract: [Objectives] To assess the impact of all-oral direct-acting antiviral agent (DAA) regimens on the risk of hepatocellular carcinoma (HCC) in HIV/HCV-coinfected patients with cirrhosis., [Methods] This was a multicentre prospective cohort study recruiting HIV/HCV-coinfected patients with a new diagnosis of compensated cirrhosis. Patients were followed up until HCC, death or the censoring date (March 2017). The primary endpoint was the emergence of HCC. The incidence rate (IR) (95% CI) of HCC in different groups was computed. Time-to-event analyses were performed to identify predictors of HCC emergence., [Results] The study included 495 HIV/HCV-coinfected patients with cirrhosis. After a median (IQR) follow-up of 59 (27–84) months, 22 (4.4%; 95% CI 2.6–6.3) patients developed an HCC. The IR (95% CI) of HCC was 0.93 (0.06–1.42) per 100 person-years (PY). Three hundred and three (61%) patients achieved sustained virological response (SVR) during follow-up, 79 after interferon (IFN)-based regimens and 224 after an all-oral DAA regimen. The IR (95% CI) of HCC after all-oral DAA was 0.35 (0.14–0.85) per 100 PY whereas it was 1.79 (1.11–2.88) per 100 PY in the remaining cohort (P = 0.0005). When only patients with SVR were considered, the IR (95% CI) of HCC after all-oral DAA was 0.32 (0.12–0.86) whereas it was 0 per 100 PY among those with SVR after IFN-based therapies (P = 0.27). Achieving SVR with an all-oral DAA regimen during follow-up was independently associated with a lower risk of HCC emergence (subhazard ratio 0.264; 95% CI 0.070–0.991; P = 0.049)., [Conclusions] SVR with all-oral DAA regimens reduces the risk of HCC in HIV/HCV-coinfected patients with compensated cirrhosis.
Published: 2018

35. Ceftolozane-tazobactam: When, how and why using it?

Author: López Montesinos, Inmaculada, Luisa Sorlí, Milagro Montero, and Horcajada, Juan P.
Subjects: TAZOBACTAM, MEROPENEM, URINARY tract infections, VENTILATOR-associated pneumonia, CLINICAL trials
Abstract: Ceftolozane-tazobactam is currently the most active antipseudomonal agent, including multidrug-resistant extensively drug-resistant strains. Tazobactam provides additional activity against many extended-spectrum beta-lactamases Enterobacterales. Ceftolozane-tazobactam is formally approved for complicated urinary tract infection, complicated intra-abdominal infection, and hospital-acquired and ventilator-associated bacterial pneumonia. The clinical and microbiological success is over 70-80% in many series. However, resistant mutants to ceftolozane-tazobactam have been already described. Combination therapies with colistin or meropenem could be among the strategies to avoid the resistance emergence. [ABSTRACT FROM AUTHOR]
Published: 2021
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36. Oral and intravenous fosfomycin in complicated urinary tract infections.

Author: López-Montesinos, Inmaculada and Horcajada, Juan P.
Subjects: FOSFOMYCIN, URINARY tract infection treatment, MULTIDRUG resistance in bacteria, PHARMACOKINETICS, PHARMACODYNAMICS
Abstract: Urinary tract infections are one of the most common health problems and entail a high consumption of health system resources. Due to the increase in global antibiotic resistances in recent years, it is increasingly common to find uropathogens with multiple resistance mechanisms, including quinolone-resistant bacteria, broad-spectrum β-lactamase producers and carbapenemase producers. In this scenario, the role of fosfomycin has gained considerable importance, given its spectrum of activity against multidrug resistant microorganisms (Gram-positive and Gram-negative), becoming an attractive alternative therapy. Regarding the use of fosfomycin in complicated urinary tract infections, there is increasing clinical experience with patients with infections caused by multidrug resistant bacteria, those with recurrent urinary tract infection and special populations such as those with kidney transplants. Randomized comparative studies and series are underway, which will provide greater evidence. Nevertheless, more studies are needed to confirm the enormous potential of fosfomycin in complicated urinary tract infection in the era of multiresistance. [ABSTRACT FROM AUTHOR]
Published: 2019

37. Liver stiffness predicts variceal bleeding in HIV/HCV-coinfected patients with compensated cirrhosis

Author: Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Merchante, Nicolás, Rivero-Juárez, Antonio, Téllez, Francisco, Merino, Dolores, Ríos-Villegas, María José, Ojeda Burgos, Guillermo, Omar, Mohamed, Macías Sánchez, Juan, Rivero, Antonio, Pérez-Pérez, Monserrat, Raffo, Miguel, López-Montesinos, Inmaculada, Marquez-Solero, Manuel, Gómez-Vidal, María Amparo, Pineda, Juan A., Junta de Andalucía, Instituto de Salud Carlos III, European Commission, Merchante, Nicolás, Rivero-Juárez, Antonio, Téllez, Francisco, Merino, Dolores, Ríos-Villegas, María José, Ojeda Burgos, Guillermo, Omar, Mohamed, Macías Sánchez, Juan, Rivero, Antonio, Pérez-Pérez, Monserrat, Raffo, Miguel, López-Montesinos, Inmaculada, Marquez-Solero, Manuel, Gómez-Vidal, María Amparo, and Pineda, Juan A.
Abstract: [Background] A liver stiffness below 21 kPa has a high negative predictive value to exclude the presence of esophageal varices at risk of bleeding in HIV/hepatitis C virus (HCV)-coinfected patients. Consequently, upper gastrointestinal endoscopy (UGE) for the screening of esophageal varices could be avoided in these patients. However, this strategy has not been widely accepted due to concerns about its safety., [Objective] To assess the ability of liver stiffness to predict the risk of portal hypertensive gastrointestinal bleeding (PHGB) in HIV/HCV-coinfected patients with compensated cirrhosis., [Methods] Prospective study of 446 HIV/HCV-coinfected patients with a new diagnosis of cirrhosis and no previous decompensation. All patients underwent a UGE for the screening of esophageal varices at entry in the cohort before November 2009. From this date, UGE was not recommended in patients with liver stiffness below 21 kPa. The time from diagnosis of cirrhosis to the emergence of PHGB was evaluated., [Results] After a median (quartile1–quartile3) follow-up of 49 (25–68) months, 15 (3.4%, 95% confidence interval 1.7–5%) patients developed a first PHGB episode. In all cases, baseline liver stiffness was at least 21 kPa. Thus, the negative predictive value of a liver stiffness below 21 kPa to predict PHGB during follow-up was 100%. At the time of the bleeding episode, liver stiffness was above this threshold in all patients., [Conclusions] Liver stiffness identifies HIV/HCV-coinfected patients with compensated cirrhosis with a very low risk of PHGB. In fact, no individual with liver stiffness below 21 kPa developed this outcome. Our results confirm that UGE can be safely spared in patients with liver stiffness below 21 kPa.
Published: 2017

38. Comparison of Hospitalized Coronavirus Disease 2019 and Influenza Patients Requiring Supplemental Oxygen in a Cohort Study: Clinical Impact and Resource Consumption.

Author: López Montesinos I, Arrieta-Aldea I, Dicastillo A, Zuccarino F, Sorli L, Guerri-Fernández R, Arnau-Barrés I, Montero MM, Siverio-Parès A, Durán X, Del Mar Arenas M, Arnau AB, Cañas-Ruano E, Castañeda S, Kamber ID, Gómez-Junyent J, Pelegrín I, Martínez FS, Sendra E, Leiro LS, Villar-García J, Nogués X, Grau S, Knobel H, Gomez-Zorrilla S, and Horcajada JP
Subjects: Humans, Aged, Cohort Studies, SARS-CoV-2, Retrospective Studies, Hospitalization, Oxygen, Hospital Mortality, COVID-19, Influenza, Human
Abstract: Background: To compare clinical characteristics, outcomes, and resource consumption of patients with coronavirus disease 2019 (COVID-19) and seasonal influenza requiring supplemental oxygen., Methods: Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted because of seasonal influenza between 2017 and 2019, or with COVID-19 between March and May 2020 requiring supplemental oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality and hospitalization costs. Attempted sample size to detect an 11% difference in mortality was 187 patients per group., Results: COVID-19 cases were younger (median years of age, 67; interquartile range [IQR] 54-78 vs 76 [IQR 64-83]; P < .001) and more frequently overweight, whereas influenza cases had more hypertension, immunosuppression, and chronic heart, respiratory, and renal disease. Compared with influenza, COVID-19 cases had more pneumonia (98% vs 60%, <.001), higher Modified Early Warning Score (MEWS) and CURB-65 (confusion, blood urea nitrogen, respiratory rate, systolic blood pressure, and age >65 years) scores and were more likely to show worse progression on the World Health Organization ordinal scale (33% vs 4%; P < .001). The 30-day mortality rate was higher for COVID-19 than for influenza: 15% vs 5% (P = .001). The median age of nonsurviving cases was 81 (IQR 74-88) and 77.5 (IQR 65-84) (P = .385), respectively. COVID-19 was independently associated with 30-day (hazard ratio [HR], 4.6; 95% confidence interval [CI], 2-10.4) and 90-day (HR, 5.2; 95% CI, 2.4-11.4) mortality. Sensitivity and subgroup analyses, including a subgroup considering only patients with pneumonia, did not show different trends. Regarding resource consumption, COVID-19 patients had longer hospital stays and higher critical care, pharmacy, and complementary test costs., Conclusions: Although influenza patients were older and had more comorbidities, COVID-19 cases requiring supplemental oxygen on admission had worse clinical and economic outcomes., Competing Interests: Potential conflicts of interest. I. L. M. reports Rio Hortega Grant Instituto Carlos III CM18/00047 from January 2018 to December 2020, unrelated to this work; and support by Pfizer and Angelini to attend meetings (no payment to author; registration to meetings only). I. A. A. reports Rio Hortega Grant Instituto Carlos III, unrelated to this work. L. S. reports payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Pfizer, Angelini, and Menarini. R. G. F. reports grants or contracts unrelated to this work: FIS ISCIII PI19/00019; honoraria for lectures and presentations from Gilead Inc, MSD, GSK; and participation on GC2010 DSMB Interim Safety Data Review. S. C. reports support by Pfizer, Angelini, and MSD to attend meetings (no payments to author; registration to meetings only). J. G. J. reports support by Pfizer, Angelini, and MSD to attend meetings (no payments to author; registration to meetings only). X. N. reports payment or honoraria for Amgen UCB lectures; support for attending meetings and/or travel from Amgen, Lilly; and participation on a Data Safety Monitoring Board or Advisory Board for Amgen UCB. S. G. Z. reports grants or contracts unrelated to this study: FIS ISCIII PI21/00509, Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC). J. P. H. reports honoraria for lectures from Pfizer, Angelini, Menarini, and MSD; and participation on advisory boards for Menarini, MSD, and GILEAD. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2022. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Published: 2022
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