24 results on '"López García, M. J."'
Search Results
2. Urban expansión of the Valencia Metropolitan Area during the period 1984-2011 from Landsat TM and ETM+ imagery
- Author
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Fernández-Gimeno, L. and López-García, M. J.
- Subjects
SIOSE ,Área metropolitana de Valencia ,Cambios usos del suelo ,Clasificación digital ,Urbanization ,Digital classification ,Valencia Metropolitan area ,lcsh:G1-922 ,Cobertura artificial ,Artificial soil ,Área Metropolitana de Valencia ,Land use change ,Urbanización ,Landsat ,lcsh:Geography (General) - Abstract
[EN] The accelerated urban expansion produced in large metropolitan areas such as Valencia Metropolitan Area in recent decades has important environmental impacts including “soil sealing” and the loss of valuable natural areas. The aim of this paper is to analyze the evolution of artificial soil in the Metropolitan Area of Valencia (AMV) between 1984-2011 using Landsat TM and ETM+ images, that have been validated from SIOSE data with larger spatial resolution. Results point out, with an accuracy of 71%, that artificial surface raised in 8000 ha which represents an increase of 10% for sealing soil and 34% of the whole land covers of the AMV., [ES] La expansión urbana acelerada producida en décadas recientes en las grandes áreas metropolitanas como Valencia conlleva importantes impactos ambientales, entre ellos la impermeabilización o “sellado antropogénico” del suelo y la pérdida de espacios naturales de gran valor paisajístico. Este trabajo analiza la evolución de la cobertura artificial en el Área Metropolitana de Valencia (AMV) en el periodo 1984-2011 a partir de imágenes Landsat TM y ETM+, validadas a partir de datos SIOSE de mayor resolución espacial. Los resultados muestran, con una precisión del 71%, un aumento de la superficie artificial en el AMV de 8000 ha en dicho periodo, lo que supone un incremento del 10% del suelo sellado que representa globalmente el 34% del AMV
- Published
- 2015
3. Expansión urbana del Área Metropolitana de Valencia en el periodo 1984-2011 a partir de imágenes Landsat TM y ETM+
- Author
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Fernández-Gimeno, L., primary and López-García, M. J., additional
- Published
- 2015
- Full Text
- View/download PDF
4. Sedimentología química de los sedimentos miocenos con diatomeas de la Cuenca del Guadalquivir
- Author
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López García, M. J. and Bustillo, M. A.
- Subjects
Geachemistry , ,diatomeas ,lcsh:Geology ,« ,majar elements ,elementos mayores ,lcsh:QE1-996.5 ,coastal upwelling ,Geoquímica ,» ,diatams ,«coastal upwelling» - Abstract
The chemical data of major elements is used to study the precise lithological composition and the sedimentology of Miocene diatomaceous sediments from 24 sections of the Guadalquivir Basin. Three main episodes (Lower, Middle and Upper), defined on the basis of diatom zones have been studied. They record a highly productive coastal upwelling regime in the area during the Miocene. The wide range of variation of SiO2 (12.1878.00), CaO (1.60-43.73) and Al2O3 (2.76-10.32) contents reflects the important variations of the main components: Opal A, calcite (mainly biogenic) and clay minerals-terrigenous components. Biogenic silica has been estimated by using normative calculations after determination of the mineralogical compositions of the samples by means of X-ray diffraction. Maximum and minimum contents in biogenic silica are related to the dominant diatom taxa, the structure of the rock and the geographicallocation in the basin. The ternary diagrams SiO2 biogenic- Al2O3-CaO reveal that the Upper Episode has the highest amounts of clay minerals-terrigenous components. Plots of SiO2 biogenic/CaO versus Al2O3show a relation between the biogenic calcite and the clay-minerals-terrigenous components. The plots of Fe2O3/TiO2 versus Al2O3/ Al2O3+ Fe2O3 show that most of the samples may be interpreted as deposited in a continental margin enviranment. The data obtained fram the slope of linear regressions Fe (y) - Al (x) are indicative of areas with varying influence of a terrigenous source. The MnO/ Al2O3 ratio is used to estimate rates of sedimentation of the diatomaceous sediments. The range is between 1.7 and 180 mm/103 years, which is consistent with the sedimentation rate values fram sediments formed in coastal upwelling regimes. The rate of sedimentation varies in relation to the structure of the rack, the dominant diatom taxa and the age of the episodes.La composición química de elementos mayores es utilizada para analizar las características composicionales y sedimentológicas en 24 afloramientos de sedimentos miocenos con diatomeas de la Cuenca del Guadalquivir. En función de las biozonas de diatomeas, se consideran tres episodios de sedimentación diatomítica (Inferior, Medio y Superior) que reflejan un medio de sedimentación de alta productividad biogénica ocasionada por corrientes ascensionales costeras («coastal upwelling»). Los grandes márgenes de variación de los tres óxidos más importantes SiO2 (12,1878,00), CaO (1,60-43,73) y Al2O3 (2,76-10,32) definen la gran variación que presentan los tres componentes mayoritarios de estos sedimentos: Opalo A, calcita y minerales de la arcilla-terrígenos. A través de cálculos normativos en función de la composición mineralógica de las muestras y de los análisis de difracción de RX, se ha definido el porcentaje de sílice biogénica. El estudio de los máximos y mínimos de sílice biogénica ha puesto de manifiesto su relación con tipos dominantes de diatomeas, la estructura de la roca y la posición geográfica dentro de la Cuenca. La proyección de las muestras en los diagramas triangulares SiO2 biogénica- Al2O3-CaO ha revelado que el Episodio Superior es el que manifiesta mayor proporción relativa de Al2O3 (arcillas-componentes terrígenos). Los diagramas SiO2 biogénicalCaO versus Al2O3 han demostrado que existe frecuentemente una asociación preferente entre el plancton calcáreo y los minerales de arcilla-terrígenos. La proyección de las muestras en el diagrama Fe2O3/TiO2 versus Al2O3/ Al2O3+FeO, junto con la pendiente de la recta de regresión Fe (y) - Al (x) indican que todas las series se pueden considerar de plataforma continental existiendo zonas con mayor o menor influencia del continente. La relación MnO/ Al2O3, se ha utilizado para medir la tasa sedimentación; los valores obtenidos (entre 1,7 y 180 mm/103 años) concuerdan con los hallados en otras zonas de corrientes ascensionales costeras, encontrándose diferencias en función de las estructura de la roca, las diatomeas dominantes y los episodios considerados.
- Published
- 1995
5. Los sedimentos con diatomeas del Mioceno en la Cuenca del Guadalquivir: edad y composición litológica
- Author
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López García, M. J. and Bustillo, M. A.
- Subjects
diatomeas ,QE1-996.5 ,Mioceno Medio-Superior ,«coastal upwelling» ,Middle and Late Miocene ,Geology ,coastal upwelling ,ópalo A ,ópalo a ,diatoms ,opal A ,mioceno medio-superior - Abstract
The lithological composition and biostratigraphy of diatomaceous marls have been defined in 93 outcrops of the Guadalquivir Basin. The diatomaceous marls display a wide variety of lithological types, mainly comprised of opal A (10-85 %) (mainly diatoms and to a lesser extent silicoflagellates, spicules and radiolarians), calcite (5-80 %) (principally foraminifers, nannoplankton, sparite, micrite and microspar), c1ay minerals (5-40 %) (smectite in greater quantities than illite; and kaolinite in small quantities) and terrigenous quartz (< 15 %). The diatom assemblages in the marls reflect the occurrence of temperate to warm water conditions in this area during middle and late Miocene. The diatoms are dominated by the fol1owing upwelling species: Thalassiosira nitzshoides, Thalassiotrix longuissima and Thalassionema baci//aris. Benthic diatoms are scarce but they have great species diversity. However, in sorne outcrops the genus Delphineis is more frequent thus indicating environments c10ser to shore areas. Three episodes based on Barron's (1985) low latitude zonation have been defined. The Lower Episode includes Cestodiscus peplum and Coscinodiscus lewisianus Zone and is assigned to the upper Langhian- lower Serravalian. After a period of no diatom occurrence (e. gigas var. diorama Zone is missing), the Middle Episode is defined by Craspedodiscus coscinodiscus and Actinocyclus moronensis Zones and covers the latest Serravalian-early Tortonian. The Upper Episode corresponds to Thalassiosira yabei Zone and it is assigned to middle Tortonian. The fundamental types of dilutants in diatomic sedimentation (biogenic calcareous, terrigenous and c1ay minerals), do not vary throughout the three episodes but there are great variations in the proportions. The coastal upwelling regime produces tongue-like patterns of sedimentation and the sedimentary record displays different changes of facies. The Upper Episode, where the c1ay-terrigenous dilutants predominate over calcareous dilutants and Delphineis appear in greater quantities, is interpreted as having been formed in an environment closer to the shore than other episodes. El estudio de 93 puntos en el Mioceno de la cuenca del Guadalquivir ha permitido definir en esta cuenca la situación, bioestratigráfica y composición litológica de las margas con diatomeas o «moronitas». Dichas rocas incluyen gran variedad de términos litológicos estando constituidos principalmente por ópalo A (10-85 %) (mayoritariamente diatomeas; silicoflagelados, espículas de esponja y radiolarios en menor proporción), calcita (5-80 %) (microforaminíferos, nanoplancton calcáreo, micrita y esparita fundamentalmente), minerales de la arcilla (5-40 %) (esmectita predominando sobre illita y caolinita en menores proporciones) y cuarzo terrígeno « 15 %). Las asociaciones de diatomeas están constituidas fundamentalmente por diatomeas planctónicas de aguas templado-cálidas, con dominio de Thalassionema nitzschoides, Thalassionema bacillaris y Thalassiotrix longuissima, definiendo áreas de alta productividad (upwelling) en la zona durante el Mioceno Medio y Superior. El componente bentónico es escaso y diversificado, sin embargo localmente adquiere importancia el género Delphineis indicando zonas más litorales. Se determinan tres episodios de sedimentación diatomítica basados en la zonación de baja latitud de Barron (1985c). El Episodio Inferior definido por las biozonas Cestodiscus peplum y Coscinodiscus lewisianus, comprende desde el Langhiense superior al Serrava¡ iense inferior. Después de un período de tiempo sin deposición de diatomeas comienza el Episodio Medio definido por las biozonas Craspedodiscus coscinodiscus y Actinocyclus moronensis, y que incluye el techo del Serravaliense y el Tortoniense Inferior. El Episodio Superior que corresponde a la biozona Thalassiosira yabei comprende el Tortoniense Medio. Los tipos de diluyentes fundamentales de la sedimentación diatomítica (componentes biogénicos calcáreos, terrígenos y arcillas), se mantienen en los tres episodios pero presentan gran variación en sus proporciones debido a la morfología «en lenguas» y composición de los depósitos sedimentarios formados bajo zonas de «coastal upwelling». El Episodio Superior diferenciado por el predominio del diluyente arcilloso-terrígeno y por una mayor proporción de Delphineis en las asociaciones de diatomeas. se interpreta formado más cerca del continente.
- Published
- 1994
- Full Text
- View/download PDF
6. Los sedimentos con diatomeas del Mioceno en la Cuenca del Guadalquivir: edad y composición litológica
- Author
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Bustillo, M. A. and López García, M. J.
- Subjects
diatomeas ,lcsh:Geology ,Mioceno Medio-Superior ,lcsh:QE1-996.5 ,Middle and Late Miocene ,coastal upwelling ,«coastal upwelling» ,ópalo A ,diatoms ,opal A - Abstract
The lithological composition and biostratigraphy of diatomaceous marls have been defined in 93 outcrops of the Guadalquivir Basin. The diatomaceous marls display a wide variety of lithological types, mainly comprised of opal A (10-85 %) (mainly diatoms and to a lesser extent silicoflagellates, spicules and radiolarians), calcite (5-80 %) (principally foraminifers, nannoplankton, sparite, micrite and microspar), c1ay minerals (5-40 %) (smectite in greater quantities than illite; and kaolinite in small quantities) and terrigenous quartz (< 15 %). The diatom assemblages in the marls reflect the occurrence of temperate to warm water conditions in this area during middle and late Miocene. The diatoms are dominated by the fol1owing upwelling species: Thalassiosira nitzshoides, Thalassiotrix longuissima and Thalassionema baci//aris. Benthic diatoms are scarce but they have great species diversity. However, in sorne outcrops the genus Delphineis is more frequent thus indicating environments c10ser to shore areas. Three episodes based on Barron's (1985) low latitude zonation have been defined. The Lower Episode includes Cestodiscus peplum and Coscinodiscus lewisianus Zone and is assigned to the upper Langhian- lower Serravalian. After a period of no diatom occurrence (e. gigas var. diorama Zone is missing), the Middle Episode is defined by Craspedodiscus coscinodiscus and Actinocyclus moronensis Zones and covers the latest Serravalian-early Tortonian. The Upper Episode corresponds to Thalassiosira yabei Zone and it is assigned to middle Tortonian. The fundamental types of dilutants in diatomic sedimentation (biogenic calcareous, terrigenous and c1ay minerals), do not vary throughout the three episodes but there are great variations in the proportions. The coastal upwelling regime produces tongue-like patterns of sedimentation and the sedimentary record displays different changes of facies. The Upper Episode, where the c1ay-terrigenous dilutants predominate over calcareous dilutants and Delphineis appear in greater quantities, is interpreted as having been formed in an environment closer to the shore than other episodes.El estudio de 93 puntos en el Mioceno de la cuenca del Guadalquivir ha permitido definir en esta cuenca la situación, bioestratigráfica y composición litológica de las margas con diatomeas o «moronitas». Dichas rocas incluyen gran variedad de términos litológicos estando constituidos principalmente por ópalo A (10-85 %) (mayoritariamente diatomeas; silicoflagelados, espículas de esponja y radiolarios en menor proporción), calcita (5-80 %) (microforaminíferos, nanoplancton calcáreo, micrita y esparita fundamentalmente), minerales de la arcilla (5-40 %) (esmectita predominando sobre illita y caolinita en menores proporciones) y cuarzo terrígeno « 15 %). Las asociaciones de diatomeas están constituidas fundamentalmente por diatomeas planctónicas de aguas templado-cálidas, con dominio de Thalassionema nitzschoides, Thalassionema bacillaris y Thalassiotrix longuissima, definiendo áreas de alta productividad (upwelling) en la zona durante el Mioceno Medio y Superior. El componente bentónico es escaso y diversificado, sin embargo localmente adquiere importancia el género Delphineis indicando zonas más litorales. Se determinan tres episodios de sedimentación diatomítica basados en la zonación de baja latitud de Barron (1985c). El Episodio Inferior definido por las biozonas Cestodiscus peplum y Coscinodiscus lewisianus, comprende desde el Langhiense superior al Serrava¡ iense inferior. Después de un período de tiempo sin deposición de diatomeas comienza el Episodio Medio definido por las biozonas Craspedodiscus coscinodiscus y Actinocyclus moronensis, y que incluye el techo del Serravaliense y el Tortoniense Inferior. El Episodio Superior que corresponde a la biozona Thalassiosira yabei comprende el Tortoniense Medio. Los tipos de diluyentes fundamentales de la sedimentación diatomítica (componentes biogénicos calcáreos, terrígenos y arcillas), se mantienen en los tres episodios pero presentan gran variación en sus proporciones debido a la morfología «en lenguas» y composición de los depósitos sedimentarios formados bajo zonas de «coastal upwelling». El Episodio Superior diferenciado por el predominio del diluyente arcilloso-terrígeno y por una mayor proporción de Delphineis en las asociaciones de diatomeas. se interpreta formado más cerca del continente.
- Published
- 1994
7. The effect of observation timescales on the characterisation of extreme Mediterranean precipitation
- Author
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Camarasa Belmonte, A. M., primary, Soriano García, J., additional, and López-García, M. J., additional
- Published
- 2010
- Full Text
- View/download PDF
8. Estudios Geológicos
- Author
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Bustillo, M. A., primary and López García, M. J., additional
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- 1995
- Full Text
- View/download PDF
9. Estudios Geológicos
- Author
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López García, M. J., primary and Bustillo, M. A., additional
- Published
- 1994
- Full Text
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10. The effect of observation timescales on the characterisation of extreme Mediterranean precipitation.
- Author
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Belmonte, A. M. Camarasa, García, J. Soriano, and López-García, M. J.
- Subjects
RAINFALL ,METEOROLOGICAL precipitation ,WATER quality management - Abstract
This paper analyses the behaviour of five rainfall indicators (maximum intensity, cumulative rainfall, irregularity, probability of rain and persistence of rain) over different observation timescales ranging from 5 min to 24 h. It covers a large area on the Mediterranean side of the Iberian Peninsula (River J&uuacute;car Water Authority, 43 000 km²) on a continuous basis over a period of 14 years (1994-2007). The results show that the behaviour of extreme Mediterranean rainfall is heavily dependent on the observation timescale. There are a number of turning points in the indicator trends which occur on different timescales (1 and 6 h in the case of rain intensity and irregularity, 6 h for cumulative rainfall and between 15 and 30 min for the persistence of rain) and may be relevant for the determination of thresholds used in water management. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
11. A multi-temporal study of chlorophyll-a concentration in the Albufera lagoon of Valencia, Spain, using Thematic Mapper data
- Author
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LÓPEZ GARCÍA, M. J., primary and CASELLES, V., additional
- Published
- 1990
- Full Text
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12. An alternative simple approach to estimate atmospheric correction in multitemporal studies.
- Author
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CASELLES, V. and LÓPEZ GARCÍA, M. J.
- Published
- 1989
- Full Text
- View/download PDF
13. Ketoacidosis at onset of type 1 diabetes mellitus in pediatric age in Spain and review of the literature.
- Author
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Oyarzabal Irigoyen M, García Cuartero B, Barrio Castellanos R, Torres Lacruz M, Gómez Gila AL, González Casado I, Hermoso López F, Luzuriaga Tomás C, Rica Etxebarrial I, López García MJ, and Rodríguez Rigual M
- Subjects
- Age Distribution, Age of Onset, Child, Child, Preschool, Humans, Incidence, Infant, Retrospective Studies, Risk Factors, Spain epidemiology, Diabetes Mellitus, Type 1 epidemiology, Diabetic Ketoacidosis epidemiology
- Abstract
Unlabelled: DKA at diagnosis of T1DM is a life-threatening situation that represents the main cause of morbidity and mortality in pediatric patients with T1DM., Objective: To determine whether the occurrence and severity of DKA at diagnosis of T1DM has suffered any changes in recent years in the Spanish paediatric population., Patients and Methods: Data from 1169 patients with T1DM under 15 years of age was retrospectively studied (2004 -2008) for the presence and severity of DKA at the onset of T1DM, and compared to previous available studies in Spain. This study is multicentric, nationwide with eleven major Paediatric Diabetes Units involved., Results: Complete data were available from 1151 patients (98%). Frequency of DKA was 39.5%, which is not significantly different from previous Spanish studies. 33.8%, children of 0-4.9 years of age, 40.8% aged 5-10.9 and 25.2% aged 11-14.9 years. Mean age of patients with DKA was significantly lower than the one of patients without DKA (7.44 +/- 4.10 versus 8.47 +/- 3.63 years). Mild DKA was occurring more frequently than moderate and severe forms (47.8%, versus 34.4% versus 17.8%, p<0.0001). Incidence of severe DKA was significantly higher in children under 4.9 years of age, especially in those younger than 2 years (p<0.001). Severe DKA led to complications in three children (cerebral oedema [n=1]), cerebral infarction (n=1) and femoral vein thrombosis (n=1)., Conclusion: Frequency of DKA at diagnosis of T1DM in Spain is still high although most cases were mild. Children under 2 years of age seem to be at increased risk for severe DKA.
- Published
- 2012
14. [A study of variability in glycaemia in children and adolescents with diabetes mellitus type 1 on treatment with insulin glargine].
- Author
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Rodríguez Pérez C, Lizondo Escuder A, López García MJ, Escrivá Cholbi L, Alpera Lacruz R, and Collado Pérez C
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Insulin therapeutic use, Insulin Glargine, Insulin, Long-Acting, Male, Prospective Studies, Retrospective Studies, Blood Glucose analysis, Diabetes Mellitus, Type 1 blood, Diabetes Mellitus, Type 1 drug therapy, Hypoglycemic Agents therapeutic use, Insulin analogs & derivatives
- Abstract
Objective: To determine the usefulness of insulin glargine (IG) to reduce hipoglycaemias and hyperglycaemic events in children and adolescents with type 1 diabetes., Patients and Methods: In a retrospective/prospective study, 29 patients with a high number of non-severe hypoglycaemias, aged 3-18, and an average HbA1c of 8+/-0.7, received IG once daily plus regular insulin or rapid analogue before meals. Inclusion criteria were: a) previous treatment with NPH insulin; b) diagnosis of type 1 diabetes for at least 1 year before starting IG, and c) >3 blood glucose controls within a day. Incidence of severe and non-severe hypoglycaemic events, hyperglycaemic events, HbA1c values, body mass index, daily insulin dose before and after the institution of glargine therapy, were collected. Additionally, family were asked to complete a diabetes quality of life survey., Results: 1,294+/-411 glycaemias/subject were obtained. Hypoglycaemic episodes were not reduced (5.9% vs 6.2%) and hyperglycaemic events remained unchanged. Fasting blood glucose levels decreased from 195.3+/-36.6 to 162.8+/-25.8 in all patients (p<0.05) and a tendency a decrease in nocturnal hypoglycaemias was observed. The average HbA1c and total daily insulin doses also remained unchanged (0.8+/-0.2 UI/Kg/day)., Conclusions: Using IG achieves a glycaemic control similar to NPH, with a tendency to decrease the frequency of nocturnal hypoglycaemias and an improvement in fasting glycaemia values.
- Published
- 2008
- Full Text
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15. [Mosaic trisomy 9: report of a new case with a long-term survival].
- Author
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Sánchez Zahonero J, Andrés Celma M, and López García MJ
- Subjects
- Female, Humans, Infant, Newborn, Karyotyping, Phenotype, Psychomotor Disorders genetics, Chromosomes, Human, Pair 9 genetics, Mosaicism, Survival, Trisomy genetics
- Abstract
Introduction: Trisomy 9 is an uncommon chromosome abnormality that may be seen in a mosaic or non-mosaic state., Objective: To better define the phenotype and prognosis of this disorder we report a new case of mosaic trisomy 9 with a long-term survival., Clinical Report: We present the case of a female patient, born from the first pregnancy of a healthy couple. Fetal ultrasounds disclosed intrauterine growth retardation and oligohydramnios. Cesarean section was performed in the 34th week. Birth weight was 1,478 g. Neonatal examination showed: dolichocephaly; hypotelorism, microphthalmia, short palpebral fissures; broad-based nose with bulbous tip; micrognathia; low-set malformed ears; abnormal hands and feet; no other malformations. The initial karyotype determination was normal (46,XX). At 17 months of age, a second karyotype was requested because the patient developed severe psychomotor retardation. Chromosome analysis showed mosaic trisomy 9 (46,XX/47,XX, + 9). Six months later, a single upper central incisor was noted. To our knowledge, this feature has not been reported previously in the trisomy 9. The patient is now 4 years old. She shows severe psychomotor retardation, but no other complications., Comments: It is important to be aware of the possibility that mosaicism may exist in a patient with normal blood karyotype and abnormal phenotype. We conclude that a great number of cells is needed in order to obtain a correct karyotype diagnosis. Correct diagnosis is essential to define the prognosis and provide accurate genetic counselling.
- Published
- 2008
- Full Text
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16. [Endemic goiter and iodine deficiency: are they still a reality in Spain].
- Author
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Peris Roig B, Atienzar Herráez N, Merchante Alfaro AA, Calvo Rigual F, Tenías Burillo JM, Selfa Moreno S, and López García MJ
- Subjects
- Adolescent, Child, Cross-Sectional Studies, Deficiency Diseases epidemiology, Female, Goiter, Endemic diagnosis, Humans, Male, Prevalence, Spain epidemiology, Goiter, Endemic epidemiology, Iodine deficiency
- Abstract
Objective: To estimate the prevalence of goiter and iodine deficiency in a health district in the Autonomous Community of Valencia, given the absence of data in this region of Spain., Material and Methods: We conducted a descriptive, epidemiologic, cross-sectional study, stratified by age and sex, in four interior regions of the province of Valencia. We selected students aged from 6 to 14 years old in 20 centers. Thyroid examination was performed by means of palpation and inspection (goiter > or = 0B). Urinary iodine excretion was analyzed in a routine urine sample. Sociodemographic and anthropometric data, as well as nutritional iodine status, were recorded in a standardized survey. In children with goiter, thyroid-stimulating hormone (TSH), free T4, and antithyroid antibodies were determined., Results: We studied 928 children (478 boys and 450 girls). The prevalence of goiter was 33.7 % (95 % CI: 30.7-36.9 %). There were no significant differences in the prevalence of goiter by age or sex, but an inverse correlation was detected between the prevalence of goiter and parental socioeconomic position. Mean urinary iodine excretion was 155 .g/l, with no significant correlation with the prevalence of goiter. In children with goiter, 13 had positive antithyroid antibodies, 18 had high TSH (subclinical hypothyroidism), and one had suppressed TSH (subclinical hyperthyroidism)., Conclusions: There is endemic goiter in the region studied. Urinary iodine levels were in the normal range and could be interpreted as indicating a transition phase to an improvement in iodine deficiency. Autoimmune diseases would only explain 4 % of cases of goiter.
- Published
- 2006
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17. [Effects of valproate on sexual development].
- Author
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Balaguer Martínez JV, López García MJ, Andrés Celma M, Contell Villagrasa A, and Castelló Pomares ML
- Subjects
- Age Determination by Skeleton, Anthropometry, Anticonvulsants therapeutic use, Child, Female, Gonadal Steroid Hormones blood, Humans, Male, Sex Factors, Valproic Acid therapeutic use, Anticonvulsants adverse effects, Epilepsy drug therapy, Gonadal Steroid Hormones metabolism, Hyperandrogenism chemically induced, Puberty drug effects, Valproic Acid adverse effects
- Abstract
Introduction: Valproate use in young girls has been associated with the adverse endocrinological effects of weight gain and hyperandrogenism. Furthermore, polycystic ovaries and hyperinsulinism have been described in adult women. In men and young boys, however, the possible adverse endocrinological effects of valproate have scarcely been analyzed., Objectives: The aim of this study was to evaluate the effects of valproate treatment on pubertal development, especially the possible hyperandrogenic effects, in girls and boys with epilepsy., Material and Methods: Twenty-three girls and 15 boys (aged 8-16 years old) who were undergoing valproate treatment for epilepsy were compared with 15 control girls and 10 control boys of the same age range. Anthropometric indexes, sexual maturation, and hirsutism scores were evaluated. Serum concentrations of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, androstenedione, dehydroepiandrosterone, estradiol, and insulin were measured. Ultrasound examination of ovaries and estimation of bone age through X-ray of the left hand were also performed., Results: Valproate did not affect pubertal development in the study group. No hirsutism or polycystic ovaries were found. Increases in weight, relative weight, and body mass index were observed in the group undergoing valproate treatment, but no statistically significant differences compared with the control group were found. Plasma testosterone was higher in valproate-treated girls (0.71 0.51 ng/ml) than in control girls (0.35 0.15) (p 0.001). This finding was independent of valproate dose and treatment duration. Hyperandrogenism was not found in valproate-treated boys., Conclusions: Valproate may induce hyperandrogenism in epileptic girls but not in boys. This is an early adverse effect and is independent of the dose used. No changes in normal pubertal development or physical repercussions were found in epileptic patients.
- Published
- 2003
- Full Text
- View/download PDF
18. [Syndrome of multiple neoplasia type IIB (MEN IIB): a case report].
- Author
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Alpera Lacruz R, Castellanos Gómez ME, López García MJ, Ferrando Valls F, and Estañ Capell M
- Subjects
- Adolescent, Carcinoma, Medullary genetics, Female, Gastrointestinal Neoplasms genetics, Humans, Phenotype, Pheochromocytoma genetics, Thyroid Neoplasms genetics, Carcinoma, Medullary complications, Carcinoma, Medullary pathology, Digestive System pathology, Gastrointestinal Neoplasms complications, Gastrointestinal Neoplasms pathology, Pheochromocytoma complications, Pheochromocytoma pathology, Thyroid Gland pathology, Thyroid Neoplasms complications
- Published
- 1996
19. [Renal function in diabetic children and adolescents. Relation to the duration and level of control of the disease].
- Author
-
Blasco González L, López García MJ, Alpera la Cruz R, Plasencia Cochoud A, García Ballester M, and Carbonell Sales MJ
- Subjects
- Adolescent, Child, Diabetes Mellitus, Type 1 metabolism, Diabetes Mellitus, Type 1 therapy, Female, Humans, Kidney physiopathology, Kidney Function Tests, Male, Proteinuria diagnosis, Proteinuria etiology, Time Factors, Diabetes Mellitus, Type 1 physiopathology, Diabetic Nephropathies diagnosis
- Abstract
We have evaluated different aspects of the kidney function of 68 diabetic children and adolescents with the aim of estimating the prevalence of nephropathy and its influential factors. In addition, the kidney function is followed for an additional 18 months. The results are compared with those obtained from a group of healthy children of the same ages. No clinical nephropathy existed, with only 4 (5.97%) and 8 cases of incipient nephropathy and microalbuminuria, respectively, being demonstrated. The urinary albumin excretion rate (AER) is very clearly connected with the duration and the metabolic control of diabetes. Elevated values for AER were also observed in poorly controlled diabetics and those with prolonged evolution. Nevertheless, the last point may be secondary to the development of puberty, since with the same duration of diabetes (under 5 years), the proportion of pubertal patients with microalbuminuria is higher than that for prepubertal children.
- Published
- 1992
20. [Immunology of diabetes. Pathogenic bases].
- Author
-
López García MJ
- Subjects
- Child, Diabetes Mellitus, Type 1 etiology, Diabetes Mellitus, Type 1 immunology, HLA Antigens metabolism, Heterozygote, Homozygote, Humans, Diabetes Mellitus, Type 1 genetics
- Published
- 1991
21. [Theophylline toxicity in infants].
- Author
-
López García MJ, García Ballester M, Escribano Montaner A, and Roig Riu M
- Subjects
- Child, Child, Preschool, Dose-Response Relationship, Drug, Humans, Infant, Theophylline therapeutic use, Bronchiolitis drug therapy, Bronchitis drug therapy, Lung Diseases, Obstructive drug therapy, Theophylline adverse effects
- Abstract
In order to evaluate risk factors and clinical manifestations of theophylline intoxication in the infant, a comparative study between intoxicated and non intoxicated during a period of 4 years has been made. The incidence of this complication was 9.5% (7/74). Except for the cases of 2 children where there was an administrative error, everyone received a similar dose, finding great variability in the reaction to the drug. Only age seems to contribute to an increased tendency to intoxication (6/7 less than or equal to 3 months). Concerning the clinical manifestations, we do not find any correlation between the theophylline levels and severity. All the infants presented tachicardia and irritability, 3/4 tonic-clonic seizures and/or episodes and 1/7 severe metabolic disturbances. Only 1/7 had prodromic symptoms, therefore in view of the variability in individual tolerance, we believe that theophylline should not be used for small without an appropriate control of its serum concentrations.
- Published
- 1990
22. [Psychological evaluation of diabetic students and their families].
- Author
-
García López M, López García MJ, Agüero Juan A, and Blasco González L
- Subjects
- Age Factors, Child, Child Behavior, Female, Humans, Male, Sex Characteristics, Child Development, Diabetes Mellitus psychology, Family
- Abstract
A population of 29 diabetic school children has been studied with the purpose of evaluating the repercussion the disease has on the psychosocial development of the child. Eysenck's inventory of personality, Achembach's IPCDS and the drawing of the human figure have been employed as psychological test. The sociological aspects are valued through interviewing and questionnaires. The outstanding conclusions are: 1. Diabetes does not condition the development of a specific personality. 2. Psychiatric alterations and pathological behaviours are not present in the diabetic school child with a greater frequency than in the normal child. The most problematic is the pattern of behaviour found in preadolescent teenagers, individual cases stand out in relation to their antisocial and reserved behaviour. 3. The disease neither cuts down social life, nor does it condition the appearance of school-failure, but it does have a repercussion and a modifying effect on practical aspects of family life and the relations among its members.
- Published
- 1988
23. [Limitation in articular movement in diabetic children].
- Author
-
López García MJ, Grimaldos Ruiz P, Blasco González L, Pérez Yuste P, and Alpera Lacruz R
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Joints physiopathology, Male, Diabetes Mellitus, Type 1 complications, Joint Diseases etiology, Movement
- Abstract
The presence of limited movement articular (LMA) was examined in 58 insulin-dependent diabetic children 38 boys and 20 girls in a range of 1 to 18 years. The children were ill during a mean of 4 years and 7 months +/- 3 years and nine months. The MAL was present in 36.2% of diabetic children versus 2.08% in the control group (96 healthy children). The presence of MAL has a statistically significant correlation with: age (9 years or more) (p less than 0.01); poor metabolic control (specially in severe forms) (p less than 0.001) and retinopathy (p less than 0.02). The examination of LMA is very useful for the early diagnosis of retinopathy in high risk patients because of the very frequent association of both complications of diabetes.
- Published
- 1987
24. [Aberrant left pulmonary artery. Presentation of a new case and review of the literature].
- Author
-
Tomás Collado E, Rivera Otero M, Vázquez-Pérez J, López García MJ, and Ferrando Valls F
- Subjects
- Airway Obstruction diagnosis, Diagnosis, Differential, Humans, Infant, Male, Pulmonary Artery surgery, Respiration Disorders etiology, Tracheal Diseases diagnosis, Airway Obstruction etiology, Pulmonary Artery abnormalities, Tracheal Diseases etiology
- Published
- 1983
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