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In this paper we study two stochastic chemostat models, with and without wall growth, driven by a white noise. Specifically, we analyze the existence and uniqueness of solutions for these models, as well as the existence of the random attractor associated to the random dynamical system generated by the solution. The analysis will be carried out by means of the well-known Ornstein-Uhlenbeck process, that allows us to transform our stochastic chemostat models into random ones. [ABSTRACT FROM AUTHOR]

We present the case of a 75-year-old woman who presented to our hospital with upper gastrointestinal bleeding and altered liver function tests. MR cholangiography performed during hospitalization revealed a choledochoduodenal fistula. Gastroscopy confirmed the presence of this fistula, and after surgical correction, an adenocarcinoma at the biliopancreatic junction infiltrating the duodenum was diagnosed. This represents a rare and unusual presentation of biliopancreatic tumors, with endoscopy playing a crucial role in diagnosis.

We present the case of a 57-year-old woman with metastatic colorectal cancer being treated with Bevacizumab and FOLFOX, who came to the emergency department with haematemesis. Gastroscopy showed a duodenal ulcer without active bleeding. Subsequently, he suffered haemodynamic instability and an Angio-CT scan revealed an aortoenteric fistula, requiring urgent surgery. Bevacizumab can cause rare complications such as this, and early detection is crucial for effective treatment.

Background and Aims: Controversial data have been reported regarding the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) in Inflammatory Bowel Disease (IBD) population and IBD-related risk factors. The aim of the study was to assess the prevalence and risk factors associated with NAFLD and liver fibrosis in IBD participants compared with non-IBD controls., Methods: Cross-sectional, case-control study including 741 IBD cases and 170 non-IBD controls, matched by sex and age. All participants underwent liver ultrasound, transient elastography and laboratory tests. A logistic regression multivariable analysis was performed adjusting for classic metabolic risk factors and history of systemic steroid use., Results: The prevalence of NAFLD and significant liver fibrosis was 45 % and 10 % in IBD group, and 40 % and 2.9 % in non-IBD group (p = 0.255 and 0.062, respectively). Longer IBD duration (aOR 1.02 95% CI (1.001-1.04)) and older age at IBD diagnosis (aOR 1.02 95 % CI (1.001-1.04)) were independent risk factors for NAFLD in IBD group. Crohn´s Disease was an independent risk factor for significant liver fibrosis in participants with IBD and NAFLD (aOR 3.97 95 % CI (1.78-8.96)). NAFLD occurred at lower BMI levels in IBD group with NAFLD compared to non-IBD group with NAFLD (aOR 0.92 95 % CI (0.87-0.98))., Conclusions: Although we found no differences in the prevalence of NAFLD and liver fibrosis between IBD group and non-IBD group, our findings suggest that liver fibrosis progression should be closely monitored in patients with concomitant CD and NAFLD, more in particular in those with long standing active disease., Competing Interests: Declaration of Competing Interest The authors declare that there is no conflict of interest regarding this project., (Copyright © 2023 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.)

The aim of the systematic review is to assess the prevalence and risk factors of liver fibrosis in patients with Inflammatory Bowel Disease (IBD) and Non-Alcoholic Fatty Liver Disease (NAFLD) and to discuss the role of liver fibrosis in the progression to hepatocellular carcinoma (HCC). We performed a structured search in PubMed, Web of Science, Embase, and Scopus up to 3 March 2023 to identify observational studies reporting liver fibrosis in patients with NAFLD and IBD. Quality of studies was assessed using the Newcastle-Ottawa Scale (NOS) score. A total of 23 studies met our inclusion criteria, including 629,781 patients. A total of 10 cross-sectional, 3 case-control, and 10 cohort studies were included. Fourteen studies had a NOS score ≥ 7 points. NAFLD was diagnosed in 2162/6332 (34.1%) IBD participants. However, NAFLD diagnosis was established in 924/2962 (31.2%) healthy individuals without IBD. Advanced liver fibrosis was found in 116 (11.6%) of 992 IBD patients with NAFLD. Most studies found an association between NAFLD and classic cardiovascular risk factors such as older age, male sex, higher BMI, diabetes, hypertension and dyslipidemia. In addition, metabolic syndrome features were also associated with an increased risk of significant and advanced liver fibrosis. Although no strong association between NAFLD and IBD therapy was reported, some studies associated NAFLD with IBD diagnosis, Crohn's Disease, a complicated course of IBD, disease activity, and IBD duration. Advanced liver fibrosis was also associated with Crohn's disease in several studies. In conclusion, NAFLD and advanced liver fibrosis are prevalent and clinically relevant extraintestinal manifestations, so its diagnosis and potential progression to HCC should be carefully considered in daily clinical practice.

Chronic inflammation in patients with Inflammatory Bowel Disease (IBD) leads to an increased risk of colorectal cancer, small bowel cancer, intestinal lymphoma and cholangiocarcinoma. However, treatments for IBD have also been associated with an increased risk of neoplasms. Patients receiving Thiopurines (TPs) have an increased risk of hematologic malignancies, non-melanoma skin cancer, urinary tract neoplasms and cervical cancer. Anti-TNFs have been associated with a higher risk of neoplasms, mainly lymphomas and melanomas; however, the data are controversial, and some recent studies do not confirm the association. Nevertheless, other biologic agents, such as ustekinumab and vedolizumab, have not shown an increased risk of any neoplasm to date. The risk of malignancies with tofacitinib exists, but its magnitude and relationship with previous treatment with TPs is not defined, so more studies from daily clinical practice are needed. Although biologic therapy seems to be safe for patients with current cancer or a prior history of cancer, as has been demonstrated in other chronic inflammatory conditions, prospective studies in this specific population are needed. Until that time, it is crucial to manage such conditions via the combined clinical expertise of the gastroenterologist and oncologist.

We present the case of a 64-year-old man who, after a first episode of acute pancreatitis, was readmitted 20 days later due to severe epigastric pain and later an episode of upper gastrointestinal bleeding in the form of hematemesis and melena with hemodynamic instability. An urgent gastroscopy was performed at that time, revealing a probable gastrointestinal fistula in the duodenal bulb with an adherent clot without active bleeding at that time, so an urgent CT angiography was performed that revealed a necrotic peripancreatic collection with the presence of active bleeding inside from the pancreatoduodenal artery. Urgent arteriography identified an image compatible with arterial pseudoaneurysm dependent on the pancreaticoduodenal artery branch, which was successfully embolized. Unfortunately, the patient died a few hours later as a result of septic shock secondary to an infected pancreatic collection.

Internet of Things (IoT) radio networks are becoming popular in several scenarios for short-range applications (e.g., wearables and home security) and medium-range applications (e.g., shipping container tracking and autonomous farming). They have also been proposed for water monitoring in flood warning systems. IoT communications may use long range (LoRa) radios working in the 915 MHz industrial, scientific and medical (ISM) band. In this research, we study the propagation characteristics of LoRa chirp radio signals close to and over water in a tropical meadow region. We use as a case study the Colima River in Mexico. We develop a novel point-to-point IoT measurement sounding system that does not require decoding of LoRa propriety bursts and provides accurate power versus distance profiles along the riparian zone of a steeply dropping mountain river. We used this system to obtain the measurements reported in this work, which are also analyzed and modeled. The results show that the LoRa signal propagation over water exhibits a log-normal distribution. As a result of the chirp signal processing, two new experimental path loss models are presented. The path loss results show a considerable degradation of the received signal power over water within vegetation and less signal degradation at antenna heights closer to the water surface.

We revisit the chemostat model with Haldane growth function, here subject to bounded random disturbances on the input flow rate, as often met in biotechnological or waste-water industry. We prove existence and uniqueness of global positive solution of the random dynamics and existence of absorbing and attracting sets that are independent of the realizations of the noise. We study the long-time behavior of the random dynamics in terms of attracting sets, and provide first conditions under which biomass extinction cannot be avoided. We prove conditions for weak and strong persistence of the microbial species and provide lower bounds for the biomass concentration, as a relevant information for practitioners. The theoretical results are illustrated with numerical simulations.