Search

Your search keyword '"Lévi, Françis"' showing total 55 results
Start Over Author "Lévi, Françis"
55 results on '"Lévi, Françis"'

1. Safety and feasibility of chemotherapy followed by liver transplantation for patients with definitely unresectable colorectal liver metastases: insights from the TransMet randomised clinical trial

Author

Adam, René, Badrudin, David, Chiche, Laurence, Bucur, Petru, Scatton, Olivier, Granger, Victoire, Ducreux, Michel, Cillo, Umberto, Cauchy, François, Lesurtel, Mickael, Mabrut, Jean-Yves, Verslype, Chris, Coubeau, Laurent, Hardwigsen, Jean, Boleslawski, Emmanuel, Muscari, Fabrice, Jeddou, Heithem, Pezet, Denis, Heyd, Bruno, Lucidi, Valerio, Geboes, Karen, Lerut, Jan, Majno, Pietro, Grimaldi, Lamiae, Boukhedouni, Nadjia, Piedvache, Céline, Gelli, Maximiliano, Levi, Francis, and Lewin, Maïté

Published
2024
Full Text
View/download PDF

2. Association between endocrine adjuvant therapy intake timing and disease-free survival in patients with high-risk early breast cancer: results of a sub-study of the UCBG- UNIRAD trial

Author

Giacchetti, Sylvie, Laas, Enora, Bachelot, Thomas, Lemonnier, Jérome, André, Fabrice, Cameron, David, Bliss, Judith, Chabaud, Sylvie, Hardy- Bessard, Anne-Claire, Lacroix-Triki, Magali, Canon, Jean-Luc, Debled, Marc, Campone, Mario, Cottu, Paul, Dalenc, Florence, Ballesta, Annabelle, Penault-Llorca, Frederique, Asselain, Bernard, Dumas, Elise, Reyal, Fabien, Gougis, Paul, Lévi, Francis, and Hamy, Anne-Sophie

Published
2024
Full Text
View/download PDF

5. Bayesian Model Search for Nonstationary Periodic Time Series

Author

Hadj-Amar, Beniamino, Finkenstädt, Bärbel, Fiecas, Mark, Levi, Francis, and Huckstepp, Robert

Subjects
Statistics - Methodology
Abstract

We propose a novel Bayesian methodology for analyzing nonstationary time series that exhibit oscillatory behaviour. We approximate the time series using a piecewise oscillatory model with unknown periodicities, where our goal is to estimate the change-points while simultaneously identifying the potentially changing periodicities in the data. Our proposed methodology is based on a trans-dimensional Markov chain Monte Carlo (MCMC) algorithm that simultaneously updates the change-points and the periodicities relevant to any segment between them. We show that the proposed methodology successfully identifies time changing oscillatory behaviour in two applications which are relevant to e-Health and sleep research, namely the occurrence of ultradian oscillations in human skin temperature during the time of night rest, and the detection of instances of sleep apnea in plethysmographic respiratory traces., Comment: Received 23 Oct 2018, Accepted 12 May 2019

Published
2018
Full Text
View/download PDF

6. Robust Individual Circadian Parameter Estimation for Biosignal-based Personalisation of Cancer Chronotherapy

Author

Schott, Benjamin, Stegmaier, Johannes, Arbaud, Alexandre, Reischl, Markus, Mikut, Ralf, and Lévi, Francis

Subjects
Quantitative Biology - Quantitative Methods
Abstract

In cancer treatment, chemotherapy is administered according a constant schedule. The chronotherapy approach, considering chronobiological drug delivery, adapts the chemotherapy profile to the circadian rhythms of the human organism. This reduces toxicity effects and at the same time enhances efficiency of chemotherapy. To personalize cancer treatment, chemotherapy profiles have to be further adapted to individual patients. Therefore, we present a new model to represent cycle phenomena in circadian rhythms. The model enables a more precise modelling of the underlying circadian rhythms. In comparison with the standard model, our model delivers better results in all defined quality indices. The new model can be used to adapt the chemotherapy profile efficiently to individual patients. The adaption to individual patients contributes to the aim of personalizing cancer therapy., Comment: Conference Biosig 2016, Berlin

Published
2016

7. Medicine in the Fourth Dimension

Author

Cederroth, Christopher R., Albrecht, Urs, Bass, Joseph, Brown, Steven A., Dyhrfjeld-Johnsen, Jonas, Gachon, Frederic, Green, Carla B., Hastings, Michael H., Helfrich-Förster, Charlotte, Hogenesch, John B., Lévi, Francis, Loudon, Andrew, Lundkvist, Gabriella B., Meijer, Johanna H., Rosbash, Michael, Takahashi, Joseph S., Young, Michael, and Canlon, Barbara

Published
2019
Full Text
View/download PDF

10. Early tumour response as a survival predictor in previously- treated patients receiving triplet hepatic artery infusion and intravenous cetuximab for unresectable liver metastases from wild-type KRAS colorectal cancer

Author

Bouchahda, Mohamed, Boige, Valérie, Smith, Denis, Karaboué, Abdoulaye, Ducreux, Michel, Hebbar, Mohamed, Lepère, Céline, Focan, Christian, Guimbaud, Rosine, Innominato, Pasquale, Awad, Sameh, Carvalho, Carlos, Tumolo, Salvatore, Truant, Stephanie, De Baere, Thierry, Castaing, Denis, Rougier, Philippe, Morère, Jean-François, Taieb, Julien, Adam, René, and Lévi, Francis

Published
2016
Full Text
View/download PDF

32. Chronopharmacologie. Rythmes biologiques et administration des médicaments : Rythmes biologiques et administration des médicaments

Author

Labrecque, Gaston, Sirois-Labrecque, Marcelle, Beauchamp, Denis, Bélanger, Pierre M., Bjarnason, Georg A., Boivin, Diane B., Carrier, Julie, Drapeau, Caroline, Dumont, Marie, Giacchetti, Sylvie, Lévi, Francis, Mormont, Marie-Christine, Rivard, Georges B., Thibault, Louise, Vanier, Marie-Claude, Labrecque, Gaston, Sirois-Labrecque, Marcelle, Beauchamp, Denis, Bélanger, Pierre M., Bjarnason, Georg A., Boivin, Diane B., Carrier, Julie, Drapeau, Caroline, Dumont, Marie, Giacchetti, Sylvie, Lévi, Francis, Mormont, Marie-Christine, Rivard, Georges B., Thibault, Louise, and Vanier, Marie-Claude

Published
2002

34. Dosing time dependent in vitropharmacodynamics of Everolimus despite a defective circadian clock

Author

Zhang, Yuan, Giacchetti, Sylvie, Parouchev, Alexandre, Hadadi, Eva, Li, Xiaomei, Dallmann, Robert, Xandri-Monje, Helena, Portier, Lucie, Adam, René, Lévi, Françis, Dulong, Sandrine, and Chang, Yunhua

Abstract

ABSTRACTEverolimus (EV), a rapamycin analogue mTOR inhibitor, is used in the clinic to treat Estrogen positive (ER+) breast cancer in order to avoid the resistance to hormonotherapy. Here, we investigated whether EV efficacy varied according to administration timing by using the ER+breast cancer cell line MCF-7 as model system. Our results showed that instead of apoptosis, EV induced a G0/G1 phase blockage of MCF-7 cells. Following serum shock, MCF-7 cells displayed a statistically significant 24h rhythm of mammalian target of Rapamycin (mTOR) activity, but perturbed circadian clock genes oscillations. Interestingly, the different delivery schedule of EV presented different efficacy in G0/G1 phase blockage in serum shocked MCF-7 cells. Moreover, serum shock induced also a circadian-like oscillation in expression or activity of several important G1 phase progression proteins, such as Cyclin D1 and phosphorylated Retinoblastoma protein (RB). Inhibition mTOR activity by EV reduced Cyclin D1 and Cyclin D3 protein level as well as RB phosphorylation level. Taken together, the results indicated that serum shock synchronization induced a circadian oscillation in mTOR activity in MCF-7 cells, which rhythmically regulated the synthesis or phosphorylation of key G1 progression proteins, such as Cyclin D1 and phosphorylated RB, ultimately resulting in different G0/G1 blockage efficiency according to different EV administration timing.

Published
2018
Full Text
View/download PDF

35. Carcinogenicity of night shift work

Author

Ward, Elizabeth M, Germolec, Dori, Kogevinas, Manolis, McCormick, David, Vermeulen, Roel, Anisimov, Vladimir N, Aronson, Kristan J, Bhatti, Parveen, Cocco, Pierluigi, Costa, Giovanni, Dorman, David C, Fu, Loning, Garde, Anne Helene, Guénel, Pascal, Hansen, Johnni, Härmä, Mikko I, Kawai, Kazuaki, Khizkhin, Evgenii A, Knutsson, Anders, Lévi, Francis, Moreno, Claudia RC, Pukkala, Eero, Schernhammer, Eva, Travis, Ruth, Waters, Martha, Yakubovskaya, Marianna, Zeeb, Hajo, Zhu, Yong, Zienolddiny, Shanbeh, Grosse, Yann, Hall, Amy L, Benbrahim-Tallaa, Lamia, Girschik, Jennifer, Bouvard, Véronique, El Ghissassi, Fatiha, Turner, Michelle C, Diver, W Ryan, Herceg, Zdenko, Olson, Natalie, Rowan, Elaine G, Rumgay, Harriet, Guyton, Kathryn Z, and Schubauer-Berigan, Mary K

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results