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Today's radiology is experiencing two major trends, one negative and one positive. The first is the so-called turf war, in other words, the progressive invasion of the imaging domain by other specialists such as cardiologists, urologists, gastroenterologists, gynaecologists etc. who are taking over various techniques from ultrasonography (US) to computed tomography (CT) to magnetic resonance imaging (MRI). In this process, they are aided by new technologies such as picture archiving and communication systems (PACS) and computed-aided diagnosis CAD and by radiology technologists who collaborate with them, replacing radiologists. The positive aspect is the outstanding technological evolution: the advent of molecular imaging, optical imaging, nanotechnologies, teleradiology and percutaneous gene therapy. While dramatically expanding the diagnostic possibilities down to the subcellular level, these techniques demand new forms of training in radiology and interdisciplinary cooperation. Tomorrow's radiologist will need to acquire appropriate clinical knowledge, restore contact with the patient to take on a prominent role in the diagnostic process, learn the basic sciences, foster a multidisciplinary approach and finally be able to use the Internet for learning and continuing education. Tomorrow's radiologists will survive if they learn to reinvent themselves.

It is very well known that imaging low contrast details in soft tissues is the main limitation of conventional X-ray radiology. Phase contrast imaging overcomes this limitation. Up to now, however, all the applications of this technique required high radiation doses, raising several questions about its utilisation in medical radiology. The first low dose phase contrast X-ray images were obtained by the SYRMEP Collaboration at ELETTRA, the Trieste synchrotron radiation facility. We produced high contrast resolution images of phantoms and of a specimen of human breast tissue with doses comparable to those used in standard mammography by introducing an intensifier screen behind the X-ray film. Our theoretical simulations and experimental tests not only demonstrate how the ELETTRA bending-magnet beam is suitable for phase contrast imaging, but also show that the source size requirements are not very stringent. This opens the way to widespread applications of this simple and effective technique to medical radiology and to other fields.

AIM: To analyse reasons for and the nature of clinico-radiological contacts and their clinical impact. MATERIALS AND METHODS: Three different surveys were performed. (1) Data concerning contacts between staff radiologists (n = 20) and clinicians during 10 consecutive working days were collected; (2) staff clinicians (n = 174) filled in a questionnaire asking for their opinions about relationships with radiologists; (3) staff radiologists collected data about contacts with clinicians related to more urgent/complicated cases. Radiologists assessed the clinical impact of the radiological procedure and of the consultation. RESULTS: (1) During 220 working days 20 radiologists had a mean of 3.95 contacts per day (48.2% personal contacts, 51.8% telephone contacts), amounting to a personal total of 21.65 min per day. These contacts amounted to a total of 7.08 h per day, roughly one whole-time equivalent radiologist. (2) These consultations helped to refine the diagnostic strategy often (12.6%) or sometimes (71.4%) and to alter therapeutic decisions often (10.4%) or sometimes (56.6%). (3) The initial clinical diagnosis was changed in 50% of cases and the therapy was substantially changed on the basis of further radiological investigations and clinical–radiological discussion in 60% of cases. CONCLUSION: Clinical–radiological consultations are time consuming but have a beneficial diagnostic and therapeutic impact.Dalla Palma, L. (2000). Clinical Radiology55, 602–605.

From pathological point of view the chronic renal infections include two types, interstitial chronic pyelonephritis and granulomatous pyelonephritis, namely xanthogranulomatous, malacoplakia and renal tuberculosis. Indications for imaging modalities are more common compared to the acute types and allow to depict both factors causing obstruction and infection such as stones ant the renal and extrarenal extension of the disease. In this article the authors review the findings and the role of plain film and urography, computed tomography and ultrasonography.

The aims of this study were (a) to compare the MR appearance of normal articular cartilage in ex vivo MR imaging (MRI) and MR microscopy (MRM) images of disarticulated human femoral heads, (b) to evaluate by MRM the topographic variations in articular cartilage of disarticulated human femoral heads, and subsequently, (c) to compare MRM images with histology. Ten disarticulated femoral heads were examined. Magnetic resonance images were obtained using spin-echo (SE) and gradient-echo (GE) sequences. Microimages were acquired on cartilage-bone cylindrical plugs excised from four regions (superior, inferior, anterior, posterior) of one femoral head, using a modified SE sequence. Both MRI and MRM images were obtained before and after a 90 degrees rotation of the specimen, around the axis perpendicular to the examined cartilage surface. Finally, MRM images were correlated with histology. A trilaminar appearance of articular cartilage was observed with MRI and with a greater detail with MRM. A good correlation between MRI and MRM features was demonstrated. Both MRI and MRM showed a loss of the trilaminar cartilage appearance after specimen rotation, with greater evidence on MRM images. Cartilage excised from the four regions of the femoral head showed a different thickness, being thickest in the samples excised from the superior site. The MRM technique confirms the trilaminar MRI appearance of human articular cartilage, showing good correlation with histology. The loss of the trilaminar appearance of articular cartilage induced by specimen rotation suggests that this feature is partially related to the collagen-fiber orientation within the different layers. The MRM technique also shows topographic variations in thickness of human articular cartilage.

The SYRMEP Collaboration (SYnchrotron Radiation for MEdical Physics) is conducting a research project in digital mammography and plans to use a monochromatic X-ray beam provided by Elettra, the synchrotron radiation facility in operation in Trieste (Italy), in conjunction with a novel silicon pixel detector. A set of silicon strip detectors was arranged to form a vector of pixels. This prototype with a sensitive area of 24 mm2 (i.e. 2 × 48 pixels of 0.5 × 0.5 mm2) has been used to produce images with X-rays both from a 109Cd source and a standard radiological tube.

The SYRMEP Collaboration (SYnchrotron Radiation for MEdical Physics), is conducting a research project in digital mammography and plans to use a monochromatic X-ray beam provided by Elettra, the synchrotron radiation facility in operation in Trieste (Italy), in conjunction with a novel silicon pixel detector. A set of silicon strip detectors was arranged to form a matrix of pixels. This prototype with a sensitive area of 24 × 1 mm 2 (i.e. 2 × 48 pixels of 0.5 × 0.5 mm 2 ) has been used to produce images with X-rays.

There is no general agreement on which terms to use to report abnormalities on imaging studies in patients with kidney infection. The Society of Uroradiology recommends a simplified nomenclature that is based on the traditional and widely understood term acute pyelonephritis. To provide a framework for the simplified terminology, the authors review the relevant pathophysiology with its imaging correlates and offer a historic perspective on the terminology issues.

Renal sarcomas and sarcomatoid renal cell carcinomas are extremely rare neoplasms of the kidney. The Authors reviewed the pathological files and report the features of 12 renal sarcomas and 22 sarcomatoid carcinomas. Leiomyosarcomas and liposarcomas were the most common tumors among the sarcomas, while sarcomatoid carcinomas presented different proportions of carcinomatous and sarcomatous elements. The findings of diagnostic imaging modalities, including plain film and intravenous urography (with nephrotomography), arteriography, ultrasonography and computed tomography, are reported. The findings enable the diagnosis of the nature of these masses. However, the actual experience does not allow a prospective diagnosis of renal sarcoma or of sarcomatoid carcinoma. The mesenchymal nature of the tumor may be suspected when the capsular or sinusal origin is evident, a fatty component is seen within a large aggressive mass and when a hypovascular mass with capsular vessels is seen in angiography.

Urography (IVU) is considered the best first investigation in patients with suspected ureteric colic, but recently ultrasonography (US), combined with a plain film of the abdomen (KUB), has been suggested as an alternative. We have undertaken a prospective study to see if this approach can be used in an Emergency Department by radiologists with different amounts of ultrasound experience. Some 180 patients with suspected ureteric colic presenting to the Emergency Department over an 8-month period were studied. They had a plain abdominal film (KUB) and US examination of the kidneys, ureters and bladder following hydration. Some 120 patients subsequently underwent IVU at a mean interval of 3.5 days after the ultrasound examination. Of these, 15 patients passed a stone before their IVU. Of the remaining 105 patients, 44 had an IVU positive for stone and 61 had a negative IVU. Fifty of the 60 patients who did not have an IVU had clinical follow-up and 31 had ultrasound. Our findings in this prospective study suggest that in the hydrated patient the combination of KUB plus US is a sensitive but not very specific screening test (sensitivity 95%, specificity 67%). Because of the high negative predictive value of KUB plus US (95%), urography is not likely to be helpful when KUB plus US are negative. Urography is indicated only if KUB plus US findings are equivocal or if intervention is necessary. If we had used KUB plus US alone as the first test in our patients, urography would have been unnecessary in approximately 60%. Twenty per cent of our patients passed a stone in the first 48 h.

Phase contrast x-ray imaging is a powerful technique for the detection of low-contrast details in weakly absorbing objects. This method is of possible relevance in the field of diagnostic radiology. In fact, imaging low-contrast details within soft tissue does not give satisfactory results in conventional x-ray absorption radiology, mammography being a typical example. Nevertheless, up to now all applications of the phase contrast technique, carried out on thin samples, have required radiation doses substantially higher than those delivered in conventional radiological examinations. To demonstrate the applicability of the method to mammography we produced phase contrast images of objects a few centimetres thick while delivering radiation doses lower than or comparable to doses needed in standard mammographic examinations (typically approximately 1 mGy mean glandular dose (MGD)). We show images of a custom mammographic phantom and of two specimens of human breast tissue obtained at the SYRMEP bending magnet beamline at Elettra, the Trieste synchrotron radiation facility. The introduction of an intensifier screen enabled us to obtain phase contrast images of these thick samples with radiation doses comparable to those used in mammography. Low absorbing details such as 50 microm thick nylon wires or thin calcium deposits (approximately 50 microm) within breast tissue, invisible with conventional techniques, are detected by means of the proposed method. We also find that the use of a bending magnet radiation source relaxes the previously reported requirements on source size for phase contrast imaging. Finally, the consistency of the results has been checked by theoretical simulations carried out for the purposes of this experiment.

The SYRMEP (SYnchrotron Radiation for MEdical Physics) collaboration is presently taking data at a beamline at the synchrotron ELETTRA in Trieste to study the performances of a digital silicon pixel imaging system for mammography. Images are obtained with a scanning technique in the energy range 15–30 keV. The readout electronics operates in a single photon counting mode with a photon rate of about 10 6 /( mm 2 s ) , which is still 4 times lower than the maximum rate reachable with the present beamline configuration. Two different detector layouts have been designed, the first one consisting of a single-layer silicon microstrip detector positioned edge-on with respect to the beam, and the second innovative one represented by a matrix of these detectors stacked to cover the full beam dimension (100×4 mm 2 ) . We present here the results obtained with a single-layer detector and a double-layer detector (both 5 cm wide) with mammographic phantoms and human breast tissue.

In recent years some structures or features such as the "inter-renuncular septum", the "echogenic triangle" and the "echogenic line" have been described to support the concept of a kidney resulting from the fusion of two masses or renunculi. To clarify this concept and to understand the meaning of the above echographic features better, the authors have examined prospectively by sonography the kidneys of 50 children, 200 adults with a single collecting system, 25 adults with a duplicated collecting system and 32 cadavers. Furthermore, to help explain the sonographic features, we have examined 32 cadaver kidneys with sonography and 10 cadaver kidneys with magnetic resonance imaging (MRI). The sonographic, MRI and anatomical correlations have shown that the "echogenic triangle" and the "echogenic line" are not renuncular residuals, but simply an extension of the hilar fat visible when the renal sinus is rather deep. The intermediate cortical mass is not a septum dividing the kidney into an upper and lower renunculus, but a column of parenchymal tissue crossing the renal sinus, which, from an anatomical point of view, is an accessory renal lobe. The presence of two renunculi, suggested in a previous study with cortical nephrotomography, has not been confirmed.

A synchrotron radiation beamline devoted to medical imaging has been built by the SYRMEP collaboration at Elettra in Trieste, Italy, and is now in operation. The SYRMEP imaging system is based on the combination of a monochromatic, laminar X-ray beam, with a laminar, high-efficiency pixel silicon detector. To image soft tissue, including small, low-contrast details, as in mammography, beam energies should be chosen in the range from 15 keV to 30 keV and the detector should be capable of single-photon counting. The SYRMEP beamline originates from a bending magnet light port and consists basically of a Be window, a slit system and a Si(1,1,1) crystal monochromator. The experimental area is equipped with a radiation flux monitor, a sample movement stage, and a positioning system holding the silicon detector. Images are obtained by keeping the detector stationary with respect to the beam and by scanning the sample through the beam itself. The current detector is a linear array of 200/spl times/300 /spl mu/m/sup 2/ pixels, each coupled to its electronic counting chain on a custom VLSI read-out chip. We present a summary of beam studies, and digital images of standard RMI 160 and RMI 180 Ackermann Mammographic phantoms. Results show the high contrast resolution, the good spatial resolution and the large dynamic range which constitute the defining characteristics of the SYRMEP imaging system.

The SYRMEP collaboration is developing a digital mammography project using a synchrotron radiation monochromatic X-ray beam and a silicon pixel detector. The combination of a monochromatic laminar beam with a high efficiency laminar detector, capable of single-photon counting, allows one to minimize the radiation dose delivered to the sample, while maximizing contrast resolution and dynamic range. The SYRMEP detector is a silicon microstrip device used in an innovative configuration in which radiation impinges on the side rather than on the surface of the chip and is therefore totally absorbed within the detector active volume. The high contrast resolution and spatial resolution (

The SYRMEP (synchrotron radiation in medical physics) Collaboration is planning to use a beam of monochromatic x-rays provided by Elettra, the synchrotron radiation facility in operation at Trieste (Italy), in conjunction with a novel silicon pixel detector to conduct research in digital mammography. A beamline dedicated to mammography is presently under construction in Trieste; it will provide, at a distance of about 20 m from an Elettra bending magnet, a monochromatic laminar-section (150×4 mm2) x-ray beam. This beam will illuminate in vitro samples and will be detected by a fixed silicon microstrip device forming a matrix of pixels. Digital images of phantoms having a size common in the diagnostic practice (150×150 mm2), can then be produced by scanning the sample itself in front of the detector. A prototype detector with a sensitive area of 24×1 mm2 and pixels of 0.5×0.5 mm2 has been built and tested. We present the current status of the SYRMEP beamline and a digital image of a mammographic phantom exposed to a radioactive x-ray source.

The main purpose of the SYRMEP (SYnchrotron Radiation for MEdical Physics) research team is the investigation and development of innovative techniques for medical imaging. A dedicated beamline has been built at ELETTRA to evaluate the effectiveness of synchrotron-based techniques in medical radiology with particular interest to mammography, and more in general, to the imaging of biological and biomedical samples, either in planar or tomographic set-ups. Taking advantage of the high intensity and high spatial coherence of Synchrotron Radiation (SR), phase sensitive techniques such as Phase Contrast (PhC) and Diffraction Enhanced Imaging (DEI) can be applied. After successful studies carried out on test objects and in vitro samples, the research in mammography is aiming at in vivo clinical trials. For this purpose, the layout of the SYRMEP beamline has been substantially modified and the safety system has been completely redesigned to guarantee the compliance with current radiation protection guidelines. In the present paper, the main characteristics of the beamline and an overview of the results obtained in different contexts of biomedical imaging are presented. Moreover, the status of the project for clinical mammography is outlined.

The authors report on a project to evaluate a picture archiving and communication system (PACS) in operation in the hospitals of Trieste, Italy. The goal of the project is to evaluate the clinical, technical, organizational and economic aspects of the PACS. Activity in each of these areas is described. >

The aim of this study was to test different technical spiral-CT parameters to obtain optimal image quality with reduced X-ray dose. Images were acquired with a spiral-CT system Philips Tomoscan AVE1, using 250 mA, 120 kV, and 1-s rotational time. Three protocols were tested: protocol A with 5-mm thickness, pitch 1.6, slice reconstruction every 2.5 mm; protocol B with 3-mm thickness, pitch 1.6, slice reconstruction every 1.5 mm; and protocol C with 3-mm thickness, pitch 2, slice reconstruction every 1.5 mm. Two phantoms were employed to evaluate the image quality. Axial images were acquired, then sagittal and coronal images were reconstructed. Finally, the absorbed X-ray dose for each protocol was measured. Regarding image quality, 5-mm-thick images (protocol A) showed greater spatial resolution and lower noise compared with 3-mm-thick images (protocols B and C) on the axial plane; 3-mm reconstructed sagittal and coronal images (protocols B and C) showed an improved image quality compared with 5-mm reformatted images (protocol A). Concerning X-ray dose, the mean dose was: protocol A 19.6 +/- 0.8 mGy; protocol B 14.4 +/- 0.6 mGy; protocol C 12.5 +/- 1.0 mGy. Our study supports the use of thin slices (3 mm) combined with pitch of 1.6 or 2 in renal colic for X-ray dose reduction to the patient and good image quality.

The authors analyze whether the imaging approach consisting of ultrasonography and plain film in patients with renal colic is still of value when urography is replaced by unenhanced helical CT (UHCT) in unsolved cases.Eight hundred and three consecutive patients were investigated with US following hydration and KUB, 164 of whom (20.4%) subsequently underwent UHCT (42 with the aim of mapping the excretory pathway and 122 (15.2%) because US and KUB were not considered as fully diagnostic).The 42 patients with detectable ureteral stone (plus possible hydronephrosis) on KUB + US and subsequently examined by UHCT to plan interventional treatment all had a positive UHCT examination. In 62 patients the diagnosis following KUB + US was uncertain (possible stone or possible hydronephrosis) and UHCT depicted the stone and/or the hydronephrosis in 34. In 60 patients the combination of KUB + US was negative but colic recurred and UHCT was positive in 17 patients.The comparison of the present results with a previous study in which KUB and US were followed by IVU in unsolved cases underscores the value of the first approach with KUB and US. The need for further diagnostic investigations when KUB + US are either not conclusive or negative and colic recurs is also confirmed. On the basis of our present data and in agreement with the literature IVU can be safely replaced by UHCT.It is authors' opinion that in settings where KUB, US and UHCT are available throughout the 24 hr the approach consisting of KUB plus US and UHCT in unsolved cases can be preferred in view of its on lower cost and above all lower X-ray dose to patients as compared to UHCT as the sole investigation.

Since its introduction into clinical practice in the early 1930s, intravenous urography (IVU) was the primary imaging technique for the investigation of urinary system disorders for many years, until the advent of digital cross-sectional-imaging techniques gradually started to undermine many of its indications. Intravenous urography has been superseded for some indications such as renovascular arterial hypertension, prostatic dysuria, renal failure, palpable abdominal masses and recurrent urinary tract infection in women. Intravenous urography has been reduced, in the sense that it is no longer a primary examination, for other clinical indications such as renal colic, renal trauma, uroseptic fever, asymptomatic haematuria, medical haematuria, obstructive uropathies and follow-up of various disorders. Intravenous urography is indicated and often mandatory in congenital anomalies of the urinary tract, prior to endourological procedures, possible fistulas, renal transplantation, tuberculosis and ureteral pathology. In conclusion, IVU is still the examination of choice where there is a need to visualize the entire urinary system and to evaluate the state of the papillae and calyces. Computed tomography urography and MR urography are the imaging modalities ready in the near future to replace IVU.

In the past decade alternatives to urography have been proposed for the study of patients with renal colic. In 1992 it was suggested to replace urography with KUB and ultrasonography. In 1993 the combination of KUB and ultrasonography followed by urography in unresolved cases was proposed and, in 1995, it was suggested to replace urography with unenhanced helical CT (UHCT). This article illustrates the contribution of UHCT to the study of patients with renal colic and analyses advantages and shortcomings of the technique compared with other diagnostic approaches. Diagnostics of the patient with renal colic is based on the detection of direct and indirect signs which allow identification of not only the calculus, with a sensitivity of 94–100 % and accuracy of 93–98 % according different authors, but also other signs that can serve to guide patient management and evaluate long-term prognosis. Unenhanced helical CT has the capability to detect extraurinary abnormalities which present with flank pain and mimic renal colic. The examination technique affects the quality of the images and therefore diagnostic accuracy as well as the dose to the patient. With regard to setting parameters, the choice of thickness and table feed should be guided by numerous factors. Multiplanar reconstruction is indicated in the study of the entire ureter course to identify the exact site of the calcification for the urologist to perform an evaluation similar to that obtained by urography. Many authors consider UHCT to be a valuable tool for suggesting the best therapeutic approach. Among these there are also urologists. The evaluation is based on the stone detection, its size and level in the urinary tract. Cost analysis shows that the cost of UHCT is equal to or inferior to the cost of urography. With regard to the dose, different data are reported in the literature. A high pitch (more than 1.5) and a thin collimation (3-mm thickness) are good compromise between quality and dose which can be compared to the dose of normal urography. What is to be done if helical CT is not available? If helical CT is not available, plain film plus ultrasonography should be considered. This approach does not solve all the cases; in unresolved cases urography is indicated. It should also be noted that US has a good sensitivity in detecting other conditions such as biliary lithiasis, acute pancreatitis, acute appendicitis and abdomino-pelvic masses which are responsible for pain that mimics renal colic. In conclusion, IVU should not have any more the priority in investigating the patients with renal colic. Helical CT should be the first choice in imaging a patient with renal colic. If this technique is not available, plain film and ultrasonography should be considered adding urography in unresolved cases.

The aim of this study was to analyse the costs of different diagnostic approaches to patients with acute flank pain. Four different diagnostic approaches were considered: (a) spiral CT without contrast medium (CM); (b) plain film, ultrasonography (US) and intravenous urography (IVU) – the latter procedure is used in our department in cases still unsolved following the former investigations (28 % in our experience); (c) plain film, US and spiral CT without CM (as an alternative to IVU in 28 % of cases); and (d) IVU. The cost of each procedure in a university hospital was calculated, following analysis of the differential costs of each investigation (equipment, depreciation and maintenance costs, related materials and services, radiologists, radiographers, nurses) and their common costs (auxiliary personnel and indirect internal costs). Finally, we calculated the full cost of each procedure and applied it to the different diagnostic approaches. The full cost of each approach was: (a) spiral CT without CM = 74 Euro; (b) plain film, US and IVU (28 %) = 66.89 Euro; (c) plain film, US and spiral CT without CM (28 %) = 64.93 Euro; (d) IVU = 80.90 Euro. Intravenous urography alone or in unsolved cases is not to be considered because it provides higher costs and worse diagnostic results, whereas X-ray dose to patient is almost equal between IVU and spiral CT. Spiral CT integrated to plain film and US in unsolved cases could be preferred because of lower cost and dose to patient, though reaching a diagnostic conclusion may take longer than an immediate spiral CT.

From pathological point of view the chronic renal infections include two types, interstitial chronic pyelonephritis and granulomatous pyelonephritis, namely xanthogranulomatous, malacoplakia and renal tuberculosis. Indications for imaging modalities are more common compared to the acute types and allow to depict both factors causing obstruction and infection such as stones ant the renal and extrarenal extension of the disease. In this article the authors review the findings and the role of plain film and urography, computed tomography and ultrasonography.

The aim of this study was to evaluate capabilities of pulse inversion harmonic imaging (PIHI) in characterization of unifocal liver lesions. We evaluated with PIHI (HDI5000, ATL, Bothell, Wash.) and spiral CT 46 consecutive patients with a single liver lesion identified by fundamental US [7 hepatocellular carcinomas (HCC), 2 cholangiocarcinomas, 7 focal nodular hyperplasias (FNH), 17 hemangiomas and 13 metastases]. The PIHI was performed before and 30 s, 2 and 4 min after bolus administration of Levovist (2.5 g, 300 mg/ml). Scans were digitally stored and reviewed using a dedicated software. Hepatocellular carcinoma was hyperechoic on 30-s scan, and hypoechoic (n = 5) or isoechoic (n = 2) on 2-min scan. Cholangiocarcinoma had inhomogeneous persistent enhancement. Focal nodular hyperplasia was hyperechoic (n = 5) or isoechoic (n = 2) on 30-s scan, hyperechoic (n = 4), isoechoic (n = 2) or slightly hypoechoic (n = 1) on 2-min scan. Large hemangioma revealed peripheral enhancement on 30-s scan which extended centripetally on 2-min scan. Small hemangioma appeared isoechoic on 2-min scan in all but two cases in which they were hypoechoic on 2-min scans and hyperechoic on 4-min scan. Metastasis was hypoechoic on all scans, 70 % with rim enhancement. Similar changes in enhancement pattern have been observed at spiral CT.¶ The 30-s and the 2-min scans revealed a conclusive importance in characterization of HCC, cholangiocarcinoma, and large hemangioma. The 2-min scan often furnished enough information for characterization of small hemangioma and metastasis. The 4-min scan allowed characterization of two hemangiomas which appeared hypoechoic on 2-min scans. In the other cases it did not provide further information. Diagnosis of FNH is usually reached with Colour Doppler US; PIHI should be used when colour Doppler is biased by artefacts or when colour Doppler findings are not characteristic. Our results seem to show that PIHI could be a valuable alternative diagnostic approach to spiral CT for unifocal liver lesion characterization. This hypothesis needs to be confirmed with an increased number of lesions.

We examined the value of dynamic magnetic resonance imaging (MRI) in chronic renal disease with renal insufficiency. In 33 consecutive patients (21 vascular nephropathy, 12 glomerular nephropathy) MRI was performed using a 1.5-T unit and a body coil, with SE T1-weighted (TR/TE = 600/19 ms) and dynamic TFFE T1-weighted sequences (TR/TE = 12/5 ms, flip angle = 25 degrees ) after manual bolus injection (via a cubital vein) of 0.1 mmol/kg Gd-DTPA-BMA. Morphological evaluation was performed in unblinded fashion by three radiologists, evaluating renal size, cortical thickness, and corticomedullary differentiation. Functional analysis was performed by one reviewer. Time-signal intensity curves, peak intensity value (P), time to peak intensity (T), and the P/T ratio were obtained at the cortex, medulla, and pyelocaliceal system of each kidney. The relationship of these parameters to serum creatinine and with creatinine clearance was investigated. A good correlation between morphological features of the kidneys and serum creatinine values was found. Morphological findings could not distinguish between vascular and glomerular nephropathies. A statistically significant correlation (P

The authors evaluated the effect on mammographic examinations of the use of synchrotron radiation to detect phase-perturbation effects, which are higher than absorption effects for soft tissue in the energy range of 15-25 keV. Detection of phase-perturbation effects was possible because of the high degree of coherence of synchrotron radiation sources. Synchrotron radiation images were obtained of a mammographic phantom and in vitro breast tissue specimens and compared with conventional mammographic studies. On the basis of grades assigned by three reviewers, image quality of the former was considerably higher, and the delivered dose was fully compatible.

The aim of this study was to assess the potential of projection-reconstruction (PR) MR microscopy in the accurate measurement of cartilage thickness. Short-TE PR microimages were acquired at 7.05 T on bone-cartilage cylindrical plugs excised from four regions of two disarticulated femoral heads (i. e. superior, inferior, posterior and anterior), using an NMR instrument equipped with a microimaging accessory. The PR microimages were then correlated with conventional spin-echo (SE) microimages and with histology. On PR microimages, acquired with an echo time of 3.2 ms, the cartilage signal was increased, allowing an accurate delineation of the cartilage from the tidemark/cortical bone region. As a consequence, by the PR method a more precise measurement of cartilage thickness compared with that performed by the conventional SE approach was feasible. An excellent correlation between PR microimages and histology was also obtained (r = 0.90). By the proposed method it is possible to accurately determine the cartilage thickness better than with the conventional SE sequences.

The aim of this study is to evaluate capability of contrast enhanced ultrasonography (US) using pulse inversion harmonic imaging (PIHI) to detect liver metastases in comparison to fundamental B-mode ultrasound and spiral CT. Thirty-six consecutive patients with known malignancies and sonographically proved or suspicious liver metastases have been examined with fundamental B-mode US, with PIHI 2', 4' and 6' after Levovist injection and with four phase spiral-CT. Presence, conspicuity and number of lesions have been evaluated comparing PIHI with fundamental B-mode US and spiral-CT. A strong grey-scale enhancement of the liver parenchyma has been observed 2' and 4' after Levovist injection. The optimum parenchymal enhancement and contrast difference between liver and metastases was observed during the 2' measurements. PIHI revealed more lesions than fundamental B-mode US in 56 % of patients, while in 39 % and in 5 % revealed respectively the same number and fewer lesions. PIHI and spiral-CT were in agreement in 67 % of patients, while in 22 % and 11 % PIHI revealed respectively more and fewer lesions. PIHI accurancy presents restrictions in anterior superficial and in deep liver areas, whereas it may be superior to spiral-CT in studying sub-diaphragmatic liver regions.

We studied renal function and perfusion after the i.v. injection of Gd-DTPA-BMA, a nonionic paramagnetic contrast agent, to assess renal morphology and function in normal subjects, in renal insufficiency patients and in patients with hepatic failure and normal renal function. The latter were chosen because some patients with advanced hepatic failure may suffer from the hepatorenal syndrome, characterized by severe vasoconstriction in the renal cortical vessels. We investigated if dynamic MRI can detect early renal perfusion abnormalities in the patients who will eventually develop this syndrome.Thirty MR examinations were carried out on 30 subjects after the i.v. injection of Gd-DTPA-BMA. Our series consisted of: 10 normal subjects; 10 renal insufficiency patients; 10 patients with hepatic failure and normal renal function. MR examinations were performed on a Philips ACS II scanner operating at 1.5 T. Two sequences were carried out in all cases: T1-weighted SE and T1-weighted TGE sequences after the bolus injection of .1 mmol/kg contrast agent. Renal longitudinal diameter and parenchymal thickness were measured in all cases and signal intensity time curves were always made. The signal intensity of the cortex, corticomedullary junction, medulla and pyelocaliceal system of each kidney was measured using a region of interest (ROI). The signal intensity curves were made considering quantitative parameters, including the area below the curve (ASC), the peak (P) and the time to peak (T-P).Longitudinal diameter and parenchymal thickness values were significantly lower in renal insufficiency patients than in normal subjects. Four phases were demonstrated after i.v. contrast agent injection in normal subjects, namely A) the cortical phase, B) the corticomedullary junction phase, C) the medullary phase, D) the pyelocaliceal phase. No signal intensity decrease in the medullary and pyelocaliceal curves was observed in renal insufficiency patients. Signal intensity curves values were lower in hepatic failure patients than in those with normal renal function. Hepatic failure patients could be divided into two groups: 5 patients had low P and ASC values and 4 had normal P and ASC values. The patients with lower P and ASC values developed the hepatorenal syndrome within a few months of the MR examination.Signal intensity decreased in the pyelocaliceal system phase in normal subjects because of the high paramagnetic contrast agent concentration. The lack of signal intensity decrease in renal insufficiency patients was caused by the reduced capability of concentrating Gd-DTPA-BMA. Lower signal intensity values in hepatic failure patients may be considered an early sign of the hepatorenal syndrome.

The DPACS project (Data and Picture Archiving and Communication System) was undertaken at the University of Trieste by the Institute of Radiology and the DEEI (Dipartimento di Elettrotecnica, Elettronica ed Informatica), in collaboration with the CRSTBS (Centro Ricerche e Studi Tecnologie Biomediche Sanitarie) of the Area Science Park and the Azienda Ospedaliera of Trieste. The main objective of this project is to create an open system for the management of clinical data and images and for the integration of health care services. The first phase is oriented toward finding an implementation strategy for the creation of a prototype DPACS system, to serve as a starting point for the realization of a distributed structure for the extension of the service, firstly to the entire structure of the Cattinara Hospital and subsequently to all the Public Health units in Trieste. After local testing, the service will finally be expanded to a wider geographical level. The intensive computerization of the Institute of Radiology furnished the most favourable environment for the verification of the prototype, as the service provided by the existing RIS (Radiology Information System) and PACS (Picture and Archiving Communication System) has long been consolidated. One of the main goals of the project, in particular, is to replace the old, by now obsolete, PACS with the DPACS services.

To study the MR appearance of knee joint hyaline cartilage according to age, sex and body weight 120 subjects underwent MRI of the knee. Axial SE PD and T2, GE T1 and GE-MTC sequences, as well as coronal SE T1 and sagittal SE PD and T2 sequences were used. Thickness, surface, signal intensity and visibility of the patellar and femorotibial cartilages were investigated. As for cartilage thickness, a statistically significant difference was found between males and females in nearly all the measurement sites, the mean values being always higher in males. A statistically significant inverse correlation was found in males only, at the three load bearing regions of the medial femoral condyle. No significant correlation was demonstrated between the surface, the signal intensity and the trilaminar appearance of the cartilage and age, as well as body weight. The cartilage of the femoral condyles, the tibial plateaux and the patella showed a regular surface in 76%, 98% and 82% of cases respectively. The signal intensity was homogeneous in 88%, 98% and 82.5% of the cases. Mild focal inhomogeneities were seen in few cases. The visibility rate of the trilaminar appearance of cartilage was 85% for the femoral condyles, 70% for the patella, 13.5% for the tibial plateaux. GE sequence was the best sequence to evaluate cartilage thickness and signal intensity, while SE T2 sequence was the best sequence to depict the articular surface and, together with PD SE sequence, to visualize the trilaminar structure. The most relevant result of this study is the inverse correlation between cartilage thickness and age as well as body weight, mainly in males, in the three areas of greatest load (medial femoral condyle).

We present images of a mammographic test object obtained using a linear array silicon pixel detector capable of single-photon counting. The detector pixel size was 200 x 300 microns2 and images were acquired by scanning the test object between the laminar detector and the x-ray source with a scanning step of 100 microns. A molybdenum anode tube was used with two different filtrations: 2 mm aluminium and 25 microns molybdenum. Conventional film-screen images were also obtained in order to compare spatial and contrast resolution. In our digital images it is possible to recognize low-contrast details having dimensions smaller than or equal to the dimensions of details visible by means of a clinical mammographic unit. The detection of microcalcifications smaller than 150 microns was possible only when using the Mo filtration. However a copper wire of 50 microns diameter was detectable when embedded in a simulated tissue. We discuss in detail the mean glandular doses (MGDs) delivered during the image acquisition. The MGDs necessary to obtain good-quality images are always smaller than at a conventional mammographic unit. Since MGDs depend on the x-ray spectrum, the dose reduction becomes larger when the applied spectrum is harder than in film-screen acquisition (Al filtration and 35 kVp).

The SYRMEP collaboration (Synchrotron Radiation for Medical Physics) is developing a novel imaging device to be used with a laminar monochromatic synchrotron radiation X-ray beam for applications in digital mammography. Its main components are silicon microstrip detectors and a dedicated VLSI readout chip based on the single photon counting concept. The innovative geometry-several overlapped detectors with strips parallel to the beam direction-determines a matrix of pixels, each of them having an area of 200/spl times/300 /spl mu/m/sup 2/, which can detect up to 10/sup 6/ photons/(mm/sup 2/ s) with 90% efficiency at 25 keV. Front-end and readout electronics are expandable in a modular fashion and can be coupled to successive receptor versions with increasing number of channels, while a VME based DAQ system offers full testing facilities. In our view this system is providing specific and original contributions to digital mammography but it could also be useful in other modern radiology fields.

To study the MR appearance of knee joint hyaline cartilage, 120 subjects were examined with MRI of the knee. Axial SE proton-density (PD) and T2, GE T1 and GE-MTC sequences were used, as well as coronal SE T1 and sagittal SE PD and T2 sequences. At the patellar and femorotibial cartilages the following variables were investigated: thickness, surface, signal intensity and visibility. Moreover, the three patellar sequences were compared qualitatively, by giving a 1-to-4 score to the images, depending on their yield in the four variables. As for articular cartilage thickness, a statistically significant difference was found between men and women in nearly all measurement sites, the mean values being always higher in men. A statistically significant inverse correlation between cartilage thickness and age was found, in men only, at the three load-bearing regions of the medial femoral condyle. Cartilage surface was irregular and/or its signal intensity altered in 28% of patients at the femoral condyles, while the cartilage of tibial plates exhibited normal surface and homogeneous signal intensity in most cases. The visibility rate of trilaminar cartilage was 82.5% for the medial femoral condyle, 87.5% for the lateral femoral condyle, 70% for the patella, 12.5% for the medial tibial plateau and 14.5% for the lateral tibial plateau. No statistically significant correlation was found between cartilage thickness, surface, signal intensity and visibility and age, sex, and body weight. The GE sequence was the best tool to study cartilage thickness and signal intensity, while the SE T2 sequence was the most accurate one to depict the articular surface and, together with the PD SE sequence, to visualize the trilaminar structure. Our study suggests that articular cartilage surface, thickness, and signal intensity can be studied accurately with SE PD and T2 sequences, combined with a GE T1 sequence.

The term “acute renal infection” encompasses a spectrum of pathologic processes involving the renal parenchyma that vary in severity from acute pyelonephritis to a renal abscess which can progress to the peri- and pararenal spaces.