70 results on '"L, Bellanca"'
Search Results
2. Risk Perception with and Without Workers Present in Hazard Recognition Images.
- Author
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Jennica L. Bellanca, Brianna Eiter, Jonathan Hrica, Robert Weston, and Terry Weston
- Published
- 2019
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3. Automated Systems and Trust: Mineworkers' Trust in Proximity Detection Systems for Mobile Machines
- Author
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LaTasha R. Swanson, Jennica L. Bellanca, and Justin Helton
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Public aspects of medicine ,RA1-1270 - Abstract
Background: Collisions involving workers and mobile machines continue to be a major concern in underground coal mines. Over the last 30 years, these collisions have resulted in numerous injuries and fatalities. Recently, the Mine Safety and Health Administration (MSHA) proposed a rule that would require mines to equip mobile machines with proximity detection systems (PDSs) (systems designed for automated collision avoidance). Even though this regulation has not been enacted, some mines have installed PDSs on their scoops and hauling machines. However, early implementation of PDSs has introduced a variety of safety concerns. Past findings show that workers' trust can affect technology integration and influence unsafe use of automated technologies. Methods: Using a mixed-methods approach, the present study explores the effect that factors such as mine of employment, age, experience, and system type have on workers' trust in PDSs for mobile machines. The study also explores how workers are trained on PDSs and how this training influences trust. Results: The study resulted in three major findings. First, the mine of employment had a significant influence on workers' trust in mobile PDSs. Second, hands-on and classroom training was the most common types of training. Finally, over 70% of workers are trained on the system by the mine compared with 36% trained by the system manufacturer. Conclusion: The influence of workers' mine of employment on trust in PDSs may indicate that practitioners and researchers may need to give the organizational and physical characteristics of each mine careful consideration to ensure safe integration of automated systems. Keywords: automation, mining, occupational safety, proximity detection, trust
- Published
- 2019
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4. Recognizing Mine Site Hazards: Identifying Differences in Hazard Recognition Ability for Experienced and New Mineworkers.
- Author
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Brianna M. Eiter, Jennica L. Bellanca, William Helfrich, Timothy J. Orr, Jonathan Hrica, Brendan Macdonald, and Jason Navoyski
- Published
- 2017
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5. A Rapid Review of Collision Avoidance and Warning Technologies for Mining Haul Trucks
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Jonathan K. Hrica, Jennica L. Bellanca, Iman Benbourenane, Jacob L. Carr, John Homer, and Kathleen M. Stabryla
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Control and Systems Engineering ,Mechanical Engineering ,Materials Chemistry ,Metals and Alloys ,General Chemistry ,Geotechnical Engineering and Engineering Geology ,Article - Abstract
Given the recent focus on powered haulage incidents within the US mining sector, an appraisal of collision avoidance/warning systems (CXSs) through the lens of the available research literature is timely. This paper describes a rapid review that identifies, characterizes, and classifies the research literature to evaluate the maturity of CXS technology through the application of a Technology Readiness Assessment. Systematic search methods were applied to three electronic databases, and relevant articles were identified through the application of inclusion and exclusion criteria. Sixty-four articles from 2000 to 2020 met these criteria and were categorized into seven CXS technology categories. Review and assessment of the articles indicates that much of the literature-based evidence for CXS technology lies within lower levels of maturity (i.e., components and prototypes tested under laboratory conditions and in relevant environments). However, less evidence exists for CXS technology at higher levels of maturity (i.e., complete systems evaluated within operational environments) despite the existence of commercial products in the marketplace. This lack of evidence at higher maturity levels within the scientific literature highlights the need for systematic peer-reviewed research to evaluate the performance of CXS technologies and demonstrate the efficacy of prototypes or commercial products, which could be fostered by more collaboration between academia, research institutions, manufacturers, and mining companies. Additionally, results of the review reveal that most of the literature relevant to CXS technologies is focused on vehicle-to-vehicle interactions. However, this contrasts with haul truck fatal accident statistics that indicate that most haul truck fatal accidents are due to vehicle-to-environment interactions (e.g., traveling through a berm). Lastly, the relatively small amount of literature and segmented nature of the included studies suggests that there is a need for incremental progress or more stepwise research that would facilitate the improvement of CXS technologies over time. This progression over time could be achieved through continued long-term interest and support for CXS technology research.
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- 2022
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6. EE480 Cost-Effectiveness of Empagliflozin for the Treatment of Patients With Heart Failure With Above 40% Ejection Fraction in England
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S Kolovos, A Tasoulas, A Solé Angelats, S Linden, and L Bellanca
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Health Policy ,Public Health, Environmental and Occupational Health - Published
- 2022
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7. EE481 Cost-Effectiveness of Empagliflozin for Patients With Heart Failure Irrespective of Ejection Fraction in England
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M Cheen, J Gaultney, L Bellanca, and S Linden
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Health Policy ,Public Health, Environmental and Occupational Health - Published
- 2022
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8. Identify the Influence of Risk Attitude, Work Experience, and Safety Training on Hazard Recognition in Mining
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Jennica L. Bellanca and Brianna Eiter
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Mechanical Engineering ,Applied psychology ,Metals and Alloys ,General Chemistry ,Geotechnical Engineering and Engineering Geology ,Affect (psychology) ,Training (civil) ,Hazard ,Occupational safety and health ,Work environment ,Work experience ,Article ,Control and Systems Engineering ,Metallic materials ,Materials Chemistry ,Laboratory research - Abstract
Mineworkers face a challenging and dynamic work environment every workday. To maintain a safe workplace, mineworkers must be able to recognize worksite hazards while they perform their jobs. Though hazard recognition is a critical skill, recent research from the National Institute for Occupational Safety and Health (NIOSH) indicates that mineworkers fail to identify a significant number of hazards. To further the understanding of mineworkers’ hazard recognition ability and to begin to address hazard recognition performance, NIOSH researchers analyzed data collected during a laboratory research study to determine the effect of individual mineworker factors including risk attitude, work experience, and safety training on hazard recognition accuracy. The results of this study show that mineworker risk attitude and safety-specific work experience affect hazard recognition performance while hazard-specific safety training does not. These results suggest that some of these individual factors can be overcome through experience and training. Potential strategies that can be used to address these factors are also discussed.
- Published
- 2021
9. The Influence of a Continuous Mining Machine and Roof/Rib Mesh on Magnetic Proximity Detection Systems
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Chenming Zhou, Jacob Carr, Jennica L. Bellanca, Christopher C. Jobes, Jingcheng Li, and LaTasha R. Swanson
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Hazard (logic) ,Wire mesh ,Mechanical Engineering ,Acoustics ,Metals and Alloys ,Steel structures ,General Chemistry ,Geotechnical Engineering and Engineering Geology ,Magnetic field ,Generator (circuit theory) ,Control and Systems Engineering ,Metallic materials ,Materials Chemistry ,Proximity detection ,Roof - Abstract
Magnetic proximity detection systems (PDSs) are used with continuous mining machines (CMMs) to protect miners from striking and pinning accidents. Generators are used in a PDS to create magnetic fields covering the space around a CMM. The PDS determines the proximity of a miner relative to the CMM based on the magnetic flux density detected by a miner-wearable component (MWC) and simultaneously alerts the miner and stops the motion of the CMM if the miner is within a proximity that creates a striking hazard. A stable magnetic field is essential to the accuracy of the proximity calculations performed by the PDS. This paper presents the results of a systematic study of the magnetic influence of two types of steel structures found near a CMM—the body of the CMM itself and the wire mesh used for roof and rib control. The results show that the steel of the CMM body can change the magnetic field distribution and also alter electrical parameters of a PDS by changing its generator current. The study also shows that, depending on the distance between the wire mesh and a generator, the magnetic field can also be altered.
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- 2019
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10. Mineworkers’ Perceptions of Mobile Proximity Detection Systems
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LaTasha R. Swanson, Justin Helton, Jennica L. Bellanca, and Michael McNinch
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business.industry ,Unintended consequences ,Mechanical Engineering ,media_common.quotation_subject ,0211 other engineering and technologies ,Metals and Alloys ,Haulage ,Usability ,02 engineering and technology ,General Chemistry ,Geotechnical Engineering and Engineering Geology ,User input ,Article ,Risk analysis (engineering) ,Control and Systems Engineering ,Perception ,Metallic materials ,Materials Chemistry ,Proximity detection ,business ,Engineering design process ,021102 mining & metallurgy ,media_common - Abstract
Accident data indicates that mobile haulage poses a significant pinning, crushing, and striking risk. Proximity detection systems (PDSs) have the potential to protect mineworkers from these risks. However, unintended consequences of mobile PDSs can undermine the safety benefit they provide. Soliciting iterative user input can improve the design process. Users help provide a critical understanding of how mobile PDSs may hinder normal operation and endanger mineworkers. Researchers explored users’ perspectives by conducting interviews with mineworkers from seven mines that have installed mobile PDSs on some of their haulage equipment. Mineworkers reported that mobile PDSs affect loading, tramming, section setup, maintenance, and general work on the section. Mineworkers discussed the operational effects and increased burden, exposure, and risk. Mineworkers also suggested that improved task compatibility, training, logistics, and PDS performance might help address some of these identified issues. This paper also gives additional insights into mobile PDS design and implementation.
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- 2019
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11. POSA126 An Economic Analysis of Empagliflozin Versus Sacubitril/Valsartan in Patients with Heart Failure with Reduced Ejection Fraction (HFREF) in the United Kingdom (UK)
- Author
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O Reifsnider, A Tafazzoli, L Bellanca, M Litkiewicz, M Stargardter, and S Linden
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Health Policy ,Public Health, Environmental and Occupational Health - Published
- 2022
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12. POSB22 Indirect Treatment Comparisons of Empagliflozin Versus Sacubitril/Valsartan for the Treatment of Patients with Heart Failure with Reduced Ejection Fraction (HFREF)
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S Smith, H Pilkington, N Roskell, S Linden, and L Bellanca
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Health Policy ,Public Health, Environmental and Occupational Health - Published
- 2022
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13. Developing a Virtual Reality Environment for Mining Research
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Timothy J. Orr, Jason Navoyski, Brendan Demich, Jennica L. Bellanca, Brendan Macdonald, and William Helfrich
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Data collection ,Mechanical Engineering ,0211 other engineering and technologies ,Metals and Alloys ,02 engineering and technology ,General Chemistry ,Virtual reality ,Geotechnical Engineering and Engineering Geology ,Article ,Rendering (computer graphics) ,Visualization ,Control and Systems Engineering ,Human–computer interaction ,Metallic materials ,Materials Chemistry ,Proximity detection ,021102 mining & metallurgy - Abstract
Recent advances in computing, rendering, and display technologies have generated increased accessibility for virtual reality (VR). VR allows the creation of dynamic, high-fidelity environments to simulate dangerous situations, test conditions, and visualize concepts. Consequently, numerous products have been developed, but many of these are limited in scope. Therefore, the National Institute for Occupational Safety and Health researchers developed a VR framework, called VR Mine, to rapidly create an underground mine for human data collection, simulation, visualization, and training. This paper describes the features of VR Mine using self-escape and proximity detection as case studies. Features include mine generation, simulated networks, proximity detection systems, and the integration and visualization of real-time ventilation models.
- Published
- 2019
14. If the Technology Fits: an Evaluation of Mobile Proximity Detection Systems in Underground Coal Mines
- Author
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LaTasha R. Swanson and Jennica L. Bellanca
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business.industry ,Mechanical Engineering ,0211 other engineering and technologies ,Metals and Alloys ,Coal mining ,Usability ,02 engineering and technology ,General Chemistry ,Task completion ,Geotechnical Engineering and Engineering Geology ,Automation ,Article ,System characteristics ,Transport engineering ,Early adopter ,Control and Systems Engineering ,Materials Chemistry ,Technology integration ,Proximity detection ,business ,021102 mining & metallurgy - Abstract
Proximity detection systems (PDSs) for mobile machines have the potential to decrease injuries and fatalities. Early adopters of the technology have identified some challenges, which present an opportunity to explore and improve the integration of mobile PDSs in underground coal mines. The current research study applied the task-technology fit framework to investigate the fit between mobile PDS technology and mining relative to health and safety, from the perspective of leaders at two coal mines. Quantitative results from the study show that mine leaders evaluated mobile PDS favorably for training and ease of use, system feedback, user authorization and experience, and less favorably for safety, compatibility, task completion, and reliability. Qualitative results reveal specific task, mine, and system characteristics that may have influenced leaders’ evaluations. The study includes considerations and suggestions for safe technology integration.
- Published
- 2019
15. The Effect of Hazard Clustering and Risk Perception on Hazard Recognition
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Timothy J. Orr, William Helfrich, Jennica L. Bellanca, Brianna Eiter, and Elaine N. Rubinstein
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Risk perception ,Identification (information) ,Falling (accident) ,Risk analysis (engineering) ,Computer science ,medicine ,Central field ,Hazard analysis ,medicine.symptom ,Workplace safety ,Cluster analysis ,Hazard - Abstract
Active mining operations are complex, dynamic environments that can present workers with an array of potential safety and health challenges. From missing fire extinguishers to large equipment and falling rocks, hazards exist that mineworkers must be cognizant of to keep themselves and their coworkers safe. While hazard identification is a key skill that mineworkers must possess to ensure workplace safety, the location and perceived risk of the hazards may alter this ability. To further explore these effects, NIOSH researchers conducted a study to characterize how mineworkers search for and identify hazards. Researchers asked participants to search 32 static panoramic scenes depicting typical locations at a surface stone mine—pit, plant, roadway, and shop—with each containing zero to seven hazards. Mineworkers tended to miss hazards when they were in clusters—i.e., where two or more hazards appeared within the worker’s central field of view. This paper examines the relationship of clustered hazards, perceived risk and identification accuracy and how location and experience affect it. Based on the results, strategies will be suggested that mineworkers can use to help identify hazards in their workplace.
- Published
- 2018
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16. From the Laboratory to the Field: Developing a Portable Workplace Examination Simulation Tool
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Jonathan Hrica, William Helfrich, Brianna Eiter, and Jennica L. Bellanca
- Subjects
Data collection ,Computer science ,business.industry ,Software tool ,computer.software_genre ,Hazard ,Field (computer science) ,Engineering management ,Software ,Virtual machine ,Laboratory research ,business ,computer ,Mine safety - Abstract
To perform a successful workplace examination, mineworkers must be able to find and fix hazards at their workplace. NIOSH recently completed a laboratory study to identify differences in hazard recognition performance for mineworkers, safety professionals, and mining engineering students tasked with performing a simulated workplace examination in a virtual environment. The laboratory methodology and study results were used to develop a training product aimed at improving mineworker safety. The purpose of the current chapter is to describe the efforts that were taken to modify the laboratory workplace examination simulation into a portable software tool called EXAMiner, which can be used for data collection and training purposes in the field. This chapter provides an explanation of the literature and results from the NIOSH laboratory research studies used to inform and motivate development of EXAMiner. In addition, the software specifications are explained.
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- 2018
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17. Perceptions and Usability of a Mining Vest
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Lisa Steiner, Brianna Eiter, and Jennica L. Bellanca
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Engineering ,ComputingMilieux_THECOMPUTINGPROFESSION ,business.industry ,media_common.quotation_subject ,Coal mining ,InformationSystems_DATABASEMANAGEMENT ,Usability ,Medical Terminology ,Transport engineering ,Work (electrical) ,Mining engineering ,Overhead (business) ,Perception ,VEST ,business ,Medical Assisting and Transcription ,media_common - Abstract
As miners are expected to wear more and more equipment, space and capacity on their mining belt is becoming scarce. To combat this, several companies have recently developed vests for mining. We explored the usability, acceptance, and performance of one of the mining vests through a field evaluation. A total of 18 miners across various positions were recruited from high and med/low seam underground coal mines to wear a mining vest over a six-week period. Results confirm that comfort, especially related to overhead work, was a key factor to the usability of the vests, and comfort was a bigger factor in the lower seam mine than the higher. Reports of various other factors are included in this publication. Despite other concerns, the miners remained positive and interested in the concept of a mining vest, especially for certain occupations. With some modification, the mining vest could be an effective way to house the necessary equipment traditionally worn on a belt.
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- 2013
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18. Assessing Hazard Identification in Surface Stone Mines in a Virtual Environment
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Brianna Eiter, Jason Navoyski, Timothy J. Orr, Brendan Macdonald, Jennica L. Bellanca, and William Helfrich
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Engineering ,Data collection ,business.industry ,ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION ,Virtual reality ,Hazard analysis ,computer.software_genre ,Gaze ,Civil engineering ,Software ,Virtual machine ,Region of interest ,Eye tracking ,Data mining ,business ,computer - Abstract
Mine workers are expected to remain vigilant and successfully identify and mitigate hazards in both routine and non-routine locations. The goal of the current research project is to better understand how workers search and identify hazards. NIOSH researchers developed a data collection setup to measure a subject’s gaze, head position, and reaction time while examining 360° 2D-panoramic images at a surface mine. The data is integrated in semi real-time to determine region of interest (ROI) hit accuracy for hazards within the images. The purpose of this paper is to discuss the development and implementation of the hardware and software. The following aspects of the setup will be explored in the paper: (1) environment selection, (2) image creation, (3) stimulus display, (4) synchronization, (5) gaze mapping, and (6) region of interest (ROI) hit calculation.
- Published
- 2016
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19. Preformed Butyl Tapes in Glazing Applications
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Carmen L. Bellanca
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Glazing ,Materials science ,Composite material ,Elastomer ,Durability - Abstract
The different types of glazing systems currently in use today are described. This paper is directed toward wet glazing only and specifically the use of preformed butyl elastomeric tape. The development of a suitable tape formulation necessitates understanding the demands placed on the tape while in service. Adhesion to substrates, squeeze-out under load, pump out resistance, compression-deflection properties at various temperatures, and durability under long-term aging are typical parameters of a quality tape. Tests that define these characteristics and typical data are presented. Selection of tape is dependent upon whether the system requires a compressible, noncompressible, or shimmed tape. Installation techniques including the use of liquid sealants as well as proper joint preparation are discussed. Status of ASTM Subcommittee C24.50 on Preformed Tape Sealants efforts in test methods and specifications are discussed.
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- 2008
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20. The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer
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R, Sanguedolce, G, Vultaggio, F, Sanguedolce, G, Modica, F, Li Volsi, G, Diana, G, Guereio, L, Bellanca, and L, Rausa
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Male ,Time Factors ,Thymidylate Synthase ,Adenocarcinoma ,Middle Aged ,Prognosis ,Survival Rate ,Biomarkers, Tumor ,Humans ,Female ,Intestinal Mucosa ,Colorectal Neoplasms ,Aged ,Neoplasm Staging - Abstract
Inhibition of Thymidylate Synthase (TS) by the 5-Fluorouracil (5Fu) active metabolite Fluoro-deoxy-uridine-monophosphate (FdUMP) is considered to be the main mechanism of action of 5Fu. TS level from tumors and normal mucosa of 62 untreated patients who underwent surgery for primary colorectal adenocarcinoma was performed. The aim of this study was to evaluate the possibility of considering the TS level as a prognostic factor of the disease. A large variation in the level of the enzyme was found among tumors. Our data demonstrate that there is no association with age, sex, and tumor size; however there are significant relationships between TS levels and staging and histological grading. In fact the TS values are higher in Dukes' A and in G1 than in Dukes' D and G3 tumors (p0.05). Another significant association has been found between the TS level and tumor site: pts with right colon neoplasias had higher TS levels than pts with left and rectum ones. An interesting trend was found between the TS levels and survival parameters. Pts who had lower TS levels had a significantly increased risk of death (p0.05) over pts with a higher outcome. Our data support the hypothesis that a high TS level is a favourable prognostic factor in human untreated colorectal carcinomas according to our previous preliminary data (1).
- Published
- 1998
21. Plasma and CSF morphine concentrations after i.m. and epidural administration
- Author
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Papa G, A. Sansone, L. Montalbano, M.T. Latteri, L. Bellanca, and S. Latteri
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Anesthesia, Epidural ,medicine.medical_specialty ,Time Factors ,Injections, Intramuscular ,Injections ,Epidural morphine ,Route of administration ,Cerebrospinal fluid ,Internal medicine ,Blood plasma ,Humans ,Medicine ,In patient ,Epidural administration ,Pharmacology ,Morphine ,biology ,business.industry ,Middle Aged ,biology.organism_classification ,Endocrinology ,Tasa ,Anesthesia ,business ,medicine.drug - Abstract
Morphine concentrations in plasma and CSF after i.m. and epidural morphine administration were assayed in patients undergoing surgery of the low abdomen. Morphine concentration in CSF after i.m. administration of this drug is remarkably lower than morphine concentration in plasma. The highest value is attained in CSF after about 90' and is followed by a slow downsloping to lowest values, which were observed 4 hours after drug administration. Kinetics of morphine passage into plasma after epidural administration is similar to that found after i.m. administration. In the latter experimental condition (epidural administration), concentrations of morphine in CSF 30' after administration are markedly lower than those found in plasma. However, 60 min. after epidural administration plasma and CSF morphine concentrations are similar, in particular CSF concentrations are 4 to 8 times higher than those obtained after i.m. administration. Such high levels persists for a long time.
- Published
- 1985
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22. Drug induced variations of the renin-angiotensin-aldosterone system in rats. II. Antihypertensives
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L. Valdes, M. Palazzoadriano, V. Albano, L. Bellanca, and S. Latteri
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Male ,medicine.medical_specialty ,Blood Pressure ,Propranolol ,Pharmacology ,Plasma renin activity ,Internal medicine ,Renin ,Renin–angiotensin system ,medicine ,Diazoxide ,Animals ,Aldosterone ,Antihypertensive Agents ,Kidney ,Chemistry ,Angiotensin II ,Reserpine ,Diuresis ,Rats ,Clonidine ,medicine.anatomical_structure ,Endocrinology ,Vascular resistance ,medicine.drug - Abstract
Summary Groups of male rats were treated with antihypertensive drugs (alpha-methyl-dopa, clonidine, propranolol, reserpine, diazoxide) which were administered under conditions causing the onset of high plasma renin activity (PRA) and high plasma and urine aldosterone levels, i.e. together with distilled water load (5% of body weight). Alpha-methyl-dopa and propranolol, which fail to significantly alter PRA and plasma aldosterone levels when administered without distilled water load, cause a marked decrease of plasma and urine aldosterone levels and of PRA when administered together with distilled water load, while diazoxide, and reserpine cause a marked increase of these values. Clonidine causes significant decreases of PRA and plasma aldosterone levels in both experimental situations. Increases of PRA and of plasma aldosterone levels occur also in rats treated with diazoxide associated with propranolol and in those treated with an association of reserpine and propranolol. The highest values of plasma aldosterone levels were found in rats treated with reserpine for two days and receiving a further dose of reserpine associated with propranolol on the third day, which fact was ascribed to the reduction of peripheral vascular resistance and of plasma flow in the kidney (as shown by decreased diuresis) brought about by propranolol and followed by a marked compensatory activation of the renin-angiotensin-aldosterone system. Moreover there is no apparent correlation between the antihypertensive effect and the variations of the renin-angiotensin-aldosterone system.
- Published
- 1977
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23. Variations of plas14a benin activity and aldostehone levels in the rat after administration of saline, chrystalloid and colloid solutions
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M.T. Latteri, V. Albano, L. Valdes, S. Latteri, L. Bellanca, and A. Antona
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Pharmacology ,medicine.medical_specialty ,animal structures ,Chemistry ,medicine.medical_treatment ,Aldosterone levels ,urologic and male genital diseases ,Plasma volume ,Plasma renin activity ,female genital diseases and pregnancy complications ,Colloid ,Endocrinology ,Distilled water ,Internal medicine ,medicine ,Saline ,hormones, hormone substitutes, and hormone antagonists ,circulatory and respiratory physiology - Abstract
The data reported in the present paper refer to quantitative variations of plasma renin activity (PRA.) and of plasma aldosterone levels in rats after adiministration of saline, chrystalloid and colloid solutions. In our experimental conditions PRA and plasma aldosterone levels were shown to increase significantly after administration of distilled water and glucose solution. Variations of PRA and plasma aldosterone levels were only slight when plasma volume was made to increase due to administration of polyvinylpirrolidone solution. PRA, instead, was significantly lower in rats having received saline salution.
- Published
- 1976
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24. La réponse neuro-endocrinienne à l'anesthésie par isoflurane
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S. Mercanante, M.T. Latteri, L. Bellanca, V. Lanza, and S. Latteri
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Gynecology ,medicine.medical_specialty ,Anesthesiology and Pain Medicine ,business.industry ,medicine ,General Medicine ,business - Abstract
Resume Dans le contexte de la reaction endocrinienne et metabolique a l'anesthesie et a la chirurgie, les effets de l'isoflurane sur l'axe hypothalamohypophysocorticosurrenalien et le systeme hypothalamothyroidien ont ete etudies. L'ACTH, le cortisol, la TSH, la T3, la T4 et la prolactine ont ete doses chez 16 patients avant et au cours de l'intervention chirurgicale sous anesthesie avec isoflurane. Les resultats objectivent une augmentation significative des valeurs de la prolactine, du cortisol et de T4, permettant de conclure que l'isoflurane ne bloque pas l'augmentation du taux plasmatique de ces hormones au cours du stress chirurgical et se comporte donc a ce point de vue comme l'enflurane.
- Published
- 1986
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25. Effect of Liquid Rocket Fuels and Oxidizers on Elastomeric O-Ring Seals
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I. O. Salyer and C. L. Bellanca
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Polytetrafluoroethylene ,Polymers and Plastics ,Chlorine trifluoride ,Liquid-propellant rocket ,Inorganic chemistry ,Ethylene propylene rubber ,Elastomer ,law.invention ,Pentaborane ,chemistry.chemical_compound ,chemistry ,law ,Materials Chemistry ,O-ring ,Hydrogen peroxide - Abstract
O-ring seals of selected elastomeric and compliant materials were evaluated for resistance to liquid rocket fuels and oxidizers in a simulated end-use test. Oxidizers were nitrogen tetroxide, chlorine trifluoride, and 90 per cent hydrogen peroxide; fuels were mixed hydrazines, pentaborane, and Hybaline A-5. Tests were made at 73° F with all fluids; further, the effect of elevated temperature (160° F) on seals was evaluated in nitrogen tetroxide, hydrogen peroxide, and mixed hydrazines. At 73° F only polytetrafluoroethylene was resistant to all of the fluids; however, elastomeric materials were found which were satisfactory for specific fuel or oxidizer systems. Butyl and ethylene propylene rubber appear satisfactory for long term storage in the presence of mixed hydrazines and Hybaline A-5. The fluorocarbons appeared best of the elastomeric materials for use with pentaborane and hydrogen peroxide.
- Published
- 1966
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26. [Influence of L-5-hydroxytryptophan on the secretion of prolactin and on plasma levels of gonadotropins]
- Author
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L, Bellanca, M T, Latteri, S, Latteri, G, Bajardi, T, Cassano, and M, Latteri
- Subjects
5-Hydroxytryptophan ,Adult ,Humans ,Female ,Follicle Stimulating Hormone ,Luteinizing Hormone ,Middle Aged ,Prolactin - Published
- 1984
27. [Alcoholic myocardiopathy. Biochemical and ultrastructural study]
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F, Aragona, V, Franco, G, Milana, L, Bellanca, S, Latteri, and G, De Feo
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Male ,Norepinephrine ,Cardiomyopathy, Alcoholic ,Myocardium ,Animals ,Rats, Inbred Strains ,Dihydroxyphenylalanine ,Rats - Published
- 1983
28. [Behavior of the plasma level of digoxin in the rat in induced experimental hyperreninemia]
- Author
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V, Albano, L, Bellanca, S, Latteri, and L, Valdes
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Digoxin ,Renin ,Animals ,Kidney ,Aldosterone ,Rats - Abstract
PRA, plasma and urine aldosterone levels and plasma digoxin were measured in rats in which digoxin had been administered under conditions of high PRA and high aldosterone levels experimentally induced by administering distilled water load and in rats in which digoxin had been administered without distilled water load. Results show that under conditions of high PRA and high aldosterone levels, plasma digoxin concentrations as measured 6 h after treatment were higher (45,3%) than in rats having received digoxin without water load. In assays carried out on rats sacrificed 12 h after digoxin treatment (with or without water load) all values approach basic levels again, thus suggesting that in rats too aldosterone might compete with digoxin at the level of tubular excretion.
- Published
- 1979
29. [Evaluation of ferritin, CEA and AFP in patients operated on for carcinoma of the breast. Preliminary results]
- Author
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M, Latteri, G, Spinnato, G, Pantuso, G, Di Lisi, S, Latteri, L, Bellanca, M T, Latteri, B, Cirello, and M, Ciaccio
- Subjects
Adult ,Time Factors ,Ferritins ,Humans ,Breast Neoplasms ,Female ,Postoperative Period ,alpha-Fetoproteins ,Middle Aged ,Aged ,Carcinoembryonic Antigen ,Neoplasm Staging - Published
- 1987
30. Modifications induced in the renin-angiotensin-aldo-sterone system of rats by alpha-blocking drugs
- Author
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V. Albano, L. Valdes, S. Latteri, M. Palazzoadriano, L. Bellanca, and S. Mangiameli
- Subjects
Pharmacology ,medicine.medical_specialty ,Chemistry ,Phenoxybenzamine ,Angiotensin II ,Blood Pressure ,Plasma renin activity ,Blood pressure drop ,Rats ,Alpha blocking ,Phentolamine ,Endocrinology ,High plasma ,Internal medicine ,Renin–angiotensin system ,Renin ,medicine ,Standard diet ,Animals ,Aldosterone ,Adrenergic alpha-Antagonists ,medicine.drug - Abstract
Summary The data reported in the present paper refer to quantitative variations of plasma renin activity and plasma aldosterone levels after administration of alpha-blocking agents, i.e. phentolamine, phenoxybenzamine and gihydroergotoxin derivatives, either to rats kept on a standard diet with water ad libitum or to rats receiving distilled water load, the latter treatment causing an increase of both plasma renin activity and plasma aldosterone levels if compared to control values. No strict correlation between (a) drug-induced modifications of plasma renin activity and plasma aldosterone levels and (b) blood pressure drop caused by the same drugs was shown to occur under either experimental condition. Infact phentolamine and dihydroergotoxin derivatives exert all a more or less marked hypotensive action, which may be associated with relatively high plasma renin activita and plasma aldosterone levels, as is the case with phentolamine and phenoxybenzamine, or with low PRA and low plasma aldosterone levels, as is the case with dihydroergotoxin derivatives.
- Published
- 1978
31. [Action of ethrane on the force-velocity relationship of left ventricular contraction]
- Author
-
V, Albano, A, Antona, L, Bellanca, A, Latteri, and M, Palazzoadriano
- Subjects
Ethyl Ethers ,Dogs ,Coronary Circulation ,Heart Ventricles ,Animals ,Blood Pressure ,Halothane ,Ether ,Myocardial Contraction ,Blood Flow Velocity ,Anesthetics - Published
- 1974
32. [Changes in the catecholamine content and cyclic AMP concentration in the rat brain and heart after administration of alpha-methyldopa]
- Author
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V, Albano, A, Antona, L, Bellanca, S, Latteri, L, Valdes, and M T, Latteri
- Subjects
Catecholamines ,Myocardium ,Cyclic AMP ,Animals ,Brain ,Heart ,Methyldopa ,Rats - Published
- 1976
33. Changes of the renin-angiotensin and of the kallikrein-kinin system after administration of saline, christalloid and colloid solution in the rat. Effects of captopril
- Author
-
L. Valdes, A. Antona, S. Latteri, V. Albano, and L. Bellanca
- Subjects
Pharmacology ,Blood Volume ,Captopril ,Chemistry ,medicine.medical_treatment ,Kinins ,Kinin ,Sodium Chloride ,Rats ,Renin-Angiotensin System ,Solutions ,Colloid ,Glucose ,Furosemide ,Renin–angiotensin system ,medicine ,Animals ,Kallikreins ,Colloids ,Saline ,medicine.drug - Published
- 1988
34. Drug-induced variations of the renin-angiotensin-aldosterone system in rats. I. Diuretics
- Author
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L. Valdes, M. Palazzoadriano, S. Latteri, V. Albano, and L. Bellanca
- Subjects
Male ,medicine.medical_specialty ,Diuresis ,Pharmacology ,Spironolactone ,Plasma renin activity ,Excretion ,chemistry.chemical_compound ,Internal medicine ,Renin–angiotensin system ,Renin ,medicine ,Animals ,Diuretics ,Aldosterone ,Triamterene ,Angiotensin II ,Sodium ,Furosemide ,Rats ,Endocrinology ,chemistry ,Potassium ,medicine.drug - Abstract
Summary Groups of 10 rats were treated with diuretics (furosemide, hydrochlorotiazide, spironolactone, triamterene) under conditions of high or low plasma renin activity (PRA) brought about by administering distilled water or saline load, respectively. PRA, plasma aldosterone levels, urine aldosterone concentration as well as diuresis and Na+ and K+ excretion were
- Published
- 1977
35. [The neuroendocrine response during surgery and in the first 5 postoperative days in a patient under continuous peridural analgesia]
- Author
-
V, Lanza, S, Mercadante, A, Pignataro, L, Guglielmo, S, Latteri, L, Bellanca, and C, Palumbo
- Subjects
Adult ,Analgesia, Epidural ,Male ,Thyroid Hormones ,Time Factors ,Adrenocorticotropic Hormone ,Hydrocortisone ,Surgical Procedures, Operative ,Humans ,Lidocaine ,Female ,Postoperative Period ,Prolactin - Published
- 1989
36. Variations of plasma renin activity and aldosterone levels in the rat after administration of saline, chrystalloid and colloid solutions (1)
- Author
-
V, Albano, A, Antona, L, Bellanca, M T, Latteri, S, Latteri, and L, Valdes
- Subjects
Male ,Solutions ,Glucose ,Renin ,Animals ,Povidone ,Water ,Colloids ,Sodium Chloride ,Aldosterone ,Rats - Published
- 1976
37. [Variations in the catecholamine content of the rat brain and heart after administration of alpha-methyldopa, clonidine and diazoxide]
- Author
-
V, Albano, L, Bellanca, S, Latteri, and L, Valdes
- Subjects
Brain Chemistry ,Catecholamines ,Myocardium ,Diazoxide ,Animals ,Brain ,Heart ,Methyldopa ,Antihypertensive Agents ,Clonidine ,Rats - Published
- 1977
38. [Neuroendocrine response to anesthesia with isoflurane]
- Author
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V, Lanza, S, Mercadante, S, Latteri, M T, Latteri, and L, Bellanca
- Subjects
Adult ,Male ,Methyl Ethers ,Adolescent ,Hydrocortisone ,Isoflurane ,Thyrotropin ,Neurosecretory Systems ,Prolactin ,Thyroxine ,Adrenocorticotropic Hormone ,Stress, Physiological ,Humans ,Triiodothyronine ,Female ,Anesthesia, Inhalation - Abstract
The effects during surgery of a new halogenated volatile anaesthetic, isoflurane, on the hypothalamo-hypophyseal-thyroid-suprarenal axis were studied. In fact, it was important to prove whether this new halogenated anaesthetic would provide better protection, for the patient, from surgery and anaesthetic stress compared with other anaesthetic agents in use. The study was carried out in 16 young class ASA I patients who were to undergo appendicectomy. Before and during operation, blood was taken to measure ACTH, cortisol, TSH, T3, T4 and PRL plasma levels. A remarkable increase of PRL, cortisol and T4 plasmatic rate was found, especially at the end of the operation. It was concluded that isoflurane, just like enflurane, did not prevent the increase of PRL, cortisol and T4 that usually takes place during surgery.
- Published
- 1986
39. [Prolactin in pathology of the breast. Clinical study ]
- Author
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M, Latteri, G, Bajardi, C, Castiglione, F, Caronia, S, Maragliano, A, Briganti, S, Latteri, and L, Bellanca
- Subjects
Breast Diseases ,Humans ,Breast Neoplasms ,Female ,Prolactin - Abstract
In the last years many Authors on the grounds of clinical and experimental studies have assumed the possibility of a connection between the prolactin and the breast pathology especially the carcionoma. In the present work the Authors give the results of the doses of the prolactin plasmatic basal levels, performed on 122 subjects belonging to 4 different groups: 1) patients with carcinoma of the breast; 2) patients with benign tumors of the breast; 3) patients with fibrocystic breast disease; 4) subjects of control. In patients who have undergone an operation further doses of blood prolactin have been carried out on 5th, 10th, 30th day after operation. On the grounds of such results the Authors propose new hypothesis of work wich will help to clear this problem.
- Published
- 1980
40. LITERATURE SURVEY ON THE EFFECTS OF LONG-TERM SHELF AGING ON ELASTOMERIC MATERIALS
- Author
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Jay C. Harris and Carmen L. Bellanca
- Subjects
Materials science ,Compression set ,Composite material ,Literature survey ,Elastomer - Abstract
Literature was surveyed with regard to the effects of long-term storage on the properties of elastomeric compounds. Data showed that most elastomeric compounds aged well. Elongation at break appeared to be the property most commonly affected by age deterioration, although compression set and change in strain also are affected. (Author)
- Published
- 1968
- Full Text
- View/download PDF
41. EVALUATION OF ELASTOMERS AS O-RING SEALS FOR LIQUID ROCKET FUEL AND OXIDIZER SYSTEMS
- Author
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Jay C. Harris, Ival O. Salyer, and Carmen L. Bellanca
- Published
- 1964
- Full Text
- View/download PDF
42. Natriuretic peptides and circulating levels of cathecolamines in Heart Failure
- Author
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PALAZZOADRIANO, Mario, ALBANO, Valeria, BELLANCA, Lina Maria, VALDES, Laura, PALAZZOADRIANO M, V ALBANO, L BELLANCA, and L VALDES
- Published
- 2004
43. Multinational cost-effectiveness analysis of empagliflozin for heart failure patients with ejection fraction >40.
- Author
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Kolovos S, Bellanca L, Groyer H, Rosano GMC, Solé A, Gaultney J, and Linden S
- Subjects
- Humans, Stroke Volume, Quality of Life, Ventricular Function, Left, Cost-Effectiveness Analysis, Heart Failure
- Abstract
Aims: Heart failure is a chronic progressive condition, with considerable burden on patients' quality of life and economic burden for the healthcare systems. Before the approval of empagliflozin, there were no proven effective treatments for patients with heart failure with left ventricular ejection fraction (HF LVEF) > 40%. The aim of this study was to evaluate the cost-effectiveness of empagliflozin + standard of care (SoC) compared with SoC alone for patients with HF LVEF > 40%, from the perspective of the healthcare systems of the United Kingdom (UK), Spain, and France, and to quantify the healthcare costs for these patients., Methods and Results: A lifetime Markov cohort state-transition model was developed based on discrete health states defined by Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score quartiles to track disease severity. Model inputs relied primarily on the EMPEROR-Preserved trial data or obtained from published literature or country-specific databases, as well as local guidelines for the requirements for the conduct of the economic evaluation of healthcare technologies. The total lifetime cost of receiving SoC per patient was £10 092, €15 765, and €14 958 in the UK, Spain, and France, respectively, which increased by £1407, €1148, and €1485, respectively, with the addition of empagliflozin to the SoC. Empagliflozin + SoC was associated with significantly reduced number of hospitalization for HF or cardiovascular death compared with SoC alone, which was a key driver offsetting its drug acquisition costs. The incremental cost-effectiveness ratio per quality-adjusted life year (QALY) gained was consistently favourable at £14 851, €11 706, and €15 447 in the UK, Spain, and France, respectively. Scenario analysis using the New York Heart Association functional class showed similar results. Probabilistic sensitivity analyses showed more than 50% probability for cost-effectiveness for a willingness-to-pay (WTP) threshold of £/€20 000/QALY for the three countries., Conclusions: Empagliflozin was found to be the first targeted treatment option that is clinically effective and cost-effective for patients with HF LVEF > 40%. Prescribing empagliflozin with SoC to patients with HF LVEF > 40% is expected to improve clinical outcomes and patients' quality of life and substantially below accepted WTP threshold for the healthcare systems in the UK, Spain, and France., (© 2023 Boehringer Ingelheim. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
- Published
- 2023
- Full Text
- View/download PDF
44. A European multinational cost-effectiveness analysis of empagliflozin in heart failure with reduced ejection fraction.
- Author
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Tafazzoli A, Reifsnider OS, Bellanca L, Ishak J, Carrasco M, Rakonczai P, Stargardter M, and Linden S
- Subjects
- Humans, Cost-Effectiveness Analysis, Stroke Volume, Cost-Benefit Analysis, Quality-Adjusted Life Years, Heart Failure
- Abstract
Purpose: This research examined the cost-effectiveness of adding empagliflozin to standard of care (SoC) compared with SoC alone for treatment of heart failure with reduced ejection fraction (HFrEF) from the perspective of healthcare payers in the United Kingdom (UK), Spain and France., Methods: A lifetime Markov cohort model was developed to simulate patients' progression through health states based on Kansas City Cardiomyopathy Questionnaire Clinical Summary Score. The model predicted risk of death, hospitalisation for worsening heart failure (HHF), treatment-related adverse events, and treatment discontinuation each monthly cycle. Clinical inputs and utilities were derived from EMPEROR-Reduced trial data, supplemented by published literature and national costing databases. Costs (2021 pound sterling/euro) and quality-adjusted life-years (QALYs) were discounted annually for the UK (3.5%), Spain (3.0%) and France (2.5%)., Results: In the UK, Spain and France, empagliflozin plus SoC yielded additional QALYs (0.19, 0.23 and 0.21) at higher cost (£1185, €1770 and €1183 per patient) than SoC alone, yielding incremental cost-effectiveness ratios of £6152/QALY, €7736/QALY and €5511/QALY, respectively. Reduced HHF incidence provided most cost offsets for empagliflozin plus SoC. Similar results were obtained for a range of subgroups and sensitivity analyses. Probabilistic sensitivity results indicated empagliflozin plus SoC remained cost-effective vs. SoC at willingness-to-pay thresholds of £20,000/QALY, €20,000/QALY and €30,000/QALY in 79.6%, 75.5% and 97.3% of model runs for the UK, Spain and France, respectively., Conclusions: Empagliflozin added to SoC leads to health benefits for patients with HFrEF and is a cost-effective treatment option for payers in multiple European countries (UK, Spain, France)., (© 2022. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
45. Cost-effectiveness of empagliflozin in heart failure patients irrespective of ejection fraction in England.
- Author
-
Kolovos S, Bellanca L, Groyer H, Rosano G, Gaultney J, and Linden S
- Subjects
- Humans, Cost-Benefit Analysis, Stroke Volume, England, Quality-Adjusted Life Years, Ventricular Function, Left, Heart Failure diagnosis, Heart Failure drug therapy
- Abstract
Aims: Heart failure (HF) is a complex syndrome commonly categorized into two main phenotypes [left ventricular ejection fraction (LVEF) below or above 40%], and although empagliflozin is the first approved medication with proven clinical effectiveness for both phenotypes, its cost-effectiveness of treating the entire HF population remains unknown., Methods: The analysis was performed utilizing two preexisting, LVEF phenotype-specific cost-effectiveness models to estimate the cost-effectiveness of empagliflozin in adults for the treatment of symptomatic chronic HF, irrespective of ejection fraction (EF). The results of the phenotype-specific models were combined using a population-weighted approach to estimate the deterministic and probabilistic incremental cost-effectiveness ratios (ICERs)., Results: Based on combined results, empagliflozin + standard of care (SoC) is associated with 6.13 life-years (LYs) and 3.92 quality-adjusted life-years (QALYs) compared with 5.98 LYs and 3.76 QALYs for SoC alone over a lifetime, resulting in an incremental difference of 0.15 LYs and 0.16 QALYs, respectively. Total lifetime healthcare costs per patient are £15 246 for empagliflozin + SoC and £13 982 for SoC giving an incremental difference of £1264. The ICER is £7757/QALY, which is substantially lower than the willingness-to-pay (WTP) of £30 000 per QALY used by NICE. The results of the probabilistic sensitivity analyses are in line with the deterministic results., Conclusion: Empagliflozin is the first efficacious, approved, and cost-effective treatment option for all HF patients, irrespective of EF. The combined ICER was consistently below the WTP threshold. Therefore, empagliflozin offers value for money for the treatment of the full HF population in England., (Copyright © 2023 Italian Federation of Cardiology - I.F.C. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
46. Incidence and prevalence of heart failure in England: a descriptive analysis of linked primary and secondary care data - the PULSE study.
- Author
-
Bellanca L, Linden S, and Farmer R
- Subjects
- Humans, Stroke Volume, Incidence, Cohort Studies, Prevalence, Secondary Care, England epidemiology, Prognosis, Heart Failure diagnosis, Heart Failure epidemiology
- Abstract
Background: Heart failure (HF) is associated with high morbidity and mortality, yet data on HF subtype (HF with reduced ejection fraction [HFrEF] and preserved ejection fraction [HFpEF]) in broad populations are lacking. Additionally, it is unknown whether current HF incidence and prevalence rates are consistent with historical data. Here, we estimate the incidence and prevalence of HF in England and describe the characteristics of patients with HF, both overall and by subtype., Methods: This was a non-interventional cohort study based on data from the UK Clinical Practice Research Datalink (CPRD), linked to Hospital Episode Statistics data and Office for National Statistics mortality data. Patients aged ≥ 18 years who were registered in the CPRD Aurum database between 1
st January 2015 and 31st December 2019 formed the base cohort, from which patients with a recorded chronic HF diagnosis (historical or incident) from 2015-2019 contributed to the incidence and prevalence calculations., Results: The eligible denominator over the study period comprised 11,414,490 patients, from which 383,896 patients with HF were included as prevalent or incident HF cases. From 2015 to 2019, the incidence rate of newly diagnosed HF increased from 4.1/1,000 person-years to 4.9/1,000 person-years, and HF prevalence increased from 2.1% to 2.4%. Phenotype data were available for 100,224 (26.1%) patients, of which 68,780 patients had HFrEF and 31,444 had HFpEF (HFrEF/HFpEF ratio: 70.1%/29.9%). Comorbidity levels were high and broadly similar across HF subgroups., Conclusions: Primary care recording of HF subtype is suboptimal, with more than 7/10 patients with HF lacking subtype data. In patients with a recorded subtype (n = 100,224), a HFrEF/HFpEF ratio of 70%/30% was observed. Comorbidity levels were high regardless of subtype. Between 2015 and 2019, we observed modest but consistent increases in the incidence and prevalence of chronic HF in adults, in line with historical data., (© 2023. The Author(s).)- Published
- 2023
- Full Text
- View/download PDF
47. Aerobic exercise for vasomotor menopausal symptoms: A cost-utility analysis based on the Active Women trial.
- Author
-
Goranitis I, Bellanca L, Daley AJ, Thomas A, Stokes-Lampard H, Roalfe AK, and Jowett S
- Subjects
- Female, Health Care Rationing, Humans, Middle Aged, Quality of Life, State Medicine, United Kingdom, Cost-Benefit Analysis, Exercise, Menopause, Vasomotor System physiopathology
- Abstract
Objective: To compare the cost-utility of two exercise interventions relative to a control group for vasomotor menopausal symptoms., Design: Economic evaluation taking a UK National Health Service and Personal Social Services perspective and a societal perspective., Setting: Primary care., Population: Peri- and postmenopausal women who have not used hormone therapy in the past 3 months and experience ≥ 5 episodes of vasomotor symptoms daily., Methods: An individual and a social support-based exercise intervention were evaluated. The former (Exercise-DVD), aimed to prompt exercise with purpose-designed DVD and written materials, whereas the latter (Exercise-Social support) with community exercise social support groups. Costs and outcomes associated with these interventions were compared to those of a control group, who could only have an exercise consultation. An incremental cost-utility analysis was undertaken using bootstrapping to account for the uncertainty around cost-effectiveness point-estimates., Main Outcome Measure: Cost per quality-adjusted life-year (QALY)., Results: Data for 261 women were available for analysis. Exercise-DVD was the most expensive and least effective intervention. Exercise-Social support was £52 (CIs: £18 to £86) and £18 (CIs: -£68 to £105) more expensive per woman than the control group at 6 and 12 months post-randomisation and led to 0.006 (CIs: -0.002 to 0.014) and 0.013 (CIs: -0.01 to 0.036) more QALYs, resulting in an incremental cost-effectiveness ratio of £8,940 and £1,413 per QALY gained respectively. Exercise-Social support had 80%-90% probability of being cost-effective in the UK context. A societal perspective of analysis and a complete-case analysis led to similar findings., Conclusions: Exercise-Social support resulted in a small gain in health-related quality of life at a marginal additional cost in a context where broader wellbeing and long-term gains associated with exercise and social participation were not captured. Community exercise social support groups are very likely to be cost-effective in the management of vasomotor menopausal symptoms.
- Published
- 2017
- Full Text
- View/download PDF
48. The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer.
- Author
-
Sanguedolce R, Vultaggio G, Sanguedolce F, Modica G, Li Volsi F, Diana G, Guereio G, Bellanca L, and Rausa L
- Subjects
- Adenocarcinoma enzymology, Adenocarcinoma mortality, Adenocarcinoma pathology, Aged, Biomarkers, Tumor analysis, Colorectal Neoplasms enzymology, Colorectal Neoplasms mortality, Colorectal Neoplasms pathology, Female, Humans, Intestinal Mucosa enzymology, Intestinal Mucosa pathology, Male, Middle Aged, Neoplasm Staging, Prognosis, Survival Rate, Thymidylate Synthase analysis, Time Factors, Adenocarcinoma surgery, Colorectal Neoplasms surgery, Thymidylate Synthase metabolism
- Abstract
Inhibition of Thymidylate Synthase (TS) by the 5-Fluorouracil (5Fu) active metabolite Fluoro-deoxy-uridine-monophosphate (FdUMP) is considered to be the main mechanism of action of 5Fu. TS level from tumors and normal mucosa of 62 untreated patients who underwent surgery for primary colorectal adenocarcinoma was performed. The aim of this study was to evaluate the possibility of considering the TS level as a prognostic factor of the disease. A large variation in the level of the enzyme was found among tumors. Our data demonstrate that there is no association with age, sex, and tumor size; however there are significant relationships between TS levels and staging and histological grading. In fact the TS values are higher in Dukes' A and in G1 than in Dukes' D and G3 tumors (p < 0.05). Another significant association has been found between the TS level and tumor site: pts with right colon neoplasias had higher TS levels than pts with left and rectum ones. An interesting trend was found between the TS levels and survival parameters. Pts who had lower TS levels had a significantly increased risk of death (p < 0.05) over pts with a higher outcome. Our data support the hypothesis that a high TS level is a favourable prognostic factor in human untreated colorectal carcinomas according to our previous preliminary data (1).
- Published
- 1998
49. A new method to measure cardiac inositol levels in intact animals.
- Author
-
Paterna S, D'Amico C, Di Pasquale P, Antona A, Bellanca L, Bucca V, Palazzoadriano M, and Licata G
- Subjects
- Animals, Blood Pressure drug effects, Cyclic AMP metabolism, Inositol analysis, Male, Myocardial Ischemia metabolism, Myocardial Reperfusion, Rabbits, Inositol metabolism, Myocardium metabolism
- Abstract
Inositol levels have been studied in cellular cultures and recently by perfusion of isolated hearts. The study was aimed to assess inositol turnover in rabbit hearts from intact animals. Thirty rabbits were injected i.v. three times (every 12 hr) with 25 microCi/kg of myo-3H-inositol. The rabbits 12 hr after the last injection were killed and the hearts perfused according to Langerdorff technique. Systolic and diastolic ventricular pressures (SVP, DVP), dp/dt, and coronary flow (CFl) were measured. The hearts (n = 14) were perfused under aerobic conditions and 16 hearts under ischemic conditions for 30 min. In addition, 5 hearts were perfused under aerobic conditions for 10 min, and 6 hearts were perfused under ischemic conditions for 10 min. Samples of myocardial tissue were taken from both groups at the end of 10-min and 30-min period of perfusion, and cAMP and inositol phosphates were assayed. The hearts subjected to ischaemia showed changes of cAMP and 3H-inositol. The cAMP was higher in the ischaemic (10 min and 30 min) than the control hearts, 0.22 +/- 0.09 and 0.21 +/- 0.08 versus 0.41 +/- 0.12 and 0.49 +/- 0.11 pmol 10(6) cells, respectively (p < .05, p < .001. The inositol trisphosphate was higher in control than ischemic hearts (10 min, 30 min), 0.42 +/- 0.02 and 0.39 +/- 0.01 versus 0.31 +/- 0.01 and 0.23 +/- 0.02 (percent of radioactivity) respectively, p < .001. Our data suggest that 3H-inositol may be studied by i.v. administration to intact animals. The ischemia was performed to verify the validity of this new technique.
- Published
- 1996
- Full Text
- View/download PDF
50. [Behavior of the plasma level of digoxin in the rat in induced experimental hyperreninemia].
- Author
-
Albano V, Bellanca L, Latteri S, and Valdes L
- Subjects
- Aldosterone pharmacology, Animals, Digoxin metabolism, Kidney metabolism, Rats, Aldosterone blood, Digoxin blood, Renin blood
- Abstract
PRA, plasma and urine aldosterone levels and plasma digoxin were measured in rats in which digoxin had been administered under conditions of high PRA and high aldosterone levels experimentally induced by administering distilled water load and in rats in which digoxin had been administered without distilled water load. Results show that under conditions of high PRA and high aldosterone levels, plasma digoxin concentrations as measured 6 h after treatment were higher (45,3%) than in rats having received digoxin without water load. In assays carried out on rats sacrificed 12 h after digoxin treatment (with or without water load) all values approach basic levels again, thus suggesting that in rats too aldosterone might compete with digoxin at the level of tubular excretion.
- Published
- 1979
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