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231 results on '"L'Orange C"'

10. P258 ASTERIX: Adaptive stratification of COVID19 to facilitate endotype-directed intervention studies

Author

Ferguson, J, primary, Blyth, K, additional, McInnes, I, additional, Biankin, A, additional, Jones, R, additional, Lowe, D, additional, Murphy, M, additional, Thomson, E, additional, Scott, J, additional, Porter, D, additional, Goodyear, C, additional, Maguire, D, additional, Mark, P, additional, Hinsley, S, additional, Evans, C, additional, and Orange, C, additional

Published
2021
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11. Exposure to household air pollution from wood-burning cookstoves and C-reactive protein among women in rural Honduras

Author

Benka-Coker, M.L., primary, Clark, M., additional, Rajkumar, S., additional, Young, B., additional, Bachand, A., additional, Diaz-Sanchez, D., additional, Neas, L., additional, Brook, R., additional, Nelson, T., additional, Volckens, J., additional, Reynolds, S., additional, Wilson, A., additional, L'Orange, C., additional, Good, N., additional, Quinn, C., additional, Koehler, K., additional, Africano, S., additional, Osorto Pinel, A., additional, and Peel, J., additional

Published
2020
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12. Acute Differences in Inflammatory Biomarkers Following Controlled Exposures to Cookstove Air Pollution in the STOVES Study

Author

Walker, E.S., primary, Fedak, K.M., additional, Good, N., additional, Balmes, J., additional, Brook, R.D., additional, Clark, M.L., additional, Cole-Hunter, T., additional, Devlin, R.B., additional, L'Orange, C., additional, Luckasen, G., additional, Mehaffy, J., additional, Shelton, R., additional, Wilson, A., additional, Volckens, J., additional, and Peel, J.L., additional

Published
2020
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13. Effects of a randomized biomass cookstove intervention on glycated hemoglobin among women in Honduras

Author

Young, B.N., primary, Peel, J.L., additional, Rajkumar, S., additional, Benka-Coker, M.L., additional, Walker, E.S., additional, Brook, R.D., additional, Nelson, T.L., additional, Volckens, J., additional, L'Orange, C., additional, Good, N., additional, Quinn, C., additional, Keller, J.P., additional, Weller, Z.D., additional, Africano, S., additional, Osorto-Pinel, A.B., additional, and Clark, M.L., additional

Published
2020
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14. Quantifying the Contribution to Uncertainty in Mortality Attributed to Household, Ambient, and Joint Exposure to PM2.5 From Residential Solid Fuel Use

Author

Kodros, J. K., Carter, E., Brauer, M., Volckens, J., Bilsback, K. R., L'Orange, C., Johnson, M., and Pierce, J. R.

Subjects
Aerosols, lcsh:Environmental protection, health, Atmospheric Composition and Structure, PM2.5, Aerosols and Particles, air quality, cookstove, Oceanography: Biological and Chemical, Pollution: Urban and Regional, Paleoceanography, exposure, solid fuel use, lcsh:TD169-171.8, Health Impact, Natural Hazards, Research Articles, Research Article
Abstract

While there have been substantial efforts to quantify the health burden of exposure to PM2.5 from solid fuel use (SFU), the sensitivity of mortality estimates to uncertainties in input parameters has not been quantified. Moreover, previous studies separate mortality from household and ambient air pollution. In this study, we develop a new estimate of mortality attributable to SFU due to the joint exposure from household and ambient PM2.5 pollution and perform a variance‐based sensitivity analysis on mortality attributable to SFU. In the joint exposure calculation, we estimate 2.81 (95% confidence interval: 2.48–3.28) million premature deaths in 2015 attributed to PM2.5 from SFU, which is 580,000 (18%) fewer deaths than would be calculated by summing separate household and ambient mortality calculations. Regarding the sources of uncertainties in these estimates, in China, India, and Latin America, we find that 53–56% of the uncertainty in mortality attributable to SFU is due to uncertainty in the percent of the population using solid fuels and 42–50% from the concentration‐response function. In sub‐Saharan Africa, baseline mortality rate (72%) and the concentration‐response function (33%) dominate the uncertainty space. Conversely, the sum of the variance contributed by ambient and household PM2.5 exposure ranges between 15 and 38% across all regions (the percentages do not sum to 100% as some uncertainty is shared between parameters). Our findings suggest that future studies should focus on more precise quantification of solid fuel use and the concentration‐response relationship to PM2.5, as well as mortality rates in Africa., Key Points We use a sensitivity analysis to highlight inputs contributing to uncertainty in mortality, finding key contributors vary by regionIn Asia and Latin America, mortality estimates are most sensitive to uncertainty in population using solid fuel and health response functionWe develop a new estimate of mortality attributable to SFU due to the joint exposure from household and ambient PM2.5 pollution

Published
2018

15. DNA damage marker γH2AX is a potential predictive marker for progression of epithelial dysplasia of the oral cavity

Author

Leung, E.Y., McMahon, J.D., McLellan, D., Syyed, N., McCarthy, C.E., Nixon, C., Orange, C., Brock, C., Hunter, K., and Adams, P.D.

Abstract

AIMS: To evaluate the relationships between immunohistochemical markers related to cellular senescence, cell proliferation and histological grade of epithelial dysplasia of the oral cavity (OD). In addition, the predictive value of these markers for progression of OD was assessed. \ud \ud METHODS: Retrospective immunohistochemical analyses were performed on 86 formalin fixed and paraffin embedded specimens of OD and oral squamous cell carcinoma (OSCC) for Ki67, γH2AX, p53, p16, H3K9me3 and CycD1. Three separate areas representing the highest severity of OD on each slide were digitally annotated by two independent pathologists. Mean automated histoscores of the selected markers were generated and compared to that of age-matched healthy controls (n=24). Follow-up data of OD was retrieved and anonymised by a clinical team member and linked using unique participant identifiers. The median follow-up was 10.9 years (interquartile range: 10.1-11.5). \ud \ud RESULTS: Ki67 (p

Published
2017

16. Exposure to household air pollution from biomass-burning cookstoves and HbA1c and diabetic status among Honduran women

Author

Rajkumar, S., primary, Clark, M. L., additional, Young, B. N., additional, Benka-Coker, M. L., additional, Bachand, A. M., additional, Brook, R. D., additional, Nelson, T. L., additional, Volckens, J., additional, Reynolds, S. J., additional, L'Orange, C., additional, Good, N., additional, Koehler, K., additional, Africano, S., additional, Osorto Pinel, A. B., additional, and Peel, J. L., additional

Published
2018
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17. Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis

Author

Krochmal, M. Cisek, K. Filip, S. Markoska, K. Orange, C. Zoidakis, J. Gakiopoulou, C. Spasovski, G. Mischak, H. Delles, C. Vlahou, A. Jankowski, J.

Subjects
urologic and male genital diseases
Abstract

IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored. We investigated a combinatorial approach for the analysis of IgAN-relevant -omics data, aiming at identification of novel molecular signatures of the disease. Nine published urinary proteomics datasets were collected and the reported differentially expressed proteins in IgAN vs. healthy controls were integrated into known biological pathways. Proteins participating in these pathways were subjected to multi-step assessment, including investigation of IgAN transcriptomics datasets (Nephroseq database), their reported protein-protein interactions (STRING database), kidney tissue expression (Human Protein Atlas) and literature mining. Through this process, from an initial dataset of 232 proteins significantly associated with IgAN, 20 pathways were predicted, yielding 657 proteins for further analysis. Step-wise evaluation highlighted 20 proteins of possibly high relevance to IgAN and/or kidney disease. Experimental validation of 3 predicted relevant proteins, adenylyl cyclase-associated protein 1 (CAP1), SHC-transforming protein 1 (SHC1) and prolylcarboxypeptidase (PRCP) was performed by immunostaining of human kidney sections. Collectively, this study presents an integrative procedure for -omics data exploitation, giving rise to biologically relevant results. © 2017 The Author(s).

Published
2017

18. Using RPSL in Practice

Author

Meyer, D., primary, Schmitz, J., additional, Orange, C., additional, Prior, M., additional, and Alaettinoglu, C., additional

Published
1999
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22. Quantifying the Contribution to Uncertainty in Mortality Attributed to Household, Ambient, and Joint Exposure to PM2.5 From Residential Solid Fuel Use.

Author

Kodros, J. K., Carter, E., Brauer, M., Volckens, J., Bilsback, K. R., L'Orange, C., Johnson, M., and Pierce, J. R.

Subjects
HOUSEHOLDS, MORTALITY, UNCERTAINTY, FUEL, AIR pollution, CHILD mortality
Abstract

While there have been substantial efforts to quantify the health burden of exposure to PM2.5 from solid fuel use (SFU), the sensitivity of mortality estimates to uncertainties in input parameters has not been quantified. Moreover, previous studies separate mortality from household and ambient air pollution. In this study, we develop a new estimate of mortality attributable to SFU due to the joint exposure from household and ambient PM2.5 pollution and perform a variance‐based sensitivity analysis on mortality attributable to SFU. In the joint exposure calculation, we estimate 2.81 (95% confidence interval: 2.48–3.28) million premature deaths in 2015 attributed to PM2.5 from SFU, which is 580,000 (18%) fewer deaths than would be calculated by summing separate household and ambient mortality calculations. Regarding the sources of uncertainties in these estimates, in China, India, and Latin America, we find that 53–56% of the uncertainty in mortality attributable to SFU is due to uncertainty in the percent of the population using solid fuels and 42–50% from the concentration‐response function. In sub‐Saharan Africa, baseline mortality rate (72%) and the concentration‐response function (33%) dominate the uncertainty space. Conversely, the sum of the variance contributed by ambient and household PM2.5 exposure ranges between 15 and 38% across all regions (the percentages do not sum to 100% as some uncertainty is shared between parameters). Our findings suggest that future studies should focus on more precise quantification of solid fuel use and the concentration‐response relationship to PM2.5, as well as mortality rates in Africa. Key Points: We use a sensitivity analysis to highlight inputs contributing to uncertainty in mortality, finding key contributors vary by regionIn Asia and Latin America, mortality estimates are most sensitive to uncertainty in population using solid fuel and health response functionWe develop a new estimate of mortality attributable to SFU due to the joint exposure from household and ambient PM2.5 pollution [ABSTRACT FROM AUTHOR]

Published
2018
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25. NFκB signalling is upregulated in a subset of castrate-resistant prostate cancer patients and correlates with disease progression.

Author

McCall P, Bennett L, Ahmad I, Mackenzie LM, Forbes IW, Leung HY, Sansom OJ, Orange C, Seywright M, Underwood MA, Edwards J, McCall, P, Bennett, L, Ahmad, I, Mackenzie, L M, Forbes, I W G, Leung, H Y, Sansom, O J, Orange, C, and Seywright, M

Abstract

Background: Cell line models suggest that activation of NFκB is associated with progression of prostate cancer. This pathway may be a therapeutic target if these observations translate to clinical specimens.Methods: Immunohistochemistry measured NFκBp65 (p65), NFκBp65 nuclear localisation signal (NLS), NFκBp65 phosphorylated at ser 276 (p65(ser276)), NFκBp65 phosphorylated at ser 536 (p65(ser536)), IκBα phosphorylated at ser 32/36 (pIκBα(ser32/36)) and MMP-9 protein expression in 61 matched hormone naive prostate cancer (HNPC) and castrate-resistant prostate cancer (CRPC) tumours. Animal and cell models were used to investigate the role of NFκB inhibition in prostate carcinogenesis.Results: In HNPC tumours, NLS expression significantly associated with a shorter time to disease recurrence and disease-specific death. In CRPC tumours p65, pIκBα(ser32/36) and MMP-9 expression significantly associated with shorter time to death from disease recurrence and shorter disease-specific death. MMP-9 and pIκBα(ser32/36) expression significantly associated with metastases at recurrence and were independent of Gleason sum and prostate-specific antigen at recurrence. Expression of phosphorylated Akt was associated with increased p65 activation in mouse models and inhibition of NFκB in LNCaP cells significantly reduced cellular proliferation and induced apoptosis.Conclusion: These results provide further evidence that the NFκB pathway could be exploited as a target for CRPC. [ABSTRACT FROM AUTHOR]

Published
2012
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26. Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.

Author

Ohotski J, Long JS, Orange C, Elsberger B, Mallon E, Doughty J, Pyne S, Pyne NJ, Edwards J, Ohotski, J, Long, J S, Orange, C, Elsberger, B, Mallon, E, Doughty, J, Pyne, S, Pyne, N J, and Edwards, J

Abstract

Background: We previously reported that sphingosine 1-phosphate receptor 4 (S1P(4)) is expressed and stimulates the ERK-1/2 pathway via a human epidermal growth factor receptor 2 (HER2)-dependent mechanism in oestrogen receptor-negative (ER(-)) MDA-MB-453 breast cancer cells.Methods: Clinical relevance of S1P(4) and sphingosine kinase 1 (SK1, which catalyses the formation of S1P) was assessed in a cohort of 140 ER(-) breast tumours by immunohistochemistry (IHC) and the weighted histoscore method. Additional evidence for a functional interaction between S1P(4) and SK1 and between HER2 and SK1 was obtained using MDA-MB-453 cells.Results: High S1P(4) expression is associated with shorter disease-free (P=0.014) and disease-specific survival (P=0.004), and was independent on multivariate analysis. In addition, patients with tumours that contain high and low levels of SK1 and S1P(4), respectively, have a significantly shorter disease-free survival (P=0.043) and disease-specific survival (P=0.033) compared with patients whose tumours contain both low S1P(4) and SK1 levels. In addition, high tumour expression of SK1 was significantly associated with shorter disease-specific survival (P=0.0001) in patients with HER2-positive tumours. Treatment of MDA-MB-453 cells with the SK1 inhibitor, SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole) reduced the basal and S1P/S1P(4)-induced activation of ERK-1/2 and altered HER2 trafficking in these cells.Conclusion: These findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression. [ABSTRACT FROM AUTHOR]

Published
2012
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27. Comparison of visual and automated assessment of Ki-67 proliferative activity and their impact on outcome in primary operable invasive ductal breast cancer.

Author

Mohammed ZM, McMillan DC, Elsberger B, Going JJ, Orange C, Mallon E, Doughty JC, Edwards J, Mohammed, Z M A, McMillan, D C, Elsberger, B, Going, J J, Orange, C, Mallon, E, Doughty, J C, and Edwards, J

Abstract

Background: Immunohistochemistry of Ki-67 protein is widely used to assess tumour proliferation, and is an established prognostic factor in breast cancer. There is interest in automating the assessment of Ki-67 labelling index (LI) with possible benefits in handling increased workload, with improved accuracy and precision.Patients and Methods: Visual and automated assessment of Ki-67 LI and survival were examined in patients with primary operable invasive ductal breast cancer. Tissue microarrays (n=379 patients) immunostained for Ki-67 were scored visually and automatically with the Slidepath Tissue IA system.Results: Visual and automated Ki-67 LI were in excellent agreement (ICCC=0.96, P<0.001). On univariate analysis, visual (P<0.001) and automated Ki67 LI (P<0.05) were associated with cancer-specific survival in patients with invasive ductal breast cancer overall and in patients who received endocrine therapy (Tamoxifen) (P<0.01 for visual and P<0.05 for automated scoring).Conclusion: Automated assessment of Ki-67 LI would appear to be comparable to visual Ki-67 LI. However, automated Ki-67 LI assessment was inferior in predicting cancer survival in patients with breast cancer, including patients who received Tamoxifen. [ABSTRACT FROM AUTHOR]

Published
2012
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