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1,032 results on '"L'Hoste, P"'

1. Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement.

Author

Zarbock, Alexander, Forni, Lui, Koyner, Jay, Bell, Samira, Reis, Thiago, Meersch, Melanie, Bagshaw, Sean, Fuhmann, Dana, Liu, Kathleen, Pannu, Neesh, Arikan, Ayse, Angus, Derek, Duquette, DArcy, Goldstein, Stuart, Hoste, Eric, Joannidis, Michael, Jongs, Niels, Legrand, Matthieu, Mehta, Ravindra, Murray, Patrick, Nadim, Mitra, Ostermann, Marlies, Prowle, John, See, Emily, Selby, Nicholas, Shaw, Andrew, Srisawat, Nattachai, Ronco, Claudio, and Kellum, John

Subjects
AKI, Clinical trials, Endpoints, Enrichment, Prevention, Treatment, Humans, Acute Kidney Injury, Research Design, Clinical Trials as Topic, Consensus, Delphi Technique
Abstract

PURPOSE: Novel interventions for the prevention or treatment of acute kidney injury (AKI) are currently lacking. To facilitate the evaluation and adoption of new treatments, the use of the most appropriate design and endpoints for clinical trials in AKI is critical and yet there is little consensus regarding these issues. We aimed to develop recommendations on endpoints and trial design for studies of AKI prevention and treatment interventions based on existing data and expert consensus. METHODS: At the 31st Acute Disease Quality Initiative (ADQI) meeting, international experts in critical care, nephrology, involving adults and pediatrics, biostatistics and people with lived experience (PWLE) were assembled. We focused on four main areas: (1) patient enrichment strategies, (2) prevention and attenuation studies, (3) treatment studies, and (4) innovative trial designs of studies other than traditional (parallel arm or cluster) randomized controlled trials. Using a modified Delphi process, recommendations and consensus statements were developed based on existing data, with > 90% agreement among panel members required for final adoption. RESULTS: The panel developed 12 consensus statements for clinical trial endpoints, application of enrichment strategies where appropriate, and inclusion of PWLE to inform trial designs. Innovative trial designs were also considered. CONCLUSION: The current lack of specific therapy for prevention or treatment of AKI demands refinement of future clinical trial design. Here we report the consensus findings of the 31st ADQI group meeting which has attempted to address these issues including the use of predictive and prognostic enrichment strategies to enable appropriate patient selection.

Published
2024

2. Ambient neutron dosimetry in high energy and pulsed neutron fields

Author

Tarifeno-Saldivia, Ariel, Calvino, Francisco, De Blas, Alfredo, Brusasco, Benedetta, Casanovas-Hoste, Adria, Cives, Ana M., Cortes, Guillem, Garcia, Roger, Molina, Francisco, Mont-Geli, Nil, Pallas, Max, and Pavez, Cristian

Subjects
Physics - Instrumentation and Detectors, Physics - Medical Physics
Abstract

The status of the LINrem project is presented, focusing on the development of innovative neutron dosimeters with enhanced energy sensitivity, time resolution, and portability. Designed to meet the technical demands of radiation protection in modern particle and nuclear facilities, these dosimeters are discussed in detail. Results from experimental campaigns showcasing their efficacy in pulsed fields generated by fusion plasmas and high-intensity pulsed lasers are presented. Additionally, prospects and future plans for the LINrem project are outlined., Comment: Preprint submitted to Radiation Physics and Chemistry

Published
2024

6. Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Author

Mehrotra, Parul, Maschalidi, Sophia, Boeckaerts, Laura, Maueröder, Christian, Tixeira, Rochelle, Pinney, Jonathan, Burgoa Cardás, Javier, Sukhov, Vladimir, Incik, Yunus, Anderson, Christopher. J., Hu, Bing, Keçeli, Burcu N., Goncalves, Amanda, Vande Walle, Lieselotte, Van Opdenbosch, Nina, Sergushichev, Alexey, Hoste, Esther, Jain, Umang, Lamkanfi, Mohamed, and Ravichandran, Kodi S.

Published
2024
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9. Filling in the Gaps: Efficient Event Coreference Resolution using Graph Autoencoder Networks

Author

De Langhe, Loic, De Clercq, Orphée, and Hoste, Veronique

Subjects
Computer Science - Computation and Language
Abstract

We introduce a novel and efficient method for Event Coreference Resolution (ECR) applied to a lower-resourced language domain. By framing ECR as a graph reconstruction task, we are able to combine deep semantic embeddings with structural coreference chain knowledge to create a parameter-efficient family of Graph Autoencoder models (GAE). Our method significantly outperforms classical mention-pair methods on a large Dutch event coreference corpus in terms of overall score, efficiency and training speed. Additionally, we show that our models are consistently able to classify more difficult coreference links and are far more robust in low-data settings when compared to transformer-based mention-pair coreference algorithms.

Published
2023

10. EmoTwiCS: A Corpus for Modelling Emotion Trajectories in Dutch Customer Service Dialogues on Twitter

Author

Labat, Sofie, Demeester, Thomas, and Hoste, Véronique

Subjects
Computer Science - Computation and Language
Abstract

Due to the rise of user-generated content, social media is increasingly adopted as a channel to deliver customer service. Given the public character of these online platforms, the automatic detection of emotions forms an important application in monitoring customer satisfaction and preventing negative word-of-mouth. This paper introduces EmoTwiCS, a corpus of 9,489 Dutch customer service dialogues on Twitter that are annotated for emotion trajectories. In our business-oriented corpus, we view emotions as dynamic attributes of the customer that can change at each utterance of the conversation. The term `emotion trajectory' refers therefore not only to the fine-grained emotions experienced by customers (annotated with 28 labels and valence-arousal-dominance scores), but also to the event happening prior to the conversation and the responses made by the human operator (both annotated with 8 categories). Inter-annotator agreement (IAA) scores on the resulting dataset are substantial and comparable with related research, underscoring its high quality. Given the interplay between the different layers of annotated information, we perform several in-depth analyses to investigate (i) static emotions in isolated tweets, (ii) dynamic emotions and their shifts in trajectory, and (iii) the role of causes and response strategies in emotion trajectories. We conclude by listing the advantages and limitations of our dataset, after which we give some suggestions on the different types of predictive modelling tasks and open research questions to which EmoTwiCS can be applied. The dataset is available upon request and will be made publicly available upon acceptance of the paper., Comment: Preprint to Language Resources and Evaluation Journal

Published
2023
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11. Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial

Author

Benoît Misset, Anh Nguyet Diep, Axelle Bertrand, Michael Piagnerelli, Eric Hoste, Isabelle Michaux, Elisabeth De Waele, Alexander Dumoulin, Philippe G. Jorens, Emmanuel van der Hauwaert, Frédéric Vallot, Walter Swinnen, Nicolas De Schryver, Nathalie de Mey, Nathalie Layios, Jean-Baptiste Mesland, Sébastien Robinet, Etienne Cavalier, Anne-Françoise Donneau, Michel Moutschen, and Pierre-François Laterre

Subjects
COVID-19, Convalescent plasma, ARDS, Immune response, Phenotypes, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Convalescent plasma (CP) reduced the mortality in COVID-19 induced ARDS (C-ARDS) patients treated in the CONFIDENT trial. As patients are immunologically heterogeneous, we hypothesized that clusters may differ in their treatment responses to CP. Methods We measured 20 cytokines, chemokines and cell adhesion markers using a multiplex technique at the time of inclusion in the CONFIDENT trial in patients of centers having accepted to participate in this secondary study. We performed descriptive statistics, unsupervised hierarchical cluster analysis, and examined the association between the clusters and CP effect on day-28 mortality. Results Of the 475 patients included in CONFIDENT, 391 (82%) were sampled, and 196/391 (50.1%) had been assigned to CP. We identified four sub-phenotypes representing 89 (22.8%), 178 (45.5%), 38 (9.7%), and 86 (22.0%) patients. The most contributing biomarkers in the principal component analysis were IL-1β, IL-12p70, IL-6, IFN-α, IL-17A, IFN-γ, IL-13, TFN-α, total IgG, and CXCL10. Sub-phenotype-1 displayed a lower immune response, sub-phenotype-2 a higher adaptive response, sub-phenotype-3 the highest innate antiviral, pro and anti-inflammatory response, and adhesion molecule activation, and sub-phenotype-4 a higher pro and anti-inflammatory response, migration protein and adhesion molecule activation. Sub-phenotype-2 and sub-phenotype-4 had higher severity at the time of inclusion. The effect of CP treatment on mortality appeared higher than standard care in each sub-phenotype, without heterogeneity between sub-phenotypes (p = 0.97). Conclusion In patients with C-ARDS, we identified 4 sub-phenotypes based on their immune response. These sub-phenotypes were associated with different clinical profiles. The response to CP was similar across the 4 sub-phenotypes. Trial registration: Ethics Committee of the University Hospital of Liège CE 2020/239. Clinicaltrials.gov NCT04558476. Registered 2020-09-11, https://www.clinicaltrials.gov/study/NCT04558476 .

Published
2024
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12. Immunological sub-phenotypes and response to convalescent plasma in COVID-19 induced ARDS: a secondary analysis of the CONFIDENT trial

Author

Misset, Benoît, Diep, Anh Nguyet, Bertrand, Axelle, Piagnerelli, Michael, Hoste, Eric, Michaux, Isabelle, De Waele, Elisabeth, Dumoulin, Alexander, Jorens, Philippe G., van der Hauwaert, Emmanuel, Vallot, Frédéric, Swinnen, Walter, De Schryver, Nicolas, de Mey, Nathalie, Layios, Nathalie, Mesland, Jean-Baptiste, Robinet, Sébastien, Cavalier, Etienne, Donneau, Anne-Françoise, Moutschen, Michel, and Laterre, Pierre-François

Published
2024
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14. Time series of freshwater macroinvertebrate abundances and site characteristics of European streams and rivers

Author

Welti, Ellen A. R., Bowler, Diana E., Sinclair, James S., Altermatt, Florian, Álvarez-Cabria, Mario, Amatulli, Giuseppe, Angeler, David G., Archambaud, Gaït, Arrate Jorrín, Iñaki, Aspin, Thomas, Azpiroz, Iker, Baker, Nathan Jay, Bañares, Iñaki, Barquín Ortiz, José, Bodin, Christian L., Bonacina, Luca, Bonada, Núria, Bottarin, Roberta, Cañedo-Argüelles, Miguel, Csabai, Zoltán, Datry, Thibault, de Eyto, Elvira, Dohet, Alain, Domisch, Sami, Dörflinger, Gerald, Drohan, Emma, Eikland, Knut A., England, Judy, Eriksen, Tor E., Evtimova, Vesela, Feio, Maria J., Ferréol, Martial, Floury, Mathieu, Forcellini, Maxence, Forio, Marie Anne Eurie, Fornaroli, Riccardo, Friberg, Nikolai, Fruget, Jean-François, Garcia Marquez, Jaime R., Georgieva, Galia, Goethals, Peter, Graça, Manuel A. S., House, Andy, Huttunen, Kaisa-Leena, Jensen, Thomas Correll, Johnson, Richard K., Jones, J. Iwan, Kiesel, Jens, Larrañaga, Aitor, Leitner, Patrick, L’Hoste, Lionel, Lizée, Marie-Hélène, Lorenz, Armin W., Maire, Anthony, Manzanos Arnaiz, Jesús Alberto, Mckie, Brendan, Millán, Andrés, Muotka, Timo, Murphy, John F., Ozolins, Davis, Paavola, Riku, Paril, Petr, Peñas Silva, Francisco Jesús, Polasek, Marek, Rasmussen, Jes, Rubio, Manu, Sánchez Fernández, David, Sandin, Leonard, Schäfer, Ralf B., Schmidt-Kloiber, Astrid, Scotti, Alberto, Shen, Longzhu Q., Skuja, Agnija, Stoll, Stefan, Straka, Michal, Stubbington, Rachel, Timm, Henn, Tyufekchieva, Violeta G., Tziortzis, Iakovos, Uzunov, Yordan, van der Lee, Gea H., Vannevel, Rudy, Varadinova, Emilia, Várbíró, Gábor, Velle, Gaute, Verdonschot, Piet F. M., Verdonschot, Ralf C. M., Vidinova, Yanka, Wiberg-Larsen, Peter, and Haase, Peter

Published
2024
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15. Multi-decadal improvements in the ecological quality of European rivers are not consistently reflected in biodiversity metrics

Author

Sinclair, James S., Welti, Ellen A. R., Altermatt, Florian, Álvarez-Cabria, Mario, Aroviita, Jukka, Baker, Nathan J., Barešová, Libuše, Barquín, José, Bonacina, Luca, Bonada, Núria, Cañedo-Argüelles, Miguel, Csabai, Zoltán, de Eyto, Elvira, Dohet, Alain, Dörflinger, Gerald, Eriksen, Tor E., Evtimova, Vesela, Feio, Maria J., Ferréol, Martial, Floury, Mathieu, Forio, Marie Anne Eurie, Fornaroli, Riccardo, Goethals, Peter L. M., Heino, Jani, Hering, Daniel, Huttunen, Kaisa-Leena, Jähnig, Sonja C., Johnson, Richard K., Kuglerová, Lenka, Kupilas, Benjamin, L’Hoste, Lionel, Larrañaga, Aitor, Leitner, Patrick, Lorenz, Armin W., McKie, Brendan G., Muotka, Timo, Osadčaja, Diana, Paavola, Riku, Palinauskas, Vaidas, Pařil, Petr, Pilotto, Francesca, Polášek, Marek, Rasmussen, Jes J., Schäfer, Ralf B., Schmidt-Kloiber, Astrid, Scotti, Alberto, Skuja, Agnija, Straka, Michal, Stubbington, Rachel, Timm, Henn, Tyufekchieva, Violeta, Tziortzis, Iakovos, Vannevel, Rudy, Várbíró, Gábor, Velle, Gaute, Verdonschot, Ralf C. M., Vray, Sarah, and Haase, Peter

Published
2024
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16. On-Site Production of Quasi-Continuous Ultra-High Vacuum Pipes

Author

Angerhausen, Matthias, Buchholz, Guido, Hoste, Jef, Purrio, Marion, Stahl, Achim, Stein, Lars, and Toussaint, Patrick

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

We present a design study for a new production technology for ultra-high vacuum pipes. The pipes are produced in a fully automatised process in sections of hundreds of meters directly in the later location of usage. We estimate the effort for such a production and show that it might be substantially lower than the effort for an off-site production of transportable sections., Comment: 12 pages, 4 figures

Published
2023

17. Effect of ABCB1 most frequent polymorphisms on the accumulation of bictegravir in recombinant HEK293 cell lines

Author

Julien De Greef, Mathilde Akue, Nadtha Panin, Kévin-Alexandre Delongie, Marina André, Gwenaëlle Mahieu, Emilia Hoste, Laure Elens, Leïla Belkhir, and Vincent Haufroid

Subjects
Integrase strand transfer inhibitors, Pharmacogenetic, P-glycoprotein, P-gp, Multi-drug resistance protein 1, MDR1, Medicine, Science
Abstract

Abstract Bictegravir, a key second-generation integrase strand transfer inhibitor in the treatment of HIV, is subject to active efflux transport mediated by ABCB1 (P-glycoprotein). Several coding variants of ABCB1 have been described and associated with variable effects on substrate drugs pharmacokinetics. Here, we investigated the effect of the four most common coding ABCB1 single nucleotide polymorphisms (i.e., c.1199G > A, c.1236C > T, c.2677G > T and c.3435C > T) on the intracellular accumulation of bictegravir. Using a previously validated HEK293 recombinant cell line model, we found decreased bictegravir intracellular concentrations in cell lines overexpressing ABCB1 as compared to control cell lines, in line with the known role of ABCB1 in bictegravir transport. However, we were unable to demonstrate any significant difference in bictegravir intracellular accumulation when comparing HEK293 cells overexpressing the wild type (1236C-2677G-3435C, 1199G) or the variant (1236C-2677G-3435T, 1236T-2677T-3435T or 1199A) proteins. These findings suggest that the ABCB1 c.1199G > A and c.1236C > T-c.2677G > T-c.3435C > T variants have no or at least limited impact on the active transport of bictegravir by ABCB1.

Published
2024
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18. Time series of freshwater macroinvertebrate abundances and site characteristics of European streams and rivers

Author

Ellen A. R. Welti, Diana E. Bowler, James S. Sinclair, Florian Altermatt, Mario Álvarez-Cabria, Giuseppe Amatulli, David G. Angeler, Gaït Archambaud, Iñaki Arrate Jorrín, Thomas Aspin, Iker Azpiroz, Nathan Jay Baker, Iñaki Bañares, José Barquín Ortiz, Christian L. Bodin, Luca Bonacina, Núria Bonada, Roberta Bottarin, Miguel Cañedo-Argüelles, Zoltán Csabai, Thibault Datry, Elvira de Eyto, Alain Dohet, Sami Domisch, Gerald Dörflinger, Emma Drohan, Knut A. Eikland, Judy England, Tor E. Eriksen, Vesela Evtimova, Maria J. Feio, Martial Ferréol, Mathieu Floury, Maxence Forcellini, Marie Anne Eurie Forio, Riccardo Fornaroli, Nikolai Friberg, Jean-François Fruget, Jaime R. Garcia Marquez, Galia Georgieva, Peter Goethals, Manuel A. S. Graça, Andy House, Kaisa-Leena Huttunen, Thomas Correll Jensen, Richard K. Johnson, J. Iwan Jones, Jens Kiesel, Aitor Larrañaga, Patrick Leitner, Lionel L’Hoste, Marie-Hélène Lizée, Armin W. Lorenz, Anthony Maire, Jesús Alberto Manzanos Arnaiz, Brendan Mckie, Andrés Millán, Timo Muotka, John F. Murphy, Davis Ozolins, Riku Paavola, Petr Paril, Francisco Jesús Peñas Silva, Marek Polasek, Jes Rasmussen, Manu Rubio, David Sánchez Fernández, Leonard Sandin, Ralf B. Schäfer, Astrid Schmidt-Kloiber, Alberto Scotti, Longzhu Q. Shen, Agnija Skuja, Stefan Stoll, Michal Straka, Rachel Stubbington, Henn Timm, Violeta G. Tyufekchieva, Iakovos Tziortzis, Yordan Uzunov, Gea H. van der Lee, Rudy Vannevel, Emilia Varadinova, Gábor Várbíró, Gaute Velle, Piet F. M. Verdonschot, Ralf C. M. Verdonschot, Yanka Vidinova, Peter Wiberg-Larsen, and Peter Haase

Subjects
Science
Abstract

Abstract Freshwater macroinvertebrates are a diverse group and play key ecological roles, including accelerating nutrient cycling, filtering water, controlling primary producers, and providing food for predators. Their differences in tolerances and short generation times manifest in rapid community responses to change. Macroinvertebrate community composition is an indicator of water quality. In Europe, efforts to improve water quality following environmental legislation, primarily starting in the 1980s, may have driven a recovery of macroinvertebrate communities. Towards understanding temporal and spatial variation of these organisms, we compiled the TREAM dataset (Time seRies of European freshwAter Macroinvertebrates), consisting of macroinvertebrate community time series from 1,816 river and stream sites (mean length of 19.2 years and 14.9 sampling years) of 22 European countries sampled between 1968 and 2020. In total, the data include >93 million sampled individuals of 2,648 taxa from 959 genera and 212 families. These data can be used to test questions ranging from identifying drivers of the population dynamics of specific taxa to assessing the success of legislative and management restoration efforts.

Published
2024
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20. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Author

Astrid Marchal, Elizabeth T. Cirulli, Iva Neveux, Evangelos Bellos, Ryan S. Thwaites, Kelly M. Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G. Tangye, András N. Spaan, Justin B. Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Clifton L. Dalgard, Shen-Ying Zhang, Qian Zhang, Christopher Chiu, Jacques Fellay, Joseph J. Grzymski, Vanessa Sancho-Shimizu, Laurent Abel, Jean-Laurent Casanova, Aurélie Cobat, Alexandre Bolze, Alessandro Aiuti, Saleh Al-Muhsen, Fahd Al-Mulla, Ali Amara, Mark S. Anderson, Evangelos Andreakos, Andrés A. Arias, Lisa M. Arkin, Hagit Baris Feldman, Paul Bastard, Alexandre Belot, Catherine M. Biggs, Dusan Bogunovic, Anastasiia Bondarenko, Alessandro Borghesi, Ahmed A. Bousfiha, Petter Brodin, Yenan Bryceson, Manish J. Butte, Giorgio Casari, John Christodoulou, Roger Colobran, Antonio Condino-Neto, Stefan N. Constantinescu, Megan A. Cooper, Murkesh Desai, Beth A. Drolet, Xavier Duval, Jamila El Baghdadi, Philippine Eloy, Sara Espinosa-Padilla, Carlos Flores, José Luis Franco, Antoine Froidure, Peter K. Gregersen, Bodo Grimbacher, Filomeen Haerynck, David Hagin, Rabih Halwani, Lennart Hammarström, James R. Heath, Elena W.Y. Hsieh, Eystein Husebye, Kohsuke Imai, Yuval Itan, Emmanuelle Jouanguy, Elżbieta Kaja, Timokratis Karamitros, Kai Kisand, Cheng-Lung Ku, Yu-Lung Lau, Yun Ling, Carrie L. Lucas, Tom Maniatis, Davood Mansouri, László Maródi, France Mentré, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Trine H. Mogensen, Tomohiro Morio, Lisa F.P. Ng, Luigi D. Notarangelo, Antonio Novelli, Giuseppe Novelli, Cliona O'Farrelly, Satoshi Okada, Keisuke Okamoto, Tayfun Ozcelik, Qiang Pan-Hammarström, Jean W. Pape, Rebeca Perez de Diego, Jordi Perez-Tur, David S. Perlin, Graziano Pesole, Anna M. Planas, Carolina Prando, Aurora Pujol, Anne Puel, Lluis Quintana-Murci, Sathishkumar Ramaswamy, Laurent Renia, Igor Resnick, Carlos Rodríguez-Gallego, Anna Sediva, Mikko R.J. Seppänen, Mohammad Shahrooei, Anna Shcherbina, Ondrej Slaby, Andrew L. Snow, Pere Soler-Palacín, Vassili Soumelis, Ivan Tancevski, Ahmad Abou Tayoun, Şehime Gülsün Temel, Christian Thorball, Pierre Tiberghien, Sophie Trouillet-Assant, Stuart E. Turvey, K. M. Furkan Uddin, Mohammed J. Uddin, Diederik van de Beek, Donald C. Vinh, Horst von Bernuth, Joost Wauters, Mayana Zatz, Pawel Zawadzki, Serge Bureau, Yannick Vacher, Anne Gysembergh-Houal, Lauren Demerville, Abla Benleulmi-Chaachoua, Sebastien Abad, Radhiya Abassi, Abdelrafie Abdellaoui, Abdelkrim Abdelmalek, Hendy Abdoul, Helene Abergel, Fariza Abeud, Sophie Abgrall, Noemie Abisror, Marylise Adechian, Nordine Aderdour, Hakeem Farid Admane, Frederic Adnet, Sara Afritt, Helene Agostini, Claire Aguilar, Sophie Agut, Tommaso Francesco Aiello, Marc Ait Kaci, Hafid Ait Oufella, Gokula Ajeenthiravasan, Virginie Alauzy, Fanny Alby-Laurent, Lucie Allard, Marie-Alexandra Alyanakian, Blanca Amador Borrero, Sabrina Amam, Lucile Amrouche, Marc Andronikof, Dany Anglicheau, Nadia Anguel, Djillali Annane, Mohammed Aounzou, Caroline Aparicio, Gladys Aratus, Jean-Benoit Arlet, Jeremy Arzoine, Elisabeth Aslangul, Mona Assefi, Adeline Aubry, Laetitia Audiffred, Etienne Audureau, Christelle Nathalie Auger, Jean-Charles Auregan, Celine Awotar, Sonia Ayllon Milla, Delphine Azan, Laurene Azemar, Billal Azzouguen, Marwa Bachir Elrufaai, Aïda Badsi, Prissile Bakouboula, Coline Balcerowiak, Fanta Balde, Elodie Baldivia, Eliane-Flore Bangamingo, Amandine Baptiste, Fanny Baran-Marszak, Caroline Barau, Nathalie Barget, Flore Baronnet, Romain Barthelemy, Jean-Luc Baudel, Camille Baudry, Elodie Baudry, Laurent Beaugerie, Adel Belamri, Nicolas Belaube, Rhida Belilita, Pierre Bellassen, Rawan Belmokhtar, Isabel Beltran, Ruben Benainous, Mourad Benallaoua, Robert Benamouzig, Amélie Benbara, Jaouad Benhida, Anis Benkhelouf, Jihene Benlagha, Chahinez Benmostafa, Skander Benothmane, Miassa Bentifraouine, Laurence Berard, Quentin Bernier, Enora Berti, Astrid Bertier, Laure Berton, Simon Bessis, Alexandra Beurton, Celine Bianco, Clara Bianquis, Frank Bidar, Philippe Blanche, Clarisse Blayau, Alexandre Bleibtreu, Emmanuelle Blin, Coralie Bloch-Queyrat, Marie-Christophe Boissier, Diane Bollens, Marion Bolzoni, Rudy pierre Bompard, Nicolas Bonnet, Justine Bonnouvrier, Shirmonecrystal Botha, Wissam Boucenna, Fatiha Bouchama, Olivier Bouchaud, Hanane Bouchghoul, Taoueslylia Boudjebla, Noel Boudjema, Catherine Bouffard, Adrien Bougle, Meriem Bouguerra, Leila Bouras, Agnes Bourcier, Anne Bourgarit Durand, Anne Bourrier, Fabrice Bouscarat, Diane Bouvry, Nesrine Bouziri, Ons Bouzrara, Sarah Bribier, Delphine Brugier, Melanie Brunel, Eida Bui, Anne Buisson, Iryna Bukreyeva, Côme Bureau, Jacques Cadranel, Johann Cailhol, Ruxandra Calin, Clara Campos Vega, Pauline Canavaggio, Marta Cancella, Delphine Cantin, Albert Cao, Lionel Carbillon, Nicolas Carlier, Clementine Cassard, Guylaine Castor, Marion Cauchy, Olivier Cha, Benjamin Chaigne, Salima Challal, Karine Champion, Patrick Chariot, Julie Chas, Simon Chauveau, Anthony Chauvin, Clement Chauvin, Nathalie Chavarot, Kamélia Chebbout, Mustapha Cherai, Ilaria Cherubini, Amelie Chevalier, Thibault Chiarabini, Thierry Chinet, Richard Chocron, Pascaline Choinier, Juliette Chommeloux, Christophe Choquet, Laure Choupeaux, Benjamin Chousterman, Dragosmarius Ciocan, Ada Clarke, Gaëlle Clavere, Florian Clavier, Karine Clement, Sebastien Clerc, Yves Cohen, Fleur Cohen, Adrien Cohen, Audrey Coilly, Hester Colboc, Pauline Colin, Magalie Collet, Chloé Comarmond, Emeline Combacon, Alain Combes, Celine Comparon, Jean-Michel Constantin, Hugues Cordel, Anne-Gael Cordier, Adrien Costantini, Nathalie Costedoat Chalumeau, Camille Couffignal, Doriane Coupeau, Alain Creange, Yannie Cuvillier Lamarre, Charlène Da Silveira, Sandrine Dautheville Guibal El Kayani, Nathalie De Castro, Yann De Rycke, Lucie Del Pozo, Quentin Delannoy, Mathieu Delay, Robin Deleris, Juliette Delforge, Laëtitia Delphine, Noemie Demare, Sophie Demeret, Alexandre Demoule, Aurore Deniau, François Depret, Sophie Derolez, Ouda Derradji, Nawal Derridj, Vincent Descamps, Lydia Deschamps, Celine Desconclois, Cyrielle Desnos, Karine Desongins, Robin Dhote, Benjamin Diallo, Morgane Didier, Myriam Diemer, Stephane Diez, Juliette Djadi-Prat, Fatima-Zohra Djamouri Monnory, Siham Djebara, Naoual Djebra, Minette Djietcheu, Hadjer Djillali, Nouara Djouadi, Severine Donneger, Catarina Dos Santos, Nathalie Dournon, Martin Dres, Laura Droctove, Marie Drogrey, Margot Dropy, Elodie Drouet, Valérie Dubosq, Evelyne Dubreucq, Estelle Dubus, Boris Duchemann, Thibault Duchenoy, Emmanuel Dudoignon, Romain Dufau, Florence Dumas, Clara Duran, Emmanuelle Duron, Antoine Durrbach, Claudine Duvivier, Nathan Ebstein, Jihane El Khalifa, Alexandre Elabbadi, Caroline Elie, Gabriel Ernotte, Anne Esling, Martin Etienne, Xavier Eyer, Muriel Sarah Fartoukh, Takoua Fayali, Marion Fermaut, Arianna Fiorentino, Souha Fliss, Marie-Céline Fournier, Benjamin Fournier, Hélène Francois, Olivia Freynet, Yvann Frigout, Isaure Fromont, Axelle Fuentes, Thomas Furet, Joris Galand, Marc Garnier, Agnes Gaubert, Stéphane Gaudry, Samuel Gaugain, Damien Gauthier, Maxime Gautier, Sophie Georgin-Lavialle, Daniela Geromin, Mohamed Ghalayini, Bijan Ghaleh, Myriam Ghezal, Aude Gibelin, Linda Gimeno, Benoit Girard, Bénédicte Giroux Leprieur, Doryan Gomes, Elisabete Gomes-Pires, Anne Gouge, Amel Gouja, Helene Goulet, Sylvain Goupil, Jeanne Goupil De Bouille, Julien Gras, Segolene Greffe, Lamiae Grimaldi, Paul Guedeney, Bertrand Guidet, Matthias Guillo, Mariechristelle Gulczynski, Tassadit Hadjam, Didier Haguenauer, Soumeya Hammal, Nadjib Hammoudi, Olivier Hanon, Anarole Harrois, Coraline Hautem, Guillaume Hekimian, Nicholas Heming, Olivier Hermine, Sylvie Ho, Marie Houllier, Benjamin Huot, Tessa Huscenot, Wafa Ibn Saied, Ghilas Ikherbane, Meriem Imarazene, Patrick Ingiliz, Lina Iratni, Stephane Jaureguiberry, Jean-Francois Jean-Marc, Deleena Jeyarajasingham, Pauline Jouany, Veronique Jouis, Clement Jourdaine, Ouifiya Kafif, Rim Kallala, Sandrine Katsahian, Lilit Kelesyan, Vixra Keo, Flora Ketz, Warda Khamis, Enfel Khelili, Mehdi Khellaf, Christy Gaëlla Kotokpo Youkou, Ilias Kounis, Gaelle Kpalma, Jessica Krause, Vincent Labbe, Karine Lacombe, Jean-Marc 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Rousseaux, Nabila Rousseaux, Swasti Roux, Lorène Roux, Claire Rouzaud, Antoine Rozes, Emma Rubenstein, Jean-Marc Sabate, Sheila Sabet, Sophie-Caroline Sacleux, Nathalie Saidenberg Kermanach, Faouzi Saliba, Dominique Salmon, Laurent Savale, Guillaume Savary, Rebecca Sberro, Anne Scemla, Frederic Schlemmer, Mathieu Schwartz, Saïd Sedfi, Samia Sefir-Kribel, Philippe Seksik, Pierre Sellier, Agathe Selves, Nicole Sembach, Luca Semerano, Marie-Victoire Senat, Damien Sene, Alexandra Serris, Lucile Sese, Naima Sghiouar, Johanna Sigaux, Martin Siguier, Johanne Silvain, Noémie Simon, Tabassome Simon, Lina Innes Skandri, Miassa Slimani, Aurélie Snauwaert, Harry Sokol, Heithem Soliman, Nisrine Soltani, Benjamin Soyer, Gabriel Steg, Lydia Suarez, Tali-Anne Szwebel, Kossi Taffame, Yacine Tandjaoui-Lambiotte, Claire Tantet, Mariagrazia Tateo, Igor Theodose, Pierre clement Thiebaud, Caroline Thomas, Kelly Tiercelet, Julie Tisserand, Carole Tomczak, Krystel Torelino, Fatima Touam-Ext, Lilia Toumi, 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Sabelline Bouchez, Maude Bouscambert, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chirouze, Alexandra Coelho, Sandrine Couffin-Cadiergues, Eric d’Ortenzio, Marie-Pierre Debray, Laurene Deconinck, Dominique Deplanque, Diane Descamps, Mathilde Desvallée, Alpha Diallo, Alphonsine Diouf, Céline Dorival, François Dubos, Brigitte Elharrar, Vincent Enouf, Hélène Esperou, Marina Esposito-Farese, Manuel Etienne, Eglantine Ferrand Devouge, Nathalie Gault, Alexandre Gaymard, Tristan Gigante, Morgane Gilg, Jérémie Guedj, Alexandre Hoctin, Isabelle Hoffmann, Ikram Houas, Jean-Sébastien Hulot, Salma Jaafoura, Florentia Kaguelidou, Sabrina Kali, Antoine Khalil, Coralie Khan, Cédric Laouénan, Samira Laribi, Minh Le, Quentin Le Hingrat, Soizic Le Mestre, Hervé Le Nagard, François-Xavier Lescure, Sophie Letrou, Yves Levy, Bruno Lina, Guillaume Lingas, Jean-Christophe Lucet, Denis Malvy, Marina Mambert, Amina Meziane, Hugo Mouquet, Jimmy Mullaert, Nadège Neant, Duc Nguyen, Marion Noret, Saad Nseir, Aurélie Papadopoulos, Christelle Paul, Nathan Peiffer-Smadja, Thomas Perpoint, Ventzislava Petrov-Sanchez, Gilles Peytavin, Huong Pham, Olivier Picone, Oriane Puéchal, Christian Rabaud, Manuel Rosa-Calatrava, Bénédicte Rossignol, Patrick Rossignol, Carine Roy, Marion Schneider, Richa Su, Coralie Tardivon, Marie-Capucine Tellier, François Téoulé, Olivier Terrier, Jean-François Timsit, Christelle Tual, Sylvie Van Der Werf, Noémie Vanel, Aurélie Veislinger, Benoit Visseaux, Aurélie Wiedemann, Yazdan Yazdanpanah, Loubna Alavoine, Charlotte Charpentier, Aline Dechanet, Jean-Luc Ecobichon, Wahiba Frezouls, Nadhira Houhou, Jonathan Lehacaut, Pauline Manchon, Mariama Nouroudine, Caroline Quintin, Michael Thy, Sylvie van der Werf, Valérie Vignali, Abir Chahine, Nawal Waucquier, Maria-Claire Migaud, Félix Djossou, Mayka Mergeay-Fabre, Aude Lucarelli, Magalie Demar, Léa Bruneau, Patrick Gérardin, Adrien Maillot, Christine Payet, Bruno Laviolle, Fabrice Laine, Christophe Paris, Mireille 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Castro, Emilie Catherinot, Jale Bengi Celik, Alessandro Ceschi, Martin Chalumeau, Bruno Charbit, Cécile Boulanger, Père Clavé, Bonaventura Clotet, Anna Codina, Cloé Comarmond, Patrizia Comoli, Angelo G. Corsico, Taner Coşkuner, Aleksandar Cvetkovski, Cyril Cyrus, David Dalmau, François Danion, David Ross Darley, Vincent Das, Nicolas Dauby, Stéphane Dauger, Paul De Munte, Loic de Pontual, Amin Dehban, Geoffroy Delplancq, Isabelle Desguerre, Antonio Di Sabatino, Jean-Luc Diehl, Stephanie Dobbelaere, Elena Domínguez-Garrido, Clément Dubost, Olov Ekwall, Şefika Elmas Bozdemir, Marwa H. Elnagdy, Melike Emiroglu, Akifumi Endo, Emine Hafize Erdeniz, Selma Erol Aytekin, Maria Pilar Etxart Lasa, Romain Euvrard, Giovanna Fabio, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernandez Arquero, Ricard Ferrer, Jose Ferreres, Bruno Francois, Victoria Fumadó, Kitty S.C. Fung, Francesca Fusco, Alenka Gagro, Blanca Garcia Solis, Pierre Garçon, Pascale Gaussem, Zeynep Gayretli, Juana Gil-Herrera, Laurent Gilardin, Audrey Giraud Gatineau, Mònica Girona-Alarcón, Karen Alejandra Cifuentes Godínez, Jean-Christophe Goffard, Nacho Gonzales, Luis I. Gonzalez-Granado, Rafaela González-Montelongo, Antoine Guerder, Belgin Gülhan, Victor Daniel Gumucio, Leif Gunnar Hanitsch, Jan Gunst, Marta Gut, Jérôme Hadjadj, Selda Hancerli, Tetyana Hariyan, Nevin Hatipoglu, Deniz Heppekcan, Elisa Hernandez-Brito, Po-ki Ho, María Soledad Holanda-Peña, Juan P. Horcajada, Sami Hraiech, Linda Humbert, Ivan F.N. Hung, Alejandro D. Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María Jesús Arranz, Marie-Thérèse Jimeno, Iolanda Jordan, Saliha Kanık-Yüksek, Yalcin Kara, Aydın Karahan, Adem Karbuz, Kadriye Kart Yasar, Ozgur Kasapcopur, Kenichi Kashimada, Sevgi Keles, Yasemin Kendir Demirkol, Yasutoshi Kido, Can Kizil, Ahmet Osman Kılıç, Adam Klocperk, Antonia Koutsoukou, Zbigniew J. Król, Hatem Ksouri, Paul Kuentz, Arthur M.C. Kwan, Yat Wah M. Kwan, Janette S.Y. Kwok, Jean-Christophe Lagier, David S.Y. Lam, Vicky Lampropoulou, Fleur Le Bourgeois, Yee-Sin Leo, Rafael Leon Lopez, Daniel Leung, Michael Levin, Michael Levy, Romain Lévy, Zhi Li, Daniele Lilleri, Edson Jose Adrian Bolanos Lima, Agnes Linglart, Eduardo López-Collazo, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Kwok-Cheung Lung, Charles-Edouard Luyt, David C. Lye, Cinthia Magnone, Enrico Marchioni, Carola Marioli, Majid Marjani, Laura Marques, Jesus Marquez Pereira, Andrea Martín-Nalda, David Martínez Pueyo, Javier Martinez-Picado, Iciar Marzana, Carmen Mata-Martínez, Alexis Mathian, Larissa R.B. Matos, Gail V. Matthews, Julien Mayaux, Raquel McLaughlin-Garcia, Philippe Meersseman, Jean-Louis Mège, Armand Mekontso-Dessap, Isabelle Melki, Federica Meloni, Jean-François Meritet, Paolo Merlani, Özge Metin Akcan, Mehdi Mezidi, Isabelle Migeotte, Maude Millereux, Matthieu Million, Tristan Mirault, Clotilde Mircher, Mehdi Mirsaeidi, Yoko Mizoguchi, Bhavi P. Modi, Francesco Mojoli, Elsa Moncomble, Abián Montesdeoca Melián, Antonio Morales Martinez, Francisco Morandeira, Pierre-Emmanuel Morange, Clémence Mordacq, Guillaume Morelle, Stéphane J. Mouly, Adrián Muñoz-Barrera, Cyril Nafati, Shintaro Nagashima, Yu Nakagama, Bénédicte Neven, João Farela Neves, Yuk-Yung Ng, Hubert Nielly, Yeray Novoa Medina, Esmeralda Nuñez Cuadros, Semsi Nur Karabela, J. Gonzalo Ocejo-Vinyals, Mehdi Oualha, Amani Ouedrani, Tayfun Özçelik, Aslinur Ozkaya-Parlakay, Michele Pagani, Maria Papadaki, Philippe Parola, Tiffany Pascreau, Stéphane Paul, Estela Paz-Artal, Sigifredo Pedraza, Nancy Carolina González Pellecer, Silvia Pellegrini, Rebeca Pérez de Diego, Xosé Luis Pérez-Fernández, Aurélien Philippe, Quentin Philippot, Adrien Picod, Marc Pineton de Chambrun, Antonio Piralla, Laura Planas-Serra, Dominique Ploin, Julien Poissy, Géraldine Poncelet, Garyphallia Poulakou, Marie S. Pouletty, Persia Pourshahnazari, Jia Li Qiu-Chen, Paul Quentric, Thomas Rambaud, Didier Raoult, Violette Raoult, Anne-Sophie Rebillat, Claire Redin, Léa Resmini, Pilar Ricart, Jean-Christophe Richard, Raúl Rigo-Bonnin, Nadia Rivet, Jacques G. Rivière, Gemma Rocamora-Blanch, Mathieu P. 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Delmonte, Jeffrey J. Danielson, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angiò, Ilaria Beretta, Luisa Imberti, Alessandra Sottini, Virginia Quaresima, Eugenia Quiros-Roldan, Camillo Rossi, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, and Gian Luigi Marseglia

Subjects
HLA, association, asymptomatic infection, COVID-19, population stratification, Genetics, QH426-470
Abstract

Summary: Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B∗15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B∗15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the United States (191 asymptomatic vs. 945 symptomatic COVID-19 cases). Moreover, we found no such association in the international COVID Human Genetic Effort cohort (206 asymptomatic vs. 574 mild or moderate COVID-19 cases and 1,625 severe or critical COVID-19 cases). Finally, in the Human Challenge Characterisation study, the three HLA-B∗15:01 individuals infected with SARS-CoV-2 developed symptoms. As with other acute primary infections studied, no classical HLA alleles favoring an asymptomatic course of SARS-CoV-2 infection were identified.

Published
2024
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21. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Channon-Wells, Samuel, Vito, Ortensia, McArdle, Andrew J, Seaby, Eleanor G, Patel, Harsita, Shah, Priyen, Pazukhina, Ekaterina, Wilson, Clare, Broderick, Claire, D'Souza, Giselle, Keren, Ilana, Nijman, Ruud G, Tremoulet, Adriana, Munblit, Daniel, Ulloa-Gutierrez, Rolando, Carter, Michael J, Ramnarayan, Padmanabhan, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Blyuss, Oleg, Levin, Michael, consortium, Best Available Treatment Study, Chouli, Mohamed, Hamadouche, Nacera, Ladj, Mohamed Samir, Vázquez, Jorge Agrimbau, Carmona, Rodrigo, Collia, Adrian Gustavo, Ellis, Alejandro, Natta, Diego, Pérez, Laura, Rubiños, Mayra, Veliz, Natalia, Yori, Silvana, Britton, Philip N, Burgner, David P, Carey, Emma, Crawford, Nigel W, Giuliano, Hayley, McMinn, Alissa, Wong, Shirley, Wood, Nicholas, Holter, Wolfgang, Krainz, Matthias, Ulreich, Raphael, Zurl, Christoph, Dehoorne, Joke, Haerynck, Filomeen, Hoste, Levi, Schelstraete, Petra, Vandekerckhove, Kristof, Willems, Jef, Farias, Camila Giuliana Almeida, Almeida, Flávia Jacqueline, Leal, Izabel Alves, da Silva, André Ricardo Araujo, Araujo e Silva, Anna Esther, Barreiro, Sabrina TA, da Silva, Daniella Gregória Bomfim Prado, Cervi, Maria Celia, dos Santos Naja Cardoso, Mirian Viviane, Teixeira, Cristiane Henriques, Jarovsky, Daniel, Araujo, Julienne Martins, Berezin, Eitan Naaman, Sáfadi, Marco Aurélio Palazzi, la Ossa, Rolando Andres Paternina-de, Vieira, Cristina Souza, Dimitrova, Anna, Ganeva, Margarita, Stefanov, Stefan, Telcharova-Mihaylovska, Albena, Biggs, Catherine M, Lopez, Alison, Scuccimarri, Rosie, Tan, Ryan, Wasserman, Sam, Withington, Davinia, Ampuero, Camila, Aravena, Javiera, B, Raul Bustos, Casanova, Daniel, Cruces, Pablo, Diaz, Franco, García-Salum, Tamara, Godoy, Loreto, Medina, Rafael A, Galaz, Gonzalo Valenzuela, Camacho-Moreno, Germán, Avila-Aguero, María L, Brenes-Chacón, Helena, Camacho-Badilla, Kattia, Ivankovich-Escoto, Gabriela, Naranjo-Zuniga, Gabriela, and Soriano-Fallas, Alejandra

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Comparative Effectiveness Research, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Best Available Treatment Study (BATS) consortium, Clinical sciences
Abstract

BackgroundMultisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments.MethodsThe Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370.FindingsWe enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2-11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75-1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58-1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91-1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70-1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11-0·20]; p

Published
2023

23. Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Author

Pickkers, Peter, Angus, Derek C., Bass, Kristie, Bellomo, Rinaldo, van den Berg, Erik, Bernholz, Juliane, Bestle, Morten H., Doi, Kent, Doig, Chistopher J., Ferrer, Ricard, Francois, Bruno, Gammelager, Henrik, Pedersen, Ulf Goettrup, Hoste, Eric, Iversen, Susanne, Joannidis, Michael, Kellum, John A., Liu, Kathleen, Meersch, Melanie, Mehta, Ravindra, Millington, Scott, Murray, Patrick T., Nichol, Alistair, Ostermann, Marlies, Pettilä, Ville, Solling, Christoffer, Winkel, Matthias, Young, Paul J., and Zarbock, Alexander

Published
2024
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25. Use of dehydrated sainfoin (Onobrychis viciifolia) in rabbit feeding. 2 - Effects of a high dietary incorporation on performance and health of does and growing rabbits, under a sub-optimal breeding commercial environment

Author

Cécile Gayrard, Antoine Bretaudeau, Pascale Gombault, Hervé Hoste, and Thierry Gidenne

Subjects
dehydrated sainfoin, performance, growing rabbits, reproducing does, health status, coccidiosis, mortality, Animal culture, SF1-1100, Veterinary medicine, SF600-1100
Abstract

The effects of a high dietary (26%) incorporation of dehydrated sainfoin (DS) (Perly cultivar) on the performance and health of reproductive does and growing rabbits were analysed in a sub-optimal professional breeding environment (presenting previous coccidiosis), and over two non-consecutive reproductive cycles (2 replicates). Performance and health of does and growing rabbits were compared for 2 groups of 194 does and associated litters, when fed isonutritive feeds containing either 0 or 26% DS (DS0 and DS26 groups). Dietary DS incorporation had no effect on doe live weight, fertility rate, mortality, culling rate and doe coccidia excretion levels (P>0.05). In replicate 1, kit growth before weaning was similar among the two groups, but was 12% lower for the DS26 group in the 2nd replicate (significant interaction). Similarly, a significant interaction was detected between the effect of the diet and the replicate for the mortality rate of kits before weaning, i.e. a higher mortality was detected for DS26 (3.3 vs. 1.8%) in replicate 1, while in replicate 2 it was lower (2.1 vs. 4.4%). After weaning, the post-weaning growth rate was improved by 4% (P=0.02) for the DS26 group, while the mortality rate decreased (7.1 vs. 4.5%, P

Published
2024
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26. On the nonorientable 4-genus of double twist knots

Author

Hoste, Jim, Shanahan, Patrick D., and Van Cott, Cornelia A.

Subjects
Mathematics - Geometric Topology, 57K10
Abstract

We investigate the nonorientable 4-genus $\gamma_4$ of a special family of 2-bridge knots, the twist knots and double twist knots $C(m,n)$. Because the nonorientable 4-genus is bounded by the nonorientable 3-genus, it is known that $\gamma_4(C(m,n)) \le 3$. By using explicit constructions to obtain upper bounds on $\gamma_4$ and known obstructions derived from Donaldson's diagonalization theorem to obtain lower bounds on $\gamma_4$, we produce infinite subfamilies of $C(m,n)$ where $\gamma_4=0,1,2,$ and $3$, respectively. However, there remain infinitely many double twist knots where our work only shows that $\gamma_4$ lies in one of the sets $\{1,2\}, \{2,3\}$, or $\{1,2,3\}$. We tabulate our results for all $C(m,n)$ with $|m|$ and $|n|$ up to 50. We also provide an infinite number of examples which answer a conjecture of Murakami and Yasuhara., Comment: Some exposition is revised, a figure is added, and typos are corrected, following comments from the referee

Published
2022

28. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial

Author

Wald, Ron, Gaudry, Stephane, da Costa, Bruno R., Adhikari, Neill K. J., Bellomo, Rinaldo, Du, Bin, Gallagher, Martin P., Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Dreyfuss, Didier, and Bagshaw, Sean M.

Published
2023
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29. Ferroptosis and pyroptosis signatures in critical COVID-19 patients

Author

Peleman, Cédric, Van Coillie, Samya, Ligthart, Symen, Choi, Sze Men, De Waele, Jan, Depuydt, Pieter, Benoit, Dominique, Schaubroeck, Hannah, Francque, Sven M., Dams, Karolien, Jacobs, Rita, Robert, Dominique, Roelandt, Ria, Seurinck, Ruth, Saeys, Yvan, Rajapurkar, Mohan, Jorens, Philippe G., Hoste, Eric, and Vanden Berghe, Tom

Published
2023
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30. Changes in caddisflies community composition and distribution along 60 years timespan monitoring in Luxembourg

Author

Alain Dohet, Sarah Vray, and Lionel L’Hoste

Subjects
Biology (General), QH301-705.5, Zoology, QL1-991
Abstract

In Luxembourg, caddisflies have been systematically collected since the early Sixties. Three periods of exhaustive sampling may be distinguished: the Sixties; 1994 to 2002; and a long period from 2007 to the present time in the frame of the Water Framework Directive. Bearing in mind the uneven sampling procedure across periods, we aim to document changes in community composition and distribution through time including the nature of these changes (e.g. gains and losses of species). We hypothesise different trends of species gains and losses for specialist species in comparison to generalist species. Therefore, we propose a method to identify specialist and generalist species in our dataset. Historical data (1961 to 1968) lack information on precise locations and abundance of specimen collected. Consequently, cell grids of original distribution maps are used to compare caddisfly community assemblages along the three monitoring periods. We assess the changes that occur on presence/absence data in specific groups of species (i.e. cold-adapted, warm-adapted specialists and generalist species). Temporal β-diversity results reveal that survey intervals for each monitoring period are dominated by species losses when the comparison is restricted to cold-adapted species. On the other hand, warm-adapted and generalist species are increasing from the Sixties period when compared to the two next periods (1994–2002 and 2007–2020). However, the comparison of the most recent periods reveals species losses even for the warm-adapted and generalist species. This complex picture of caddisflies species losses and gains in different ways through time, amongst river types and in response to different pressures, is discussed.

Published
2023
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31. Risk factors and indications of orthodontic temporary anchorage devices: a literature review

Author

Hoste Sofie, Vercruyssen Marjolein, Quirynen Marc, and Willems Guy

Subjects
Dentistry, RK1-715
Abstract

The aims of this review are twofold, firstly, to give an overview of the general and local risk factors when using temporary anchorage devices (TADs) and the prerequisites for placement and, secondly, to illustrate the orthodontic indications of various TADs.

Published
2023
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32. Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Author

Pickkers, Peter, Angus, Derek C., Bass, Kristie, Bellomo, Rinaldo, van den Berg, Erik, Bernholz, Juliane, Bestle, Morten H., Doi, Kent, Doig, Chistopher J., Ferrer, Ricard, Francois, Bruno, Gammelager, Henrik, Pedersen, Ulf Goettrup, Hoste, Eric, Iversen, Susanne, Joannidis, Michael, Kellum, John A., Liu, Kathleen, Meersch, Melanie, Mehta, Ravindra, Millington, Scott, Murray, Patrick T., Nichol, Alistair, Ostermann, Marlies, Pettilä, Ville, Solling, Christoffer, Winkel, Matthias, Young, Paul J., and Zarbock, Alexander

Published
2024
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33. In silico drug repositioning for COVID-19 using absolute binding free energy calculations

Author

Debroise, Théau, Hoste, Rose, Chamayou, Quentin, Minoux, Hervé, Filoche-Rommé, Bruno, Bianciotto, Marc, Rameau, Jean-Philippe, Schio, Laurent, and Levesque, Maximilien

Subjects
Quantitative Biology - Quantitative Methods, Physics - Chemical Physics
Abstract

Since the rise of the SARS-CoV-2 pandemic in the winter of 2019, the need for an affordable and efficient drug has not yet been met. Leveraging its unique, fast and precise binding free energy prediction technology, Aqemia screened and ranked FDA-approved molecules against the 3ClPro protein. This protease is key to the post-translational modification of two polyproteins produced by the viral genome. We propose in our top 10 predicted molecules some drugs or prodrugs that could be repurposed and used in the treatment of COVID cases.

Published
2021

38. Fuzzy-Rough Nearest Neighbour Approaches for Emotion Detection in Tweets

Author

Kaminska, Olha, Cornelis, Chris, and Hoste, Veronique

Subjects
Computer Science - Computation and Language, Computer Science - Machine Learning
Abstract

Social media are an essential source of meaningful data that can be used in different tasks such as sentiment analysis and emotion recognition. Mostly, these tasks are solved with deep learning methods. Due to the fuzzy nature of textual data, we consider using classification methods based on fuzzy rough sets. Specifically, we develop an approach for the SemEval-2018 emotion detection task, based on the fuzzy rough nearest neighbour (FRNN) classifier enhanced with ordered weighted average (OWA) operators. We use tuned ensembles of FRNN--OWA models based on different text embedding methods. Our results are competitive with the best SemEval solutions based on more complicated deep learning methods., Comment: The paper submitted to the IJCRS 2021 conference, organized jointly with IFSA-EUSFLAT 2021

Published
2021

39. Nearest neighbour approaches for Emotion Detection in Tweets

Author

Kaminska, Olha, Cornelis, Chris, and Hoste, Veronique

Subjects
Computer Science - Computation and Language, Computer Science - Machine Learning
Abstract

Emotion detection is an important task that can be applied to social media data to discover new knowledge. While the use of deep learning methods for this task has been prevalent, they are black-box models, making their decisions hard to interpret for a human operator. Therefore, in this paper, we propose an approach using weighted $k$ Nearest Neighbours (kNN), a simple, easy to implement, and explainable machine learning model. These qualities can help to enhance results' reliability and guide error analysis. In particular, we apply the weighted kNN model to the shared emotion detection task in tweets from SemEval-2018. Tweets are represented using different text embedding methods and emotion lexicon vocabulary scores, and classification is done by an ensemble of weighted kNN models. Our best approaches obtain results competitive with state-of-the-art solutions and open up a promising alternative path to neural network methods., Comment: The paper was presented at EACL 2021 during the WASSA workshop as a poster and published at ACL Anthology

Published
2021

40. Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Author

Karel F. A. Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Aegerter, Andy Wullaert, Tino Hochepied, Esther Hoste, Lieselotte Vande Walle, Mohamed Lamkanfi, Savvas N. Savvides, Dirk Elewaut, Bart N. Lambrecht, and Geert van Loo

Subjects
Medicine, Science
Abstract

Abstract A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Experimental gene knockout studies in mice have confirmed A20 as a susceptibility gene for SLE and RA. Here, we examine the significance of protein citrullination and NET formation in the autoimmune pathology of A20 mutant mice because autoimmunity directed against citrullinated antigens released by neutrophil extracellular traps (NETs) is central to the pathogenesis of RA and SLE. Furthermore, genetic variants impairing the deubiquitinase (DUB) function of A20 have been shown to contribute to autoimmune susceptibility. Our findings demonstrate that genetic disruption of A20 DUB function in A20 C103R knockin mice does not result in autoimmune pathology. Moreover, we show that PAD4 deficiency, which abolishes protein citrullination and NET formation, does not prevent the development of autoimmunity in A20 deficient mice. Collectively, these findings provide experimental confirmation that PAD4-dependent protein citrullination and NET formation do not serve as pathogenic mechanisms in the development of RA and SLE pathology in mice with A20 mutations.

Published
2023
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41. The recovery of European freshwater biodiversity has come to a halt

Author

Haase, Peter, Bowler, Diana E., Baker, Nathan J., Bonada, Núria, Domisch, Sami, Garcia Marquez, Jaime R., Heino, Jani, Hering, Daniel, Jähnig, Sonja C., Schmidt-Kloiber, Astrid, Stubbington, Rachel, Altermatt, Florian, Álvarez-Cabria, Mario, Amatulli, Giuseppe, Angeler, David G., Archambaud-Suard, Gaït, Jorrín, Iñaki Arrate, Aspin, Thomas, Azpiroz, Iker, Bañares, Iñaki, Ortiz, José Barquín, Bodin, Christian L., Bonacina, Luca, Bottarin, Roberta, Cañedo-Argüelles, Miguel, Csabai, Zoltán, Datry, Thibault, de Eyto, Elvira, Dohet, Alain, Dörflinger, Gerald, Drohan, Emma, Eikland, Knut A., England, Judy, Eriksen, Tor E., Evtimova, Vesela, Feio, Maria J., Ferréol, Martial, Floury, Mathieu, Forcellini, Maxence, Forio, Marie Anne Eurie, Fornaroli, Riccardo, Friberg, Nikolai, Fruget, Jean-François, Georgieva, Galia, Goethals, Peter, Graça, Manuel A. S., Graf, Wolfram, House, Andy, Huttunen, Kaisa-Leena, Jensen, Thomas C., Johnson, Richard K., Jones, J. Iwan, Kiesel, Jens, Kuglerová, Lenka, Larrañaga, Aitor, Leitner, Patrick, L’Hoste, Lionel, Lizée, Marie-Helène, Lorenz, Armin W., Maire, Anthony, Arnaiz, Jesús Alberto Manzanos, McKie, Brendan G., Millán, Andrés, Monteith, Don, Muotka, Timo, Murphy, John F., Ozolins, Davis, Paavola, Riku, Paril, Petr, Peñas, Francisco J., Pilotto, Francesca, Polášek, Marek, Rasmussen, Jes Jessen, Rubio, Manu, Sánchez-Fernández, David, Sandin, Leonard, Schäfer, Ralf B., Scotti, Alberto, Shen, Longzhu Q., Skuja, Agnija, Stoll, Stefan, Straka, Michal, Timm, Henn, Tyufekchieva, Violeta G., Tziortzis, Iakovos, Uzunov, Yordan, van der Lee, Gea H., Vannevel, Rudy, Varadinova, Emilia, Várbíró, Gábor, Velle, Gaute, Verdonschot, Piet F. M., Verdonschot, Ralf C. M., Vidinova, Yanka, Wiberg-Larsen, Peter, and Welti, Ellen A. R.

Published
2023
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43. Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial

Author

Wald, Ron, Kirkham, Brian, daCosta, Bruno R, Ghamarian, Ehsan, Adhikari, Neill KJ, Beaubien-Souligny, William, Bellomo, Rinaldo, Gallagher, Martin P, Goldstein, Stuart, Hoste, Eric AJ, Liu, Kathleen D, Neyra, Javier A, Ostermann, Marlies, Palevsky, Paul M, Schneider, Antoine, Vaara, Suvi T, and Bagshaw, Sean M

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Renal and urogenital, Good Health and Well Being, Humans, Acute Kidney Injury, Critical Illness, Renal Replacement Therapy, Water-Electrolyte Balance, Water-Electrolyte Imbalance, Acute kidney injury, Renal replacement therapy, Randomized controlled trial, Fluid balance, Clinical outcomes, Medical and Health Sciences, Emergency & Critical Care Medicine, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundAmong critically ill patients with acute kidney injury (AKI), earlier initiation of renal replacement therapy (RRT) may mitigate fluid accumulation and confer better outcomes among individuals with greater fluid overload at randomization.MethodsWe conducted a pre-planned post hoc analysis of the STandard versus Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial. We evaluated the effect of accelerated RRT initiation on cumulative fluid balance over the course of 14 days following randomization using mixed models after censoring for death and ICU discharge. We assessed the modifying effect of baseline fluid balance on the impact of RRT initiation strategy on key clinical outcomes. Patients were categorized in quartiles of baseline fluid balance, and the effect of accelerated versus standard RRT initiation on clinical outcomes was assessed in each quartile using risk ratios (95% CI) for categorical variables and mean differences (95% CI) for continuous variables.ResultsAmong 2927 patients in the modified intention-to-treat analysis, 2738 had available data on baseline fluid balance and 2716 (92.8%) had at least one day of fluid balance data following randomization. Over the subsequent 14 days, participants allocated to the accelerated strategy had a lower cumulative fluid balance compared to those in the standard strategy (4509 (- 728 to 11,698) versus 5646 (0 to 13,151) mL, p = 0.03). Accelerated RRT initiation did not confer greater 90-day survival in any of the baseline fluid balance quartiles (quartile 1: RR 1.11 (95% CI 0.92 to 1.34), quartile 2: RR 1.03 (0.87 to 1.21); quartile 3: RR 1.08 (95% CI 0.91 to 1.27) and quartile 4: RR 0.87 (95% CI 0.73 to 1.03), p value for trend 0.08).ConclusionsEarlier RRT initiation in critically ill patients with AKI conferred a modest attenuation of cumulative fluid balance. Nonetheless, among patients with greater fluid accumulation at randomization, accelerated RRT initiation did not have an impact on all-cause mortality.Trial registrationClinicalTrials.gov number, https://clinicaltrials.gov/ct2/show/NCT02568722 , registered October 6, 2015.

Published
2022

44. A Million Tweets Are Worth a Few Points: Tuning Transformers for Customer Service Tasks

Author

Hadifar, Amir, Labat, Sofie, Hoste, Véronique, Develder, Chris, and Demeester, Thomas

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

In online domain-specific customer service applications, many companies struggle to deploy advanced NLP models successfully, due to the limited availability of and noise in their datasets. While prior research demonstrated the potential of migrating large open-domain pretrained models for domain-specific tasks, the appropriate (pre)training strategies have not yet been rigorously evaluated in such social media customer service settings, especially under multilingual conditions. We address this gap by collecting a multilingual social media corpus containing customer service conversations (865k tweets), comparing various pipelines of pretraining and finetuning approaches, applying them on 5 different end tasks. We show that pretraining a generic multilingual transformer model on our in-domain dataset, before finetuning on specific end tasks, consistently boosts performance, especially in non-English settings.

Published
2021

47. Performance of urinary C–C motif chemokine ligand 14 for the prediction of persistent acute kidney injury: a systematic review and meta-analysis

Author

Yih‑Ting Chen, Heng-Chih Pan, Cheng-Kai Hsu, Chiao-Yin Sun, Chun-Yu Chen, Yi-Hung Chen, Heng-Jung Hsu, I-Wen Wu, Vin-Cent Wu, and Eric Hoste

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Urinary C–C motif chemokine ligand 14 (CCL14) has been described as an effective marker for delayed recovery of acute kidney injury (AKI), yet its efficacy has been found to vary between different trials. The goal of this research was to assess the predictive performance of urinary CCL14 as a marker for persistent AKI. Methods In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched the PubMed, Embase, and Cochrane databases up to April 2023 for studies of adults (> 18 years) that reported the diagnostic performance of urinary CCL14. The sensitivity, specificity, number of events, true positive, and false positive results were extracted and evaluated. Hierarchical summary receiver operating characteristic curves (HSROCs) were used to summarize the pooled test performance, and the Grading of Recommendations, Assessment, Development and Evaluations criteria were used to appraise the quality of evidence. Results We included six studies with 952 patients in this meta-analysis. The occurrence of persistent AKI among these patients was 39.6% (377/952). The pooled sensitivity and specificity results of urinary CCL14 in predicting persistent AKI were 0.81 (95% CI 0.72–0.87) and 0.71 (95% CI 0.53–0.84), respectively. The pooled positive likelihood ratio (LR) was 2.75 (95% CI 1.63–4.66), and the negative LR was 0.27 (95% CI 0.18–0.41). The HSROC with pooled diagnostic accuracy was 0.84. Conclusion Our results suggest that urinary CCL14 can be used as an effective marker for predicting persistent AKI.

Published
2023
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48. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis

Author

Suvi T. Vaara, MD, PhD, Ary Serpa Neto, MD, PhD, Rinaldo Bellomo, MD, PhD, Neill K. J. Adhikari, MDCM, MSc, Didier Dreyfuss, MD, PhD, Martin Gallagher, MD, PhD, Stephane Gaudry, MD, PhD, Eric Hoste, MD, PhD, Michael Joannidis, MD, Ville Pettilä, MD, PhD, Amanda Y. Wang, MD, PhD, Kianoush Kashani, MD, PhD, Ron Wald, MDCM, MPH, Sean M. Bagshaw, MD, MSc, Marlies Ostermann, MD, PhD, and Sean M Bagshaw

Subjects
Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

OBJECTIVES:. Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN:. Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING:. One hundred-fifty-three ICUs in 13 countries. PATIENTS:. Altogether 2693 critically ill patients with AKI, of whom 994 were North American, 1143 European, and 556 from Australia and New Zealand (ANZ). INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Total mean FB to a maximum of 14 days was +7199 mL in North America, +5641 mL in Europe, and +2211 mL in ANZ (p < 0.001). The median time to RRT initiation among patients allocated to the standard strategy was longest in Europe compared with North America and ANZ (p < 0.001; p < 0.001). Continuous RRT was the initial RRT modality in 60.8% of patients in North America and 56.8% of patients in Europe, compared with 96.4% of patients in ANZ (p < 0.001). After adjustment for predefined baseline characteristics, compared with North American and European patients, those in ANZ were more likely to survive to ICU (p < 0.001) and hospital discharge (p < 0.001) and to 90 days (for ANZ vs. Europe: risk difference [RD], –11.3%; 95% CI, –17.7% to –4.8%; p < 0.001 and for ANZ vs. North America: RD, –10.3%; 95% CI, –17.5% to –3.1%; p = 0.007). CONCLUSIONS:. Among STARRT-AKI trial centers, significant regional practice variation exists regarding FB, timing of initiation of RRT, and initial use of continuous RRT. After adjustment, such practice variation was associated with lower ICU and hospital stay and 90-day mortality among ANZ patients compared with other regions.

Published
2024
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49. The association between Dioscorea sansibarensis and Orrella dioscoreae as a model for hereditary leaf symbiosis.

Author

Tessa Acar, Sandra Moreau, Marie-Françoise Jardinaud, Gabriella Houdinet, Felicia Maviane-Macia, Frédéric De Meyer, Bart Hoste, Olivier Leroux, Olivier Coen, Aurélie Le Ru, Nemo Peeters, and Aurelien Carlier

Subjects
Medicine, Science
Abstract

Hereditary, or vertically-transmitted, symbioses affect a large number of animal species and some plants. The precise mechanisms underlying transmission of functions of these associations are often difficult to describe, due to the difficulty in separating the symbiotic partners. This is especially the case for plant-bacteria hereditary symbioses, which lack experimentally tractable model systems. Here, we demonstrate the potential of the leaf symbiosis between the wild yam Dioscorea sansibarensis and the bacterium Orrella dioscoreae (O. dioscoreae) as a model system for hereditary symbiosis. O. dioscoreae is easy to grow and genetically manipulate, which is unusual for hereditary symbionts. These properties allowed us to design an effective antimicrobial treatment to rid plants of bacteria and generate whole aposymbiotic plants, which can later be re-inoculated with bacterial cultures. Aposymbiotic plants did not differ morphologically from symbiotic plants and the leaf forerunner tip containing the symbiotic glands formed normally even in the absence of bacteria, but microscopic differences between symbiotic and aposymbiotic glands highlight the influence of bacteria on the development of trichomes and secretion of mucilage. This is to our knowledge the first leaf symbiosis where both host and symbiont can be grown separately and where the symbiont can be genetically altered and reintroduced to the host.

Published
2024
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50. Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer’s disease

Author

Sahana Srinivasan, Daliya Kancheva, Sofie De Ren, Takashi Saito, Maude Jans, Fleur Boone, Charysse Vandendriessche, Ine Paesmans, Hervé Maurin, Roosmarijn E. Vandenbroucke, Esther Hoste, Sofie Voet, Isabelle Scheyltjens, Benjamin Pavie, Saskia Lippens, Marius Schwabenland, Marco Prinz, Takaomi Saido, Astrid Bottelbergs, Kiavash Movahedi, Mohamed Lamkanfi, and Geert van Loo

Subjects
Alzheimer’s disease, ß-amyloid, microglia, neuroinflammation, inflammasome, Immunologic diseases. Allergy, RC581-607
Abstract

BackgroundAlzheimer’s disease (AD) is the most common neurodegenerative disorder affecting memory and cognition. The disease is accompanied by an abnormal deposition of ß-amyloid plaques in the brain that contributes to neurodegeneration and is known to induce glial inflammation. Studies in the APP/PS1 mouse model of ß-amyloid-induced neuropathology have suggested a role for inflammasome activation in ß-amyloid-induced neuroinflammation and neuropathology.MethodsHere, we evaluated the in vivo role of microglia-selective and full body inflammasome signalling in several mouse models of ß-amyloid-induced AD neuropathology.ResultsMicroglia-specific deletion of the inflammasome regulator A20 and inflammasome effector protease caspase-1 in the AppNL-G-F and APP/PS1 models failed to identify a prominent role for microglial inflammasome signalling in ß-amyloid-induced neuropathology. Moreover, global inflammasome inactivation through respectively full body deletion of caspases 1 and 11 in AppNL-G-F mice and Nlrp3 deletion in APP/PS1 mice also failed to modulate amyloid pathology and disease progression. In agreement, single-cell RNA sequencing did not reveal an important role for Nlrp3 signalling in driving microglial activation and the transition into disease-associated states, both during homeostasis and upon amyloid pathology.ConclusionCollectively, these results question a generalizable role for inflammasome activation in preclinical amyloid-only models of neuroinflammation.

Published
2024
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