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The third opium war may have already started, not only due to illicit opioid trafficking from the Golden Crescent and Golden Triangle on the international front but also through indiscriminate opioid prescription and opioid diversion at home. Opioid use disorder (OUD), among unintentional injuries, has become one of the top 4 causes of death in the United States (U.S.). An OUD is defined as a problematic pattern of opioid use resulting in clinically significant impairment or distress, consisting of 2 or more of 11 problems within 1 year, as described by the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition. Observation of aberrant behaviors of OUD is also helpful for overworked clinicians. For the prevention of OUD, the Opioid Risk Tool and the Current Opioid Misuse Measure are appropriate screening tests before and during opioid administration, respectively. Treatment of OUD consists of 3 opioid-based U.S. Food and Drug Administration-approved medications, including methadone, buprenorphine, and naltrexone, and non-opioid-based symptomatic medications for reducing opioid withdrawal syndromes, such as α2 agonists, β-blockers, antidiarrheals, antiemetics, non-steroidal anti-inflammatory drugs, and benzodiazepines. There are at least 6 recommendable guidelines and essential terms related to OUD. Opioid stewardship programs are now critical to promoting appropriate use of opioid medications, improving patient outcomes, and reducing misuse of opioids, influenced by the successful implementation of antimicrobial stewardship programs. Despite the lack of previous motivation, now is the critical time for trying to reduce the risk of OUD.

PurposeThe purpose of this study is to develop the scale of the metaverse experience and examine the effect of the metaverse experience on consumer happiness in luxury brands.Design/methodology/approachA survey was distributed to metaverse users from general participants in the Republic of Korea. To reach this goal, the domain of the metaverse experience is defined, items are created through qualitative interviews, the initial scale is refined and then the scale is tested. A total of 262 valid responses were used for exploratory factor analysis (EFA), and 238 data were used for confirmatory factor analysis (CFA). The hypothesis was tested using structural equation modeling (SEM) and SmartPLS 3.0.FindingsThe results showed that the metaverse experience comprises three sub-constructs, namely fantasies, feelings and fun. Also, the metaverse experience affects consumer happiness positively in luxury brands.Originality/valueThis study investigates consumer experience in the metaverse environment. The authors examined the metaverse experience based on the experiential aspects of the consumption of luxury brands and develop the scale development of the metaverse experience. Furthermore, the relationship between metaverse experiences and consumer happiness provides a new perspective in studying metaverse marketing strategy and customer service creation.

BACKGROUND: There have been few studies to verify factors associated with a false-negative interferon-gamma release assay (IGRA) in patients with tuberculous pleurisy. We investigated the clinical relevance of false-negative results of the blood QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and its risk factors in patients diagnosed with pleural tuberculosis (TB). METHODS: Medical records of 650 pleural TB patients in a tertiary hospital between January 2009 and December 2020 were reviewed retrospectively. Patients who underwent the blood QFT-GIT assay and pleural fluid analysis before starting anti-TB medication were included. RESULTS: Of 199 patients with pleural TB who were performed QFT-GIT assay, 36 (18.1%) were false-negative results. These patients tended to be older than those with a positive result (P=0.060). The QFT-GIT-false-negative group of had significantly more comorbidities such as end-stage renal disease (ESRD), haematological cancer or pneumoconiosis than the QFT-GIT-positive group. Hypoproteinaemia and pH >6 in pleural fluid were associated with a false-negative QFT-GIT. Of the 199 patients, 163 (81.9%) were cured or completed anti-TB treatment; 13 patients (6.5%) died. The QFT-GIT-negative patients had significantly worse outcomes including mortality [unfavourable outcome: 33.3% (12/36 patients) in QFT-GIT-negative groups vs. 14.7% (24/163 patients) in QFT-GIT-positive groups, P

The demand for high-performance graphics systems used for artificial intelligence, cloud game, and virtual reality continues to grow; this trend requires graphics systems to achieve ever higher bandwidths. This article proposes a GDDR6 dynamic random access memory (DRAM) with a half-rate clocking architecture and optimized receiver and transmitter to improve high-speed operation. Furthermore, this article adopts a staggered PAD using the redistribution layer (RDL) to reduce the distance to four PADs; it enables the mitigation of bandwidth limitation of half-rate clocking, a lower phase mismatch, and a reduced propagation delay. The proposed half-rate clocking-based GDDR6 DRAM achieves 24 Gb/s/pin on a 1.35-V DRAM process. Also, the power-supply-induced-jitter (PSIJ) value is improved from 9.97 to 3.22 ps, compared to a GDDR6 design using a quarter-rate clocking. In addition, the phase mismatch of the proposed clock distribution network (CDN) is reduced compared to the conventional CDN, resulting in an improvement of the 3-σ value of the phase skew from 4.16 to 2.25 ps.

Auscultation is an important diagnostic method for lung diseases. However, it is a subjective modality and requires a high degree of expertise. To overcome this constraint, artificial intelligence models are being developed. However, these models require performance improvements and do not reflect the actual clinical situation. We aimed to develop an improved deep-learning model learning to detect wheezing in children, based on data from real clinical practice. In this prospective study, pediatric pulmonologists recorded and verified respiratory sounds in 76 pediatric patients who visited a university hospital in South Korea. In addition, structured data, such as sex, age, and auscultation location, were collected. Using our dataset, we implemented an optimal model by transforming it based on the convolutional neural network model. Finally, we proposed a model using a 34-layer residual network with the convolutional block attention module for audio data and multilayer perceptron layers for tabular data. The proposed model had an accuracy of 91.2%, area under the curve of 89.1%, precision of 94.4%, recall of 81%, and F1-score of 87.2%. The deep-learning model proposed had a high accuracy for detecting wheeze sounds. This high-performance model will be helpful for the accurate diagnosis of respiratory diseases in actual clinical practice.

Urinary concentrations of phenols, parabens, and triclocarban have been extensively used as biomarkers of exposure. However, because these compounds are quickly metabolized and excreted in urine, characterizing participants' long-term average exposure from a few spot samples is challenging. To examine the variability of urinary concentrations of these compounds during pregnancy, we quantified four phenols, four parabens, and triclocarban in 357 first morning voids (FMVs) and 203 pooled samples collected during the second and third trimesters of 173 pregnancies. We computed intraclass correlation coefficients (ICCs) by the sample type (FMV and pool) across two trimesters and by the number of composite samples in pools, ranging from 2 to 4, within the same trimester. Among the three compounds detected in more than 50% of the samples, the ICCs across two trimesters were higher in pools (0.29-0.68) than in FMVs (0.17-0.52) and the highest ICC within the same trimester was observed when pooling either two or three composites. Methyl paraben and propyl paraben primarily exposed via cosmetic use had approximately 2-3 times higher ICCs than bisphenol A primarily exposed via diet. Our findings support that within-subject pooling of biospecimens can increase the reproducibility of pregnant women's exposure to these compounds and thus could potentially minimize exposure misclassification.

Artificial graphites have been used in various applications, for example, as anode materials for Li-ion batteries, C/C composites, and electrodes for aluminum smelting, due to their unique mechanical strength and high thermal and electrical conductivity. Artificial graphites can be manufactured by a series of kneading, molding, carbonization and graphitization processes with an additional impregnation process. In this study, the influence of the process variables in the kneading and carbonization/graphitization process on the properties of the resulting carbon block was systemically investigated. During the kneading process, the optimum kneading temperature was 90 °C higher than the softening point of the binder pitch; thus, the binder pitch reached its maximum fluidity. On the other hand, during the carbonization and graphitization process, the structural properties of carbon blocks prepared at different heat treatment temperatures were examined and their structural change and evolution were closely described according to the temperature and divided into low-temperature carbonization and high-temperature carbonization/graphitization. Based on this study, we expect to provide a better understanding of setting the parameters for thermally conductive carbon block manufacturing.

Percutaneous osteoplasty (POP) is defined as the injection of bone cement into various painful bony lesions, refractory to conventional therapy, as an extended technique of percutaneous vertebroplasty (PVP). POP can be applied to benign osteochondral lesions and malignant metastatic lesions throughout the whole skeleton, whereas PVP is restricted to the vertebral body. Common spinal metastases occur in the thoracic (70%), lumbosacral (20%), and cervical (10%) vertebrae, in order of frequency. Extraspinal metastases into the ribs, scapulae, sternum, and humeral head commonly originate from lung and breast cancers; extraspinal metastases into the pelvis and femoral head come from prostate, urinary bladder, colon, and uterine cervical cancers. Pain is aggravated in the dependent (or weight bearing) position, or during movement (or respiration). The tenderness and imaging diagnosis should match. The supposed mechanism of pain relief in POP is the augmentation of damaged bones, thermal and chemical ablation of the nociceptive nerves, and local inhibition of tumor invasion. Adjacent (facet) joint injections may be needed prior to POP (PVP). The length and thickness of the applied needle should be chosen according to the targeted bone. Bone cement is also selected by its osteoconduction, osteoinduction, and osteogenesis. Needle route should be chosen as a shortcut to reach the target bony lesions, without damage to the nerves and vessels. POP is a promising minimally invasive procedure for immediate pain relief. This review provides a technical survey for POPs in painful bony lesions.

Immense research is conducted on the importance and role of omni-channel integration, which affects consumer decision-making. However, considering omni-channel integration in particular is insufficient to account for changes in consumer behavior. Omni-channel agility can provide an understanding of how companies deliver services that meet consumer expectations in response to market changes, such as COVID-19. This research examines the effect of perceived agility on integration quality and intention to reuse omni-channel based on idiosyncratic service experience (ISE). Data were collected for those who have used omni-channel in the US through M-Turk and analyzed on the basis of SEM. Results reveal a positive relationship between perceived agility of digitalized omni-channel and channel integration quality. A positive relationship also exists between perceived agility and reuse intention, which is mediated by the integration quality of omni-channel. This study expands the research on omni-channel integration quality including digital-based perceived agility in channel integration research based on ISE.

A solid electrolyte interphase (SEI) on an anode is a critical issue in lithium-ion batteries because it is related to cycling stability. In this study, we introduce a semi-ionic C F bond on the surface of graphite (SICF) via plasma fluorination to introduce a LiF-based SEI layer on the anode during the first cycle. In the charge-discharge profiles and cyclic voltammetry curves, a peak related to the LiF-based SEI formation was clearly observed for SICF. In particular, SICF had an excellent long-term cycling stability of 98.8% for 100 cycles (1.0 C-rate). From the anodes of the disassembled coin cells, it was found that semi-ionic C F bonds improved the formation of a stable LiF-based SEI layer and decreased the number of side reactions with HF, which was produced from PF5. Moreover, SICF exhibited a lower volume expansion compared to that of the pristine anode and the anode with covalent C F bonds. Therefore, introducing a semi-ionic C F bond via plasma fluorination is a key strategy for forming a LiF-based SEI layer on the graphite anode surface that enhances the cycling stability of lithium-ion batteries.

Service innovation with digital technology such as augmented reality allows brands to deliver additional values to customers, as interactions between brand and customer improve a brand’s performanc...

Servitization, the convergence between new services with the existing products, creates significant value-in-use for both customers and firms. The current study develops measures of servitization experience based on the service-dominant logic and investigates their effect on customer retention, mediated by value-in-use of servitization and brand resonance. First, servitization measures were developed across five stages. Next, the effect of servitization experiences on customer retention was demonstrated. The results show that integrated servitization experience, customized servitization experience, relational servitization experience, and playful servitization experience are the measures of servitization experience, and this servitization experience has a positive influence on customer retention. Additionally, value-in-use of servitization and brand resonance fully and serially mediated the effect of servitization experience on customer retention. Servitization measures help scholars and marketers understand the importance of servitization experience and provide an empirical demonstration of the effect of servitization experience on customers and firms.

With the global rise of the internet economy, firms are increasingly involved in marketing processes with social networking sites (SNSs) as the carrier. In this context, it is important for firms to use parasocial relationships as a promotional tool. This research examines the role that parasocial relationships can play as a strategic tool. It seeks to reveal which attributes possessed by fashion web celebrity endorsers impact parasocial relationship. The work also explores how customer equity is affected by parasocial relationship. The study also investigates the moderating role of brand love in the relationship between fashion web celebrity endorser attributes and parasocial relationship. The findings show that fashion web celebrity endorser attributes of popularity, fashionable and affinity positively affect parasocial relationship. Also, a positive association is found between parasocial relationships and customer equity. The relationships between fashion web celebrity endorser attributes and parasocial relationship are affected differently by brand love.

This special issue of Industrial Marketing Management aims to develop useful knowledge and generate new insights into and applications of digital marketing in B2B markets. This special edition features 11 articles that cover topics related to digital marketing in a B2B context. This introductory paper briefly summarizes the themes of the special issue, introduces each of the eleven articles on innovative digital marketing management in B2B, and provides a rationale for the inclusion of each article.

Effective capture and rapid detection of pathogenic bacteria causing pandemic/epidemic diseases is an important task for global surveillance and prevention of human health threats. Here, we present an advanced approach for the on-site capture and detection of pathogenic bacteria through the combination of hierarchical nanostructures and a nuclease-responsive DNA probe. The specially designed hierarchical nanocilia and network structures on the pillar arrays, termed 3D bacterial capturing nanotopographical trap, exhibit excellent mechanical reliability and rapid (

Augmented Reality (AR) technology shows great potential for marketers and simultaneously puts forward a challenge for established marketing practice. This paper explores the driving factors of flow...

Except for carbamazepine for trigeminal neuralgia, gabapentinoid anticonvulsants have been the standard for the treatment of neuropathic pain. Pregabalin, which followed gabapentin, was developed with the benefit of rapid peak blood concentration and better bioavailability. Mirogabalin besylate (DS-5565, Tarlige®) shows greater sustained analgesia due to a high affinity to, and slow dissociation from, the α2δ-1 subunits in the dorsal root ganglion (DRG). Additionally, it produces a lower level of central nervous system-specific adverse drug reactions (ADRs), due to a low affinity to, and rapid dissociation from, the α2δ-2 subunits in the cerebellum. Maximum plasma concentration is achieved in less than 1 hour, compared to 1 hour for pregabalin and 3 hours for gabapentin. The plasma protein binding is relatively low, at less than 25%. As with all gabapentinoids, it is also largely excreted via the kidneys in an unchanged form, and so the administration dose should also be adjusted according to renal function. The equianalgesic daily dose for 30 mg of mirogabalin is 600 mg of pregabalin and over 1,200 mg of gabapentin. The initial adult dose starts at 5 mg, given orally twice a day, and is gradually increased by 5 mg at an interval of at least a week, to 15 mg. In conclusion, mirogabalin is anticipated to be a novel, safe gabapentinoid anticonvulsant with a greater therapeutic effect for neuropathic pain in the DRG and lower ADRs in the cerebellum.

With the meteoric progress of digital technology and the advent of network economy, there has been increasing interest in the business model of purchasing with B2B network among B2B e-commerce platforms and customer firms. Based on the perspective of parasocial relationship and dual-process theory, this study constructs a model of cognitive and emotional influences on customer firms' behavior, and analyzes the influence of features of entrepreneur endorser and online purchasing platform on B2B parasocial relationship, and how this relationship can affect repeat purchase intention. Furthermore, this paper examines the moderating effect of trust in the relationship between B2B parasocial relationship and repeat purchase intention. Findings indicate that perceived interactivity and trustworthiness of entrepreneur endorser and the service and product quality of online purchasing platform have a positive impact on B2B parasocial relationship. B2B parasocial relationship has a significant and positive impact on repeat purchase intention, while trust moderates the relationship between B2B parasocial relationship and repeat purchase intention.

Although sustainable product companies provide various environmental cues to promote consumer purchasing, these cues do not have the intended effect in many cases. Therefore, this study investigates the effect of the following on purchase intention: interaction between representative environmental cues, that is, sustainable label and traceability, and interaction between sustainable label and consumer knowledge of certification. The results demonstrate that consumers’ purchase intention is highest when sustainable label and traceability information are provided simultaneously. Moreover, when consumer knowledge is high, purchase intention increases only when a sustainable label is provided. However, when consumer knowledge is low, purchase intention increases with a non-sustainable label. Furthermore, perceived risk and product efficacy dually mediate the effect of these interactions on purchase intention. The results imply that purchase intention can be increased by providing more transparent and diverse environmental cues based on information technology, and by increasing consumers’ certification knowledge.