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406 results on '"Kyriacou, C."'

2. Genetic Variants Predict Optimal Timing of Radiotherapy to Reduce Side-effects in Breast Cancer Patients

Author

Azria, David, Brookes, Anthony, Burr, Tom, Chang-Claude, Jenny, Davidson, Susan, De Ruysscher, Dirk, Dunning, Alison, Elliott, Rebecca, Gutiérrez Enríquez, Sara, Lambin, Philippe, Rancati, Tiziana, Rosenstein, Barry, Seibold, Petra, Symonds, R. Paul, Talbot, Chris, Thierens, Hubert, Valdagni, Riccardo, Vega, Ana, Veldeman, Liv, Wenz, Frederik, Yuille, Martin, West, Catharine, Johnson, K., Chang-Claude, J., Critchley, A.-M., Kyriacou, C., Lavers, S., Rattay, T., Seibold, P., Webb, A., West, C., Symonds, R.P., and Talbot, C.J.

Published
2019
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3. Updating M6 pregnancy of unknown location risk‐prediction model including evaluation of clinical factors.

Author

Kyriacou, C., Ledger, A., Bobdiwala, S., Ayim, F., Kirk, E., Abughazza, O., Guha, S., Vathanan, V., Gould, D., Timmerman, D., Van Calster, B., Bourne, T., Pikovsky, M., Mitchell‐Jones, N., Parker, N., Barcroft, J., Kapur, S., Chohan, B., Guruwadahyarhalli, B., and Stalder, C.

Subjects
*MATERNAL age, *TRANSVAGINAL ultrasonography, *PREGNANCY outcomes, *PREGNANCY, *ECTOPIC pregnancy
Abstract

Objectives: Ectopic pregnancy (EP) is a major high‐risk outcome following a pregnancy of unknown location (PUL) classification. Biochemical markers are used to triage PUL as high vs low risk to guide appropriate follow‐up. The M6 model is currently the best risk‐prediction model. We aimed to update the M6 model and evaluate whether performance can be improved by including clinical factors. Methods: This prospective cohort study recruited consecutive PUL between January 2015 and January 2017 at eight units (Phase 1), with two centers continuing recruitment between January 2017 and March 2021 (Phase 2). Serum samples were collected routinely and sent for β‐human chorionic gonadotropin (β‐hCG) and progesterone measurement. Clinical factors recorded were maternal age, pain score, bleeding score and history of EP. Based on transvaginal ultrasonography and/or biochemical confirmation during follow‐up, PUL were classified subsequently as failed PUL (FPUL), intrauterine pregnancy (IUP) or EP (including persistent PUL (PPUL)). The M6 models with (M6P) and without (M6NP) progesterone were refitted and extended with clinical factors. Model validation was performed using internal–external cross‐validation (IECV) (Phase 1) and temporal external validation (EV) (Phase 2). Missing values were handled using multiple imputation. Results: Overall, 5473 PUL were recruited over both phases. A total of 709 PUL were excluded because maternal age was < 16 years or initial β‐hCG was ≤ 25 IU/L, leaving 4764 (87%) PUL for analysis (2894 in Phase 1 and 1870 in Phase 2). For the refitted M6P model, the area under the receiver‐operating‐characteristics curve (AUC) for EP/PPUL vs IUP/FPUL was 0.89 for IECV and 0.84–0.88 for EV, with respective sensitivities of 94% and 92–93%. For the refitted M6NP model, the AUCs were 0.85 for IECV and 0.82–0.86 for EV, with respective sensitivities of 92% and 93–94%. Calibration performance was good overall, but with heterogeneity between centers. Net Benefit confirmed clinical utility. The change in AUC when M6P was extended to include maternal age, bleeding score and history of EP was between −0.02 and 0.01, depending on center and phase. The corresponding change in AUC when M6NP was extended was between −0.01 and 0.03. At the 5% threshold to define high risk of EP/PPUL, extending M6P altered sensitivity by −0.02 to −0.01, specificity by 0.03 to 0.04 and Net Benefit by −0.005 to 0.006. Extending M6NP altered sensitivity by −0.03 to −0.01, specificity by 0.05 to 0.07 and Net Benefit by −0.005 to 0.006. Conclusions: The updated M6 model offers accurate diagnostic performance, with excellent sensitivity for EP. Adding clinical factors to the model improved performance in some centers, especially when progesterone levels were not suitable or unavailable. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Published
2024
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4. OP03.03: MicroRNAs to predict outcome of pregnancy of unknown location and diagnose ectopic pregnancy: localising expression in tubal and trophoblast tissue

Author

Kyriacou, C., primary, Kim, S., additional, Pikovsky, M., additional, Bobdiwala, S., additional, Cooper, N., additional, Barcroft, J., additional, Parker, N., additional, Novak, A., additional, Murugesu, S., additional, Al‐Memar, M., additional, Bennett, P., additional, MacIntyre, D., additional, Bourne, T., additional, and Terzidou, V., additional

Published
2023
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5. OC04.01: A prospective cohort study to assess the use of cfDNA in miscarriage to detect chromosomal abnormalities*

Author

Parker, N., primary, Grewal, K., additional, Fisher, A., additional, Novak, A., additional, Kyriacou, C., additional, Barcroft, J., additional, Pikovsky, M., additional, Morgan, S., additional, Barrett, A., additional, Colley, E., additional, Young, E., additional, Allen, S., additional, Bennett, P., additional, and Bourne, T., additional

Published
2023
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6. OC04.05: Exploring novel serum biomarkers for pregnancy of unknown location risk prediction and ectopic pregnancy diagnosis

Author

Kyriacou, C., primary, Tuttle, I., additional, Kim, S., additional, Bobdiwala, S., additional, Fourie, H., additional, Pikovsky, M., additional, Parker, N., additional, Barcroft, J., additional, Novak, A., additional, Murugesu, S., additional, Cooper, N., additional, Al‐Memar, M., additional, Bennett, P., additional, Terzidou, V., additional, and Bourne, T., additional

Published
2023
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7. OP14.05: The classification and management of adnexal masses identified in pregnancy

Author

Barcroft, J., primary, Pandrich, M., additional, Landolfo, C., additional, Del Forno, S., additional, Parker, N., additional, Cooper, N., additional, Pikovsky, M., additional, Murugesu, S., additional, Novak, A., additional, Kyriacou, C., additional, Al‐Memar, M., additional, Yazbek, J., additional, Timmerman, D., additional, Saso, S., additional, and Bourne, T., additional

Published
2023
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10. OP18.01: Transabdominal and transvaginal ultrasonography assessment of the female pelvis in children, adolescents and young adults

Author

Cooper, N., primary, Meehan, H., additional, Linton‐Reid, K., additional, Barcroft, J., additional, Murugesu, S., additional, Kyriacou, C., additional, Novak, A., additional, Pikovsky, M., additional, Parker, N., additional, Yazbek, J., additional, Landolfo, C., additional, Saso, S., additional, Fotopoulou, C., additional, Bharwani, N., additional, Timmerman, D., additional, Bourne, T., additional, and Al‐Memar, M., additional

Published
2023
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12. OC03.08: Automated segmentation and radiomics based classification of adnexal masses on ultrasound

Author

Barcroft, J., primary, Linton‐Reid, K., additional, Munaretto, M., additional, Lee, S., additional, Kim, J., additional, Savelli, L., additional, Bharwani, N., additional, Posma, J., additional, Landolfo, C., additional, Kyriacou, C., additional, Parker, N., additional, Al‐Memar, M., additional, Saso, S., additional, Aboagye, E., additional, and Bourne, T., additional

Published
2023
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13. OC03.05: Ovarian masses found at ultrasonography assessment of the pelvis in children, adolescents and young adults: a review of 1,429 cases

Author

Cooper, N., primary, Meehan, H., additional, Linton‐Reid, K., additional, Barcroft, J., additional, Murugesu, S., additional, Kyriacou, C., additional, Novak, A., additional, Pikovsky, M., additional, Parker, N., additional, Yazbek, J., additional, Fotopoulou, C., additional, Landolfo, C., additional, Saso, S., additional, Bharwani, N., additional, Timmerman, D., additional, Bourne, T., additional, and Al‐Memar, M., additional

Published
2023
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17. EP23.10: Comparing handheld point of care ultrasound with high specification ultrasound in gynecology.

Author

Novak, A.M., Cooper, N., Parker, N., Pikovsky, M., Barcroft, J., Murugesu, S., Kyriacou, C., Lockett, G., Thomson, A.R., Stalder, C., Landolfo, C., Al‐Memar, M., and Bourne, T.

Subjects
TRANSVAGINAL ultrasonography, POINT-of-care testing, TEACHING hospitals, ULTRASONIC imaging, OVARIES
Abstract

This article discusses a study that compared the performance of handheld point of care ultrasound (POCUS) with high-specification ultrasound in gynecology. The study involved 155 patients at a London teaching hospital, with one sonologist using POCUS and another using the standard high-specification machine. The results showed moderate correlation in uterine measurements, fair agreement for endometrial thickness, and slight agreement on ovary visualization. However, POCUS had improved performance when a cyst was present. The article concludes that POCUS may be a useful adjunct in gynecology, particularly in settings with limited access to ultrasound, but more data is needed for certain populations. [Extracted from the article]

Published
2024
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21. Comparing time effectiveness and convenience of ultraviolet vaginal ultrasound probe disinfection with chlorine dioxide multistep wipe system: prospective survey study

Author

Kyriacou, C, Robinson, E, Barcroft, J, Parker, N, Tuomey, M, Stalder, C, Gould, D, Al-Memar, M, and Bourne, T

Subjects
Disinfection, ultraviolet, gynecology, Humans, 1114 Paediatrics and Reproductive Medicine, health and safety, Oxides, Prospective Studies, ultrasonography, chlorine dioxide, Chlorine Compounds, Obstetrics & Reproductive Medicine, health & safety
Abstract

OBJECTIVES: To compare efficiency, ease of use, and user satisfaction of two methods of transvaginal ultrasound probe high-level disinfection: Ultraviolet (UV-C) (Germitec Hypernova Chronos) and a chlorine dioxide multi-step wipe system (Tristel Trio). METHODS: This was a prospective survey study. UV-C units were introduced into a busy Early Pregnancy Assessment Unit and compared with a multi-wipe system. Healthcare professionals (HCP's) measured time taken to complete a cycle of disinfection before each patient with the system allocated to that room using a stopwatch and recorded their responses using a quick response (QR) code-linked survey. Additional necessary tasks that could be completed before seeing the next patient as probe disinfection was ongoing were also documented. Using another QR code-linked survey, data on ease of use, satisfaction of the system used, and preference was collected. A section for free-text comments was then completed. RESULTS: Disinfection using UV-C (n=331) was 60% faster than the chlorine dioxide multi-wipe system (n=332) (101 vs 250 seconds, p

Published
2021

22. Ultrasound characteristics, serum biochemistry and outcomes for ectopic pregnancies presenting during the SARS-CoV-2 pandemic: retrospective analysis

Author

Kyriacou, C, Cooper, N, Robinson, E, Parker, N, Barcroft, J, Kundu, S, Letchworth, P, Sur, S, Gould, D, Stalder, C, and Bourne, T

Subjects
Technology, early pregnancy, Science & Technology, SARS-CoV-2, ultrasound, Radiology, Nuclear Medicine & Medical Imaging, gynecology, Obstetrics & Gynecology, COVID-19, Acoustics, ectopic pregnancy, 1114 Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Life Sciences & Biomedicine
Abstract

OBJECTIVES: To describe and then compare the characteristics of ectopic pregnancies (EP) in the year prior to and then during the SARS-CoV-2 pandemic. METHODS: This was a retrospective analysis from 1st January 2019 to 31st December 2020 of women diagnosed with an EP (n=275) at a London dual center early pregnancy assessment service. Women were identified via the AstraiaTM ultrasound reporting system using coded and non-coded outcomes of 'EP' or 'pregnancy outside the uterine cavity'. Data relating to predefined outcomes were collected using AstraiaTM and CernerTM electronic reporting systems. Main outcome measures included clinical, ultrasound and biochemical features of EP, in addition to reported complications and management. Statistical analysis was carried out using GraphPad Prism v8.2.1. RESULTS: Similar numbers and proportions of EP were seen in 2019 (n=141, 1%) and 2020 (n=134, 1%). Both cohorts were comparable in age, ethnicity, weight and method of conception. Gestational age at first ultrasound and at diagnosis was similar, with no difference in EP location, size or morphology. Human chorionic gonadotrophin (hCG) levels at time of EP diagnosis were higher in 2020 than 2019 (1005 IU/L vs 665 IU/L, p=0.03). The type of final EP management was similar, but more failed first line management during the pandemic (16% vs 6%, p=0.01). Rates of blood visualized on ultrasound within the pelvis (hemoperitoneum) (23% vs 27%, p=0.58) and of rupture confirmed surgically (9% vs 3%, p=0.07) were both similar. CONCLUSIONS: No difference was observed in the location, size, morphology and gestational age of ectopic pregnancies. Complication rates and management were also unchanged. HCG levels were higher, and a greater proportion of conservative management measures failed during the pandemic. Our findings suggest women continued to access appropriate care for EP during the SARS-CoV-2 pandemic, with no evidence of diagnostic delay or increase in adverse outcomes in our population. This article is protected by copyright. All rights reserved.

Published
2021

25. OC15.02: Development, validation and comparison of models predicting outcomes in pregnancies of unknown location using regression and machine learning models.

Author

Kyriacou, C., Ledger, A., Bobdiwala, S., Ayim, F., Kirk, E., Abughazza, O., Guha, S., Vathanan, V., Gould, D., Timmerman, D., Van Calster, B., and Bourne, T.

Subjects
*MACHINE learning, *PREGNANCY outcomes, *RECEIVER operating characteristic curves, *ECTOPIC pregnancy, *SUPPORT vector machines
Abstract

This article discusses the development, validation, and comparison of multiclass prediction models for ectopic pregnancy (EP) following a pregnancy of unknown location (PUL) classification. The study used two datasets and six algorithms to develop and validate the models. The results showed that most models performed similarly well, but the estimated risks for an individual varied between models. This research provides valuable insights into predicting outcomes in pregnancies of unknown location and highlights the importance of considering different algorithms for accurate risk assessment. [Extracted from the article]

Published
2024
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26. EP21.27: Reducing intrusive memories after early pregnancy loss using a brief cognitive task involving Tetris computer gameplay: a randomised controlled trial.

Author

Parker, N., Elhag, B., Barcroft, J., Kyriacou, C., Novak, A.M., Pikovsky, M., Holmes, E.A., and Bourne, T.

Subjects
EPISODIC memory, MISCARRIAGE, ECTOPIC pregnancy, MENTAL illness, RANDOMIZED controlled trials, POST-traumatic stress disorder
Abstract

A study published in the journal "Ultrasound in Obstetrics & Gynecology" explores the effectiveness of a brief cognitive intervention in reducing intrusive memories following early pregnancy loss (EPL). The intervention involved a memory reminder and playing Tetris computer gameplay using mental rotation. Participants were randomly assigned to either the intervention group or a control group, and the frequency of intrusive memories was recorded for one week. The results showed that the intervention group reported significantly fewer intrusive memories compared to the control group. Further analysis is needed to assess the long-term impact of the intervention on mental health problems associated with EPL. [Extracted from the article]

Published
2024
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27. EP21.09: A pilot study to evaluate the use of virtual reality as a distraction technique during manual vacuum aspiration.

Author

Parker, N., Sandhar, S., Tuomey, M., Kyriacou, C., Barcroft, J., Elhag, B., Pikovsky, M., Murugesu, S., Stalder, C., Sur, S., Al‐Memar, M., and Bourne, T.

Subjects
VACUUM curettage, PATIENT experience, SATISFACTION, PATIENT satisfaction, LIKERT scale
Abstract

This article discusses a pilot study that aimed to evaluate the use of virtual reality (VR) as a distraction technique during manual vacuum aspiration (MVA) treatment of miscarriage. The study found that most women who used VR reported a reduction in procedural anxiety and pain, as well as an improved overall experience. However, there was no significant difference in pain or anxiety scores between the VR group and the group without VR during or after the procedure. Overall, the study suggests that VR can be a useful tool in improving patient experience during MVA, but further research is needed to eliminate potential biases. [Extracted from the article]

Published
2024
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28. OP09.02: Comparing handheld point of care ultrasound to standard care with transvaginal ultrasound in early pregnancy.

Author

Novak, A.M., Cooper, N., Parker, N., Pikovsky, M., Barcroft, J., Murugesu, S., Kyriacou, C., Elhag, B., Lockett, G., Thomson, A.R., Stalder, C., Al‐Memar, M., and Bourne, T.

Subjects
TRANSVAGINAL ultrasonography, FETAL heart, POINT-of-care testing, TEACHING hospitals, ULTRASONIC imaging
Abstract

A study conducted at a London teaching hospital compared the performance of handheld Point of Care Ultrasound (POCUS) to standard care with transvaginal ultrasound (TVUS) in early pregnancy. The study found that there was almost perfect agreement between POCUS and TVUS in identifying the presence or absence of a gestational sac, embryo, fetal heart motion, and diagnostic outcome. There was also a very high correlation between the two methods for measuring mean sac diameter and Crown-rump length. The study concludes that while POCUS can provide similar diagnosis and management plans, it should be used for triage purposes and not as a replacement for standard care. [Extracted from the article]

Published
2024
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29. OC05.01: *Prospective validation of an end‐to‐end machine learning‐based model for the classification of adnexal masses using ultrasonography.

Author

Barcroft, J., Linton‐Reid, K., Munaretto, M., Fantauzzi, M., Kim, J., Murugesu, S., Parker, N., Kyriacou, C., Novak, A.M., Pikovsky, M., Cooper, N., Lee, S., Savelli, L., Thomson, A.R., Yazbek, J., Stalder, C., Bharwani, N., Posma, J., Timmerman, D., and Al‐Memar, M.

Subjects
TRANSVAGINAL ultrasonography, PEARSON correlation (Statistics), SENSITIVITY & specificity (Statistics), DEEP learning, RECEIVER operating characteristic curves
Abstract

This article discusses the validation of a machine learning model for classifying adnexal masses using ultrasonography. The model was tested on two cohorts of women with adnexal masses, one in London and one in Seoul. The model's performance was compared to the Assessment of Different NEoplasia's in the adneXa (ADNEX) model. The results showed that the machine learning model had comparable performance to the ADNEX model in both cohorts. However, further validation is needed before the model can be integrated into clinical practice. [Extracted from the article]

Published
2024
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31. OC03.02: *Management of adnexal masses identified during pregnancy

Author

Barcroft, J., primary, Landolfo, C., additional, Del Forno, S., additional, Chang, K., additional, Parker, N., additional, Kyriacou, C., additional, Al‐Memar, M., additional, Yazbek, J., additional, Stalder, C., additional, Timmerman, D., additional, Srdjan, S., additional, and Bourne, T., additional

Published
2021
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41. A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila

Author

Allebrandt, K V, Amin, N, Müller-Myhsok, B, Esko, T, Teder-Laving, M, Azevedo, R V D M, Hayward, C, van Mill, J, Vogelzangs, N, Green, E W, Melville, S A, Lichtner, P, Wichmann, H-E, Oostra, B A, Janssens, A C J W, Campbell, H, Wilson, J F, Hicks, A A, Pramstaller, P P, Dogas, Z, Rudan, I, Merrow, M, Penninx, B, Kyriacou, C P, Metspalu, A, van Duijn, C M, Meitinger, T, and Roenneberg, T

Published
2013
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44. External validation of models to predict the outcome of pregnancies of unknown location: a multicentre cohort study

Author

Christodoulou, E, primary, Bobdiwala, S, additional, Kyriacou, C, additional, Farren, J, additional, Mitchell‐Jones, N, additional, Ayim, F, additional, Chohan, B, additional, Abughazza, O, additional, Guruwadahyarhalli, B, additional, Al‐Memar, M, additional, Guha, S, additional, Vathanan, V, additional, Gould, D, additional, Stalder, C, additional, Wynants, L, additional, Timmerman, D, additional, Bourne, T, additional, and Van Calster, B, additional

Published
2020
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45. OC09.04: Assessing progesterone cut‐off levels in pregnancies classified as a pregnancy of unknown location using transvaginal ultrasonography

Author

Kyriacou, C., primary, Bobdiwala, S., additional, Doulgeraki, T., additional, Fourie, H., additional, Farren, J., additional, Mitchell‐Jones, N., additional, Ayim, F., additional, Chohan, B., additional, Guha, S., additional, Kirk, E., additional, Abhugazza, O., additional, Al‐Memar, M., additional, Vathanan, V., additional, Gould, D., additional, Stalder, C., additional, Timmerman, D., additional, and Bourne, T., additional

Published
2020
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