1. Evaluation of a Magnetic Compression Anastomosis for Jejunoileal Partial Diversion in Rhesus Macaques
- Author
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Evans, Lauren L, Lee, William G, Karimzada, Mohammad, Patel, Veeshal H, Aribindi, Vamsi K, Kwiat, Dillon, Graham, James L, Cummings, David E, Havel, Peter J, and Harrison, Michael R
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Nutrition and Dietetics ,Nutrition ,Obesity ,Diabetes ,Metabolic and endocrine ,Insulin resistance ,Metabolic surgery ,Staple-free anastomosis ,Magnetic compression device ,Magnamosis ,Small-bowel anastomosis ,Public Health and Health Services ,Surgery ,Clinical sciences ,Nutrition and dietetics ,Public health - Abstract
PurposeMetabolic surgery remains underutilized for treating type 2 diabetes, as less invasive alternative interventions with improved risk profiles are needed. We conducted a pilot study to evaluate the feasibility of a novel magnetic compression device to create a patent limited caliber side-to-side jejunoileal partial diversion in a nonhuman primate model.Materials and methodsUsing an established nonhuman primate model of diet-induced insulin resistance, a magnetic compression device was used to create a side-to-side jejunoileal anastomosis. Primary outcomes evaluated feasibility (e.g., device mating and anastomosis patency) and safety (e.g., device-related complications). Secondary outcomes evaluated the device's ability to produce metabolic changes associated with jejunoileal partial diversion (e.g., homeostatic model assessment of insulin resistance [HOMA-IR] and body weight).ResultsDevice mating, spontaneous detachment, and excretion occurred in all animals (n = 5). There were no device-related adverse events. Upon completion of the study, ex vivo anastomoses were widely patent with healthy mucosa and no evidence of stricture. At 6 weeks post-device placement, HOMA-IR improved to below baseline values (p
- Published
- 2023