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590 results on '"Kwee, Ivo"'

1. PI3Kδ activation, IL6 overexpression, and CD37 loss cause resistance to naratuximab emtansine in lymphomas

Author

Arribas, Alberto J., Napoli, Sara, Gaudio, Eugenio, Herbaux, Charles, Cannas, Eleonora, Tarantelli, Chiara, Pittau Bordone, Roberta, Cascione, Luciano, Munz, Nicolas, Aresu, Luca, Sgrignani, Jacopo, Rinaldi, Andrea, Kwee, Ivo, Rossi, Davide, Cavalli, Andrea, Zucca, Emanuele, Stussi, Georg, Stathis, Anastasios, Sloss, Callum, Davids, Matthew S., and Bertoni, Francesco

Published
2024
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2. Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing

Author

Delaleu, Nicolas, Marti, Hans-Peter, Strauss, Philipp, Sekulic, Miroslav, Osman, Tarig, Tøndel, Camilla, Skrunes, Rannveig, Leh, Sabine, Svarstad, Einar, Nowak, Albina, Gaspert, Ariana, Rusu, Elena, Kwee, Ivo, Rinaldi, Andrea, Flatberg, Arnar, and Eikrem, Oystein

Published
2023
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4. Patients with ankylosing spondylitis present a distinct CD8 T cell subset with osteogenic and cytotoxic potential

Author

Martini, Veronica; https://orcid.org/0000-0002-6086-0358, Silvestri, Ylenia, Ciurea, Adrian; https://orcid.org/0000-0002-7870-7132, Möller, Burkhard; https://orcid.org/0000-0001-8769-6167, Danelon, Gabriela, Flamigni, Flavio, Jarrossay, David; https://orcid.org/0000-0002-0924-6395, Kwee, Ivo, Foglierini, Mathilde; https://orcid.org/0000-0001-7538-4262, Rinaldi, Andrea, Cecchinato, Valentina; https://orcid.org/0000-0001-7415-8706, Uguccioni, Mariagrazia; https://orcid.org/0000-0002-9570-7011, Martini, Veronica; https://orcid.org/0000-0002-6086-0358, Silvestri, Ylenia, Ciurea, Adrian; https://orcid.org/0000-0002-7870-7132, Möller, Burkhard; https://orcid.org/0000-0001-8769-6167, Danelon, Gabriela, Flamigni, Flavio, Jarrossay, David; https://orcid.org/0000-0002-0924-6395, Kwee, Ivo, Foglierini, Mathilde; https://orcid.org/0000-0001-7538-4262, Rinaldi, Andrea, Cecchinato, Valentina; https://orcid.org/0000-0001-7415-8706, and Uguccioni, Mariagrazia; https://orcid.org/0000-0002-9570-7011

Abstract

OBJECTIVES Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease affecting mainly the axial skeleton. Peripheral involvement (arthritis, enthesitis and dactylitis) and extra-musculoskeletal manifestations, including uveitis, psoriasis and bowel inflammation, occur in a relevant proportion of patients. AS is responsible for chronic and severe back pain caused by local inflammation that can lead to osteoproliferation and ultimately spinal fusion. The association of AS with the human leucocyte antigen-B27 gene, together with elevated levels of chemokines, CCL17 and CCL22, in the sera of patients with AS, led us to study the role of CCR4$^{+}$ T cells in the disease pathogenesis. METHODS CD8$^{+}$CCR4$^{+}$ T cells isolated from the blood of patients with AS (n=76) or healthy donors were analysed by multiparameter flow cytometry, and gene expression was evaluated by RNA sequencing. Patients with AS were stratified according to the therapeutic regimen and current disease score. RESULTS CD8$^{+}$CCR4$^{+}$ T cells display a distinct effector phenotype and upregulate the inflammatory chemokine receptors CCR1, CCR5, CX3CR1 and L-selectin CD62L, indicating an altered migration ability. CD8$^{+}$CCR4$^{+}$ T cells expressing CX3CR1 present an enhanced cytotoxic profile, expressing both perforin and granzyme B. RNA-sequencing pathway analysis revealed that CD8$^{+}$CCR4$^{+}$ T cells from patients with active disease significantly upregulate genes promoting osteogenesis, a core process in AS pathogenesis. CONCLUSIONS Our results shed light on a new molecular mechanism by which T cells may selectively migrate to inflammatory loci, promote new bone formation and contribute to the pathological ossification process observed in AS.

Published
2024

5. Copanlisib synergizes with conventional and targeted agents including venetoclax in B- and T-cell lymphoma models

Author

Tarantelli, Chiara, Lange, Martin, Gaudio, Eugenio, Cascione, Luciano, Spriano, Filippo, Kwee, Ivo, Arribas, Alberto J., Rinaldi, Andrea, Jourdan, Thibaud, Berthold, Melanie, Sturz, Andrea, Sperl, Carolyn, Margheriti, Francesco, Scalise, Lorenzo, Gritti, Giuseppe, Rossi, Davide, Stathis, Anastasios, Liu, Ningshu, Zucca, Emanuele, Politz, Oliver, and Bertoni, Francesco

Published
2020
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6. Patients with ankylosing spondylitis present a distinct CD8 T cell subset with osteogenic and cytotoxic potential

Author

Martini, Veronica, primary, Silvestri, Ylenia, additional, Ciurea, Adrian, additional, Möller, Burkhard, additional, Danelon, Gabriela, additional, Flamigni, Flavio, additional, Jarrossay, David, additional, Kwee, Ivo, additional, Foglierini, Mathilde, additional, Rinaldi, Andrea, additional, Cecchinato, Valentina, additional, and Uguccioni, Mariagrazia, additional

Published
2024
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7. Dynamics in protein translation sustaining T cell preparedness

Author

Wolf, Tobias, Jin, Wenjie, Zoppi, Giada, Vogel, Ian A., Akhmedov, Murodzhon, Bleck, Christopher K. E., Beltraminelli, Tim, Rieckmann, Jan C., Ramirez, Neftali J., Benevento, Marco, Notarbartolo, Samuele, Bumann, Dirk, Meissner, Felix, Grimbacher, Bodo, Mann, Matthias, Lanzavecchia, Antonio, Sallusto, Federica, Kwee, Ivo, and Geiger, Roger

Published
2020
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8. PI3Kδ activation, IL6 over-expression, and CD37 loss cause resistance to the targeting of CD37-positive lymphomas with the antibody-drug conjugate naratuximab emtansine

Author

Arribas, Alberto J., primary, Gaudio, Eugenio, additional, Napoli, Sara, additional, Yvon Herbaux, Charles Jean, additional, Tarantelli, Chiara, additional, Bordone, Roberta Pittau, additional, Cascione, Luciano, additional, Munz, Nicolas, additional, Aresu, Luca, additional, Sgrignani, Jacopo, additional, Rinaldi, Andrea, additional, Kwee, Ivo, additional, Rossi, Davide, additional, Cavalli, Andrea, additional, Zucca, Emanuele, additional, Stussi, Georg, additional, Stathis, Anastasios, additional, Sloss, Callum, additional, Davids, Matthew S., additional, and Bertoni, Francesco, additional

Published
2023
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10. A Fast Prize-Collecting Steiner Forest Algorithm for Functional Analyses in Biological Networks

Author

Akhmedov, Murodzhon, LeNail, Alexander, Bertoni, Francesco, Kwee, Ivo, Fraenkel, Ernest, Montemanni, Roberto, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Salvagnin, Domenico, editor, and Lombardi, Michele, editor

Published
2017
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11. BET bromodomain inhibitor birabresib in mantle cell lymphoma: in vivo activity and identification of novel combinations to overcome adaptive resistance

Author

Tarantelli, Chiara, Bernasconi, Elena, Gaudio, Eugenio, Cascione, Luciano, Restelli, Valentina, Arribas, Alberto Jesus, Spriano, Filippo, Rinaldi, Andrea, Mensah, Afua Adjeiwaa, Kwee, Ivo, Ponzoni, Maurilio, Zucca, Emanuele, Carrassa, Laura, Riveiro, Maria E., Rezai, Keyvan, Stathis, Anastasios, Cvitkovic, Esteban, and Bertoni, Francesco

Published
2018
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12. Gradient-based Reinforcement Planning in Policy-Search Methods

Author

Kwee, Ivo, Hutter, Marcus, and Schmidhuber, Juergen

Subjects
Computer Science - Artificial Intelligence, I.2, I.2.6, I.2.8
Abstract

We introduce a learning method called ``gradient-based reinforcement planning'' (GREP). Unlike traditional DP methods that improve their policy backwards in time, GREP is a gradient-based method that plans ahead and improves its policy before it actually acts in the environment. We derive formulas for the exact policy gradient that maximizes the expected future reward and confirm our ideas with numerical experiments., Comment: This is an extended version of the paper presented at the EWRL 2001 in Utrecht (The Netherlands)

Published
2001

13. Market-Based Reinforcement Learning in Partially Observable Worlds

Author

Kwee, Ivo, Hutter, Marcus, and Schmidhuber, Juergen

Subjects
Computer Science - Artificial Intelligence, Computer Science - Learning, Computer Science - Multiagent Systems, Computer Science - Neural and Evolutionary Computing, I.2
Abstract

Unlike traditional reinforcement learning (RL), market-based RL is in principle applicable to worlds described by partially observable Markov Decision Processes (POMDPs), where an agent needs to learn short-term memories of relevant previous events in order to execute optimal actions. Most previous work, however, has focused on reactive settings (MDPs) instead of POMDPs. Here we reimplement a recent approach to market-based RL and for the first time evaluate it in a toy POMDP setting., Comment: 8 LaTeX pages, 2 postscript figures

Published
2001

14. Towards a Bayesian framework for optical tomography

Author

Kwee, Ivo Widjaja

Subjects
519.5, Maximum likelihood, Image reconstruction
Abstract

Maximum likelihood (ML) is a well established method for general parameter estimation. However in its original formulation, ML applied to the image reconstruction problem in Optical Tomography has two serious inadequacies. One is that ML is incapable of distinguishing noise in the data, leading to spurious artifact in the image. The other drawback is that ML does not provide a way to include any prior information about the object that might be available. Noise regularisation is a major concern in imaging and ill-posed inverse problems in general. The aim of this research is to improve the existing imaging algorithm for Optical Tomography. In this thesis we have taken two approaches to the problem. In the first approach we introduce a full maximum likelihood (FML) method which estimates the noise level concurrently. We show that FML in combination with a proposed method of hold-out validation is able to determine a nearly optimal estimate without overfitting to the noise in the data. In the second approach, we will propose a Bayesian method that uses the so-called normal- Wishart density as a parametric prior. We will show that for low degrees of freedom this choice of prior has robust imaging properties and that in some cases the prior can even increase the image resolution (compared to the ML image) but still retain good suppression of noise. We show how graphical modelling can assist in building complex probabilistic models and give examples for the implementation using a developed C++ library. Throughout the thesis, methods are validated by reconstruction examples using simulated data. In the final chapter, we will also present images from real experimental data.

Published
2000

15. Myc controls NK cell development, IL-15-driven expansion, and translational machinery

Author

Khameneh, Hanif J, primary, Fonta, Nicolas, additional, Zenobi, Alessandro, additional, Niogret, Charlène, additional, Ventura, Pedro, additional, Guerra, Concetta, additional, Kwee, Ivo, additional, Rinaldi, Andrea, additional, Pecoraro, Matteo, additional, Geiger, Roger, additional, Cavalli, Andrea, additional, Bertoni, Francesco, additional, Vivier, Eric, additional, Trumpp, Andreas, additional, and Guarda, Greta, additional

Published
2023
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16. Data from Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis

Author

Virgilio, Tommaso, primary, Bordini, Joy, primary, Cascione, Luciano, primary, Sartori, Giulio, primary, Latino, Irene, primary, Molina Romero, Daniel, primary, Leoni, Cristina, primary, Akhmedov, Murodzhon, primary, Rinaldi, Andrea, primary, Arribas, Alberto J., primary, Morone, Diego, primary, Seyed Jafari, S. Morteza, primary, Bersudsky, Marina, primary, Ottolenghi, Aner, primary, Kwee, Ivo, primary, Chiaravalli, Anna Maria, primary, Sessa, Fausto, primary, Hunger, Robert E., primary, Bruno, Antonino, primary, Mortara, Lorenzo, primary, Voronov, Elena, primary, Monticelli, Silvia, primary, Apte, Ron N., primary, Bertoni, Francesco, primary, and Gonzalez, Santiago F., primary

Published
2023
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17. Supplementary Figure from Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis

Author

Virgilio, Tommaso, primary, Bordini, Joy, primary, Cascione, Luciano, primary, Sartori, Giulio, primary, Latino, Irene, primary, Molina Romero, Daniel, primary, Leoni, Cristina, primary, Akhmedov, Murodzhon, primary, Rinaldi, Andrea, primary, Arribas, Alberto J., primary, Morone, Diego, primary, Seyed Jafari, S. Morteza, primary, Bersudsky, Marina, primary, Ottolenghi, Aner, primary, Kwee, Ivo, primary, Chiaravalli, Anna Maria, primary, Sessa, Fausto, primary, Hunger, Robert E., primary, Bruno, Antonino, primary, Mortara, Lorenzo, primary, Voronov, Elena, primary, Monticelli, Silvia, primary, Apte, Ron N., primary, Bertoni, Francesco, primary, and Gonzalez, Santiago F., primary

Published
2023
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18. Supplementary Data from Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis

Author

Virgilio, Tommaso, primary, Bordini, Joy, primary, Cascione, Luciano, primary, Sartori, Giulio, primary, Latino, Irene, primary, Molina Romero, Daniel, primary, Leoni, Cristina, primary, Akhmedov, Murodzhon, primary, Rinaldi, Andrea, primary, Arribas, Alberto J., primary, Morone, Diego, primary, Seyed Jafari, S. Morteza, primary, Bersudsky, Marina, primary, Ottolenghi, Aner, primary, Kwee, Ivo, primary, Chiaravalli, Anna Maria, primary, Sessa, Fausto, primary, Hunger, Robert E., primary, Bruno, Antonino, primary, Mortara, Lorenzo, primary, Voronov, Elena, primary, Monticelli, Silvia, primary, Apte, Ron N., primary, Bertoni, Francesco, primary, and Gonzalez, Santiago F., primary

Published
2023
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19. Supplemental Table S4 from The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs

Author

Boi, Michela, primary, Gaudio, Eugenio, primary, Bonetti, Paola, primary, Kwee, Ivo, primary, Bernasconi, Elena, primary, Tarantelli, Chiara, primary, Rinaldi, Andrea, primary, Testoni, Monica, primary, Cascione, Luciano, primary, Ponzoni, Maurilio, primary, Mensah, Afua Adjeiwaa, primary, Stathis, Anastasios, primary, Stussi, Georg, primary, Riveiro, María Eugenia, primary, Herait, Patrice, primary, Inghirami, Giorgio, primary, Cvitkovic, Esteban, primary, Zucca, Emanuele, primary, and Bertoni, Francesco, primary

Published
2023
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20. Supplemental Figures S1-2 from The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs

Author

Boi, Michela, primary, Gaudio, Eugenio, primary, Bonetti, Paola, primary, Kwee, Ivo, primary, Bernasconi, Elena, primary, Tarantelli, Chiara, primary, Rinaldi, Andrea, primary, Testoni, Monica, primary, Cascione, Luciano, primary, Ponzoni, Maurilio, primary, Mensah, Afua Adjeiwaa, primary, Stathis, Anastasios, primary, Stussi, Georg, primary, Riveiro, María Eugenia, primary, Herait, Patrice, primary, Inghirami, Giorgio, primary, Cvitkovic, Esteban, primary, Zucca, Emanuele, primary, and Bertoni, Francesco, primary

Published
2023
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21. Table S5 from The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents

Author

Spriano, Filippo, primary, Chung, Elaine Yee Lin, primary, Gaudio, Eugenio, primary, Tarantelli, Chiara, primary, Cascione, Luciano, primary, Napoli, Sara, primary, Jessen, Katti, primary, Carrassa, Laura, primary, Priebe, Valdemar, primary, Sartori, Giulio, primary, Graham, Garrett, primary, Selvanathan, Saravana P., primary, Cavalli, Andrea, primary, Rinaldi, Andrea, primary, Kwee, Ivo, primary, Testoni, Monica, primary, Genini, Davide, primary, Ye, B. Hilda, primary, Zucca, Emanuele, primary, Stathis, Anastasios, primary, Lannutti, Brian, primary, Toretsky, Jeffrey A., primary, and Bertoni, Francesco, primary

Published
2023
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22. Table S2 from PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy

Author

Tarantelli, Chiara, primary, Gaudio, Eugenio, primary, Arribas, Alberto J., primary, Kwee, Ivo, primary, Hillmann, Petra, primary, Rinaldi, Andrea, primary, Cascione, Luciano, primary, Spriano, Filippo, primary, Bernasconi, Elena, primary, Guidetti, Francesca, primary, Carrassa, Laura, primary, Pittau, Roberta Bordone, primary, Beaufils, Florent, primary, Ritschard, Reto, primary, Rageot, Denise, primary, Sele, Alexander, primary, Dossena, Barbara, primary, Rossi, Francesca Maria, primary, Zucchetto, Antonella, primary, Taborelli, Monica, primary, Gattei, Valter, primary, Rossi, Davide, primary, Stathis, Anastasios, primary, Stussi, Georg, primary, Broggini, Massimo, primary, Wymann, Matthias P., primary, Wicki, Andreas, primary, Zucca, Emanuele, primary, Cmiljanovic, Vladimir, primary, Fabbro, Doriano, primary, and Bertoni, Francesco, primary

Published
2023
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23. Supplemental Figures S6 from The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs

Author

Boi, Michela, primary, Gaudio, Eugenio, primary, Bonetti, Paola, primary, Kwee, Ivo, primary, Bernasconi, Elena, primary, Tarantelli, Chiara, primary, Rinaldi, Andrea, primary, Testoni, Monica, primary, Cascione, Luciano, primary, Ponzoni, Maurilio, primary, Mensah, Afua Adjeiwaa, primary, Stathis, Anastasios, primary, Stussi, Georg, primary, Riveiro, María Eugenia, primary, Herait, Patrice, primary, Inghirami, Giorgio, primary, Cvitkovic, Esteban, primary, Zucca, Emanuele, primary, and Bertoni, Francesco, primary

Published
2023
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24. Supplemental Table S2-3 from The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs

Author

Boi, Michela, primary, Gaudio, Eugenio, primary, Bonetti, Paola, primary, Kwee, Ivo, primary, Bernasconi, Elena, primary, Tarantelli, Chiara, primary, Rinaldi, Andrea, primary, Testoni, Monica, primary, Cascione, Luciano, primary, Ponzoni, Maurilio, primary, Mensah, Afua Adjeiwaa, primary, Stathis, Anastasios, primary, Stussi, Georg, primary, Riveiro, María Eugenia, primary, Herait, Patrice, primary, Inghirami, Giorgio, primary, Cvitkovic, Esteban, primary, Zucca, Emanuele, primary, and Bertoni, Francesco, primary

Published
2023
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25. Supplemental Figures S3-5 from The BET Bromodomain Inhibitor OTX015 Affects Pathogenetic Pathways in Preclinical B-cell Tumor Models and Synergizes with Targeted Drugs

Author

Boi, Michela, primary, Gaudio, Eugenio, primary, Bonetti, Paola, primary, Kwee, Ivo, primary, Bernasconi, Elena, primary, Tarantelli, Chiara, primary, Rinaldi, Andrea, primary, Testoni, Monica, primary, Cascione, Luciano, primary, Ponzoni, Maurilio, primary, Mensah, Afua Adjeiwaa, primary, Stathis, Anastasios, primary, Stussi, Georg, primary, Riveiro, María Eugenia, primary, Herait, Patrice, primary, Inghirami, Giorgio, primary, Cvitkovic, Esteban, primary, Zucca, Emanuele, primary, and Bertoni, Francesco, primary

Published
2023
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26. Supplementary figures, table legends, Table S1, S9 from PQR309 Is a Novel Dual PI3K/mTOR Inhibitor with Preclinical Antitumor Activity in Lymphomas as a Single Agent and in Combination Therapy

Author

Tarantelli, Chiara, primary, Gaudio, Eugenio, primary, Arribas, Alberto J., primary, Kwee, Ivo, primary, Hillmann, Petra, primary, Rinaldi, Andrea, primary, Cascione, Luciano, primary, Spriano, Filippo, primary, Bernasconi, Elena, primary, Guidetti, Francesca, primary, Carrassa, Laura, primary, Pittau, Roberta Bordone, primary, Beaufils, Florent, primary, Ritschard, Reto, primary, Rageot, Denise, primary, Sele, Alexander, primary, Dossena, Barbara, primary, Rossi, Francesca Maria, primary, Zucchetto, Antonella, primary, Taborelli, Monica, primary, Gattei, Valter, primary, Rossi, Davide, primary, Stathis, Anastasios, primary, Stussi, Georg, primary, Broggini, Massimo, primary, Wymann, Matthias P., primary, Wicki, Andreas, primary, Zucca, Emanuele, primary, Cmiljanovic, Vladimir, primary, Fabbro, Doriano, primary, and Bertoni, Francesco, primary

Published
2023
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28. Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts

Author

Scarfò, Irene, Pellegrino, Elisa, Mereu, Elisabetta, Kwee, Ivo, Agnelli, Luca, Bergaggio, Elisa, Garaffo, Giulia, Vitale, Nicoletta, Caputo, Manuel, Machiorlatti, Rodolfo, Circosta, Paola, Abate, Francesco, Barreca, Antonella, Novero, Domenico, Mathew, Susan, Rinaldi, Andrea, Tiacci, Enrico, Serra, Sara, Deaglio, Silvia, Neri, Antonino, Falini, Brunangelo, Rabadan, Raul, Bertoni, Francesco, Inghirami, Giorgio, and Piva, Roberto

Published
2016
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30. DNA methylation profiling identifies two splenic marginal zone lymphoma subgroups with different clinical and genetic features

Author

Arribas, Alberto J., Rinaldi, Andrea, Mensah, Afua A., Kwee, Ivo, Cascione, Luciano, Robles, Eloy F., Martinez-Climent, Jose A., Oscier, David, Arcaini, Luca, Baldini, Luca, Marasca, Roberto, Thieblemont, Catherine, Briere, Josette, Forconi, Francesco, Zamò, Alberto, Bonifacio, Massimiliano, Mollejo, Manuela, Facchetti, Fabio, Dirnhofer, Stephan, Ponzoni, Maurilio, Bhagat, Govind, Piris, Miguel A., Gaidano, Gianluca, Zucca, Emanuele, Rossi, Davide, and Bertoni, Francesco

Published
2015
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31. Myc controls IL-15-driven expansion and translational machinery of NK cells

Author

Khameneh, Hanif J., primary, Fonta, Nicolas, additional, Zenobi, Alessandro, additional, Niogret, Charlène, additional, Ventura, Pedro, additional, Guerra, Concetta, additional, Kwee, Ivo, additional, Rinaldi, Andrea, additional, Pecoraro, Matteo, additional, Geiger, Roger, additional, Cavalli, Andrea, additional, Bertoni, Francesco, additional, Vivier, Eric, additional, Trumpp, Andreas, additional, and Guarda, Greta, additional

Published
2022
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32. Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis

Author

Virgilio, Tommaso, primary, Bordini, Joy, additional, Cascione, Luciano, additional, Sartori, Giulio, additional, Latino, Irene, additional, Molina Romero, Daniel, additional, Leoni, Cristina, additional, Akhmedov, Murodzhon, additional, Rinaldi, Andrea, additional, Arribas, Alberto J., additional, Morone, Diego, additional, Seyed Jafari, S. Morteza, additional, Bersudsky, Marina, additional, Ottolenghi, Aner, additional, Kwee, Ivo, additional, Chiaravalli, Anna Maria, additional, Sessa, Fausto, additional, Hunger, Robert E., additional, Bruno, Antonino, additional, Mortara, Lorenzo, additional, Voronov, Elena, additional, Monticelli, Silvia, additional, Apte, Ron N., additional, Bertoni, Francesco, additional, and Gonzalez, Santiago F., additional

Published
2022
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33. Bayesian Joint Estimation of CN and LOH Aberrations

Author

Rancoita, Paola M. V., Hutter, Marcus, Bertoni, Francesco, Kwee, Ivo, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Omatu, Sigeru, editor, Rocha, Miguel P., editor, Bravo, José, editor, Fernández, Florentino, editor, Corchado, Emilio, editor, Bustillo, Andrés, editor, and Corchado, Juan M., editor

Published
2009
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35. Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

Author

Perruzza, Lisa, primary, Strati, Francesco, additional, Raneri, Matteo, additional, Li, Hai, additional, Gargari, Giorgio, additional, Rezzonico-Jost, Tanja, additional, Palatella, Martina, additional, Kwee, Ivo, additional, Morone, Diego, additional, Seehusen, Frauke, additional, Sonego, Paolo, additional, Donati, Claudio, additional, Franceschi, Pietro, additional, Macpherson, Andrew J., additional, Guglielmetti, Simone, additional, Greiff, Victor, additional, and Grassi, Fabio, additional

Published
2022
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36. PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma

Author

Boi, Michela, Rinaldi, Andrea, Kwee, Ivo, Bonetti, Paola, Todaro, Maria, Tabbò, Fabrizio, Piva, Roberto, Rancoita, Paola M.V., Matolcsy, András, Timar, Botond, Tousseyn, Thomas, Rodríguez-Pinilla, Socorro Maria, Piris, Miguel A., Beà, Sílvia, Campo, Elias, Bhagat, Govind, Swerdlow, Steven H., Rosenwald, Andreas, Ponzoni, Maurilio, Young, Ken H., Piccaluga, Pier Paolo, Dummer, Reinhard, Pileri, Stefano, Zucca, Emanuele, Inghirami, Giorgio, and Bertoni, Francesco

Published
2013
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37. Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome

Author

Chigrinova, Ekaterina, Rinaldi, Andrea, Kwee, Ivo, Rossi, Davide, Rancoita, Paola M.V., Strefford, Jonathan C., Oscier, David, Stamatopoulos, Kostas, Papadaki, Theodora, Berger, Francoise, Young, Ken H., Murray, Fiona, Rosenquist, Richard, Greiner, Timothy C., Chan, Wing C., Orlandi, Ester M., Lucioni, Marco, Marasca, Roberto, Inghirami, Giorgio, Ladetto, Marco, Forconi, Francesco, Cogliatti, Sergio, Votavova, Hana, Swerdlow, Steven H., Stilgenbauer, Stephan, Piris, Miguel A., Matolcsy, Andras, Spagnolo, Dominic, Nikitin, Eugene, Zamò, Alberto, Gattei, Valter, Bhagat, Govind, Ott, German, Zucca, Emanuele, Gaidano, Gianluca, and Bertoni, Francesco

Published
2013
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39. Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

Author

Perruzza, L, Strati, F, Raneri, M, Li, H, Gargari, G, Rezzonico-Jost, T, Palatella, M, Kwee, I, Morone, D, Seehusen, F, Sonego, P, Donati, C, Franceschi, P, Macpherson, A, Guglielmetti, S, Greiff, V, Grassi, F, Perruzza, Lisa, Strati, Francesco, Raneri, Matteo, Li, Hai, Gargari, Giorgio, Rezzonico-Jost, Tanja, Palatella, Martina, Kwee, Ivo, Morone, Diego, Seehusen, Frauke, Sonego, Paolo, Donati, Claudio, Franceschi, Pietro, Macpherson, Andrew J, Guglielmetti, Simone, Greiff, Victor, Grassi, Fabio, Perruzza, L, Strati, F, Raneri, M, Li, H, Gargari, G, Rezzonico-Jost, T, Palatella, M, Kwee, I, Morone, D, Seehusen, F, Sonego, P, Donati, C, Franceschi, P, Macpherson, A, Guglielmetti, S, Greiff, V, Grassi, F, Perruzza, Lisa, Strati, Francesco, Raneri, Matteo, Li, Hai, Gargari, Giorgio, Rezzonico-Jost, Tanja, Palatella, Martina, Kwee, Ivo, Morone, Diego, Seehusen, Frauke, Sonego, Paolo, Donati, Claudio, Franceschi, Pietro, Macpherson, Andrew J, Guglielmetti, Simone, Greiff, Victor, and Grassi, Fabio

Abstract

Secretory immunoglobulin A (SIgA) interaction with commensal bacteria conditions microbiota composition and function. However, mechanisms regulating reciprocal control of microbiota and SIgA are not defined. Bacteria-derived adenosine triphosphate (ATP) limits T follicular helper (Tfh) cells in the Peyer's patches (PPs) via P2X7 receptor (P2X7R) and thereby SIgA generation. Here we show that hydrolysis of extracellular ATP (eATP) by apyrase results in amplification of the SIgA repertoire. The enhanced breadth of SIgA in mice colonized with apyrase-releasing Escherichia coli influences topographical distribution of bacteria and expression of genes involved in metabolic versus immune functions in the intestinal epithelium. SIgA-mediated conditioning of bacteria and enterocyte function is reflected by differences in nutrient absorption in mice colonized with apyrase-expressing bacteria. Apyrase-induced SIgA improves intestinal homeostasis and attenuates barrier impairment and susceptibility to infection by enteric pathogens in antibiotic-induced dysbiosis. Therefore, amplification of SIgA by apyrase can be leveraged to restore intestinal fitness in dysbiotic conditions.

Published
2022

40. Apyrase-mediated amplification of secretory IgA promotes intestinal homeostasis

Author

Perruzza, Lisa, Strati, Francesco, Raneri, Matteo, Li, Hai, Gargari, Giorgio, Rezzonico-Jost, Tanja, Palatella, Martina, Kwee, Ivo, Morone, Diego, Seehusen, Frauke; https://orcid.org/0000-0001-6701-7868, Sonego, Paolo, Donati, Claudio, Franceschi, Pietro, Macpherson, Andrew J, Guglielmetti, Simone, Greiff, Victor, Grassi, Fabio, Perruzza, Lisa, Strati, Francesco, Raneri, Matteo, Li, Hai, Gargari, Giorgio, Rezzonico-Jost, Tanja, Palatella, Martina, Kwee, Ivo, Morone, Diego, Seehusen, Frauke; https://orcid.org/0000-0001-6701-7868, Sonego, Paolo, Donati, Claudio, Franceschi, Pietro, Macpherson, Andrew J, Guglielmetti, Simone, Greiff, Victor, and Grassi, Fabio

Abstract

Secretory immunoglobulin A (SIgA) interaction with commensal bacteria conditions microbiota composition and function. However, mechanisms regulating reciprocal control of microbiota and SIgA are not defined. Bacteria-derived adenosine triphosphate (ATP) limits T follicular helper (Tfh) cells in the Peyer's patches (PPs) via P2X7 receptor (P2X7R) and thereby SIgA generation. Here we show that hydrolysis of extracellular ATP (eATP) by apyrase results in amplification of the SIgA repertoire. The enhanced breadth of SIgA in mice colonized with apyrase-releasing Escherichia coli influences topographical distribution of bacteria and expression of genes involved in metabolic versus immune functions in the intestinal epithelium. SIgA-mediated conditioning of bacteria and enterocyte function is reflected by differences in nutrient absorption in mice colonized with apyrase-expressing bacteria. Apyrase-induced SIgA improves intestinal homeostasis and attenuates barrier impairment and susceptibility to infection by enteric pathogens in antibiotic-induced dysbiosis. Therefore, amplification of SIgA by apyrase can be leveraged to restore intestinal fitness in dysbiotic conditions.

Published
2022

45. Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome

Author

Rinaldi, Andrea, Mian, Michael, Chigrinova, Ekaterina, Arcaini, Luca, Bhagat, Govind, Novak, Urban, Rancoita, Paola M.V., De Campos, Cassio P., Forconi, Francesco, Gascoyne, Randy D., Facchetti, Fabio, Ponzoni, Maurilio, Govi, Silvia, Ferreri, Andrés J.M., Mollejo, Manuela, Piris, Miguel A., Baldini, Luca, Soulier, Jean, Thieblemont, Catherine, Canzonieri, Vincenzo, Gattei, Valter, Marasca, Roberto, Franceschetti, Silvia, Gaidano, Gianluca, Tucci, Alessandra, Uccella, Silvia, Tibiletti, Maria Grazia, Dirnhofer, Stephan, Tripodo, Claudio, Doglioni, Claudio, Dalla Favera, Riccardo, Cavalli, Franco, Zucca, Emanuele, Kwee, Ivo, and Bertoni, Francesco

Published
2011
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47. Protein Expression of AEBP1, MCM4, and FABP4 Differentiate Osteogenic, Adipogenic, and Mesenchymal Stromal Stem Cells

Author

Sauer, Thorben, primary, Facchinetti, Giulia, additional, Kohl, Michael, additional, Kowal, Justyna M., additional, Rozanova, Svitlana, additional, Horn, Julia, additional, Schmal, Hagen, additional, Kwee, Ivo, additional, Schulz, Arndt-Peter, additional, Hartwig, Sonja, additional, Kassem, Moustapha, additional, Habermann, Jens K., additional, and Gemoll, Timo, additional

Published
2022
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49. IL-1α secreted by subcapsular sinus macrophages promotes melanoma metastasis in the sentinel lymph node by upregulating STAT3 signaling in the tumor

Author

Virgilio, Tommaso, primary, Bordini, Joy, additional, Sartori, Giulio, additional, Latino, Irene, additional, Molina-Romero, Daniel, additional, Leoni, Cristina, additional, Akhmedov, Murodzhon, additional, Rinaldi, Andrea, additional, Arribas, Alberto J., additional, Morone, Diego, additional, Jafari, S. Morteza Seyed, additional, Bersudsky, Marina, additional, Ottolenghi, Aner, additional, Kwee, Ivo, additional, Chiaravalli, Anna Maria, additional, Sessa, Fausto, additional, Hunger, Robert E., additional, Bruno, Antonino, additional, Mortara, Lorenzo, additional, Voronov, Elena, additional, Monticelli, Silvia, additional, Apte, Ron N., additional, Bertoni, Francesco, additional, and Gonzalez, Santiago F., additional

Published
2021
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