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1. HyperCLOVA X Technical Report

Author

Yoo, Kang Min, Han, Jaegeun, In, Sookyo, Jeon, Heewon, Jeong, Jisu, Kang, Jaewook, Kim, Hyunwook, Kim, Kyung-Min, Kim, Munhyong, Kim, Sungju, Kwak, Donghyun, Kwak, Hanock, Kwon, Se Jung, Lee, Bado, Lee, Dongsoo, Lee, Gichang, Lee, Jooho, Park, Baeseong, Shin, Seongjin, Yu, Joonsang, Baek, Seolki, Byeon, Sumin, Cho, Eungsup, Choe, Dooseok, Han, Jeesung, Jin, Youngkyun, Jun, Hyein, Jung, Jaeseung, Kim, Chanwoong, Kim, Jinhong, Kim, Jinuk, Lee, Dokyeong, Park, Dongwook, Sohn, Jeong Min, Han, Sujung, Heo, Jiae, Hong, Sungju, Jeon, Mina, Jung, Hyunhoon, Jung, Jungeun, Jung, Wangkyo, Kim, Chungjoon, Kim, Hyeri, Kim, Jonghyun, Kim, Min Young, Lee, Soeun, Park, Joonhee, Shin, Jieun, Yang, Sojin, Yoon, Jungsoon, Lee, Hwaran, Bae, Sanghwan, Cha, Jeehwan, Gylleus, Karl, Ham, Donghoon, Hong, Mihak, Hong, Youngki, Hong, Yunki, Jang, Dahyun, Jeon, Hyojun, Jeon, Yujin, Jeong, Yeji, Ji, Myunggeun, Jin, Yeguk, Jo, Chansong, Joo, Shinyoung, Jung, Seunghwan, Kim, Adrian Jungmyung, Kim, Byoung Hoon, Kim, Hyomin, Kim, Jungwhan, Kim, Minkyoung, Kim, Minseung, Kim, Sungdong, Kim, Yonghee, Kim, Youngjun, Kim, Youngkwan, Ko, Donghyeon, Lee, Dughyun, Lee, Ha Young, Lee, Jaehong, Lee, Jieun, Lee, Jonghyun, Lee, Jongjin, Lee, Min Young, Lee, Yehbin, Min, Taehong, Min, Yuri, Moon, Kiyoon, Oh, Hyangnam, Park, Jaesun, Park, Kyuyon, Park, Younghun, Seo, Hanbae, Seo, Seunghyun, Sim, Mihyun, Son, Gyubin, Yeo, Matt, Yeom, Kyung Hoon, Yoo, Wonjoon, You, Myungin, Ahn, Doheon, Ahn, Homin, Ahn, Joohee, Ahn, Seongmin, An, Chanwoo, An, Hyeryun, An, Junho, An, Sang-Min, Byun, Boram, Byun, Eunbin, Cha, Jongho, Chang, Minji, Chang, Seunggyu, Cho, Haesong, Cho, Youngdo, Choi, Dalnim, Choi, Daseul, Choi, Hyoseok, Choi, Minseong, Choi, Sangho, Choi, Seongjae, Choi, Wooyong, Chun, Sewhan, Go, Dong Young, Ham, Chiheon, Han, Danbi, Han, Jaemin, Hong, Moonyoung, Hong, Sung Bum, Hwang, Dong-Hyun, Hwang, Seongchan, Im, Jinbae, Jang, Hyuk Jin, Jang, Jaehyung, Jang, Jaeni, Jang, Sihyeon, Jang, Sungwon, Jeon, Joonha, Jeong, Daun, Jeong, Joonhyun, Jeong, Kyeongseok, Jeong, Mini, Jin, Sol, Jo, Hanbyeol, Jo, Hanju, Jo, Minjung, Jung, Chaeyoon, Jung, Hyungsik, Jung, Jaeuk, Jung, Ju Hwan, Jung, Kwangsun, Jung, Seungjae, Ka, Soonwon, Kang, Donghan, Kang, Soyoung, Kil, Taeho, Kim, Areum, Kim, Beomyoung, Kim, Byeongwook, Kim, Daehee, Kim, Dong-Gyun, Kim, Donggook, Kim, Donghyun, Kim, Euna, Kim, Eunchul, Kim, Geewook, Kim, Gyu Ri, Kim, Hanbyul, Kim, Heesu, Kim, Isaac, Kim, Jeonghoon, Kim, Jihye, Kim, Joonghoon, Kim, Minjae, Kim, Minsub, Kim, Pil Hwan, Kim, Sammy, Kim, Seokhun, Kim, Seonghyeon, Kim, Soojin, Kim, Soong, Kim, Soyoon, Kim, Sunyoung, Kim, Taeho, Kim, Wonho, Kim, Yoonsik, Kim, You Jin, Kim, Yuri, Kwon, Beomseok, Kwon, Ohsung, Kwon, Yoo-Hwan, Lee, Anna, Lee, Byungwook, Lee, Changho, Lee, Daun, Lee, Dongjae, Lee, Ha-Ram, Lee, Hodong, Lee, Hwiyeong, Lee, Hyunmi, Lee, Injae, Lee, Jaeung, Lee, Jeongsang, Lee, Jisoo, Lee, Jongsoo, Lee, Joongjae, Lee, Juhan, Lee, Jung Hyun, Lee, Junghoon, Lee, Junwoo, Lee, Se Yun, Lee, Sujin, Lee, Sungjae, Lee, Sungwoo, Lee, Wonjae, Lee, Zoo Hyun, Lim, Jong Kun, Lim, Kun, Lim, Taemin, Na, Nuri, Nam, Jeongyeon, Nam, Kyeong-Min, Noh, Yeonseog, Oh, Biro, Oh, Jung-Sik, Oh, Solgil, Oh, Yeontaek, Park, Boyoun, Park, Cheonbok, Park, Dongju, Park, Hyeonjin, Park, Hyun Tae, Park, Hyunjung, Park, Jihye, Park, Jooseok, Park, Junghwan, Park, Jungsoo, Park, Miru, Park, Sang Hee, Park, Seunghyun, Park, Soyoung, Park, Taerim, Park, Wonkyeong, Ryu, Hyunjoon, Ryu, Jeonghun, Ryu, Nahyeon, Seo, Soonshin, Seo, Suk Min, Shim, Yoonjeong, Shin, Kyuyong, Shin, Wonkwang, Sim, Hyun, Sim, Woongseob, Soh, Hyejin, Son, Bokyong, Son, Hyunjun, Son, Seulah, Song, Chi-Yun, Song, Chiyoung, Song, Ka Yeon, Song, Minchul, Song, Seungmin, Wang, Jisung, Yeo, Yonggoo, Yi, Myeong Yeon, Yim, Moon Bin, Yoo, Taehwan, Yoo, Youngjoon, Yoon, Sungmin, Yoon, Young Jin, Yu, Hangyeol, Yu, Ui Seon, Zuo, Xingdong, Bae, Jeongin, Bae, Joungeun, Cho, Hyunsoo, Cho, Seonghyun, Cho, Yongjin, Choi, Taekyoon, Choi, Yera, Chung, Jiwan, Han, Zhenghui, Heo, Byeongho, Hong, Euisuk, Hwang, Taebaek, Im, Seonyeol, Jegal, Sumin, Jeon, Sumin, Jeong, Yelim, Jeong, Yonghyun, Jiang, Can, Jiang, Juyong, Jin, Jiho, Jo, Ara, Jo, Younghyun, Jung, Hoyoun, Jung, Juyoung, Kang, Seunghyeong, Kim, Dae Hee, Kim, Ginam, Kim, Hangyeol, Kim, Heeseung, Kim, Hyojin, Kim, Hyojun, Kim, Hyun-Ah, Kim, Jeehye, Kim, Jin-Hwa, Kim, Jiseon, Kim, Jonghak, Kim, Jung Yoon, Kim, Rak Yeong, Kim, Seongjin, Kim, Seoyoon, Kim, Sewon, Kim, Sooyoung, Kim, Sukyoung, Kim, Taeyong, Ko, Naeun, Koo, Bonseung, Kwak, Heeyoung, Kwon, Haena, Kwon, Youngjin, Lee, Boram, Lee, Bruce W., Lee, Dagyeong, Lee, Erin, Lee, Euijin, Lee, Ha Gyeong, Lee, Hyojin, Lee, Hyunjeong, Lee, Jeeyoon, Lee, Jeonghyun, Lee, Jongheok, Lee, Joonhyung, Lee, Junhyuk, Lee, Mingu, Lee, Nayeon, Lee, Sangkyu, Lee, Se Young, Lee, Seulgi, Lee, Seung Jin, Lee, Suhyeon, Lee, Yeonjae, Lee, Yesol, Lee, Youngbeom, Lee, Yujin, Li, Shaodong, Liu, Tianyu, Moon, Seong-Eun, Moon, Taehong, Nihlenramstroem, Max-Lasse, Oh, Wonseok, Oh, Yuri, Park, Hongbeen, Park, Hyekyung, Park, Jaeho, Park, Nohil, Park, Sangjin, Ryu, Jiwon, Ryu, Miru, Ryu, Simo, Seo, Ahreum, Seo, Hee, Seo, Kangdeok, Shin, Jamin, Shin, Seungyoun, Sin, Heetae, Wang, Jiangping, Wang, Lei, Xiang, Ning, Xiao, Longxiang, Xu, Jing, Yi, Seonyeong, Yoo, Haanju, Yoo, Haneul, Yoo, Hwanhee, Yu, Liang, Yu, Youngjae, Yuan, Weijie, Zeng, Bo, Zhou, Qian, Cho, Kyunghyun, Ha, Jung-Woo, Park, Joonsuk, Hwang, Jihyun, Kwon, Hyoung Jo, Kwon, Soonyong, Lee, Jungyeon, Lee, Seungho, Lim, Seonghyeon, Noh, Hyunkyung, Choi, Seungho, Lee, Sang-Woo, Lim, Jung Hwa, and Sung, Nako

Subjects
Computer Science - Computation and Language, Computer Science - Artificial Intelligence
Abstract

We introduce HyperCLOVA X, a family of large language models (LLMs) tailored to the Korean language and culture, along with competitive capabilities in English, math, and coding. HyperCLOVA X was trained on a balanced mix of Korean, English, and code data, followed by instruction-tuning with high-quality human-annotated datasets while abiding by strict safety guidelines reflecting our commitment to responsible AI. The model is evaluated across various benchmarks, including comprehensive reasoning, knowledge, commonsense, factuality, coding, math, chatting, instruction-following, and harmlessness, in both Korean and English. HyperCLOVA X exhibits strong reasoning capabilities in Korean backed by a deep understanding of the language and cultural nuances. Further analysis of the inherent bilingual nature and its extension to multilingualism highlights the model's cross-lingual proficiency and strong generalization ability to untargeted languages, including machine translation between several language pairs and cross-lingual inference tasks. We believe that HyperCLOVA X can provide helpful guidance for regions or countries in developing their sovereign LLMs., Comment: 44 pages; updated authors list and fixed author names

Published
2024

2. EHRNoteQA: An LLM Benchmark for Real-World Clinical Practice Using Discharge Summaries

Author

Kweon, Sunjun, Kim, Jiyoun, Kwak, Heeyoung, Cha, Dongchul, Yoon, Hangyul, Kim, Kwanghyun, Yang, Jeewon, Won, Seunghyun, and Choi, Edward

Subjects
Computer Science - Computation and Language
Abstract

Discharge summaries in Electronic Health Records (EHRs) are crucial for clinical decision-making, but their length and complexity make information extraction challenging, especially when dealing with accumulated summaries across multiple patient admissions. Large Language Models (LLMs) show promise in addressing this challenge by efficiently analyzing vast and complex data. Existing benchmarks, however, fall short in properly evaluating LLMs' capabilities in this context, as they typically focus on single-note information or limited topics, failing to reflect the real-world inquiries required by clinicians. To bridge this gap, we introduce EHRNoteQA, a novel benchmark built on the MIMIC-IV EHR, comprising 962 different QA pairs each linked to distinct patients' discharge summaries. Every QA pair is initially generated using GPT-4 and then manually reviewed and refined by three clinicians to ensure clinical relevance. EHRNoteQA includes questions that require information across multiple discharge summaries and covers eight diverse topics, mirroring the complexity and diversity of real clinical inquiries. We offer EHRNoteQA in two formats: open-ended and multi-choice question answering, and propose a reliable evaluation method for each. We evaluate 27 LLMs using EHRNoteQA and examine various factors affecting the model performance (e.g., the length and number of discharge summaries). Furthermore, to validate EHRNoteQA as a reliable proxy for expert evaluations in clinical practice, we measure the correlation between the LLM performance on EHRNoteQA, and the LLM performance manually evaluated by clinicians. Results show that LLM performance on EHRNoteQA have higher correlation with clinician-evaluated performance (Spearman: 0.78, Kendall: 0.62) compared to other benchmarks, demonstrating its practical relevance in evaluating LLMs in clinical settings., Comment: Under Review

Published
2024

3. Drug-disease Graph: Predicting Adverse Drug Reaction Signals via Graph Neural Network with Clinical Data

Author

Kwak, Heeyoung, Lee, Minwoo, Yoon, Seunghyun, Chang, Jooyoung, Park, Sangmin, and Jung, Kyomin

Subjects
Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

Adverse Drug Reaction (ADR) is a significant public health concern world-wide. Numerous graph-based methods have been applied to biomedical graphs for predicting ADRs in pre-marketing phases. ADR detection in post-market surveillance is no less important than pre-marketing assessment, and ADR detection with large-scale clinical data have attracted much attention in recent years. However, there are not many studies considering graph structures from clinical data for detecting an ADR signal, which is a pair of a prescription and a diagnosis that might be a potential ADR. In this study, we develop a novel graph-based framework for ADR signal detection using healthcare claims data. We construct a Drug-disease graph with nodes representing the medical codes. The edges are given as the relationships between two codes, computed using the data. We apply Graph Neural Network to predict ADR signals, using labels from the Side Effect Resource database. The model shows improved AUROC and AUPRC performance of 0.795 and 0.775, compared to other algorithms, showing that it successfully learns node representations expressive of those relationships. Furthermore, our model predicts ADR pairs that do not exist in the established ADR database, showing its capability to supplement the ADR database., Comment: To appear at PAKDD 2020

Published
2020

4. EHRNoteQA: A Patient-Specific Question Answering Benchmark for Evaluating Large Language Models in Clinical Settings

Author

Kweon, Sunjun, Kim, Jiyoun, Kwak, Heeyoung, Cha, Dongchul, Yoon, Hangyul, Kim, Kwanghyun, Won, Seunghyun, Choi, Edward, Kweon, Sunjun, Kim, Jiyoun, Kwak, Heeyoung, Cha, Dongchul, Yoon, Hangyul, Kim, Kwanghyun, Won, Seunghyun, and Choi, Edward

Abstract

This study introduces EHRNoteQA, a novel patient-specific question answering benchmark tailored for evaluating Large Language Models (LLMs) in clinical environments. Based on MIMIC-IV Electronic Health Record (EHR), a team of three medical professionals has curated the dataset comprising 962 unique questions, each linked to a specific patient's EHR clinical notes. What makes EHRNoteQA distinct from existing EHR-based benchmarks is as follows: Firstly, it is the first dataset to adopt a multi-choice question answering format, a design choice that effectively evaluates LLMs with reliable scores in the context of automatic evaluation, compared to other formats. Secondly, it requires an analysis of multiple clinical notes to answer a single question, reflecting the complex nature of real-world clinical decision-making where clinicians review extensive records of patient histories. Our comprehensive evaluation on various large language models showed that their scores on EHRNoteQA correlate more closely with their performance in addressing real-world medical questions evaluated by clinicians than their scores from other LLM benchmarks. This underscores the significance of EHRNoteQA in evaluating LLMs for medical applications and highlights its crucial role in facilitating the integration of LLMs into healthcare systems. The dataset will be made available to the public under PhysioNet credential access, promoting further research in this vital field., Comment: Under Review

Published
2024

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