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7. Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study

Author

Demmo, Christine, primary, Lagerberg, Trine V, additional, Kvitland, Levi R, additional, Aminoff, Sofie R, additional, Hellvin, Tone, additional, Simonsen, Carmen, additional, Haatveit, Beathe, additional, Andreassen, Ole A, additional, Melle, Ingrid, additional, and Ueland, Torill, additional

Published
2017
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8. Continued cannabis use at one year follow up is associated with elevated mood and lower global functioning in bipolar I disorder

Author

Kvitland, Levi R, Melle, Ingrid, Aminoff, Sofie R, Demmo, Christine, Lagerberg, Trine V, Andreassen, Ole A, and Ringen, Petter A

Abstract

Background There is limited knowledge about how environmental factors affect the course of bipolar disorder (BD). Cannabis has been proposed as a potential risk factor for poorer course of illness, but the role of cannabis use has not been studied in a first treatment BD I sample. Methods The present study examines the associations between course of illness in first treatment BD I and continued cannabis use, from baseline to one year follow up. Patients (N = 62) with first treatment DSM-IV BD I were included as part of the Thematically Organized Psychosis study (TOP), and completed interviews and self-report questionnaires at both baseline and follow up. Cannabis use within the last six months at baseline and use between baseline and follow up (“continued use”) was recorded. Results After controlling for confounders, continued cannabis use was significantly associated with elevated mood (YMRS) and inferior global functioning (GAF-F) at follow up. Elevated mood mediated the effect of cannabis use on global functioning. Conclusions These results suggest that cannabis use has clinical implications for the early course of BD by increasing mood level. More focus on reducing cannabis use in clinical settings seems to be useful for improving outcome in early phase of the disorder.

Published
2015

9. Neurocognitive functioning, clinical course and functional outcome in first‐treatment bipolar I disorder patients with and without clinical relapse: A 1‐year follow‐up study.

Author

Demmo, Christine, Lagerberg, Trine V., Kvitland, Levi R., Aminoff, Sofie R., Hellvin, Tone, Simonsen, Carmen, Haatveit, Beathe, Andreassen, Ole A., Melle, Ingrid, and Ueland, Torill

Subjects
BIPOLAR disorder, THERAPEUTICS, HEALTH outcome assessment, TREATMENT effectiveness, DISEASE relapse, PATIENTS
Abstract

Objectives: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. Methods: The current study investigated the longitudinal relationship between neurocognition, recurrence of mood episodes and functional outcome in a sample of first‐treatment (FT) BD I patients (N = 42), with and without relapse, during a 1‐year follow‐up period. The longitudinal course of neurocognitive functioning in the patients was also compared to that of a group of healthy controls (N = 143). Results: Compared to both patients with relapse and healthy controls, no‐relapse patients showed neurocognitive improvements. The polarity of the relapse episodes was mostly depressive, and for the no‐relapse patients, reduction of symptoms was associated with neurocognitive improvement. No‐relapse patients showed better global and occupational functioning. Conclusions: The current study found different neurocognitive and functional trajectories in FT BD I patients with and without relapse, with differences at follow‐up to some degree being mediated by current symptoms. The current findings highlight the importance of treatment focusing on neurocognition and symptom states with the aim of improving functional recovery. [ABSTRACT FROM AUTHOR]

Published
2018
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