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3 results on '"Kvβ3"'

1. Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

Author

Alexander Campbell, Mike Lyne, Harold H. Zakon, Clare V. H. Baker, Marcus C. Davis, David Buckley, Gos Micklem, Melinda S. Modrell, Adrian Carr, Micklem, Gos [0000-0002-6883-6168], Baker, Clare [0000-0002-4434-3107], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Cavβ2, Stem cells, Organ development, Hair cells, hh, Transcriptome, Ampullary organs, Vglut3, beta-parvalbumins, Biology (General), Biological sciences, Kv1.5, General Neuroscience, Gene Expression Regulation, Developmental, General Medicine, Anatomy, Electroreceptors, Vertebrates, Medicine, Pou4f3, Beta-parvalbumins, Research Article, hair cells, QH301-705.5, Science, Biology, General Biochemistry, Genetics and Molecular Biology, voltage-gated ion channels, Oncomodulin, 03 medical and health sciences, otoferlin, electroreceptors, Neurod4, Developmental biology, Polyodon spathula (Mississippi paddlefish), Animals, 14. Life underwater, oncomodulin, synaptic ribbons, General Immunology and Microbiology, Kvβ3, Atoh1, Sequence Analysis, RNA, Gene Expression Profiling, Animal Structures, Hh, Neuromasts, 030104 developmental biology, Developmental Biology and Stem Cells, CAV1, Research council, Evolutionary biology, ampullary organs, Voltage-gated ion channels, Synaptic ribbons, Kv1, Other, neuromasts, Cav1.3, Otoferlin, Neuroscience
Abstract

The anamniote lateral line system, comprising mechanosensory neuromasts and electrosensory ampullary organs, is a useful model for investigating the developmental and evolutionary diversification of different organs and cell types. Zebrafish neuromast development is increasingly well understood, but neither zebrafish nor Xenopus is electroreceptive and our molecular understanding of ampullary organ development is rudimentary. We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefish (Polyodon spathula). Validation of a subset reveals expression in developing ampullary organs of transcription factor genes critical for hair cell development, and genes essential for glutamate release at hair cell ribbon synapses, suggesting close developmental, physiological and evolutionary links between non-teleost electroreceptors and hair cells. We identify an ampullary organ-specific proneural transcription factor, and candidates for the voltage-sensing L-type Ca channel and rectifying K channel predicted from skate (cartilaginous fish) ampullary organ electrophysiology. Overall, our results illuminate ampullary organ development, physiology and evolution.

Published
2017

2. Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome.

Author

Modrell MS, Lyne M, Carr AR, Zakon HH, Buckley D, Campbell AS, Davis MC, Micklem G, and Baker CV

Subjects
Animals, Gene Expression Profiling, Sequence Analysis, RNA, Animal Structures embryology, Gene Expression Regulation, Developmental, Vertebrates embryology
Abstract

The anamniote lateral line system, comprising mechanosensory neuromasts and electrosensory ampullary organs, is a useful model for investigating the developmental and evolutionary diversification of different organs and cell types. Zebrafish neuromast development is increasingly well understood, but neither zebrafish nor Xenopus is electroreceptive and our molecular understanding of ampullary organ development is rudimentary. We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefish ( Polyodon spathula ). Validation of a subset reveals expression in developing ampullary organs of transcription factor genes critical for hair cell development, and genes essential for glutamate release at hair cell ribbon synapses, suggesting close developmental, physiological and evolutionary links between non-teleost electroreceptors and hair cells. We identify an ampullary organ-specific proneural transcription factor, and candidates for the voltage-sensing L-type Ca v channel and rectifying K v channel predicted from skate (cartilaginous fish) ampullary organ electrophysiology. Overall, our results illuminate ampullary organ development, physiology and evolution.

Published
2017
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3. Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

Author

Modrell, MS, Lyne, M, Carr, AR, Zakon, HH, Buckley, D, Campbell, AS, Davis, MC, Micklem, G, and Baker, CV

Subjects
Kv1.5, synaptic ribbons, Cavβ2, Kvβ3, hair cells, Atoh1, hh, voltage-gated ion channels, neuroscience, developmental biology, otoferlin, Vglut3, stem cells, Neurod4, electroreceptors, Polyodon spathula (Mississippi paddlefish), ampullary organs, Pou4f3, beta-parvalbumins, 14. Life underwater, oncomodulin, neuromasts, Cav1.3
Abstract

The anamniote lateral line system, comprising mechanosensory neuromasts and electrosensory ampullary organs, is a useful model for investigating the developmental and evolutionary diversification of different organs and cell types. Zebrafish neuromast development is increasingly well understood, but neither zebrafish nor $\textit{Xenopus}$ is electroreceptive and our molecular understanding of ampullary organ development is rudimentary. We have used RNA-seq to generate a lateral line-enriched gene-set from late-larval paddlefish ($\textit{Polyodon spathula}$). Validation of a subset reveals expression in developing ampullary organs of transcription factor genes critical for hair cell development, and genes essential for glutamate release at hair cell ribbon synapses, suggesting close developmental, physiological and evolutionary links between non-teleost electroreceptors and hair cells. We identify an ampullary organ-specific proneural transcription factor, and candidates for the voltage-sensing L-type Ca$_v$ channel and rectifying K$_v$ channel predicted from skate (cartilaginous fish) ampullary organ electrophysiology. Overall, our results illuminate ampullary organ development, physiology and evolution.

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