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5 results on '"Kuzeawu A"'

2. Retrospective analysis of 104 histologically proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors

Author

Thomas, Reithmeier, Aanyo, Kuzeawu, Bettina, Hentschel, Markus, Loeffler, Michael, Trippel, and Guido, Nikkhah

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Stereotactic surgery, Biopsy, Age Factors, Neuroimaging, Glioma, Middle Aged, Prognosis, Combined Modality Therapy, Magnetic Resonance Imaging, Young Adult, Treatment Outcome, Brain Stem Neoplasms, Humans, Female, Neoplasm Grading, Brainstem glioma, Neuropathology, Aged, Retrospective Studies, Research Article
Abstract

Background Adult brainstem gliomas are rare primary brain tumors (

Published
2013

3. Expression of gastrin/CCK-B receptors does not lead to a mitogenic response to gastrin in two colon cell lines

Author

A. Imdahl, Theo Mantamadiotis, Graham S. Baldwin, Monika Hock, and Aanyo Kuzeawu

Subjects
medicine.medical_specialty, Skin Neoplasms, Colon, Mice, Nude, Biology, Transfection, digestive system, Cholecystokinin receptor, Mice, Internal medicine, Gastrins, medicine, Tumor Cells, Cultured, Animals, Humans, Receptor, Cholecystokinin, Gastrin, Cell Line, Transformed, Splenic Neoplasms, digestive, oral, and skin physiology, Molecular biology, Pentagastrin, Endocrinology, Cell culture, Cancer cell, Surgery, Receptors, Cholecystokinin, Mitogens, hormones, hormone substitutes, and hormone antagonists, Cell Division, Neoplasm Transplantation, medicine.drug
Abstract

To clarify the impact of the classic gastrin/CCK-B receptor on the growth of benign and malignant colonic cells, two permanent cell lines expressing this receptor have been established. The conditionally immortalized nonmalignant colonic cell line YAMC and the colonic carcinoma cell line SW 403 were stably transfected with a plasmid encoding the gastrin/CCK-B receptor (GR), or with plasmid alone (V). Expression of the gastrin/CCK-B receptor in the transfected YAMC-GR and SW 403-GR cells was demonstrated by gastrin binding experiments. The YAMC-GR cell line did not respond mitogenically to pentagastrin or gastrin(17) in vitro and was not tumorigenic. The SW 403-GR cell line was stimulated by gastrin(17) in vitro, but the growth patterns of SW 403-GR and SW 403-V were the same in nude mice with cells injected either subcutaneously or into the spleen. These results provide further evidence that the gastrin/CCK-B receptor is not responsible for gastrin-stimulated growth in colonic tumors.

Published
1999

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