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12. Anticonvulsant Drugs1 II

Author

Kutt H and Louis S

Subjects
business.industry, Medicine, Pharmacology (medical), Pharmacology, business, Anticonvulsant drugs
Published
1972
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13. Feasibility and pharmacokinetics of carbamazepine oral loading doses.

Author

Cohen, H, Howland, M A, Luciano, D J, Rubin, R N, Kutt, H, Hoffman, R S, Leung, L K, Devinsky, O, and Goldfrank, L R

Abstract

The pharmacokinetics and adverse effects of an oral loading dose of carbamazepine administered in tablet or suspension form were studied. Patients on a hospital epilepsy unit who were to receive carbamazepine as a discharge medication were randomly assigned to receive either an oral 8-mg/kg loading dose of the tablet formulation or the same dose of the suspension on an empty stomach. Blood samples were drawn before and at intervals up to 12 hours after the loading dose. Adverse effects were evaluated subjectively and objectively. Total and free serum carbamazepine and carbamazepine-10, 11-epoxide (CBZE) concentrations were determined by high-performance liquid chromatography. Six adult patients were enrolled in and completed the study. All the patients achieved therapeutic total carbamazepine levels; the suspension group did so within two hours and the tablet group within five hours. Maximum serum carbamazepine concentrations ranged from 7.10 to 9.92 mg/L, area under the concentration-versus-time curve from 54.85 to 82.23 micrograms.hr/L, and terminal elimination half-life from 14.05 to 15.71 hours. Adverse effects were mild, few, and short-lived; none of the patients developed gastrointestinal toxicity. Adverse effects were not associated with total or free carbamazepine and CBZE concentrations or with total or free CBZE:carbamazepine ratios. An oral loading dose of carbamazepine 8 mg/kg achieved therapeutic levels within two hours when given as a suspension and within five hours when given as tablets and was well tolerated in all patients.

Published
1998
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14. An Improved GasLiquid Chromatographic Procedure for the Determination of Amitriptyline and Nortriptyline Levels in Plasma Using NitrogenSensitive Detectors

Author

Dhar, A. K. and Kutt, H.

Abstract

An improved gasliquid chromatographic procedure for the plasma level determination of amitriptyline and nortriptyline using nitrogensensitive detectors is described. Derivatization of the secondary amines using trifluoroacetic anhydride greatly improves the response and reproducibility of the assay. Plasma samples containing as little as 5 ngml of amitriptyline and nortriptyline can be assayed precisely and reproducibly, using protriptyline as internal reference standard.

Published
1979

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