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6. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity

Author

National Institutes of Health (US), European Commission, Junta de Castilla y León, National Natural Science Foundation of China, Consejo Superior de Investigaciones Científicas (España), Shin, Junghee [0000-0002-4765-7988], Mitchell, P. D. [0000-0001-5705-9618], Garami, A. [0000-0003-2493-0571], Shin, Junghee, Fan, W., Par-Young, J., Piecychna, M., Leng, L., Israni-Winger, K., Qing, H., Gu, J., Zhao, H., Schulz, W. L., Unlu, S., Kuster, J., Young, G., Liu, J., Ko, A. I., Baeza Garcia, A., Sauler, M., Wisnewski, A. V., Young, L., Orduña, Antonio, Wang, A., Ocskay, K., Garcia-Blesa, A., Hegyi, P., Armstrong, M. E., Mitchell, P. D., Bernardo, David, Garami, A., Kang, I., Bucala, R., National Institutes of Health (US), European Commission, Junta de Castilla y León, National Natural Science Foundation of China, Consejo Superior de Investigaciones Científicas (España), Shin, Junghee [0000-0002-4765-7988], Mitchell, P. D. [0000-0001-5705-9618], Garami, A. [0000-0003-2493-0571], Shin, Junghee, Fan, W., Par-Young, J., Piecychna, M., Leng, L., Israni-Winger, K., Qing, H., Gu, J., Zhao, H., Schulz, W. L., Unlu, S., Kuster, J., Young, G., Liu, J., Ko, A. I., Baeza Garcia, A., Sauler, M., Wisnewski, A. V., Young, L., Orduña, Antonio, Wang, A., Ocskay, K., Garcia-Blesa, A., Hegyi, P., Armstrong, M. E., Mitchell, P. D., Bernardo, David, Garami, A., Kang, I., and Bucala, R.

Abstract

Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute to its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, functional polymorphisms in macrophage migration inhibitory factor (MIF) are associated with COVID-19 infection or disease severity.

Published
2023

8. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity

Author

Shin, J J, primary, Fan, W, additional, Par-Young, J, additional, Piecychna, M, additional, Leng, L, additional, Israni-Winger, K, additional, Qing, H, additional, Gu, J, additional, Zhao, H, additional, Schulz, W L, additional, Unlu, S, additional, Kuster, J, additional, Young, G, additional, Liu, J, additional, Ko, A I, additional, Baeza Garcia, A, additional, Sauler, M, additional, Wisnewski, A V, additional, Young, L, additional, Orduña, A, additional, Wang, A, additional, Ocskay, K, additional, Garcia-Blesa, A, additional, Hegyi, P, additional, Armstrong, M E, additional, Mitchell, P D, additional, Bernardo, D, additional, Garami, A, additional, Kang, I, additional, and Bucala, R, additional

Published
2022
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9. MIF is a common genetic determinant of COVID-19 symptomatic infection and severity.

Author

Shin, J J, Fan, W, Par-Young, J, Piecychna, M, Leng, L, Israni-Winger, K, Qing, H, Gu, J, Zhao, H, Schulz, W L, Unlu, S, Kuster, J, Young, G, Liu, J, Ko, A I, Garcia, A Baeza, Sauler, M, Wisnewski, A V, Young, L, and Orduña, A

Subjects
CORONAVIRUS diseases, COVID-19, MACROPHAGE migration inhibitory factor, COVID-19 pandemic
Abstract

Background Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute to its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, functional polymorphisms in macrophage migration inhibitory factor (MIF) are associated with COVID-19 infection or disease severity. Aim To determine associations of common functional polymorphisms in MIF with symptomatic COVID-19 or its severity. Methods This retrospective case–control study utilized 1171 patients with COVID-19 from three tertiary medical centers in the USA, Hungary and Spain, together with a group of 637 pre-pandemic, healthy control subjects. Functional MIF promoter alleles (-794 CATT5-8, rs5844572), serum MIF and soluble MIF receptor levels, and available clinical characteristics were measured and correlated with COVID-19 diagnosis and hospitalization. Experimental mice genetically engineered to express human high- or low-expression MIF alleles were studied for response to coronavirus infection. Results In patients with COVID-19, there was a lower frequency of the high-expression MIF CATT7 allele when compared to healthy controls [11% vs. 19%, odds ratio (OR) 0.54 [0.41–0.72], P  < 0.0001]. Among inpatients with COVID-19 (n  = 805), there was a higher frequency of the MIF CATT7 allele compared to outpatients (n  = 187) (12% vs. 5%, OR 2.87 [1.42–5.78], P  = 0.002). Inpatients presented with higher serum MIF levels when compared to outpatients or uninfected healthy controls (87 ng/ml vs. 35 ng/ml vs. 29 ng/ml, P  < 0.001, respectively). Among inpatients, circulating MIF concentrations correlated with admission ferritin (r  = 0.19, P  = 0.01) and maximum CRP (r  = 0.16, P  = 0.03) levels. Mice with a human high-expression MIF allele showed more severe disease than those with a low-expression MIF allele. Conclusions In this multinational retrospective study of 1171 subjects with COVID-19, the commonly occurring -794 CATT7 MIF allele is associated with reduced susceptibility to symptomatic SARS-CoV-2 infection but increased disease progression as assessed by hospitalization. These findings affirm the importance of the high-expression CATT7 MIF allele, which occurs in 19% of the population, in different stages of COVID-19 infection. [ABSTRACT FROM AUTHOR]

Published
2023
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17. C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation

Author

Marneth, A E, primary, Prange, K H M, additional, Al Hinai, A S A, additional, Bergevoet, S M, additional, Tesi, N, additional, Janssen-Megens, E M, additional, Kim, B, additional, Sharifi, N, additional, Yaspo, M L, additional, Kuster, J, additional, Sanders, M A, additional, Stoetman, E C G, additional, Knijnenburg, J, additional, Arentsen-Peters, T C J M, additional, Zwaan, C M, additional, Stunnenberg, H G, additional, van den Heuvel-Eibrink, M M, additional, Haferlach, T, additional, Fornerod, M, additional, Jansen, J H, additional, Valk, P J M, additional, van der Reijden, B A, additional, and Martens, J H A, additional

Published
2017
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18. Estudio y caracterización de modos normales en neumáticos para vehículos de pasajeros

Author

Dalmau, María Eugenia, Jaureguizahar, L. F., Kuster, J., and Marzocca, A. J.

Subjects
MODAL ANALYSIS, ANALISIS MODAL, TIRE CAVITY RESONANCE, CAVIDAD DE RESONANCIA, TIRE, NEUMATICO
Abstract

Se analizaron las frecuencias naturales de vibración mediante análisis modal con martillo instrumentado para dos neumáticos radiales de automóvil de distintas medidas. Se prestó particular interés en las frecuencias de cavidad y el comportamiento según distintas condiciones de servicio: presión de inflado y carga aplicada, analizándose la Función de Respuesta en Frecuencia (respuesta de la estructura en dominio de la frecuencia normalizada respecto de la excitación de entrada). Se estudió además el comportamiento íntegro de la rueda (neumático y llanta) y la suspensión en un automóvil. Se relevaron los espectros en frecuencia de la llanta y la suspensión separadamente para una mejor comprensión de cómo éstas acoplan con el neumático. Se montó también un micrófono en el interior de la cavidad de resonancia. Finalmente, se realizó una simulación de la cavidad de aire del neumático mediante el Análisis de Elementos Finitos utilizando el software Abaqus bajo distintas condiciones de carga The natural frequencies of vibration for two car radial tires of diferent sizes were analyzed by modal analysis using an impact hammer. Special attention was paid to the tire air cavity resonance and its behavior with pressure and applied load, by analyzing The Frequency Response Function (response of the structure in the frequency domain normalized by input excitation). The behavior of the entire wheel (tire and rim) and the behavior of the suspension of a car were also studied. The frequency spectra of the rim and the suspension were relevated separately for better understanding of how they couple with the tire. Also, a microphone was mounted inside the resonance cavity. Finally, the air cavity of the tire was simulated for different load conditions using Finite Element Analysis with the Abaqus software. Fil: Dalmau, María Eugenia. Fate S.A.I.C.I. Gerencia de Investigación y Desarrollo. CABA. Argentina Fil: Jaureguizahar, L. F.. Fate S.A.I.C.I. Gerencia de Investigación y Desarrollo. CABA. Argentina Fil: Kuster, J.. Fate S.A.I.C.I. Gerencia de Investigación y Desarrollo. CABA. Argentina Fil: Marzocca, A. J.. Fate S.A.I.C.I. Gerencia de Investigación y Desarrollo. CABA. Argentina

Published
2014

27. Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study

Author

Bousser, M, Amarenco, P, Chamorro, A, Fisher, M, Ford, I, Fox, K, Hennerici, M, Mattle, H, Rothwell, P, Julian, D, Fieschi, G, Fieschi, C, Boysen, G, Pocock, S, Conard, J, Orgogozo, J, Inzitari, D, Erkinjuntti, T, Pasquier, F, O'Brien, J, Mas, J, Gueret, P, Lenzi, G, Leys, D, Lopez Sendon, J, Norrving, B, Ferro, J, Thygesen, K, Cowpply, B, P, Ameriso, S, Donnan, D, Lang, W, Thijs, V, Fernandes, J, Stamenova, P, Teal, P, Lavados, P, Lu, C, Poljakovic, Z, Kalita, Z, Kaste, M, Moulin, T, Vemmos, K, Diener, H, Wong, L, Nagy, Z, Chopra, J, Mccormack, P, Gensini, G, Budrys, V, Droste, D, Tan, K, Benomar, A, Cantu Brito, C, Barber, A, Koudstaal, P, Thomassen, L, Czlonkowska, A, Cunha, L, Bajenaru, O, Yakhno, N, Chen, C, Lisy, L, Zvan, B, Bryer, A, Kim, J, Vivancos, J, Wahlgren, N, Liu, S, Poungvarin, N, Hentati, F, Bahar, S, Mischenko, T, Lees, K, Abdel Masih, M, Barboza, A, Cirio, J, Crespo, E, Escaray, G, Esnaola, M, Rojas Estol, C, Ferrari, J, Fraiman, H, Garrote, M, Gatto, E, Giannaula, R, Gori, H, Herrera, G, Ioli, P, Losano, J, Povedano Reich, E, Rey, R, Rotta Escalante, R, Saredo, G, Zurru, M, Anderson, C, Bladin, C, Crimmins, D, Davis, S, Donnan, G, Dunbabin, D, Frayne, J, Gates, P, Hankey, G, Helme, R, Herkes, G, Karrasch, J, Kimber, T, Jannes, J, Landau, P, Levi, C, Lueck, C, Markus, R, Phan, T, Schwartz, R, Schultz, D, Blacker, D, Read, S, Williams, M, Aichner, F, Auff, E, Bancher, C, Binder, H, Brainin, M, Brucke, T, Eggers, C, Fertl, E, Ladurner, G, Lalouschek, W, Mamoli, B, Mitrovic, N, Noisternig, G, Schmidt, R, Vosko, M, Willeit, J, Zaruba, E, Boon, P, Bourgeois, P, Caekebeke, J, Cals, N, Cras, P, Desfontaines, P, De Deyn, P, Dieudonne, L, De Klippel, N, Laloux, P, Maertens de Noordhout, A, Merlevede, K, Michotte, A, Pandolfo, M, Peeters, A, Peeters, D, Tack, P, Van Buggenhout, E, Van Landegem, W, Vanhooren, G, Vermylen, P, Annes, M, Brondani, R, De Carvalho, J, Cendes, F, Fabio, S, Ferraz, A, De Freitas, G, Gagliardi, R, Gomes Neto, A, Haussen, S, Kowacs, P, Martins, S, Minelli, C, Moro, C, Noujaim, J, Rocha, M, Da Silva, M, Silveira, J, Yamamoto, F, Zetola, V, Baldaranov, D, Deleva, N, Haralanov, L, Milanov, I, Mintchev, D, Petrova, N, Shotekov, P, Stamenov, B, Zahariev, Z, Arts, R, Bayer, N, Beaudry, M, Berger, L, Bozek, C, Collier, T, Cote, R, Desai, H, Durocher, A, Hachinski, V, Hill, M, Hoppe, B, Howse, D, Mackey, A, Maharaj, M, Minuk, J, Moddel, G, Novak, D, Penn, A, Rabinovitch, H, Selchen, D, Shuaib, A, Silva, J, Silver, F, Spence, D, Stotts, G, Tamayo, A, Teitelbaum, J, Veloso, F, Voll, C, Winder, T, Barrientos Uribe, N, Galdames Poblete, D, Garcia Figueroa, P, Gasic Yaconi, K, Jaramillo Munoz, A, Lavados Germain, P, Lavados Montes, M, Nancupil Bello, C, Prina Pacheco, L, Vargas Canas, A, Venegas, F, Chen, P, H, Cheng, Y, Cui, L, Di, Q, Dong, Q, Fan, D, Feng, H, Huang, Y, Li, J, Li, W, Li, Z, Lin, H, Liu, M, Miao, L, Ren, H, Wang, Y, Wu, J, Zhang, W, Zhao, G, Zhao, H, Zhou, H, Antoncic, I, Demarin, V, Lusic, I, Pavlicek, I, Soldo Butkovic, S, Bar, M, Bauer, J, Kalina, M, Kanovsky, P, Jura, R, Neumann, J, Rektor, I, Skoda, O, Vaclavik, D, Eerola, A, Hillbom, M, Kinnunen, E, Koivisto, K, Numminen, H, Rissanen, A, Roine, R, Sivenius, J, Alamowitch, S, Autret, A, Avendano, S, Bataillard, M, Berthier, E, Besson, G, Bille Turc, F, Boulliat, J, Boulesteix, J, Brosset, C, Cesaro, P, Albucher, J, Clavelou, P, Colamarino, R, Crassard, I, de Broucker, T, de Bray, J, Desbordes, P, Diot, E, Ducrocq, X, Ellie, E, Faucheux, J, Giroud, M, Godefroy, O, Guillon, B, Huttin, H, Just, A, Lamy, C, Lejeune, P, Lucas, C, Macian Montoro, F, Mackowiak, A, Maillet Vioud, M, Pico, F, Milandre, L, Milhaud, D, Malbec, M, Neau, J, Pinel, J, Robin, C, Rodier, G, Rosolacci, T, Rouanet, F, Rouhart, F, Sablot, D, Servan, J, Smadja, D, Trouillas, P, Valance, J, Viader, F, Viallet, F, Wolff, V, Zagnoli, F, Zuber, M, Angerer, M, Becker, U, Berlit, P, Berrouschot, J, Biniek, R, Bitsch, A, Brodhun, R, Dichgans, M, Druschky, K, Dux, R, Faiss, J, Ferbert, A, Gahn, G, Grotemeyer, K, Goertler, M, Grau, A, Griewing, B, Grond, M, Haan, J, Haberl, R, Hamann, G, Hamer, H, Harms, L, Heide, W, Henningsen, H, Hetzel, A, Hoffmann, F, Huber, R, Isenmann, S, Jander, S, Joerg, J, Kaps, M, Kastrup, A, Kessler, C, Koehler, W, Koelmel, H, Lichy, C, Luckner, K, Malessa, R, Mallmann, A, Meyding Lamade, U, Molitor, H, Mueller Jensen, A, Muellges, W, Noth, J, Nueckel, M, Ochs, G, Poppert, H, Roether, J, Rosenkranz, M, Sander, D, Schaebitz, W, Schlachetzki, F, Schlegel, U, Schmid, E, Schneider, D, Schwarz, M, Seidel, G, Sieble, M, Sliwka, U, Stingele, R, Stoegbauer, F, Szabo, K, Topper, R, Treib, J, Weissenborn, K, Widder, B, Witte, O, Karageorgiou, K, Mitsikostas, D, Papadimitriou, A, Papathanasopoulos, P, Chan, H, Ng, P, Tsoi, T, Bartos, L, Csanyi, A, Csiba, L, Csornai, M, Dioszeghy, P, Fazekas, A, Harcos, P, Horvath, S, Kaposzta, Z, Kerenyi, L, Kincses, J, Koves, A, Nikl, J, Panczel, G, Pongracz, E, Sebestyen, K, Semjen, J, Szabo, M, Szegedi, N, Valikovics, A, Varszegi, R, Vecsei, L, Borah, N, Ichaporia, N, Kaul, S, Meenakshi Sundaram, S, Mehndiratta, M, Misra, U, Murthy, J, Nayak, D, Poncha, F, Shah, A, Singh, G, Srinivasa, R, Venkateswarlu, K, Wadia, R, Collins, R, Harbison, J, Hickey, P, Kelly, P, Murphy, S, Adami, A, Agnelli, G, Agostoni, E, Anzola, G, Arnaboldi, M, Bassi, P, Billo, G, Bottacchi, E, Bovi, P, Cappa, S, Cappelletti, C, Carolei, A, Cavallini, A, Chiodo Grandi, F, Comi, G, Consoli, D, Corsi, F, Costanzo, E, De Falco, F, Devetag, F, Di Lazzaro, V, Di Piero, V, Diomedi, M, Fattorello Salimbeni, C, Federico, F, Feleppa, M, Ferrarese, C, Gandolfo, C, Giaccaglini, E, Giaquinto, S, Giobbe, D, Giometto, B, Greco, G, Guidetti, D, Guidotti, M, Iudice, A, Lembo, G, Marengo, C, Marini, P, Melis, M, Micieli, G, Musolino, R, Mutani, R, Neri, G, Parati, E, Pastore, L, Porazzi, D, Prati, P, Procaccianti, G, Rasura, M, Rossini, P, Santilli, I, Semplicini, A, Silvestrini, M, Tanganelli, P, Tedeschi, G, Tezzon, F, Tola, M, Villani, A, Zanferrari, C, Zarcone, D, Bickuviene, I, Gumbrevicius, G, Obelieniene, D, Skaringa, A, Virketiene, I, Tharakan, J, Aleman Pedroza, J, Escamilla Garza, J, Fernandez Vera, J, Leal Cantu, R, Leon Flores, L, Lopez Ruiz, M, Reyes Gutierrez, G, Reyes Morales, S, Rivera Castano, L, Rodrigues Leyva, I, Ruiz Sandoval, J, Vega Boada, F, Belahsen, F, Kissani, N, Mosseddaq, R, Slassi, I, Yahyaoui, M, Boiten, J, Bornebroek, M, De Kort, P, De Leeuw, H, Donders, R, Franke, C, Hertzberger, L, Jansen, B, Kappelle, L, Keizer, K, Kuster, J, Limburg, M, Mulleners, W, Pop, P, Van Den Berg, J, Van Gemert, H, Verbiest, H, Weinstein, H, Clark, M, Fink, J, Gommans, J, Jayathissa, S, Kilfoyle, D, Kumar, A, Hurtig, U, Indredavik, B, Kloster, R, Salvesen, R, Drozdowski, W, Fryze, W, Klimek, A, Kochanowski, J, Kozubski, W, Ksiazkiewicz, B, Kwiecinski, H, Kuczynska Zardzewialy, A, Motta, E, Nowacki, P, Nyka, W, Opala, G, Pierzchala, K, Pniewski, J, Podemski, R, Selmaj, K, Stelmasiak, Z, Stepien, A, Strzelecka Gorzynska, M, Szczudlik, A, Wajgt, A, Wiszniewska, M, Wlodek, A, Canhao, P, Correia, C, Grilo Goncalves, J, Machado Candido, J, Salgado, A, Bulboaca, A, Campeanu, A, Lazar, T, Marginean, I, Minea, D, Pascu, I, Pereanu, M, Perju Dumbrava, L, Popescu, C, Simu, M, Stefanache, F, Toldisan, I, Tuta, S, Zaharia, C, Alifirova, V, Arkhipov, S, Balunov, O, Balyazin, V, Belkin, A, Belova, A, Boiko, A, Bogdanov, E, Butko, D, Chukhlovina, M, Doronin, B, Ermilova, E, Evzelman, M, Fedin, A, Fedorova, N, Golikov, K, Golovkin, V, Gusev, E, Gustov, A, Jakupov, E, Kamchatnov, P, Khabirov, F, Kirienko, A, Klimov, I, Klocheva, E, Kotov, S, Kuznetsov, A, Laskov, V, Levin, Y, Mashkova, N, Nazarov, A, Novikova, L, Odinak, M, Parfenov, V, Pilipenko, P, Pokrovsky, A, Poverennova, I, Rodoman, G, Roshkovskaya, L, Shirokov, E, Shmyriov, V, Sholomov, I, Skoromets, A, Skvortsova, V, Spirin, N, Stakhovskaya, L, Sharov, M, Sherman, M, Shutov, A, Strachunskaya, E, Stulin, I, Suslina, Z, Volosevitch, A, Vorobiev, P, Vorobyeva, O, Voronkova, L, Voskresenskaya, O, Zhuliov, N, Chan, B, Chang, H, Ramani, N, Brozman, M, Dvorak, M, Dzugan, J, Garay, R, Gdovinova, Z, Gurcik, L, Krastev, G, Kukumberg, P, Kurca, E, Meluch, S, Nyeky, M, Turcani, P, Vyletelka, J, Klanjscek, G, Zujovic, E, Zupan, M, Bester, F, Carr, J, Coetzee, C, Frost, A, Gardiner, J, Giampaolo, D, Kesler, S, Lurie, D, Retief, C, Roos, J, Bae, H, Cha, J, Cho, K, Heo, J, Kim, E, Lee, B, Lee, K, Lee, J, Rha, J, Yoon, B, Alvarez Sabin, J, Arboix Damunt, A, De Arce Borda, A, Asensi Alvarez JM, Bermejo Pareja, F, Botia Paniagua, E, Casado, I, Naranjo, I, Castillo Sanchez, J, Chamorro Sanchez, A, Davalos Errando, A, Diaz Marin, C, Diez Tejedor, E, Egido Herrero JA, Fernandez Bolanos, R, Fernandez Fernandez, O, Figuerola Roig, A, Geffner Sclarsky, D, Gil Nunez, A, Gomez Sanchez JC, Gomez Escalonilla Escobar CI, Gonzalez Masegosa, A, Gonzalez Menacho, J, Gracia Fleta, F, Izquierdo Ayuso, G, Jimenez Hernandez, D, Jimenez Martinez, C, Lago Martin, A, Lainez Andres JM, Larracoechea Jausoro, J, Lopez Fernandez JC, Maestre Moreno, J, Marti Vilalta JL, Martin Gonzalez, R, Masjuan Vallejo, J, Medina Rodriguez, A, Molto Jorda JM, Moreno Carre tero MJ, Moris de le Tassa, G, Morlan Gracia, L, Mostacero Miguez, E, Osuna Pulido, T, Pareja Martinez, A, Pinedo Brochado, A, Pons Amate JM, Rodriguez Alvarez JR, Roquer Gonzalez, J, Sanahuja Montesinos, J, Sanchez Sanchez MC, Segura Martin, T, Serena Leal, J, Tejada Garcia, J, Trejo Gabriel JM, Vivancos Mora, J, Andersson, B, Bysell, S, Cederin, B, Laska, A, Lindgren, A, Petersson, T, Wallen, T, Baumgartner, R, Beer, H, Hirt, L, Hungerbuehler, H, Lyrer, P, Michel, P, Mueller, F, Tettenborn, B, Chang, K, Jeng, J, Lien, L, Lin, R, Liu, C, Po, H, Wu, S, Chankrachang, S, Laptikultham, S, Nidhinandana, S, Pongpakdee, S, Benammou, S, Frih Ayed, M, Gouider, R, Mhiri, C, M'Rabet, A, Mrissa, R, Balkan, S, Can, U, Dalkara, T, Kirbas, D, Kumral, E, Ozdemir, G, Ozeren, A, Ozmenoglu, M, Ozturk, S, Lebedynets, V, Maly, V, Moskovko, S, Orzheshkovskyy, V, Smolanka, V, Yavors'Ka, V, Zozulya, I, Bamford, J, Barber, M, Barer, D, Baron, J, Bath, P, Broughton, D, Brown, M, Chataway, J, Curless, R, Darawil, K, Datta, P, Dennis, M, Durairaj, R, Egbuji, J, Ellis, S, Ford, G, Freeman, A, Fulcher, R, Gray, C, Harrington, F, Hudson, C, Iveson, E, James, M, Jenkinson, D, Kalra, L, Kelly, D, Krishnamoorthy, S, Langhorne, P, Magorrian, M, Macleod, M, Macwalter, R, Markus, H, Muhiddin, K, Muir, K, Murphy, P, Power, M, Price, C, Rashed, K, Robinson, T, Rudd, A, Sanmuganathan, P, Sharma, J, Shaw, L, Shetty, H, Smithard, D, Tyrrell, P, Vahidassr, M, Venables, G, Watt, M, White, R, Bousser, M, Amarenco, P, Chamorro, A, Fisher, M, Ford, I, Fox, K, Hennerici, M, Mattle, H, Rothwell, P, Ferrarese, C, PERFORM study, I, PERFORM STUDY, Investigator, Tedeschi, Gioacchino, Cras, Patrick, De Deyn, Peter Paul, and et al.

Subjects
perform study, Male, Thromboxane, International Cooperation, Receptors, Thromboxane, antiplatelet therapy, terutroban, Cardiovascular Disease, Receptors, 80 and over, Stroke, Aged, 80 and over, Aspirin, Ischemic Attack, Transient, Ischemic Attack, Transient, Double-Blind Method, Endpoint Determination, Dose-Response Relationship, Drug, Humans, Aged, Propionates, Naphthalenes, Treatment Outcome, Platelet Aggregation Inhibitors, Cardiovascular Diseases, Middle Aged, Female, Propionic Acids, Neurology, Terutroban, Anesthesia, tp receptor antagonist, stroke, secondary prevention, aspirin, Cardiology, Platelet aggregation inhibitor, Settore MED/26 - Neurologia, stroke prevention, Drug, Cardiology and Cardiovascular Medicine, medicine.drug, Human, medicine.medical_specialty, Dose-Response Relationship, Internal medicine, medicine, Dementia, In patient, business.industry, Platelet Aggregation Inhibitor, schemic, medicine.disease, DementiaI, transient ischemic attack, Ischemic stroke, Human medicine, Neurology (clinical), business, Propionic Acid, Naphthalene
Abstract

Background: Ischemic stroke is the leading cause of mortality worldwide and a major contributor to neurological disability and dementia. Terutroban is a specific TP receptor antagonist with antithrombotic, antivasoconstrictive, and antiatherosclerotic properties, which may be of interest for the secondary prevention of ischemic stroke. This article describes the rationale and design of the Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic Attack (PERFORM) Study, which aims to demonstrate the superiority of the efficacy of terutroban versus aspirin in secondary prevention of cerebrovascular and cardiovascular events. Methods and Results: The PERFORM Study is a multicenter, randomized, double-blind, parallel-group study being carried out in 802 centers in 46 countries. The study population includes patients aged ≥55 years, having suffered an ischemic stroke (≤3 months) or a transient ischemic attack (≤8 days). Participants are randomly allocated to terutroban (30 mg/day) or aspirin (100 mg/day). The primary efficacy endpoint is a composite of ischemic stroke (fatal or nonfatal), myocardial infarction (fatal or nonfatal), or other vascular death (excluding hemorrhagic death of any origin). Safety is being evaluated by assessing hemorrhagic events. Follow-up is expected to last for 2–4 years. Assuming a relative risk reduction of 13%, the expected number of primary events is 2,340. To obtain statistical power of 90%, this requires inclusion of at least 18,000 patients in this event-driven trial. The first patient was randomized in February 2006. Conclusions: The PERFORM Study will explore the benefits and safety of terutroban in secondary cardiovascular prevention after a cerebral ischemic event.

Published
2009

31. C-terminal BRE overexpression in 11q23-rearranged and t(8;16) acute myeloid leukemia is caused by intragenic transcription initiation

Author

Marneth, A E, Prange, K H M, Al Hinai, A S A, Bergevoet, S M, Tesi, N, Janssen-Megens, E M, Kim, B, Sharifi, N, Yaspo, M L, Kuster, J, Sanders, M A, Stoetman, E C G, Knijnenburg, J, Arentsen-Peters, T C J M, Zwaan, C M, Stunnenberg, H G, van den Heuvel-Eibrink, M M, Haferlach, T, Fornerod, M, Jansen, J H, Valk, P J M, van der Reijden, B A, and Martens, J H A

Abstract

Overexpression of the BRE (brain and reproductive organ-expressed) gene defines a distinct pediatric and adult acute myeloid leukemia (AML) subgroup. Here we identify a promoter enriched for active chromatin marks in BRE intron 4 causing strong biallelic expression of a previously unknown C-terminal BRE transcript. This transcript starts with BRE intron 4 sequences spliced to exon 5 and downstream sequences, and if translated might code for an N terminally truncated BRE protein. Remarkably, the new BRE transcript was highly expressed in over 50% of 11q23/KMT2A (lysine methyl transferase 2A)-rearranged and t(8;16)/KAT6A-CREBBP cases, while it was virtually absent from other AML subsets and normal tissues. In gene reporter assays, the leukemia-specific fusion protein KMT2A-MLLT3 transactivated the intragenic BRE promoter. Further epigenome analyses revealed 97 additional intragenic promoter marks frequently bound by KMT2A in AML with C-terminal BRE expression. The corresponding genes may be part of a context-dependent KMT2A-MLLT3-driven oncogenic program, because they were higher expressed in this AML subtype compared with other groups. C-terminal BRE might be an important contributor to this program because in a case with relapsed AML, we observed an ins(11;2) fusing CHORDC1 to BRE at the region where intragenic transcription starts in KMT2A-rearranged and KAT6A-CREBBP AML.

Published
2018
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32. Nachtelijke (rug)pijn; het miskende weksignaal van een spinale tumor

Author

Groen, R J, Kuster, J A, Noske, D P, Tjahja, S I, and de Vries, L

Subjects
Male, Middle Aged, Decompression, Surgical, Magnetic Resonance Imaging, Liposarcoma, Myxoid, Circadian Rhythm, Diagnosis, Differential, Treatment Outcome, Back Pain, Supine Position, Humans, Female, Spinal Cord Neoplasms, Spinal Cord Compression, Neurilemmoma
Abstract

Four patients had nocturnal back pain or pain that worsened when lying down. In one of these, a 49-year-old man, the medical history mentioned a malignancy, as a result of which a spinal metastasis was suspected. In the other three patients, a 52-year old woman and two men aged 48 and 60 years, the nocturnal back pain and the back pain worsening when lying down was not recognised as indication of a spinal tumour. As objective neurological symptoms were not established at initial investigation, a long period of discomfort and frustration followed before the spinal tumour was diagnosed eventually. The importance of recognising these early complaints is stressed. Nowadays, MRI is the technique of choice to answer the question whether there is a space occupying process in the spine.

Published
2001

34. Serie oercollectie : deel 7: Oud-Hollandse Kapucijner

Author

Kuster, J. and Kuster, J.

Abstract

Jan Kuster fokt in het Achterhoekse Didam met acht koppels oud-Hollandse kapucijners en heeft aan het eind van het fokseizoen jaarlijks zo'n veertig duiven in de kleurslag zwart-gemonnikt. Hij fokt al 38 jaar Oud-Hollandse Kapucijnduiven (waarvan ruim dertig jaar zwart). Het was de heer Moezelaar die de Boerenkapucijner in Nederland in 1959 erkend kreeg. In de jaren zeventig verdwenen de beste fokdieren naar West- Duitsland

Published
2010

37. ChemInform Abstract: C-Attached Aminoalkylindoles: Potent Cannabinoid Mimetics

Author

D'AMBRA, T. E., primary, EISSENSTAT, M. A., additional, ABT, J., additional, ACKERMAN, J. H., additional, BACON, E. R., additional, BELL, M. R., additional, CARABATEAS, P. M., additional, JOSEF, K. A., additional, KUMAR, V., additional, WEAVER, J. D. III, additional, ARNOLD, R., additional, CASIANO, F. M., additional, CHIPPARI, S. M., additional, HAYCOCK, D. A., additional, KUSTER, J. E., additional, LUTTINGER, D. A., additional, STEVENSON, J. I., additional, WARD, S. J., additional, HILL, W. A., additional, KHANOLKAR, A., additional, and ET AL., ET AL., additional

Published
2010
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45. ChemInform Abstract: Aminoalkylindoles: Structure‐Activity Relationships of Novel Cannabinoid Mimetics.

Author

EISSENSTAT, M. A., primary, BELL, M. R., additional, D'AMBRA, T. E., additional, ALEXANDER, E. J., additional, DAUM, S. J., additional, ACKERMAN, J. H., additional, GRUETT, M. D., additional, KUMAR, V., additional, ESTEP, K. G., additional, OLEFIROWICZ, E. M., additional, WETZEL, J. R., additional, ALEXANDER, M. D., additional, WEAVER, J. D. III, additional, HAYCOCK, D. A., additional, LUTTINGER, D. A., additional, CASIANO, F. M., additional, CHIPPARI, S. M., additional, KUSTER, J. E., additional, and et al., et al., additional

Published
1995
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46. Colonization with cagA-Positive Helicobacter pylori Strains Inversely Associated with Reflux Esophagitis and Barrett’s Esophagus.

Author

Loffeld, R. J. L. F., Werdmuller, B. F. M., Kuster, J. G., Pérez-Pérez, G. I., Blaser, M. J., and Kuipers, E. J.

Subjects
HELICOBACTER pylori, GASTROESOPHAGEAL reflux, ESOPHAGUS diseases, PROTEINS, BIOPSY
Abstract

Aim: The hypothesis that colonization with cagA[sup +] Helicobacter pylori strains protects against the development of gastroesophageal reflux disease (GERD) and its complications is tested. Methods: Patients with reflux esophagitis and Barrett’s esophagus were studied. Antral biopsy specimens were obtained for detection of H. pylori. A serum sample was obtained for determination of IgG antibodies to H. pylori and to the CagA protein. Results: 736 patients were studied. 118 patients had reflux esophagitis, 36 had Barrett’s esophagus, 108 had hiatal hernia without signs of inflammation (the reflux group), and 20 patients had esophageal or stomach cancer. The remaining 454 patients had no signs of GERD. The 262 patients with reflux disease had a significantly lower prevalence of H. pylori (34.9%) than the 454 controls (54.6%; p < 0.001). Among 310 H. pylori-positive patients from whom serum was available, colonization with cagA[sup +] strains was detected in 59% in the control group versus 35% in the reflux group (p < 0.001). Conclusion: Patients with reflux esophagitis and Barrett’s esophagus have a significantly lower prevalence of H. pylori colonization than controls, in particular of the cagA[sup +] type. These data suggest that colonization with cagA[sup +] H. pylori strains may be protective against the development of GERDCopyright © 2000 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2000
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48. UPDATE ON THE OUTLOOK FOR THE SAP SITUATION.

Author

Kuster, J. Blake

Abstract

The article is an update of an article previously published in the June-July 2005 issue of the journal "Nonwovens World," which was entitled "Causes and Consequences of the Current SAP Crisis." Some of the main points of the first article are summarized by the author. The first article endeavored to provide an understanding of market conditions leading to a shortage of superabsorbent polymer (SAP). It also tried to project potential duration and effect on price. The SAP market has had significant activity. Both SAP and acrylic acid markets seemed in balance by the second quarter of 2005, but it proved to be short-lived by the third quarter.

Published
2005

49. CAUSES AND CONSEQUENCES OF THE CURRENT SAP CRISIS.

Author

Kuster, J. Blake

Abstract

The prices of superabsorbent polymer have continually decreased. The supply also was widely available, except for a few brief periods of tight capacities, but even then the price, at worst, held its level. When the occasional short supply developed, companies were assured that the shortage was short-lived and mostly regional in scope. Single sourcing of SAP supply, along with other raw material supplies became common in North America and Europe.

Published
2005

50. DIAPER CORE CONTENT AND PERFORMANCE - A GLOBAL SAMPLING.

Author

Blake, Kuster, J.

Abstract

This article presents a summary of several analytical efforts, compiled over a two-year period, of baby diapers available in the world today. The work was done by the technical service laboratories of Sumitomo Seika Chemical Co. in Japan and Singapore. The diapers tested include several global offerings from the familiar brands from Procter and Gamble Co. and Kimberly-Clark Corp. It is noted that design parameters greatly influence the performance of the product's core. Generally, more advanced core designs are found in the mature diaper markets of North America, Europe and Japan. However, a surprising number of the thinner compressed-core diapers are making their way into the developing markets of Asia-Pacific, South America and the Middle East, along with Eastern Europe.

Published
2004

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