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28 results on '"Kusadasi, Nuray"'

3. Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration

Author

Apotheek O&O&O, Apotheek Klinische Farmacie, Longziekten, Infection & Immunity, Apotheek Opleiding, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Apotheek Onderzoek, Regenerative Medicine and Stem Cells, van Dommelen, Julia E M, Grootjans, Heleen, Uijtendaal, Esther V, Ruigrok, Dieuwertje, Luijk, Bart, van Luin, Matthijs, Bult, Wouter, de Lange, Dylan W, Kusadasi, Nuray, Droogh, Joep M, Egberts, Toine C G, Verschuuren, Erik A M, Sikma, Maaike A, Apotheek O&O&O, Apotheek Klinische Farmacie, Longziekten, Infection & Immunity, Apotheek Opleiding, Medische Staf Intensive Care, NVIC bedrijfsvoering, Brain, Apotheek Onderzoek, Regenerative Medicine and Stem Cells, van Dommelen, Julia E M, Grootjans, Heleen, Uijtendaal, Esther V, Ruigrok, Dieuwertje, Luijk, Bart, van Luin, Matthijs, Bult, Wouter, de Lange, Dylan W, Kusadasi, Nuray, Droogh, Joep M, Egberts, Toine C G, Verschuuren, Erik A M, and Sikma, Maaike A

Published
2024

4. Tacrolimus Variability and Clinical Outcomes in the Early Post-lung Transplantation Period: Oral Versus Continuous Intravenous Administration

Author

Afd Pharmacoepi & Clinical Pharmacology, PECP – Centre for Clinical Therapeutics, Pharmacoepidemiology and Clinical Pharmacology, van Dommelen, Julia E M, Grootjans, Heleen, Uijtendaal, Esther V, Ruigrok, Dieuwertje, Luijk, Bart, van Luin, Matthijs, Bult, Wouter, de Lange, Dylan W, Kusadasi, Nuray, Droogh, Joep M, Egberts, Toine C G, Verschuuren, Erik A M, Sikma, Maaike A, Afd Pharmacoepi & Clinical Pharmacology, PECP – Centre for Clinical Therapeutics, Pharmacoepidemiology and Clinical Pharmacology, van Dommelen, Julia E M, Grootjans, Heleen, Uijtendaal, Esther V, Ruigrok, Dieuwertje, Luijk, Bart, van Luin, Matthijs, Bult, Wouter, de Lange, Dylan W, Kusadasi, Nuray, Droogh, Joep M, Egberts, Toine C G, Verschuuren, Erik A M, and Sikma, Maaike A

Published
2024

9. Thrombosis pathways in COVID-19 vs. influenza-associated ARDS: a targeted proteomics approach

Author

Infection & Immunity, Epi Infectieziekten Team 1, MMB Research line 1, Medische Staf Intensive Care, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, CTI Computational Immunology Core, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Rademaker, Emma, Doorduijn, Dennis J, Kusadasi, Nuray, Maas, Coen, Drylewicz, Julia, Huisman, Albert, Hoefer, Imo E, Bonten, Marc J M, Derde, Lennie P G, Rooijakkers, Suzan H M, Cremer, Olaf L, Infection & Immunity, Epi Infectieziekten Team 1, MMB Research line 1, Medische Staf Intensive Care, CDL Cluster Onderzoek en Onderwijs, Circulatory Health, CTI Computational Immunology Core, CDL Cluster 24/7 centraal laboratorium, Other research (not in main researchprogram), Centraal Diagnostisch Laboratorium, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Rademaker, Emma, Doorduijn, Dennis J, Kusadasi, Nuray, Maas, Coen, Drylewicz, Julia, Huisman, Albert, Hoefer, Imo E, Bonten, Marc J M, Derde, Lennie P G, Rooijakkers, Suzan H M, and Cremer, Olaf L

Published
2022

10. Outcome of cancer patients considered for intensive care unit admission in two university hospitals in the Netherlands:the danger of delayed ICU admissions and off-hour triage decisions

Author

van der Zee, Esther N., Benoit, Dominique D., Hazenbroek, Marinus, Bakker, Jan, Kompanje, Erwin J.O., Kusadasi, Nuray, Epker, Jelle L., van der Zee, Esther N., Benoit, Dominique D., Hazenbroek, Marinus, Bakker, Jan, Kompanje, Erwin J.O., Kusadasi, Nuray, and Epker, Jelle L.

Abstract

Background: Very few studies assessed the association between Intensive Care Unit (ICU) triage decisions and mortality. The aim of this study was to assess whether an association could be found between 30-day mortality, and ICU admission consultation conditions and triage decisions. Methods: We conducted a retrospective cohort study in two large referral university hospitals in the Netherlands. We identified all adult cancer patients for whom ICU admission was requested from 2016 to 2019. Via a multivariable logistic regression analysis, we assessed the association between 30-day mortality, and ICU admission consultation conditions and triage decisions. Results: Of the 780 cancer patients for whom ICU admission was requested, 332 patients (42.6%) were considered ‘too well to benefit’ from ICU admission, 382 (49%) patients were immediately admitted to the ICU and 66 patients (8.4%) were considered ‘too sick to benefit’ according to the consulting intensivist(s). The 30-day mortality in these subgroups was 30.1%, 36.9% and 81.8%, respectively. In the patient group considered ‘too well to benefit’, 258 patients were never admitted to the ICU and 74 patients (9.5% of the overall study population, 22.3% of the patients ‘too well to benefit’) were admitted to the ICU after a second ICU admission request (delayed ICU admission). Thirty-day mortality in these groups was 25.6% and 45.9%. After adjustment for confounders, ICU consultations during off-hours (OR 1.61, 95% CI 1.09–2.38, p-value 0.02) and delayed ICU admission (OR 1.83, 95% CI 1.00–3.33, p-value 0.048 compared to “ICU admission”) were independently associated with 30-day mortality. Conclusion: The ICU denial rate in our study was high (51%). Sixty percent of the ICU triage decisions in cancer patients were made during off-hours, and 22.3% of the patients initially considered “too well to benefit” from ICU admission were subsequently admitted to the ICU. Both decisions during off-hours and a delayed ICU admissi

Published
2021

11. A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy

Author

Medische Staf Intensive Care, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), MS Interne Geneeskunde, Circulatory Health, CDL Staf Research, Poli Van Creveldkliniek Medisch, Infection & Immunity, Kusadasi, Nuray, Sikma, Maaike, Huisman, Albert, Westerink, Jan, Maas, Coen, Schutgens, Roger, Medische Staf Intensive Care, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), MS Interne Geneeskunde, Circulatory Health, CDL Staf Research, Poli Van Creveldkliniek Medisch, Infection & Immunity, Kusadasi, Nuray, Sikma, Maaike, Huisman, Albert, Westerink, Jan, Maas, Coen, and Schutgens, Roger

Published
2020

12. Involvement of ADAMTS13 and von Willebrand factor in thromboembolic events in patients infected with SARS-CoV-2

Author

CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), AIOS Anesthesiologie, Medische Staf Intensive Care, MS Interne Geneeskunde, Circulatory Health, Huisman, Albert, Beun, Robert, Sikma, Maaike, Westerink, Jan, Kusadasi, Nuray, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), AIOS Anesthesiologie, Medische Staf Intensive Care, MS Interne Geneeskunde, Circulatory Health, Huisman, Albert, Beun, Robert, Sikma, Maaike, Westerink, Jan, and Kusadasi, Nuray

Published
2020

13. Thromboembolic events and apparent heparin resistance in patients infected with SARS-CoV-2

Author

AIOS Anesthesiologie, Medische Staf Intensive Care, MS Interne Geneeskunde, Circulatory Health, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Beun, Robert, Kusadasi, Nuray, Sikma, Maaike, Westerink, Jan, Huisman, Albert, AIOS Anesthesiologie, Medische Staf Intensive Care, MS Interne Geneeskunde, Circulatory Health, CDL Staf Patiëntenzorg KC, Other research (not in main researchprogram), Beun, Robert, Kusadasi, Nuray, Sikma, Maaike, Westerink, Jan, and Huisman, Albert

Published
2020

17. Predictors of short-term and long-term mortality in critically ill patients admitted to the intensive care unit following allogeneic stem cell transplantation

Author

van der Heiden, P. L. J., Arbous, M. S., van Beers, E. J., van den Bergh, W. M., le Cessie, S., Demandt, A. M. P., Eefting, M., Hess, C., Kusadasi, N., Marijt, W. A. F., van Mook, W. N. K. A., Müller, M. C. A., Tuinman, P. R., van Vliet, M., van Westerloo, D. J., Blijlevens, N. M. A., Biemond, Bart J., Müller, Marcella C. A., Vlaar, Alexander J., Tuinman, Pieter R., Spoelstra, Angelique M., Arbous, M. Sesmu, van Westerloo, David J., van der Heiden, Pim L. J., van Vliet, Maarten, Blijlevens, Nicole M. A., Hilkens, Murielle, van den Bergh, Walter M., Kluin, Hanneke C., van Mook, Walther N. K. A., Demandt, Astrid M. P., Kusadasi, Nuray, Intensive care medicine, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes, Hematology, ACS - Pulmonary hypertension & thrombosis, Other Research, Intensive Care Medicine, Clinical Haematology, AII - Inflammatory diseases, Interne Geneeskunde, MUMC+: MA Hematologie (9), Intensive Care, MUMC+: MA Medische Staf IC (9), RS: FHML non-thematic output, and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)

Subjects
Adult, MEDICAL PROGRESS, medicine.medical_specialty, Transplantation Conditioning, Surviving Sepsis Campaign, Critical Illness, Neutropenia, GUIDELINES, law.invention, 03 medical and health sciences, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, law, Internal medicine, MANAGEMENT, Humans, Transplantation, Homologous, Medicine, Transplantation, OUTCOMES, SURVIVING SEPSIS CAMPAIGN, business.industry, Critically ill, Hematopoietic Stem Cell Transplantation, Hematology, ADULTS, Middle Aged, medicine.disease, Intensive care unit, ADMISSION, TRENDS, Intensive Care Units, RECIPIENTS, SEVERITY, 030220 oncology & carcinogenesis, SURVIVAL, Long term mortality, Stem cell, business, 030215 immunology, Cohort study, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Historically, the mortality of patients admitted to the ICU after allogeneic stem cell transplantation (alloSCT) is high. Advancements in transplantation procedures, infectious monitoring and supportive care may have improved the outcome. This study aimed to determine short-term and long-term mortality after ICU admission of patients after alloSCT and to identify prognostic clinical and transplantation-related determinants present at ICU admission for long-term outcome. A multicenter cohort study was performed to determine 30-day and 1-year mortality within 2 years following alloSCT. A total of 251 patients were included. The 30-day and 1-year mortality was 55% and 80%, respectively. Platelet count 19 μmol/L (OR: 2.47 CI: 1.08–5.65) at admission, other donor than a HLA-matched-related or HLA-matched-unrelated donor (OR: 4.59, CI: 1.49–14.1) and vasoactive medication within 24 h (OR: 2.35, CI: 1.28–4.31) were associated with increased 30-day mortality. Other donor than a HLA-matched-related or HLA-matched-unrelated donor (OR: 1.9, CI: 1.13–3.19), serum bilirubin >77 (OR: 2.05, CI: 1.28–3.30) and vasoactive medication within 24 h (OR: 1.65, CI: 1.12–2.43) were associated with increased 1-year mortality. Neutropenia was associated with decreased 30-day and 1-year mortality (OR: 0.29, CI: 0.14–0.59 and OR: 0.70, CI: 0.48–0.98). Myeloablative conditioning and T cell-depleted transplantation were not associated with increased mortality.

Published
2019

18. Long-Term Outcome of Patients With a Hematologic Malignancy and Multiple Organ Failure Admitted at the Intensive Care

Author

de Vries, VA, Muller, MCA, Arbous, MS, Biemond, BJ, Blijlevens, NMA, Kusadasi, Nuray, Span, LRF, Vlaar, APJ, van Westerloo, DJ, Kluin-Nelemans, HC, Bergh, WM, Tuinman, PR, Spoelstra, A, Marijt, E, Blijlevens, N, Hilkens, M, Epker, J, Broers, A, Choi, G, Demandt, A, van Mook, W, de Vries, VA, Muller, MCA, Arbous, MS, Biemond, BJ, Blijlevens, NMA, Kusadasi, Nuray, Span, LRF, Vlaar, APJ, van Westerloo, DJ, Kluin-Nelemans, HC, Bergh, WM, Tuinman, PR, Spoelstra, A, Marijt, E, Blijlevens, N, Hilkens, M, Epker, J, Broers, A, Choi, G, Demandt, A, and van Mook, W

Published
2019

22. Time trend analysis of long term outcome of patients with haematological malignancies admitted at dutch intensive care units.

Author

de Vries, Vera A., Müller, Marcella C. A., Sesmu Arbous, M., Biemond, Bart J., Blijlevens, Nicole M. A., Kusadasi, Nuray, Choi, Goda C. W., Vlaar, Alexander P. J., van Westerloo, David J., Kluin‐Nelemans, Hanneke C., van den Bergh, Walter M., and the HEMA‐ICU Study Group

Subjects
HEALTH outcome assessment, INTENSIVE care units, PROGRESSION-free survival, DISEASE prevalence, ACUTE myeloid leukemia
Abstract

Summary: A few decades ago, the chances of survival for patients with a haematological malignancy needing Intensive Care Unit (ICU) support were minimal. As a consequence, ICU admission policy was cautious. We hypothesized that the long‐term outcome of patients with a haematological malignancy admitted to the ICU has improved in recent years. Furthermore, our objective was to evaluate the predictive value of the Acute Physiology and Chronic Health Evaluation (APACHE) II score. A total of 1095 patients from 5 Dutch university hospitals were included from 2003 until 2015. We studied the prevalence of patients' characteristics over time. By using annual odds ratios, we analysed which patients' characteristics could have had influenced possible trends in time. A approximated mortality rate was compared with the ICU mortality rate, to study the predictive value of the APACHE II score. Overall one‐year mortality was 62%. The annual decrease in one‐year mortality was 7%, whereas the APACHE II score increased over time. Decreased mortality rates were particularly observed in high‐risk patients (acute myeloid leukaemia, old age, low platelet count, bleeding as admission reason and need for mechanical ventilation within 24 h of ICU admission). Furthermore, the APACHE II score overestimates mortality in this patient category. [ABSTRACT FROM AUTHOR]

Published
2018
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27. Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis

Author

Oostendorp, Robert A. J., primary, Medvinsky, Alexander J., additional, Kusadasi, Nuray, additional, Nakayama, Naoki, additional, Harvey, Kirsty, additional, Orelio, Claudia, additional, Ottersbach, Katrin, additional, Covey, Todd, additional, Ploemacher, Rob E., additional, Saris, Chris, additional, and Dzierzak, Elaine, additional

Published
2002
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