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2. Death associated protein kinase 1 dampens keratinocyte necroptosis and expression of inflammatory genes in lichen planus

Author

Kurzen, Nils, Mubarak, Menna, Eigemann, Jessica, Seiringer, Peter, Wasserer, Sophia, Hillig, Christina, Menden, Michael, Biedermann, Tilo, Schmidt-Weber, Carsten B., Eyerich, Kilian, Jargosch, Manja, Eyerich, Stefanie, and Lauffer, Felix

Abstract

Lichen planus (LP) is a chronic inflammatory disease (ISD) affecting skin, mucosa, nail, and hair. Previous studies demonstrated a pivotal role of type 1 immunity in LP, as infiltrating T cells trigger apoptosis and necroptosis in the epidermis. In this study, we investigated the role of DAPK1 in LP with special focus on its role in mediating cell death and inflammation.

Published
2025
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