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1. Leisure-time physical activity and gastric cancer risk: A pooled study within the Stomach cancer Pooling (StoP) Project.

Author

Mariani, Marco, Pastorino, Roberta, Pires Marafon, Denise, Johnson, Ken C, Hu, Jinfu, Molina de la Torre, Antonio Jose, Fernández-Tardón, Guillermo, Zaridze, David, Maximovich, Dmitry, Negri, Eva, La Vecchia, Carlo, Zhang, Zuo-Feng, Kurtz, Robert C, Pelucchi, Claudio, Rota, Matteo, and Boccia, Stefania

Subjects
Humans, Stomach Neoplasms, Exercise, Motor Activity, Leisure Activities, Middle Aged, Clinical Research, Prevention, Cancer, General Science & Technology
Abstract

BackgroundAlthough physical activity (PA) has been recognized as a favourable factor in the prevention of various diseases, including certain forms of cancer, the relationship between PA and gastric cancer (GC) is not yet fully understood. This study aims to provide data from a pooled analysis of case-control studies within the Stomach cancer Pooling (StoP) Project to estimate the association between leisure-time PA and the occurrence of GC.MethodsSix case-control studies from StoP project collected data on leisure-time PA, for a total of 2,343 cases and 8,614 controls. Subjects were classified into three leisure-time PA categories, either none/low, intermediate or high, based on study-specific tertiles. We used a two-stage approach. Firstly, we applied multivariable logistic regression models to obtain study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) then, we used a random-effect models to obtain pooled effect estimates. We performed stratified analyses according to demographic, lifestyle and clinical covariates.ResultsThe meta-analysis showed ORs of GC with no significant differences between intermediate vs low and high vs low PA level (OR 1.05 [95%CI 0.76-1.45]; OR 1.23 [95%CI 0.78-1.94], respectively). GC risk estimates did not strongly differ across strata of selected covariates except for age ≤ 55 years old (high vs low level: OR 0.72 [95%CI 0.55-0.94]) and for control population-based studies (high vs low level: OR 0.79 [95%CI 0.68-0.93]).ConclusionsNo association was found between leisure time PA and GC, apart from a slight suggestion of decreased risk below age 55 and in control population-based studies. These results may reflect specific characteristics of GC at a younger age, or the presence of a cohort effect mediating and interacting with socioeconomic determinants of GC The different distribution of PA levels among hospitalized controls could have led to an underestimated effect of PA on GC risk.

Published
2023

2. Tea consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling (StoP) Project consortium

Author

Martimianaki, Georgia, Alicandro, Gianfranco, Pelucchi, Claudio, Bonzi, Rossella, Rota, Matteo, Hu, Jinfu, Johnson, Kenneth C, Rabkin, Charles S, Liao, Linda M, Sinha, Rashmi, Zhang, Zuo-Feng, Dalmartello, Michela, Lunet, Nuno, Morais, Samantha, Palli, Domenico, Ferraroni, Monica, Yu, Guo-Pei, Tsugane, Shoichiro, Hidaka, Akihisa, Curado, Maria Paula, Dias-Neto, Emmanuel, Zaridze, David, Maximovitch, Dmitry, Vioque, Jesus, Garcia de la Hera, Manoli, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Hamada, Gerson Shigueaki, Ward, Mary H, Mu, Lina, Malekzadeh, Reza, Pourfarzi, Farhad, Trichopoulou, Antonia, Karakatsani, Anna, Kurtz, Robert C, Lagiou, Areti, Lagiou, Pagona, Boccia, Stefania, Boffetta, Paolo, Camargo, M Constanza, Negri, Eva, and La Vecchia, Carlo

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Digestive Diseases, Clinical Research, Cancer, Case-Control Studies, Helicobacter Infections, Humans, Odds Ratio, Risk Factors, Stomach Neoplasms, Tea, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundEvidence from epidemiological studies on the role of tea drinking in gastric cancer risk remains inconsistent. We aimed to investigate and quantify the relationship between tea consumption and gastric cancer in the Stomach cancer Pooling (StoP) Project consortium.MethodsA total of 9438 cases and 20,451 controls from 22 studies worldwide were included. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) of gastric cancer for regular versus non-regular tea drinkers were estimated by one and two-stage modelling analyses, including terms for sex, age and the main recognised risk factors for gastric cancer.ResultsCompared to non-regular drinkers, the estimated adjusted pooled OR for regular tea drinkers was 0.91 (95% CI: 0.85-0.97). When the amount of tea consumed was considered, the OR for consumption of 1-2 cups/day was 1.01 (95% CI: 0.94-1.09) and for >3 cups/day was 0.91 (95% CI: 0.80-1.03). Stronger inverse associations emerged among regular drinkers in China and Japan (OR: 0.67, 95% CI: 0.49-0.91) where green tea is consumed, in subjects with H. pylori infection (OR: 0.68, 95% CI: 0.58-0.80), and for gastric cardia cancer (OR: 0.64, 95% CI: 0.49-0.84).ConclusionOur results indicate a weak inverse association between tea consumption and gastric cancer.

Published
2022

3. The mediating role of combined lifestyle factors on the relationship between education and gastric cancer in the Stomach cancer Pooling (StoP) Project

Author

Alicandro, Gianfranco, Bertuccio, Paola, Collatuzzo, Giulia, Pelucchi, Claudio, Bonzi, Rossella, Liao, Linda M, Rabkin, Charles S, Sinha, Rashmi, Negri, Eva, Dalmartello, Michela, Zaridze, David, Maximovich, Dmitry, Vioque, Jesus, Garcia de la Hera, Manoli, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Malekzadeh, Reza, Pourfarzi, Farhad, Zhang, Zuo-Feng, Kurtz, Robert C, Camargo, M Constanza, Curado, Maria Paula, Lunet, Nuno, Boffetta, Paolo, and La Vecchia, Carlo

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Substance Misuse, Prevention, Nutrition, Cancer, Digestive Diseases, Quality Education, Case-Control Studies, Educational Status, Humans, Life Style, Male, Risk Factors, Stomach Neoplasms, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThe causal pathway between high education and reduced risk of gastric cancer (GC) has not been explained. The study aimed at evaluating the mediating role of lifestyle factors on the relationship between education and GC METHODS: Ten studies with complete data on education and five lifestyle factors (smoking, alcohol drinking, fruit and vegetable intake, processed meat intake and salt consumption) were selected from a consortium of studies on GC including 4349 GC cases and 8441 controls. We created an a priori score based on the five lifestyle factors, and we carried out a counterfactual-based mediation analysis to decompose the total effect of education on GC into natural direct effect and natural indirect effect mediated by the combined lifestyle factors. Effects were expressed as odds ratios (ORs) with a low level of education as the reference category.ResultsThe natural direct and indirect effects of high versus low education were 0.69 (95% CI: 0.62-0.77) and 0.96 (95% CI: 0.95-0.97), respectively, corresponding to a mediated percentage of 10.1% (95% CI: 7.1-15.4%). The mediation effect was limited to men.ConclusionsThe mediation effect of the combined lifestyle factors on the relationship between education and GC is modest. Other potential pathways explaining that relationship warrants further investigation.

Published
2022

4. The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium

Author

Dabo, Bashir, Pelucchi, Claudio, Rota, Matteo, Jain, Harshonnati, Bertuccio, Paola, Bonzi, Rossella, Palli, Domenico, Ferraroni, Monica, Zhang, Zuo-Feng, Sanchez-Anguiano, Aurora, Pham, Yen Thi-Hai, Tran, Chi Thi-Du, Pham, Anh Gia, Yu, Guo-Pei, Nguyen, Tin C, Muscat, Joshua, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson S, Zaridze, David, Maximovitch, Dmitry, Kogevinas, Manolis, de Larrea, Nerea Fernàndez, Boccia, Stefania, Pastorino, Roberta, Kurtz, Robert C, Lagiou, Areti, Lagiou, Pagona, Vioque, Jesus, Camargo, M Constanza, Curado, Maria Paula, Lunet, Nuno, Boffetta, Paolo, Negri, Eva, La Vecchia, Carlo, and Luu, Hung N

Subjects
Epidemiology, Health Sciences, Prevention, Infectious Diseases, Clinical Research, Emerging Infectious Diseases, Digestive Diseases, Diabetes, Cancer, Metabolic and endocrine, Case-Control Studies, Diabetes Mellitus, Type 2, Helicobacter Infections, Helicobacter pylori, Humans, Risk Factors, Stomach Neoplasms, diabetes, gastric cancer, risk factors, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

BackgroundPrior epidemiologic studies on the association between diabetes and gastric cancer risk provided inconclusive findings, while traditional, aggregate data meta-analyses were characterized by high between-study heterogeneity.ObjectiveTo investigate the association between type 2 diabetes and gastric cancer using data from the 'Stomach Cancer Pooling (StoP) Project', an international consortium of more than 30 case-control and nested case-control studies, which is large and provides harmonized definition of participants' characteristics across individual studies. The data have the potential to minimize between-study heterogeneity and provide greater statistical power for subgroup analysis.MethodsWe included 5592 gastric cancer cases and 12 477 controls from 14 studies from Europe, Asia, North America, and South America in a two-stage individual-participant data meta-analysis. Random-effect models were used to estimate summary odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) by pooling study-specific ORs.ResultsWe did not find an overall association between diabetes and gastric cancer (pooled OR = 1.01, 95% CI, 0.94-1.07). However, the risk of cardia gastric cancer was significantly higher among individuals with type 2 diabetes (OR = 1.16, 95% CI, 1.02-1.33). There was no association between diabetes and gastric cancer risk in strata of Helicobacter pylori infection serostatus, age, sex, BMI, smoking status, alcohol consumption, fruit/vegetable intake, gastric cancer histologic type, and source of controls.ConclusionThis study provides additional evidence that diabetes is unrelated to gastric cancer overall but may be associated with excess cardia gastric cancer risk.

Published
2022

5. The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium

Author

Paragomi, Pedram, Dabo, Bashir, Pelucchi, Claudio, Bonzi, Rossella, Bako, Abdulaziz T, Sanusi, Nabila Muhammad, Nguyen, Quan H, Zhang, Zuo-Feng, Palli, Domenico, Ferraroni, Monica, Vu, Khanh Truong, Yu, Guo-Pei, Turati, Federica, Zaridze, David, Maximovitch, Dmitry, Hu, Jinfu, Mu, Lina, Boccia, Stefania, Pastorino, Roberta, Tsugane, Shoichiro, Hidaka, Akihisa, Kurtz, Robert C, Lagiou, Areti, Lagiou, Pagona, Camargo, M Constanza, Curado, Maria Paula, Lunet, Nuno, Vioque, Jesus, Boffetta, Paolo, Negri, Eva, La Vecchia, Carlo, and Luu, Hung N

Subjects
Cancer, Rare Diseases, Emerging Infectious Diseases, Digestive Diseases, Gastric ulcers, duodenal ulcers, risk factors, gastric cancer, Oncology and Carcinogenesis
Abstract

BackgroundGastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by H. pylori infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium.MethodsHistory of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth's penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC.ResultsHistory of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07-4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77-1.39).ConclusionsIn the pooled analysis of 11 case-control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.

Published
2022

7. Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

Author

Martimianaki, Georgia, Bertuccio, Paola, Alicandro, Gianfranco, Pelucchi, Claudio, Bravi, Francesca, Carioli, Greta, Bonzi, Rossella, Rabkin, Charles S, Liao, Linda M, Sinha, Rashmi, Johnson, Ken, Hu, Jinfu, Palli, Domenico, Ferraroni, Monica, Lunet, Nuno, Morais, Samantha, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Martin, Vicente, Ward, Mary H, Vioque, Jesus, de la Hera, Manoli Garcia, Zhang, Zuo-Feng, Kurtz, Robert C, Lagiou, Pagona, Lagiou, Areti, Trichopoulou, Antonia, Karakatsani, Anna, Malekzadeh, Reza, Camargo, M Constanza, Curado, Maria Paula, Boccia, Stefania, Boffetta, Paolo, Negri, Eva, and La Vecchia, Carlo

Subjects
Clinical Research, Cancer, Coffee, Humans, Logistic Models, Observational Studies as Topic, Odds Ratio, Risk Factors, Stomach Neoplasms, cardia cancer, case-control study, coffee, gastric cancer, pooled analysis, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis
Abstract

ObjectiveThis study aimed to evaluate and quantify the relationship between coffee and gastric cancer using a uniquely large dataset from an international consortium of observational studies on gastric cancer, including data from 18 studies, for a total of 8198 cases and 21 419 controls.MethodsA two-stage approach was used to obtain the pooled odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for coffee drinkers versus never or rare drinkers. A one-stage logistic mixed-effects model with a random intercept for each study was used to estimate the dose-response relationship. Estimates were adjusted for sex, age and the main recognized risk factors for gastric cancer.ResultsCompared to never or rare coffee drinkers, the estimated pooled OR for coffee drinkers was 1.03 (95% CI, 0.94-1.13). When the amount of coffee intake was considered, the pooled ORs were 0.91 (95% CI, 0.81-1.03) for drinkers of 1-2 cups per day, 0.95 (95% CI, 0.82-1.10) for 3-4 cups, and 0.95 (95% CI, 0.79-1.15) for five or more cups. An OR of 1.20 (95% CI, 0.91-1.58) was found for heavy coffee drinkers (seven or more cups of caffeinated coffee per day). A positive association emerged for high coffee intake (five or more cups per day) for gastric cardia cancer only.ConclusionsThese findings better quantify the previously available evidence of the absence of a relevant association between coffee consumption and gastric cancer.

Published
2021

8. The p.Ser64Leu and p.Pro104Leu missense variants of PALB2 identified in familial pancreatic cancer patients compromise the DNA damage response

Author

Zhang, Yue, Park, Jung‐Young, Zhang, Fan, Olson, Sara H, Orlow, Irene, Li, Yirong, Kurtz, Robert C, Ladanyi, Marc, Chen, Jie, Toland, Amanda E, Zhang, Liying, and Andreassen, Paul R

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Oncology and Carcinogenesis, Orphan Drug, Cancer, Breast Cancer, Rare Diseases, Digestive Diseases, Clinical Research, Pancreatic Cancer, 2.1 Biological and endogenous factors, Aetiology, DNA Damage, Fanconi Anemia Complementation Group N Protein, Humans, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Pancreatic Neoplasms, Rad51 Recombinase, functional studies, homologous recombination, missense variants, PALB2, pancreatic cancer, variant of uncertain significance, Clinical Sciences, Genetics & Heredity, Clinical sciences
Abstract

PALB2 has been identified as a breast and pancreatic cancer susceptibility gene. Utilizing a targeted sequencing approach, we discovered two novel germline missense PALB2 variants c.191C>T and c.311C>T, encoding p.Ser64Leu and p.Pro104Leu, respectively, in individuals in a pancreatic cancer registry. No missense PALB2 variants from familial pancreatic cancer patients, and few PALB2 variants overall, have been functionally characterized. Given the known role of PALB2, we tested the impact of p.Ser64Leu and p.Pro104Leu variants on DNA damage responses. Neither p.Ser64Leu nor p.Pro104Leu have clear effects on interactions with BRCA1 and KEAP1, which are mediated by adjacent motifs in PALB2. However, both variants are associated with defective recruitment of PALB2, and the RAD51 recombinase downstream, to DNA damage foci. Furthermore, p.Ser64Leu and p.Pro104Leu both largely compromise DNA double-strand break-initiated homologous recombination, and confer increased cellular sensitivity to ionizing radiation (IR) and the poly (ADP-ribose) polymerase (PARP) inhibitor Olaparib. Taken together, our results represent the first demonstration of functionally deleterious PALB2 missense variants associated with familial pancreatic cancer and of deleterious variants in the N-terminus outside of the coiled-coil domain. Furthermore, our results suggest the possibility of personalized treatments, using IR or PARP inhibitor, of pancreatic and other cancers that carry a deleterious PALB2 variant.

Published
2021

9. Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project

Author

Ferro, Ana, Costa, Ana Rute, Morais, Samantha, Bertuccio, Paola, Rota, Matteo, Pelucchi, Claudio, Hu, Jinfu, Johnson, Kenneth C, Zhang, Zuo‐Feng, Palli, Domenico, Ferraroni, Monica, Yu, Guo‐Pei, Bonzi, Rossella, Peleteiro, Bárbara, López‐Carrillo, Lizbeth, Tsugane, Shoichiro, Hamada, Gerson Shigueaki, Hidaka, Akihisa, Malekzadeh, Reza, Zaridze, David, Maximovich, Dmitry, Vioque, Jesus, Navarrete‐Muñoz, Eva M, Alguacil, Juan, Castaño‐Vinyals, Gemma, Wolk, Alicja, Håkansson, Niclas, Hernández‐Ramírez, Raúl Ulises, Pakseresht, Mohammadreza, Ward, Mary H, Pourfarzi, Farhad, Mu, Lina, López‐Cervantes, Malaquias, Persiani, Roberto, Kurtz, Robert C, Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Boccia, Stefania, Negri, Eva, Camargo, Maria Constanza, Curado, Maria Paula, La Vecchia, Carlo, and Lunet, Nuno

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Digestive Diseases, Nutrition, Cancer, Prevention, Adult, Aged, Case-Control Studies, Diet, Female, Food Preferences, Fruit, Humans, Life Style, Male, Middle Aged, Odds Ratio, Stomach Neoplasms, Surveys and Questionnaires, Vegetables, fruits, gastric cancer, nutrition, pooled analyses, vegetables, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two-stage approach based on random-effects models was used to pool study-specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure-response relations, including linear and nonlinear associations, were modeled using one- and two-order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64-0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73-1.02), vegetables (OR: 0.68, 95% CI: 0.56-0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49-0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure-response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57-0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61-0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43-0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.

Published
2020

10. Meat intake and risk of gastric cancer in the Stomach cancer Pooling (StoP) project

Author

Ferro, Ana, Rosato, Valentina, Rota, Matteo, Costa, Ana Rute, Morais, Samantha, Pelucchi, Claudio, Johnson, Kenneth C, Hu, Jinfu, Palli, Domenico, Ferraroni, Monica, Zhang, Zuo‐Feng, Bonzi, Rossella, Yu, Guo‐Pei, Peleteiro, Bárbara, López‐Carrillo, Lizbeth, Tsugane, Shoichiro, Hamada, Gerson Shigueaki, Hidaka, Akihisa, Zaridze, David, Maximovitch, Dmitry, Vioque, Jesus, Navarrete‐Munoz, Eva M, Aragonés, Nuria, Martín, Vicente, Hernández‐Ramírez, Raúl Ulisses, Bertuccio, Paola, Ward, Mary H, Malekzadeh, Reza, Pourfarzi, Farhad, Mu, Lina, López‐Cervantes, Malaquias, Persiani, Roberto, Kurtz, Robert C, Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Boccia, Stefania, Negri, Eva, Camargo, M Constanza, Curado, Maria Paula, La Vecchia, Carlo, and Lunet, Nuno

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Cancer, Clinical Research, Adult, Aged, Case-Control Studies, Cohort Studies, Diet, Female, Humans, Male, Meat, Meat Products, Middle Aged, Red Meat, Stomach Neoplasms, diet, meat, nutrition, pooled analysis, stomach neoplasms, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

The consumption of processed meat has been associated with noncardia gastric cancer, but evidence regarding a possible role of red meat is more limited. Our study aims to quantify the association between meat consumption, namely white, red and processed meat, and the risk of gastric cancer, through individual participant data meta-analysis of studies participating in the "Stomach cancer Pooling (StoP) Project". Data from 22 studies, including 11,443 cases and 28,029 controls, were used. Study-specific odds ratios (ORs) were pooled through a two-stage approach based on random-effects models. An exposure-response relationship was modeled, using one and two-order fractional polynomials, to evaluate the possible nonlinear association between meat intake and gastric cancer. An increased risk of gastric cancer was observed for the consumption of all types of meat (highest vs. lowest tertile), which was statistically significant for red (OR: 1.24; 95% CI: 1.00-1.53), processed (OR: 1.23; 95% CI: 1.06-1.43) and total meat (OR: 1.30; 95% CI: 1.09-1.55). Exposure-response analyses showed an increasing risk of gastric cancer with increasing consumption of both processed and red meat, with the highest OR being observed for an intake of 150 g/day of red meat (OR: 1.85; 95% CI: 1.56-2.20). This work provides robust evidence on the relation between the consumption of different types of meat and gastric cancer. Adherence to dietary recommendations to reduce meat consumption may contribute to a reduction in the burden of gastric cancer.

Published
2020

11. Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project

Author

Morais, Samantha, Costa, Adriana, Albuquerque, Gabriela, Araújo, Natália, Pelucchi, Claudio, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, Zhang, Zuo-Feng, Hu, Jinfu, Johnson, Kenneth C., Palli, Domenico, Ferraroni, Monica, Bonzi, Rossella, Yu, Guo-Pei, López-Carrillo, Lizbeth, Malekzadeh, Reza, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, Zaridze, David, Maximovitch, Dmitry, Vioque, Jesus, de la Hera, Manoli García, Moreno, Victor, Vanaclocha-Espi, Mercedes, Ward, Mary H., Pakseresht, Mohammadreza, Hernández-Ramirez, Raúl Ulises, López-Cervantes, Malaquias, Pourfarzi, Farhad, Mu, Lina, Kurtz, Robert C., Boccia, Stefania, Pastorino, Roberta, Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Camargo, M. Constanza, Curado, Maria Paula, Negri, Eva, La Vecchia, Carlo, and Lunet, Nuno

Published
2022
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14. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Author

Machiela, Mitchell J, Zhou, Weiyin, Karlins, Eric, Sampson, Joshua N, Freedman, Neal D, Yang, Qi, Hicks, Belynda, Dagnall, Casey, Hautman, Christopher, Jacobs, Kevin B, Abnet, Christian C, Aldrich, Melinda C, Amos, Christopher, Amundadottir, Laufey T, Arslan, Alan A, Beane-Freeman, Laura E, Berndt, Sonja I, Black, Amanda, Blot, William J, Bock, Cathryn H, Bracci, Paige M, Brinton, Louise A, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie E, Butler, Mary A, Canzian, Federico, Carreon, Tania, Chaffee, Kari G, Chang, I-Shou, Chatterjee, Nilanjan, Chen, Chu, Chen, Constance, Chen, Kexin, Chung, Charles C, Cook, Linda S, Bou, Marta Crous, Cullen, Michael, Davis, Faith G, De Vivo, Immaculata, Ding, Ti, Doherty, Jennifer, Duell, Eric J, Epstein, Caroline G, Fan, Jin-Hu, Figueroa, Jonine D, Fraumeni, Joseph F, Friedenreich, Christine M, Fuchs, Charles S, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, Gaudet, Mia M, Gaziano, J Michael, Giles, Graham G, Gillanders, Elizabeth M, Giovannucci, Edward L, Goldin, Lynn, Goldstein, Alisa M, Haiman, Christopher A, Hallmans, Goran, Hankinson, Susan E, Harris, Curtis C, Henriksson, Roger, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Hsiung, Chao A, Hu, Nan, Hu, Wei, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Johansen, Christoffer, Khaw, Kay-Tee, Kim, Hee Nam, Kim, Yeul Hong, Kim, Young Tae, Klein, Alison P, Klein, Robert, Koh, Woon-Puay, Kolonel, Laurence N, Kooperberg, Charles, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, LaCroix, Andrea, Lan, Qing, Landi, Maria Teresa, Le Marchand, Loic, Li, Donghui, Liang, Xiaolin, Liao, Linda M, Lin, Dongxin, Liu, Jianjun, Lissowska, Jolanta, Lu, Lingeng, Magliocco, Anthony M, and Malats, Nuria

Published
2016

15. Coffee consumption and gastric cancer: a pooled analysis from the Stomach cancer Pooling Project consortium

Author

Martimianaki, Georgia, Bertuccio, Paola, Alicandro, Gianfranco, Pelucchi, Claudio, Bravi, Francesca, Carioli, Greta, Bonzi, Rossella, Rabkin, Charles S., Liao, Linda M., Sinha, Rashmi, Johnson, Ken, Hu, Jinfu, Palli, Domenico, Ferraroni, Monica, Lunet, Nuno, Morais, Samantha, Tsugane, Shoichiro, Hidaka, Akihisa, Hamada, Gerson Shigueaki, López-Carrillo, Lizbeth, Hernández-Ramírez, Raúl Ulises, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Martin, Vicente, Ward, Mary H., Vioque, Jesus, Garcia de la Hera, Manoli, Zhang, Zuo-Feng, Kurtz, Robert C., Lagiou, Pagona, Lagiou, Areti, Trichopoulou, Antonia, Karakatsani, Anna, Malekzadeh, Reza, Camargo, M. Constanza, Curado, Maria Paula, Boccia, Stefania, Boffetta, Paolo, Negri, Eva, and La Vecchia, Carlo

Published
2022
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16. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

Author

Wolpin, Brian M, Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M, Wang, Zhaoming, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Canzian, Federico, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Jacobs, Eric J, Kamineni, Aruna, Klein, Alison P, Kolonel, Laurence N, Kulke, Matthew H, Li, Donghui, Malats, Núria, Olson, Sara H, Risch, Harvey A, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A, Barfield, Richard, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Büchler, Markus W, Bueno-de-Mesquita, H Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J Michael, Giese, Nathalia A, Giovannucci, Edward L, Goggins, Michael, Gorman, Megan J, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Henderson, Brian E, Holly, Elizabeth A, Hu, Nan, Hunter, David J, Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, LaCroix, Andrea, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Nakamura, Yusuke, Oberg, Ann L, Owzar, Kouros, Patel, Alpa V, Peeters, Petra HM, Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R, and Theodoropoulos, George E

Subjects
Cancer, Aged, Case-Control Studies, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, White People, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.

Published
2014

17. Serum Immunoglobulin E and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Author

Olson, Sara H, Hsu, Meier, Wiemels, Joseph L, Bracci, Paige M, Zhou, Mi, Patoka, Joseph, Reisacher, William R, Wang, Julie, Kurtz, Robert C, Silverman, Debra T, and Stolzenberg-Solomon, Rachael Z

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Ovarian Cancer, Prevention, Clinical Research, Rare Diseases, Pancreatic Cancer, Food Allergies, Cancer, Clinical Trials and Supportive Activities, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, 2.2 Factors relating to the physical environment, Adenocarcinoma, Aged, Case-Control Studies, Early Detection of Cancer, Female, Humans, Hypersensitivity, Immunoglobulin E, Incidence, Male, Mass Screening, Middle Aged, Odds Ratio, Pancreatic Neoplasms, Risk Factors, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Epidemiologic studies have consistently found that self-reported allergies are associated with reduced risk of pancreatic cancer. Our aim was to prospectively assess the relationship between serum immunoglobulin E (IgE), a marker of allergy, and risk. This nested case-control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) included subjects enrolled in 1994 to 2001 and followed through 2010. There were 283 cases of pancreatic cancer and 544 controls matched on age, gender, race, and calendar date of blood draw. Using the ImmunoCAP system, we measured total IgE (normal, borderline, elevated), IgE to respiratory allergens, and IgE to food allergens (negative or positive) in serum collected at baseline. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using conditional logistic regression. We assessed interactions with age, gender, smoking, body mass index, and time between randomization and case diagnosis. Overall, there was no association between the IgE measures and risk. We found a statistically significant interaction by baseline age: in those aged ≥65 years, elevated risks were observed for borderline total IgE (OR, 1.43; 95% CI, 0.88-2.32) and elevated total IgE (OR, 1.98; 95% CI, 1.16-3.37) and positive IgE to food allergens (OR, 2.83; 95% CI, 1.29-6.20); among participants

Published
2014

18. Supplementary Figure S2 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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19. Supplementary Table S6 from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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20. Data from Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, primary, Brouwers, Martijn C.G.J., primary, Ren, Zhewen, primary, Zheng, Wei, primary, Setiawan, Veronica W., primary, Wilkens, Lynne R., primary, Shu, Xiao-Ou, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige M., primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven J., primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Haiman, Christopher A., primary, Kogevinas, Manolis, primary, Kooperberg, Charles, primary, LeMarchand, Loic, primary, Neale, Rachel E., primary, Visvanathan, Kala, primary, White, Emily, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Berndt, Sonja I., primary, Brais, Lauren K., primary, Brennan, Paul, primary, Buring, Julie E., primary, Rabe, Kari G., primary, Bamlet, William R., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Hackert, Thilo, primary, Hassan, Manal M., primary, Katzke, Verena, primary, Kurtz, Robert C., primary, Lee, I.-Min, primary, Malats, Núria, primary, Murphy, Neil, primary, Oberg, Ann L., primary, Orlow, Irene, primary, Porta, Miquel, primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Yu, Kai, primary, Wolpin, Brian M., primary, Duell, Eric J., primary, Li, Donghui, primary, Hung, Rayjean J., primary, Perdomo, Sandra, primary, McCullough, Marjorie L., primary, Freedman, Neal D., primary, Patel, Alpa V., primary, Peters, Ulrike, primary, Riboli, Elio, primary, Sund, Malin, primary, Tjønneland, Anne, primary, Zhong, Jun, primary, Van Den Eeden, Stephen K., primary, Kraft, Peter, primary, Risch, Harvey A., primary, Amundadottir, Laufey T., primary, Klein, Alison P., primary, Stolzenberg-Solomon, Rachael Z., primary, and Antwi, Samuel O., primary

Published
2023
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21. Cigarette smoking and gastric cancer in the Stomach Cancer Pooling (StoP) Project

Author

Praud, Delphine, Rota, Matteo, Pelucchi, Claudio, Bertuccio, Paola, Rosso, Tiziana, Galeone, Carlotta, Zhang, Zuo-Feng, Matsuo, Keitaro, Ito, Hidemi, Hu, Jinfu, Johnson, Kenneth C., Yu, Guo-Pei, Palli, Domenico, Ferraroni, Monica, Muscat, Joshua, Lunet, Nuno, Peleteiro, Bárbara, Malekzadeh, Reza, Ye, Weimin, Song, Huan, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Castaño-Vinyals, Gemma, Vioque, Jesus, Navarrete-Muñoz, Eva M., Pakseresht, Mohammadreza, Pourfarzi, Farhad, Wolk, Alicja, Orsini, Nicola, Bellavia, Andrea, Håkansson, Niclas, Mu, Lina, Pastorino, Roberta, Kurtz, Robert C., Derakhshan, Mohammad H., Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Boccia, Stefania, Negri, Eva, and La Vecchia, Carlo

Published
2018

22. Tobacco smoking and gastric cancer : meta-analyses of published data versus pooled analyses of individual participant data (StoP Project)

Author

Ferro, Ana, Morais, Samantha, Rota, Matteo, Pelucchi, Claudio, Bertuccio, Paola, Bonzi, Rossella, Galeone, Carlotta, Zhang, Zuo-Feng, Matsuo, Keitaro, Ito, Hidemi, Hu, Jinfu, Johnson, Kenneth C., Yu, Guo-Pei, Palli, Domenico, Ferraroni, Monica, Muscat, Joshua, Ye, Weimin, Song, Huan, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Castaño-Vinyals, Gemma, Vioque, Jesus, Navarrete-Muñoz, Eva M., Pakseresht, Mohammadreza, Pourfarzi, Farhad, Wolk, Alicja, Orsini, Nicola, Bellavia, Andrea, Håkansson, Niclas, Mu, Lina, Pastorino, Roberta, Kurtz, Robert C., Derakhshan, Mohammad H., Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Boccia, Stefania, Negri, Eva, La Vecchia, Carlo, Peleteiro, Bárbara, and Lunet, Nuno

Published
2018

23. Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)

Author

Ferro, Ana, Morais, Samantha, Rota, Matteo, Pelucchi, Claudio, Bertuccio, Paola, Bonzi, Rossella, Galeone, Carlotta, Zhang, Zuo-Feng, Matsuo, Keitaro, Ito, Hidemi, Hu, Jinfu, Johnson, Kenneth C., Yu, Guo-Pei, Palli, Domenico, Ferraroni, Monica, Muscat, Joshua, Malekzadeh, Reza, Ye, Weimin, Song, Huan, Zaridze, David, Maximovitch, Dmitry, Fernández de Larrea, Nerea, Kogevinas, Manolis, Vioque, Jesus, Navarrete-Muñoz, Eva M., Pakseresht, Mohammadreza, Pourfarzi, Farhad, Wolk, Alicja, Orsini, Nicola, Bellavia, Andrea, Håkansson, Niclas, Mu, Lina, Pastorino, Roberta, Kurtz, Robert C., Derakhshan, Mohammad H., Lagiou, Areti, Lagiou, Pagona, Boffetta, Paolo, Boccia, Stefania, Negri, Eva, La Vecchia, Carlo, Peleteiro, Bárbara, and Lunet, Nuno

Published
2018
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24. Polymorphisms in genes related to one-carbon metabolism are not related to pancreatic cancer in PanScan and PanC4

Author

Leenders, Max, Bhattacharjee, Samsiddhi, Vineis, Paolo, Stevens, Victoria, Bueno-de-Mesquita, H Bas, Shu, Xiao-Ou, Amundadottir, Laufey, Gross, Myron, Tobias, Geoffrey S, Wactawski-Wende, Jean, Arslan, Alan A, Duell, Eric J, Fuchs, Charles S, Gallinger, Steven, Hartge, Patricia, Hoover, Robert N, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, Kooperberg, Charles, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T, Olson, Sara H, Petersen, Gloria, Risch, Harvey A, Yu, Kai, Wolpin, Brian M, Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Buring, Julie E, Canzian, Federico, Chang, Kenneth, Chanock, Stephen J, Cotterchio, Michelle, Gaziano, J Michael, Giovanucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hoffman-Bolton, Judith A, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Jenab, Mazda, Khaw, Kay-Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, McWilliams, Robert R, Mendelsohn, Julie B, Patel, Alpa V, Rabe, Kari G, Riboli, Elio, Tjønneland, Anne, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Elena, Joanne W, Yu, Herbert, Zeleniuch-Jacquotte, Anne, and Stolzenberg-Solomon, Rachael Z

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Cancer, Digestive Diseases, Genetics, Pancreatic Cancer, Prevention, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Carbon, Case-Control Studies, Cohort Studies, Germ-Line Mutation, Humans, Pancreatic Neoplasms, Polymorphism, Single Nucleotide, United States, Pancreatic cancer, One-carbon metabolism, Polymorphisms, Biomarkers, Public Health and Health Services, Oncology and carcinogenesis
Abstract

PurposeThe evidence of a relation between folate intake and one-carbon metabolism (OCM) with pancreatic cancer (PanCa) is inconsistent. In this study, the association between genes and single-nucleotide polymorphisms (SNPs) related to OCM and PanCa was assessed.MethodsUsing biochemical knowledge of the OCM pathway, we identified thirty-seven genes and 834 SNPs to examine in association with PanCa. Our study included 1,408 cases and 1,463 controls nested within twelve cohorts (PanScan). The ten SNPs and five genes with lowest p values (

Published
2013

25. Pathway analysis of genome-wide association study data highlights pancreatic development genes as susceptibility factors for pancreatic cancer.

Author

Li, Donghui, Duell, Eric J, Yu, Kai, Risch, Harvey A, Olson, Sara H, Kooperberg, Charles, Wolpin, Brian M, Jiao, Li, Dong, Xiaoqun, Wheeler, Bill, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Fuchs, Charles S, Gallinger, Steven, Gross, Myron, Hartge, Patricia, Hoover, Robert N, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, LaCroix, Andrea, Mandelson, Margaret T, Petersen, Gloria, Zheng, Wei, Agalliu, Ilir, Albanes, Demetrius, Boutron-Ruault, Marie-Christine, Bracci, Paige M, Buring, Julie E, Canzian, Federico, Chang, Kenneth, Chanock, Stephen J, Cotterchio, Michelle, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hoffman Bolton, Judith A, Hunter, David J, Hutchinson, Amy, Jacobs, Kevin B, Jenab, Mazda, Khaw, Kay-Tee, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, McWilliams, Robert R, Mendelsohn, Julie B, Patel, Alpa V, Rabe, Kari G, Riboli, Elio, Shu, Xiao-Ou, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Virtamo, Jarmo, Visvanathan, Kala, Watters, Joanne, Yu, Herbert, Zeleniuch-Jacquotte, Anne, Amundadottir, Laufey, and Stolzenberg-Solomon, Rachael Z

Subjects
Humans, Pancreatic Neoplasms, Genetic Predisposition to Disease, Case-Control Studies, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Polymorphism, Single Nucleotide, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

Four loci have been associated with pancreatic cancer through genome-wide association studies (GWAS). Pathway-based analysis of GWAS data is a complementary approach to identify groups of genes or biological pathways enriched with disease-associated single-nucleotide polymorphisms (SNPs) whose individual effect sizes may be too small to be detected by standard single-locus methods. We used the adaptive rank truncated product method in a pathway-based analysis of GWAS data from 3851 pancreatic cancer cases and 3934 control participants pooled from 12 cohort studies and 8 case-control studies (PanScan). We compiled 23 biological pathways hypothesized to be relevant to pancreatic cancer and observed a nominal association between pancreatic cancer and five pathways (P < 0.05), i.e. pancreatic development, Helicobacter pylori lacto/neolacto, hedgehog, Th1/Th2 immune response and apoptosis (P = 2.0 × 10(-6), 1.6 × 10(-5), 0.0019, 0.019 and 0.023, respectively). After excluding previously identified genes from the original GWAS in three pathways (NR5A2, ABO and SHH), the pancreatic development pathway remained significant (P = 8.3 × 10(-5)), whereas the others did not. The most significant genes (P < 0.01) in the five pathways were NR5A2, HNF1A, HNF4G and PDX1 for pancreatic development; ABO for H.pylori lacto/neolacto; SHH for hedgehog; TGFBR2 and CCL18 for Th1/Th2 immune response and MAPK8 and BCL2L11 for apoptosis. Our results provide a link between inherited variation in genes important for pancreatic development and cancer and show that pathway-based approaches to analysis of GWAS data can yield important insights into the collective role of genetic risk variants in cancer.

Published
2012

26. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

Author

Petersen, Gloria M, Amundadottir, Laufey, Fuchs, Charles S, Kraft, Peter, Stolzenberg-Solomon, Rachael Z, Jacobs, Kevin B, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gallinger, Steven, Gross, Myron, Helzlsouer, Kathy, Holly, Elizabeth A, Jacobs, Eric J, Klein, Alison P, LaCroix, Andrea, Li, Donghui, Mandelson, Margaret T, Olson, Sara H, Risch, Harvey A, Zheng, Wei, Albanes, Demetrius, Bamlet, William R, Berg, Christine D, Boutron-Ruault, Marie-Christine, Buring, Julie E, Bracci, Paige M, Canzian, Federico, Clipp, Sandra, Cotterchio, Michelle, de Andrade, Mariza, Duell, Eric J, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, Hallmans, Göran, Hankinson, Susan E, Hassan, Manal, Howard, Barbara, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Kaaks, Rudolf, Kooperberg, Charles, Krogh, Vittorio, Kurtz, Robert C, Lynch, Shannon M, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Parikh, Hemang, Patel, Alpa V, Peeters, Petra HM, Rajkovic, Aleksandar, Riboli, Elio, Rodriguez, Laudina, Seminara, Daniela, Shu, Xiao-Ou, Thomas, Gilles, Tjønneland, Anne, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Van Den Eeden, Stephen K, Virtamo, Jarmo, Wactawski-Wende, Jean, Wang, Zhaoming, Wolpin, Brian M, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Fraumeni, Joseph F, Hoover, Robert N, Hartge, Patricia, and Chanock, Stephen J

Subjects
Chromosomes, Human, Pair 1, Chromosomes, Human, Pair 5, Chromosomes, Human, Pair 13, Humans, Carcinoma, Pancreatic Neoplasms, Genetic Predisposition to Disease, Case-Control Studies, Cohort Studies, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci, Rare Diseases, Cancer, Genetics, Clinical Research, Pancreatic Cancer, Digestive Diseases, Human Genome, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

Published
2010

28. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

Author

Amundadottir, Laufey, Kraft, Peter, Stolzenberg-Solomon, Rachael Z, Fuchs, Charles S, Petersen, Gloria M, Arslan, Alan A, Bueno-de-Mesquita, H Bas, Gross, Myron, Helzlsouer, Kathy, Jacobs, Eric J, LaCroix, Andrea, Zheng, Wei, Albanes, Demetrius, Bamlet, William, Berg, Christine D, Berrino, Franco, Bingham, Sheila, Buring, Julie E, Bracci, Paige M, Canzian, Federico, Clavel-Chapelon, Françoise, Clipp, Sandra, Cotterchio, Michelle, de Andrade, Mariza, Duell, Eric J, Fox, John W, Gallinger, Steven, Gaziano, J Michael, Giovannucci, Edward L, Goggins, Michael, González, Carlos A, Hallmans, Göran, Hankinson, Susan E, Hassan, Manal, Holly, Elizabeth A, Hunter, David J, Hutchinson, Amy, Jackson, Rebecca, Jacobs, Kevin B, Jenab, Mazda, Kaaks, Rudolf, Klein, Alison P, Kooperberg, Charles, Kurtz, Robert C, Li, Donghui, Lynch, Shannon M, Mandelson, Margaret, McWilliams, Robert R, Mendelsohn, Julie B, Michaud, Dominique S, Olson, Sara H, Overvad, Kim, Patel, Alpa V, Peeters, Petra HM, Rajkovic, Aleksandar, Riboli, Elio, Risch, Harvey A, Shu, Xiao-Ou, Thomas, Gilles, Tobias, Geoffrey S, Trichopoulos, Dimitrios, Van Den Eeden, Stephen K, Virtamo, Jarmo, Wactawski-Wende, Jean, Wolpin, Brian M, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Chanock, Stephen J, Hartge, Patricia, and Hoover, Robert N

Subjects
Chromosomes, Human, Pair 9, Humans, Pancreatic Neoplasms, Genetic Predisposition to Disease, ABO Blood-Group System, Logistic Models, Odds Ratio, Risk Factors, Case-Control Studies, Cohort Studies, Prospective Studies, Gene Frequency, Genotype, Haplotypes, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Alleles, Introns, United States, Female, Male, Genetic Variation, Genome-Wide Association Study, Prevention, Rare Diseases, Cancer, Genetics, Clinical Research, Pancreatic Cancer, Digestive Diseases, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.

Published
2009

29. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Author

King, Sontoria D., primary, Veliginti, Swathi, additional, Brouwers, Martijn C.G.J., additional, Ren, Zhewen, additional, Zheng, Wei, additional, Setiawan, Veronica W., additional, Wilkens, Lynne R., additional, Shu, Xiao-Ou, additional, Arslan, Alan A., additional, Beane Freeman, Laura E., additional, Bracci, Paige M., additional, Canzian, Federico, additional, Du, Mengmeng, additional, Gallinger, Steven J., additional, Giles, Graham G., additional, Goodman, Phyllis J., additional, Haiman, Christopher A., additional, Kogevinas, Manolis, additional, Kooperberg, Charles, additional, LeMarchand, Loic, additional, Neale, Rachel E., additional, Visvanathan, Kala, additional, White, Emily, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Babic, Ana, additional, Berndt, Sonja I., additional, Brais, Lauren K., additional, Brennan, Paul, additional, Buring, Julie E., additional, Rabe, Kari G., additional, Bamlet, William R., additional, Chanock, Stephen J., additional, Fuchs, Charles S., additional, Gaziano, J. Michael, additional, Giovannucci, Edward L., additional, Hackert, Thilo, additional, Hassan, Manal M., additional, Katzke, Verena, additional, Kurtz, Robert C., additional, Lee, I.-Min, additional, Malats, Núria, additional, Murphy, Neil, additional, Oberg, Ann L., additional, Orlow, Irene, additional, Porta, Miquel, additional, Real, Francisco X., additional, Rothman, Nathaniel, additional, Sesso, Howard D., additional, Silverman, Debra T., additional, Thompson, Ian M., additional, Wactawski-Wende, Jean, additional, Wang, Xiaoliang, additional, Wentzensen, Nicolas, additional, Yu, Herbert, additional, Zeleniuch-Jacquotte, Anne, additional, Yu, Kai, additional, Wolpin, Brian M., additional, Duell, Eric J., additional, Li, Donghui, additional, Hung, Rayjean J., additional, Perdomo, Sandra, additional, McCullough, Marjorie L., additional, Freedman, Neal D., additional, Patel, Alpa V., additional, Peters, Ulrike, additional, Riboli, Elio, additional, Sund, Malin, additional, Tjønneland, Anne, additional, Zhong, Jun, additional, Van Den Eeden, Stephen K., additional, Kraft, Peter, additional, Risch, Harvey A., additional, Amundadottir, Laufey T., additional, Klein, Alison P., additional, Stolzenberg-Solomon, Rachael Z., additional, and Antwi, Samuel O., additional

Published
2023
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30. Data from Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

Author

Roberts, Nicholas J., primary, Norris, Alexis L., primary, Petersen, Gloria M., primary, Bondy, Melissa L., primary, Brand, Randall, primary, Gallinger, Steven, primary, Kurtz, Robert C., primary, Olson, Sara H., primary, Rustgi, Anil K., primary, Schwartz, Ann G., primary, Stoffel, Elena, primary, Syngal, Sapna, primary, Zogopoulos, George, primary, Ali, Syed Z., primary, Axilbund, Jennifer, primary, Chaffee, Kari G., primary, Chen, Yun-Ching, primary, Cote, Michele L., primary, Childs, Erica J., primary, Douville, Christopher, primary, Goes, Fernando S., primary, Herman, Joseph M., primary, Iacobuzio-Donahue, Christine, primary, Kramer, Melissa, primary, Makohon-Moore, Alvin, primary, McCombie, Richard W., primary, McMahon, K. Wyatt, primary, Niknafs, Noushin, primary, Parla, Jennifer, primary, Pirooznia, Mehdi, primary, Potash, James B., primary, Rhim, Andrew D., primary, Smith, Alyssa L., primary, Wang, Yuxuan, primary, Wolfgang, Christopher L., primary, Wood, Laura D., primary, Zandi, Peter P., primary, Goggins, Michael, primary, Karchin, Rachel, primary, Eshleman, James R., primary, Papadopoulos, Nickolas, primary, Kinzler, Kenneth W., primary, Vogelstein, Bert, primary, Hruban, Ralph H., primary, and Klein, Alison P., primary

Published
2023
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31. Supplementary Tables S1 - S12 from Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

Author

Roberts, Nicholas J., primary, Norris, Alexis L., primary, Petersen, Gloria M., primary, Bondy, Melissa L., primary, Brand, Randall, primary, Gallinger, Steven, primary, Kurtz, Robert C., primary, Olson, Sara H., primary, Rustgi, Anil K., primary, Schwartz, Ann G., primary, Stoffel, Elena, primary, Syngal, Sapna, primary, Zogopoulos, George, primary, Ali, Syed Z., primary, Axilbund, Jennifer, primary, Chaffee, Kari G., primary, Chen, Yun-Ching, primary, Cote, Michele L., primary, Childs, Erica J., primary, Douville, Christopher, primary, Goes, Fernando S., primary, Herman, Joseph M., primary, Iacobuzio-Donahue, Christine, primary, Kramer, Melissa, primary, Makohon-Moore, Alvin, primary, McCombie, Richard W., primary, McMahon, K. Wyatt, primary, Niknafs, Noushin, primary, Parla, Jennifer, primary, Pirooznia, Mehdi, primary, Potash, James B., primary, Rhim, Andrew D., primary, Smith, Alyssa L., primary, Wang, Yuxuan, primary, Wolfgang, Christopher L., primary, Wood, Laura D., primary, Zandi, Peter P., primary, Goggins, Michael, primary, Karchin, Rachel, primary, Eshleman, James R., primary, Papadopoulos, Nickolas, primary, Kinzler, Kenneth W., primary, Vogelstein, Bert, primary, Hruban, Ralph H., primary, and Klein, Alison P., primary

Published
2023
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33. Bayesian copy number detection and association in large-scale studies

Author

Cristiano, Stephen, McKean, David, Carey, Jacob, Bracci, Paige, Brennan, Paul, Chou, Michael, Du, Mengmeng, Gallinger, Steven, Goggins, Michael G., Hassan, Manal M., Hung, Rayjean J., Kurtz, Robert C., Li, Donghui, Lu, Lingeng, Neale, Rachel, Olson, Sara, Petersen, Gloria, Rabe, Kari G., Fu, Jack, Risch, Harvey, Rosner, Gary L., Ruczinski, Ingo, Klein, Alison P., and Scharpf, Robert B.

Published
2020
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35. Data from PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Author

Sinha, Smrita, primary, Fu, Ya-Yuan, primary, Grimont, Adrien, primary, Ketcham, Maren, primary, Lafaro, Kelly, primary, Saglimbeni, Joseph A., primary, Askan, Gokce, primary, Bailey, Jennifer M., primary, Melchor, Jerry P., primary, Zhong, Yi, primary, Joo, Min Geol, primary, Grbovic-Huezo, Olivera, primary, Yang, In-Hong, primary, Basturk, Olca, primary, Baker, Lindsey, primary, Park, Young, primary, Kurtz, Robert C., primary, Tuveson, David, primary, Leach, Steven D., primary, and Pasricha, Pankaj J., primary

Published
2023
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36. Video V2 from PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Author

Sinha, Smrita, primary, Fu, Ya-Yuan, primary, Grimont, Adrien, primary, Ketcham, Maren, primary, Lafaro, Kelly, primary, Saglimbeni, Joseph A., primary, Askan, Gokce, primary, Bailey, Jennifer M., primary, Melchor, Jerry P., primary, Zhong, Yi, primary, Joo, Min Geol, primary, Grbovic-Huezo, Olivera, primary, Yang, In-Hong, primary, Basturk, Olca, primary, Baker, Lindsey, primary, Park, Young, primary, Kurtz, Robert C., primary, Tuveson, David, primary, Leach, Steven D., primary, and Pasricha, Pankaj J., primary

Published
2023
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37. Supplementary table 8 from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3

Author

Mocci, Evelina, primary, Kundu, Prosenjit, primary, Wheeler, William, primary, Arslan, Alan A., primary, Beane-Freeman, Laura E., primary, Bracci, Paige M., primary, Brennan, Paul, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Blackford, Amanda L., primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campa, Daniele, primary, Chanock, Stephen J., primary, Childs, Erica J., primary, Duell, Eric J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Goggins, Michael G., primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Hung, Rayjean J., primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Núria, primary, Milne, Roger L., primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Panico, Salvatore, primary, Peters, Ulrike, primary, Porta, Miquel, primary, Rabe, Kari G., primary, Riboli, Elio, primary, Rothman, Nathaniel, primary, Scelo, Ghislaine, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Stevens, Victoria L., primary, Strobel, Oliver, primary, Thompson, Ian M., primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Van Den Eeden, Stephen K., primary, Wactawski-Wende, Jean, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Yuan, Fangcheng, primary, Zeleniuch-Jacquotte, Anne, primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Jacobs, Eric J., primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Kraft, Peter, primary, Chatterjee, Nilanjan, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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38. Supplemental Figures from PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Author

Sinha, Smrita, primary, Fu, Ya-Yuan, primary, Grimont, Adrien, primary, Ketcham, Maren, primary, Lafaro, Kelly, primary, Saglimbeni, Joseph A., primary, Askan, Gokce, primary, Bailey, Jennifer M., primary, Melchor, Jerry P., primary, Zhong, Yi, primary, Joo, Min Geol, primary, Grbovic-Huezo, Olivera, primary, Yang, In-Hong, primary, Basturk, Olca, primary, Baker, Lindsey, primary, Park, Young, primary, Kurtz, Robert C., primary, Tuveson, David, primary, Leach, Steven D., primary, and Pasricha, Pankaj J., primary

Published
2023
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39. Supplementary Tables from Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk

Author

Yuan, Fangcheng, primary, Hung, Rayjean J., primary, Walsh, Naomi, primary, Zhang, Han, primary, Platz, Elizabeth A., primary, Wheeler, William, primary, Song, Lei, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Rosendahl, Jonas, primary, Scelo, Ghislaine, primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Amiano, Pilar, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Brennan, Paul, primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campbell, Peter T., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Goggins, Michael G., primary, Hackert, Thilo, primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Katzke, Verena, primary, Kirsten, Holger, primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Nuria, primary, Milne, Roger L., primary, Murphy, Neil, primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Porta, Miquel, primary, Rabe, Kari G., primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Shi, Jianxin, primary, Duell, Eric J., primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Yu, Kai, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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40. Data from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3

Author

Mocci, Evelina, primary, Kundu, Prosenjit, primary, Wheeler, William, primary, Arslan, Alan A., primary, Beane-Freeman, Laura E., primary, Bracci, Paige M., primary, Brennan, Paul, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Blackford, Amanda L., primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campa, Daniele, primary, Chanock, Stephen J., primary, Childs, Erica J., primary, Duell, Eric J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Goggins, Michael G., primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Hung, Rayjean J., primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Núria, primary, Milne, Roger L., primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Panico, Salvatore, primary, Peters, Ulrike, primary, Porta, Miquel, primary, Rabe, Kari G., primary, Riboli, Elio, primary, Rothman, Nathaniel, primary, Scelo, Ghislaine, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Stevens, Victoria L., primary, Strobel, Oliver, primary, Thompson, Ian M., primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Van Den Eeden, Stephen K., primary, Wactawski-Wende, Jean, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Yuan, Fangcheng, primary, Zeleniuch-Jacquotte, Anne, primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Jacobs, Eric J., primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Kraft, Peter, primary, Chatterjee, Nilanjan, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
Full Text
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41. Data from Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk

Author

Yuan, Fangcheng, primary, Hung, Rayjean J., primary, Walsh, Naomi, primary, Zhang, Han, primary, Platz, Elizabeth A., primary, Wheeler, William, primary, Song, Lei, primary, Arslan, Alan A., primary, Beane Freeman, Laura E., primary, Bracci, Paige, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Rosendahl, Jonas, primary, Scelo, Ghislaine, primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Amiano, Pilar, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Brennan, Paul, primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campbell, Peter T., primary, Chanock, Stephen J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Goggins, Michael G., primary, Hackert, Thilo, primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Katzke, Verena, primary, Kirsten, Holger, primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Nuria, primary, Milne, Roger L., primary, Murphy, Neil, primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Porta, Miquel, primary, Rabe, Kari G., primary, Real, Francisco X., primary, Rothman, Nathaniel, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Thompson, Ian M., primary, Wactawski-Wende, Jean, primary, Wang, Xiaoliang, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Zeleniuch-Jacquotte, Anne, primary, Shi, Jianxin, primary, Duell, Eric J., primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Yu, Kai, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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42. Supplemental Figure Legends from PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Author

Sinha, Smrita, primary, Fu, Ya-Yuan, primary, Grimont, Adrien, primary, Ketcham, Maren, primary, Lafaro, Kelly, primary, Saglimbeni, Joseph A., primary, Askan, Gokce, primary, Bailey, Jennifer M., primary, Melchor, Jerry P., primary, Zhong, Yi, primary, Joo, Min Geol, primary, Grbovic-Huezo, Olivera, primary, Yang, In-Hong, primary, Basturk, Olca, primary, Baker, Lindsey, primary, Park, Young, primary, Kurtz, Robert C., primary, Tuveson, David, primary, Leach, Steven D., primary, and Pasricha, Pankaj J., primary

Published
2023
Full Text
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43. Supplementary Data from Smoking Modifies Pancreatic Cancer Risk Loci on 2q21.3

Author

Mocci, Evelina, primary, Kundu, Prosenjit, primary, Wheeler, William, primary, Arslan, Alan A., primary, Beane-Freeman, Laura E., primary, Bracci, Paige M., primary, Brennan, Paul, primary, Canzian, Federico, primary, Du, Mengmeng, primary, Gallinger, Steven, primary, Giles, Graham G., primary, Goodman, Phyllis J., primary, Kooperberg, Charles, primary, Le Marchand, Loic, primary, Neale, Rachel E., primary, Shu, Xiao-Ou, primary, Visvanathan, Kala, primary, White, Emily, primary, Zheng, Wei, primary, Albanes, Demetrius, primary, Andreotti, Gabriella, primary, Babic, Ana, primary, Bamlet, William R., primary, Berndt, Sonja I., primary, Blackford, Amanda L., primary, Bueno-de-Mesquita, Bas, primary, Buring, Julie E., primary, Campa, Daniele, primary, Chanock, Stephen J., primary, Childs, Erica J., primary, Duell, Eric J., primary, Fuchs, Charles S., primary, Gaziano, J. Michael, primary, Giovannucci, Edward L., primary, Goggins, Michael G., primary, Hartge, Patricia, primary, Hassan, Manal M., primary, Holly, Elizabeth A., primary, Hoover, Robert N., primary, Hung, Rayjean J., primary, Kurtz, Robert C., primary, Lee, I-Min, primary, Malats, Núria, primary, Milne, Roger L., primary, Ng, Kimmie, primary, Oberg, Ann L., primary, Panico, Salvatore, primary, Peters, Ulrike, primary, Porta, Miquel, primary, Rabe, Kari G., primary, Riboli, Elio, primary, Rothman, Nathaniel, primary, Scelo, Ghislaine, primary, Sesso, Howard D., primary, Silverman, Debra T., primary, Stevens, Victoria L., primary, Strobel, Oliver, primary, Thompson, Ian M., primary, Tjonneland, Anne, primary, Trichopoulou, Antonia, primary, Van Den Eeden, Stephen K., primary, Wactawski-Wende, Jean, primary, Wentzensen, Nicolas, primary, Wilkens, Lynne R., primary, Yu, Herbert, primary, Yuan, Fangcheng, primary, Zeleniuch-Jacquotte, Anne, primary, Amundadottir, Laufey T., primary, Li, Donghui, primary, Jacobs, Eric J., primary, Petersen, Gloria M., primary, Wolpin, Brian M., primary, Risch, Harvey A., primary, Kraft, Peter, primary, Chatterjee, Nilanjan, primary, Klein, Alison P., primary, and Stolzenberg-Solomon, Rachael, primary

Published
2023
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44. Supplemental Table S1 from PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Author

Sinha, Smrita, primary, Fu, Ya-Yuan, primary, Grimont, Adrien, primary, Ketcham, Maren, primary, Lafaro, Kelly, primary, Saglimbeni, Joseph A., primary, Askan, Gokce, primary, Bailey, Jennifer M., primary, Melchor, Jerry P., primary, Zhong, Yi, primary, Joo, Min Geol, primary, Grbovic-Huezo, Olivera, primary, Yang, In-Hong, primary, Basturk, Olca, primary, Baker, Lindsey, primary, Park, Young, primary, Kurtz, Robert C., primary, Tuveson, David, primary, Leach, Steven D., primary, and Pasricha, Pankaj J., primary

Published
2023
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45. Supplementary Materials and Methods from PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Author

Sinha, Smrita, primary, Fu, Ya-Yuan, primary, Grimont, Adrien, primary, Ketcham, Maren, primary, Lafaro, Kelly, primary, Saglimbeni, Joseph A., primary, Askan, Gokce, primary, Bailey, Jennifer M., primary, Melchor, Jerry P., primary, Zhong, Yi, primary, Joo, Min Geol, primary, Grbovic-Huezo, Olivera, primary, Yang, In-Hong, primary, Basturk, Olca, primary, Baker, Lindsey, primary, Park, Young, primary, Kurtz, Robert C., primary, Tuveson, David, primary, Leach, Steven D., primary, and Pasricha, Pankaj J., primary

Published
2023
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47. The stomach cancer pooling (StoP) project : study design and presentation

Author

Pelucchi, Claudio, Lunet, Nuno, Boccia, Stefania, Zhang, Zuo-Feng, Praud, Delphine, Boffetta, Paolo, Levi, Fabio, Matsuo, Keitaro, Ito, Hidemi, Hu, Jinfu, Johnson, Kenneth C., Ferraroni, Monica, Yu, Guo-Pei, Peleteiro, Bárbara, Malekzadeh, Reza, Derakhshan, Mohammad H., Ye, Weimin, Zaridze, David, Maximovitch, Dmitry, Aragonés, Nuria, Martín, Vicente, Pakseresht, Mohammadreza, Pourfarzi, Farhad, Bellavia, Andrea, Orsini, Nicola, Wolk, Alicja, Mu, Lina, Arzani, Dario, Kurtz, Robert C., Lagiou, Pagona, Trichopoulos, Dimitrios, Muscat, Joshua, La Vecchia, Carlo, and Negri, Eva

Published
2015

49. Alcohol consumption and gastric cancer risk—A pooled analysis within the StoP project consortium

Author

Rota, Matteo, Pelucchi, Claudio, Bertuccio, Paola, Matsuo, Keitaro, Zhang, Zuo‐Feng, Ito, Hidemi, Hu, Jinfu, Johnson, Kenneth C., Palli, Domenico, Ferraroni, Monica, Yu, Guo‐Pei, Muscat, Joshua, Lunet, Nuno, Peleteiro, Bárbara, Ye, Weimin, Song, Huan, Zaridze, David, Maximovitch, Dmitry, Guevara, Marcela, Fernández‐Villa, Tania, Vioque, Jesus, Navarrete‐Muñoz, Eva M., Wolk, Alicja, Orsini, Nicola, Bellavia, Andrea, Håkansson, Niclas, Mu, Lina, Persiani, Roberto, Kurtz, Robert C., Lagiou, Areti, Lagiou, Pagona, Galeone, Carlotta, Bonzi, Rossella, Boffetta, Paolo, Boccia, Stefania, Negri, Eva, and La Vecchia, Carlo

Published
2017
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