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8 results on '"Kurosawa, Miho"'

2. Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

Author

Okubo, Koshu, Kurosawa, Miho, Kamiya, Mako, Urano, Yasuteru, Suzuki, Akari, Yamamoto, Kazuhiko, Hase, Koji, Homma, Koichiro, Sasaki, Junichi, Miyauchi, Hiroaki, Hoshino, Tatsuo, Hayashi, Matsuhiko, Mayadas, Tanya N, and Hirahashi, Junichi

Subjects
Macrophages -- Physiological aspects -- Genetic aspects -- Research, Rhabdomyolysis -- Complications and side effects -- Genetic aspects -- Research, Blood platelets -- Physiological aspects -- Genetic aspects -- Research, Acute kidney failure -- Development and progression -- Genetic aspects -- Research, Biological sciences, Health
Abstract

Author(s): Koshu Okubo [1, 2]; Miho Kurosawa [2]; Mako Kamiya [3]; Yasuteru Urano [3]; Akari Suzuki [4]; Kazuhiko Yamamoto [4, 5]; Koji Hase [6, 7]; Koichiro Homma [8]; Junichi Sasaki [...]

Published
2018
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4. 横紋筋融解症に続発する急性腎不全におけるマクロファージ由来クロマチン毒性の解析

Author

慶應義塾大学・医学部(信濃町)・共同研究員, オオクボ, コウシュウ, クロサワ, ミホ, ウラノ, ヤステル, Okubo, Koshu, Kurosawa, Miho, Urano, Yasuteru, 大久保, 光修, 黒澤, 美穂, 浦野, 泰照, 慶應義塾大学・医学部(信濃町)・共同研究員, オオクボ, コウシュウ, クロサワ, ミホ, ウラノ, ヤステル, Okubo, Koshu, Kurosawa, Miho, Urano, Yasuteru, 大久保, 光修, 黒澤, 美穂, and 浦野, 泰照

Abstract

Research team head, Research team member, Publisher, 横紋筋融解症は骨格筋の破綻とそれに続発する筋内容物の血中への流入が原因となり引き起こされる全身性症候群である。特に横紋筋融解症に引き続いて起こる急性腎障害(acute kidney injury, AKI)は患者予後を深刻に悪化させる合併症である。最近になって白血球の一つであるマクロファージがAKIの発症に重要な役割を持つ事が知られるようになったが, メカニズムについては不明な部分が多い。 本研究ではマクロファージ由来クロマチン放出(macrophage extracellular traps, METs)が病態の原因の一つであり, それを制御する事で病態を軽減させる可能性がある事を見出した。 Rhabdomyolysis is a serious syndrome caused by skeletal muscle injury and the subsequent release of breakdown products from damaged muscle cells into systemic circulation. The muscle damage can lead to acute kidney injury (AKI). Recently, macrophages were implicated in the disease pathogenesis of rhabdomyolysis-induced AKI, but the precise molecular mechanism remains unclear. In the present study, we show that macrophages released extracellular traps (ETs) comprising DNA fibers and granule proteins in a mouse model of rhabdomyolysis. Heme-activated platelets released from necrotic muscle cells during rhabdomyolysis enhanced the production of macrophage extracellular traps (METs). Here we report, this unanticipated role for METs and platelets as a sensor of myoglobin-derived heme in rhabdomyolysis-induced AKI. Also, we found a new therapeutic tool for prevention of AKI after rhabdomyolysis, which might rescue some sufferers of this pathology., 研究種目 : 若手研究(B) 研究期間 : 2016～2017 課題番号 : 16K19497 研究分野 : 内科学, 腎臓学, 透析医学

Published
2018

5. Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation

Author

Okubo, Koshu, primary, Kamiya, Mako, additional, Urano, Yasuteru, additional, Nishi, Hiroshi, additional, Herter, Jan M., additional, Mayadas, Tanya, additional, Hirohama, Daigoro, additional, Suzuki, Kazuo, additional, Kawakami, Hiroshi, additional, Tanaka, Mototsugu, additional, Kurosawa, Miho, additional, Kagaya, Shinji, additional, Hishikawa, Keiichi, additional, Nangaku, Masaomi, additional, Fujita, Toshiro, additional, Hayashi, Matsuhiko, additional, and Hirahashi, Junichi, additional

Published
2016
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8. The high prevalence of hepatitis E virus infection in wild boars in Ibaraki Prefecture, Japan.

Author

Motoya T, Nagata N, Komori H, Doi I, Kurosawa M, Keta T, Sasaki N, and Ishii K

Subjects
Animals, Antibodies, Viral, Enzyme-Linked Immunosorbent Assay veterinary, Feces virology, Hepatitis E epidemiology, Hepatitis E virology, Hepatitis E virus genetics, Japan epidemiology, Liver virology, Phylogeny, Polymerase Chain Reaction veterinary, Prevalence, RNA, Viral isolation & purification, Hepatitis E veterinary, Hepatitis E virus isolation & purification, Sus scrofa
Abstract

Hepatitis E virus (HEV) is known as a causative agent of zoonosis and food poisoning. Pigs and some species of wild animals, including wild boar, are known to be a reservoir of HEV. In this study, we investigated the situation regarding HEV infection in wild boars in Ibaraki Prefecture, Japan. Serum, liver and feces samples from 68 animals were collected, and the presence or absence of HEV genomic RNA and HEV antibodies were analyzed. The viral genome was detected in samples from 7 (10.3%) animals, with all HEVs classified as genotype 3, subtype 3b. HEV antibodies were detected in samples from 28 (41%) animals. This report demonstrates for the first time the high prevalence of HEV infection in wild boars in Ibaraki Prefecture.

Published
2016
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