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12 results on '"Kuromiya, Keisuke"'

4. Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells

Author

Ito, Shoko, primary, Kuromiya, Keisuke, additional, Sekai, Miho, additional, Sako, Hiroaki, additional, Sai, Kazuhito, additional, Morikawa, Riho, additional, Mukai, Yohei, additional, Ida, Yoko, additional, Anzai, Moe, additional, Ishikawa, Susumu, additional, Kozawa, Kei, additional, Shirai, Takanobu, additional, Tanimura, Nobuyuki, additional, Sugie, Kenta, additional, Ikenouchi, Junichi, additional, Ogawa, Motoyuki, additional, Naguro, Isao, additional, Ichijo, Hidenori, additional, and Fujita, Yasuyuki, additional

Published
2023
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6. FBP17-mediated finger-like membrane protrusions in cell competition between normal and RasV12-transformed cells

Author

Kamasaki, Tomoko, Miyazaki, Yumi, Ishikawa, Susumu, Hoshiba, Kazuya, Kuromiya, Keisuke, Tanimura, Nobuyuki, Mori, Yusuke, Tsutsumi, Motosuke, Nemoto, Tomomi, Uehara, Ryota, Suetsugu, Shiro, Itoh, Toshiki, Fujita, Yasuyuki, Kamasaki, Tomoko, Miyazaki, Yumi, Ishikawa, Susumu, Hoshiba, Kazuya, Kuromiya, Keisuke, Tanimura, Nobuyuki, Mori, Yusuke, Tsutsumi, Motosuke, Nemoto, Tomomi, Uehara, Ryota, Suetsugu, Shiro, Itoh, Toshiki, and Fujita, Yasuyuki

Abstract

At the initial stage of carcinogenesis, cell competition often occurs between newly emerging transformed cells and the neighboring normal cells, leading to the elimination of transformed cells from the epithelial layer. For instance, when RasV12-transformed cells are surrounded by normal cells, RasV12 cells are apically extruded from the epithelium. However, the underlying mechanisms of this tumor-suppressive process still remain enigmatic. We first show by electron microscopic analysis that characteristic finger-like membrane protrusions are projected from both normal and RasV12 cells at their interface. In addition, FBP17, a member of the F-BAR proteins, accumulates in RasV12 cells, as well as surrounding normal cells, which plays a positive role in the formation of finger-like protrusions and apical elimination of RasV12 cells. Furthermore, cdc42 acts upstream of these processes. These results suggest that the cdc42/FBP17 pathway is a crucial trigger of cell competition, inducing “protrusion to protrusion response” between normal and RasV12-transformed cells.

Published
2023

9. Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells

Author

Kuromiya, Keisuke, primary, Aoki, Kana, additional, Ishibashi, Kojiro, additional, Yotabun, Moe, additional, Sekai, Miho, additional, Tanimura, Nobuyuki, additional, Iijima, Sayuri, additional, Ishikawa, Susumu, additional, Kamasaki, Tomoko, additional, Akieda, Yuki, additional, Ishitani, Tohru, additional, Hayashi, Takashi, additional, Toda, Satoshi, additional, Yokoyama, Koji, additional, Lee, Chol Gyu, additional, Usami, Ippei, additional, Inoue, Haruki, additional, Takigawa, Ichigaku, additional, Gauquelin, Estelle, additional, Sugimura, Kaoru, additional, Hino, Naoya, additional, and Fujita, Yasuyuki, additional

Published
2022
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10. The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia

Author

Kozawa, Kei, primary, Sekai, Miho, additional, Ohba, Kenji, additional, Ito, Shoko, additional, Sako, Hiroaki, additional, Maruyama, Takeshi, additional, Kakeno, Mai, additional, Shirai, Takanobu, additional, Kuromiya, Keisuke, additional, Kamasaki, Tomoko, additional, Kohashi, Koki, additional, Tanaka, Shinya, additional, Ishikawa, Susumu, additional, Sato, Nanami, additional, Asano, Shota, additional, Suzuki, Hironori, additional, Tanimura, Nobuyuki, additional, Mukai, Yohei, additional, Gotoh, Noriko, additional, Tanino, Mishie, additional, Natsuga, Ken, additional, Soga, Tomoyoshi, additional, Nakamura, Tomonori, additional, Yabuta, Yukihiro, additional, Saitou, Mitinori, additional, Ito, Takahiro, additional, Matsuura, Kenkyo, additional, Tsunoda, Makoto, additional, Kikumori, Toyone, additional, Iida, Tadashi, additional, Mizutani, Yasuyuki, additional, Miyai, Yuki, additional, Kaibuchi, Kozo, additional, Enomoto, Atsushi, additional, and Fujita, Yasuyuki, additional

Published
2021
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11. Calcium Wave Promotes Cell Extrusion

Author

Takeuchi, Yasuto, Narumi, Rika, Akiyama, Ryutaro, Vitiello, Elisa, Shirai, Takanobu, Tanimura, Nobuyuki, Kuromiya, Keisuke, Ishikawa, Susumu, Kajita, Mihoko, Tada, Masazumi, Haraoka, Yukinari, Akieda, Yuki, Ishitani, Tohru, Fujioka, Yoichiro, Ohba, Yusuke, Yamada, Sohei, Hosokawa, Yoichiroh, Toyama, Yusuke, Matsui, Takaaki, Fujita, Yasuyuki, Takeuchi, Yasuto, Narumi, Rika, Akiyama, Ryutaro, Vitiello, Elisa, Shirai, Takanobu, Tanimura, Nobuyuki, Kuromiya, Keisuke, Ishikawa, Susumu, Kajita, Mihoko, Tada, Masazumi, Haraoka, Yukinari, Akieda, Yuki, Ishitani, Tohru, Fujioka, Yoichiro, Ohba, Yusuke, Yamada, Sohei, Hosokawa, Yoichiroh, Toyama, Yusuke, Matsui, Takaaki, and Fujita, Yasuyuki

Abstract

When oncogenic transformation or apoptosis occurs within epithelia, the harmful or dead cells are apically extruded from tissues to maintain epithelial homeostasis. However, the underlying molecular mechanism still remains elusive. In this study, we first show, using mammalian cultured epithelial cells and zebrafish embryos, that prior to apical extrusion of RasV12-transformed cells, calcium wave occurs from the transformed cell and propagates across the surrounding cells. The calcium wave then triggers and facilitates the process of extrusion. IP3 receptor, gap junction, and mechanosensitive calcium channel TRPC1 are involved in calcium wave. Calcium wave induces the polarized movement of the surrounding cells toward the extruding transformed cells. Furthermore, calcium wave facilitates apical extrusion, at least partly, by inducing actin rearrangement in the surrounding cells. Moreover, comparable calcium propagation also promotes apical extrusion of apoptotic cells. Thus, calcium wave is an evolutionarily conserved, general regulatory mechanism of cell extrusion.

Published
2020

12. Calcium Wave Promotes Cell Extrusion

Author

Takeuchi, Yasuto, primary, Narumi, Rika, additional, Akiyama, Ryutaro, additional, Vitiello, Elisa, additional, Shirai, Takanobu, additional, Tanimura, Nobuyuki, additional, Kuromiya, Keisuke, additional, Ishikawa, Susumu, additional, Kajita, Mihoko, additional, Tada, Masazumi, additional, Haraoka, Yukinari, additional, Akieda, Yuki, additional, Ishitani, Tohru, additional, Fujioka, Yoichiro, additional, Ohba, Yusuke, additional, Yamada, Sohei, additional, Hosokawa, Yoichiroh, additional, Toyama, Yusuke, additional, Matsui, Takaaki, additional, and Fujita, Yasuyuki, additional

Published
2020
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