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10. Chromosomal instability and the abrogated G2/M arrest in X-irradiated myelodysplastic syndrome cells

Author

Ban, Sadayuki, Sudou, Hitomi, Saegusa, Kumiko, Sagara, Masashi, Imai, Takashi, Oda, Kenji, Kuramoto, Ken, Tanaka, Hideo, and Kimura, Akiro

Subjects
hemic and lymphatic diseases
Abstract

A preliminary epidemiological study demonstrated that myelodysplastic syndrome (MDS) has an excess relative risk per sievert of 13 in atomic bomb survivors in Hiroshima. MDS is the only other radiogenic blood disease apart from leukemia. Clinically, MDS involves dysplastic hematopoiesis and an increased risk of leukemic transformation. Because it is uncertain whether MDS pathogenesis affects lymphoid progenitor cells as well as myeloid progenitor cells, we investigated the karyotypes of bone marrow cells and the micronucleus (MN) frequency in peripheral T lymphocytes of twenty- three atomic bomb survivors with MDS and five normal individuals. Aneuploidy was observed in 10 of 23 patients. Chromosome aberrations were observed in 3 of 12 patients with mild symptoms, and six of 11 patients of severe symptoms. The spontaneous- and X-ray-induced-MN frequencies were significantly higher in MDS patients than in normal individuals. Interestingly, radiation sensitivity increased along with the severity of MDS clinical subtypes. Because many of the patients in this study had not been exposed to chemo- or radiation- therapy, their unusual radiosensitivity may be related to their chromosomal or genomic instability. Immortalized lymphoid cell lines were established from B-lymphocytes infected with Epstein-Barr virus in vitro. The abrogation of radiation-induced-G2/M arrest was observed in the MDS-B lymphoid cell lines, but not in the normal B lymphoid cell lines. Our data suggest that the control of chromosomal stability is impaired in pluripotent stem cells of MDS patients, and that the abrogated G2/M arrest may be involved in the pathophysiology of disease progression and the high radiation sensitivity of patients., The 12th International Congress of Radiation Research(ICRR)

Published
2003

11. Radiosensitivity and Expression of Nucleotide Excision Repair Genes in Peripheral Blood Mononuclear Cells of Myelodysplastic Syndrome Patients

Author

Ban, Sadayuki, Kuramoto, Ken, Oda, Kenji, Tanaka, Hideo, Kimura, Akiro, and Suzuki, Gen

Subjects
endocrine system, health care facilities, manpower, and services, fungi, education, food and beverages, reproductive and urinary physiology, humanities, health care economics and organizations
Abstract

8th International Conference on Environmental Mutagens

Published
2001

12. Radiosensitivity of Myelodysplastic Syndrome Cells

Author

Ban, Sadayuki, Kuramoto, Ken, Oda, Kenji, Tanaka, Hideo, Kimura, Akiro, Suzuki, Gen, and Imai, Takashi

Subjects
surgical procedures, operative, education, technology, industry, and agriculture, equipment and supplies, neoplasms
Abstract

International NIRS Workshop - Radiation Biology in Cancer Research

Published
2001

18. Long-Term Clinical and Molecular Follow-up of Large Animals Receiving Retrovirally Transduced Stem and Progenitor Cells: No Progression to Clonal Hematopoiesis or Leukemia

Author

Kiem, Hans-Peter, primary, Sellers, Stephanie, additional, Thomasson, Bobbie, additional, Morris, Julia C, additional, Tisdale, John F, additional, Horn, Peter A, additional, Hematti, Peiman, additional, Adler, Rima, additional, Kuramoto, Ken, additional, Calmels, Boris, additional, Bonifacino, Aylin, additional, Hu, Jiong, additional, von Kalle, Christof, additional, Schmidt, Manfred, additional, Sorrentino, Brian, additional, Nienhuis, Arthur, additional, Blau, C.Anthony, additional, Andrews, Robert G, additional, Donahue, Robert E, additional, and Dunbar, Cynthia E, additional

Published
2004
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22. Rock-Like Oxide Fuels and Their Burning in LWRs

Author

YAMASHITA, Toshiyuki, primary, KURAMOTO, Ken-ichi, additional, AKIE, Hiroshi, additional, NAKANO, Yoshihiro, additional, NITANI, Noriko, additional, NAKAMURA, Takehiko, additional, KUSAGAYA, Kazuyuki, additional, and OHMICHI, Toshihiko, additional

Published
2002
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29. Clinical Efficacy of Fosfomycin in Combination with Sulbactam/Cefoperazone in the Treatment of Severe Infections Complicated to Blood Dyscrasia

Author

KITAMURA, Kiyoshi, primary, HIRAI, Hisamaru, additional, HOSOYA, Noriko, additional, SUGAI, Masao, additional, KARASAWA, Masamitu, additional, NARUSE, Takuji, additional, MIURA, Yasusada, additional, OHMINE, Ken, additional, TAKAGI, Syojiro, additional, HIRASHIMA, Kunitake, additional, BESSHO, Masami, additional, FUKUDA, Masataka, additional, KAWAI, Nobutaka, additional, DAN, Kazuo, additional, AN, Emi, additional, HOSHINO, Tetsuo, additional, OSHIMI, Kazuo, additional, NOGUCHI, Masaaki, additional, EGASHIRA, Motoki, additional, IKEDA, Yasuo, additional, KIZAKI, Masahiro, additional, TOYAMA, Keisuke, additional, MIYAZAWA, Keisuke, additional, NAGASU, Masaya, additional, INATOMI, Yuka, additional, KURIYAMA, Yuzuru, additional, IWASE, Osamu, additional, MIZOGUCHI, Hideaki, additional, KOBAYASHI, Shoko, additional, TSURUOKA, Nobuyoshi, additional, TOMOYASU, Shigeru, additional, NAKAMAKI, Tsuyoshi, additional, AKIMOTO, Yoshihisa, additional, KAKIMOTO, Tsunayuki, additional, MUTO, Yoshitomo, additional, UEYAMA, Junichi, additional, TOGAWA, Atsushi, additional, MIWA, Akiyoshi, additional, NAGAI, Mari, additional, URABE, Akio, additional, ENDO, Mitsue, additional, MORI, Mayumi, additional, KURAMOTO, Ken, additional, KIKUKAWA, Masayuki, additional, NAKAMURA, Noriko, additional, SUZUKI, Kenshi, additional, INOUE, Yasuyuki, additional, SAWANOBORI, Masakazu, additional, NAKAGAWA, Yasuaki, additional, ISHIKAWA, Kyozo, additional, KAWANO, Koichi, additional, HOMORI, Masashi, additional, MURAI, Yoshiro, additional, MIZUTANI, Ryoko, additional, NAKAMURA, Kyoko, additional, OMINE, Mitsuhiro, additional, FUJIWARA, Hikaru, additional, CHIBA, Shyozo, additional, and HIRASAWA, Akira, additional

Published
1998
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31. Infection in Elderly Leukemic Patients.

Author

Kikukawa, Masayuki, primary, Ishida, Yuiko, additional, Kuramoto, Ken, additional, Yoshida, Atsushi, additional, Tsutsumi, Hisashi, additional, Hirai, Makiko, additional, Kumakawa, Toshiro, additional, and Mori, Mayumi, additional

Published
1996
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39. Radiosensitivity and expression of nucleotide excision repair genes in peripheral blood mononuclear cells of myelodysplastic syndrome patients

Author

Ban, Sadayuki, Kuramoto, Ken, Oda, Kenji, Tanaka, Hideo, Kimura, Akiro, Suzuki, Gen, and Imai, Takashi

Abstract

Myelodysplastic syndrome (MDS) is the only other radiogenic blood disease apart from leukemia. Clinically, MDS involves dysplastic hematopoisis and an increased risk of leukemic transformation. We compared the micronucleus (MN) frequency in the peripheral T lymphocytes of atomic bomb survivors with MDS and normal individuals. The spontaneous and X-ray-induced MN frequencies were significantly higher in MDS patients than in normal individuals. To explain the cause of unusual radiosensitivity, we measured the expression levels of nucleotide excision repair (NER) genes in peripheral blood mononuclear cells using an RT-PCR method. The reduction of NER genes was expressed in only 1 of the 10 patients with mild symptoms, but in 4 of the 11 patients with severe symptoms. Our data suggest that chromosomal instability and DNA repair defects may be involved in the pathophysiology of disease progression.

Published
2002
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