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Your search keyword '"Kurahashi, Toshifumi"' showing total 219 results
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219 results on '"Kurahashi, Toshifumi"'

1. Efficacy and safety of second-line cabozantinib after immuno-oncology combination therapy for advanced renal cell carcinoma: Japanese multicenter retrospective study

Author

Sazuka, Tomokazu, Matsushita, Yuto, Sato, Hiroaki, Osawa, Takahiro, Hinata, Nobuyuki, Hatakeyama, Shingo, Numakura, Kazuyuki, Ueda, Kosuke, Kimura, Takahiro, Takahashi, Masayuki, Tanaka, Hajime, Kawasaki, Yoshihide, Kurahashi, Toshifumi, Kato, Takuma, Fujita, Kazutoshi, Miyake, Makito, Kojima, Takahiro, Kitamura, Hiroshi, Miyake, Hideaki, and Ichikawa, Tomohiko

Published
2023
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2. Prognostic outcomes in patients with metastatic renal cell carcinoma receiving second‐line treatment with tyrosine kinase inhibitor following first‐line immune‐oncology combination therapy.

Author

Matsushita, Yuto, Kojima, Takahiro, Osawa, Takahiro, Sazuka, Tomokazu, Hatakeyama, Shingo, Goto, Keisuke, Numakura, Kazuyuki, Yamana, Kazutoshi, Kandori, Shuya, Fujita, Kazutoshi, Ueda, Kosuke, Tanaka, Hajime, Tomida, Ryotaro, Kurahashi, Toshifumi, Bando, Yukari, Nishiyama, Naotaka, Kimura, Takahiro, Yamashita, Shimpei, Kitamura, Hiroshi, and Miyake, Hideaki

Subjects
RENAL cell carcinoma, PROTEIN-tyrosine kinase inhibitors, IPILIMUMAB, ALBUMINS, TREATMENT effectiveness, METASTASIS
Abstract

Objectives: This study aimed to assess the prognostic outcomes in mRCC patients receiving second‐line TKI following first‐line IO combination therapy. Methods: This study retrospectively included 243 mRCC patients receiving second‐line TKI after first‐line IO combination therapy: nivolumab plus ipilimumab (n = 189, IO–IO group) and either pembrolizumab plus axitinib or avelumab plus axitinib (n = 54, IO–TKI group). Oncological outcomes between the two groups were compared, and prognostication systems were developed for these patients. Results: In the IO–IO and IO–TKI groups, the objective response rates to second‐line TKI were 34.4% and 25.9% (p = 0.26), the median PFS periods were 9.7 and 7.1 months (p = 0.79), and the median OS periods after the introduction of second‐line TKI were 23.1 and 33.5 months (p = 0.93), respectively. Among the several factors examined, non‐CCRCC, high CRP, and low albumin levels were identified as independent predictors of both poor PFS and OS by multivariate analyses. It was possible to precisely classify the patients into 3 risk groups regarding both PFS and OS according to the positive numbers of the independent prognostic factors. Furthermore, the c‐indices of this study were superior to those of previous systems as follows: 0.75, 0.64, and 0.61 for PFS prediction and 0.76, 0.70, and 0.65 for OS prediction by the present, IMDC, and MSKCC systems, respectively. Conclusions: There were no significant differences in the prognostic outcomes after introducing second‐line TKI between the IO–IO and IO–TKI groups, and the histopathology, CRP and albumin levels had independent impacts on the prognosis in mRCC patients receiving second‐line TKI, irrespective of first‐line IO combination therapies. [ABSTRACT FROM AUTHOR]

Published
2024
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37. 精巣鞘膜に発生した悪性中皮腫の1例

Author

Tei, Hiromoto, Kurahashi, Toshifumi, Maruyama, Satoshi, Tanaka, Hirokazu, and Tashiro, Takashi

Subjects
endocrine system, Testis, 494.9, Malignant mesothelioma
Abstract

Malignant mesothelioma of the tunica vaginalis is rare, and is usually not diagnosed until surgery is undertaken. We report here a case in a 62-year-old man with malignant mesothelioma tunica vaginalis testis. He was referred to our hospital with a painless swelling of the left scrotal contents. There is a thickening of mesothelia of the tunica vaginalis with left sided hydrocele by ultrasonography and computed tomography scan. The tumor was resected under the diagnosis of testicular malignant tumor. However, the pathologist reported malignant mesothelioma and positive margin. He received external beam radiation therapy at a total dose of 44 Gy. Disease progression was not apparent 2 years after treatment. To our knowledge, 26 cases of malignant mesothelioma in the perineum or intrascrotum have been reported in Japan and this case is thought to be the 27th case in Japan.

Published
2013

39. Silent Intravascular Lymphoma Initially Manifesting as a Unilateral Adrenal Incidentaloma

Author

Takahashi, Yoshiko, Iida, Keiji, Hino, Yasuhisa, Ohara, Takeshi, Kurahashi, Toshifumi, Tashiro, Takashi, and Chihara, Kazuo

Subjects
Article Subject
Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of malignant lymphoma. Although the involvement of adrenal glands in IVLBCL is often observed, primary adrenal IVLBCL is rare. Most reported cases of adrenal IVLBCL showed bilateral lesions resulting in rapidly progressive adrenal failure and poor prognosis. Here, we report a case of slowly progressive primary adrenal IVLBCL manifesting initially with unilateral adrenal incidentaloma. This case is a silent IVLBCL and shows that the enlargement of both adrenal glands can be followed.

Published
2012
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41. This title is unavailable for guests, please login to see more information.

Author

Tei, Hiromoto, Kurahashi, Toshifumi, Maruyama, Satoshi, Tanaka, Hirokazu, Tashiro, Takashi, Tei, Hiromoto, Kurahashi, Toshifumi, Maruyama, Satoshi, Tanaka, Hirokazu, and Tashiro, Takashi

Abstract

Malignant mesothelioma of the tunica vaginalis is rare, and is usually not diagnosed until surgery is undertaken. We report here a case in a 62-year-old man with malignant mesothelioma tunica vaginalis testis. He was referred to our hospital with a painless swelling of the left scrotal contents. There is a thickening of mesothelia of the tunica vaginalis with left sided hydrocele by ultrasonography and computed tomography scan. The tumor was resected under the diagnosis of testicular malignant tumor. However, the pathologist reported malignant mesothelioma and positive margin. He received external beam radiation therapy at a total dose of 44 Gy. Disease progression was not apparent 2 years after treatment. To our knowledge, 26 cases of malignant mesothelioma in the perineum or intrascrotum have been reported in Japan and this case is thought to be the 27th case in Japan.

Published
2013

43. A Case of Primary Aldosteronism Caused by Multiple Adrenocortical Macronodules

Author

Hashimoto, Naoko, primary, Kawamura, Yoko, additional, Nakamura, Tomoaki, additional, Murawaki, Ayumi, additional, Nishiumi, Tomoko, additional, Hirota, Yushi, additional, Sakagushi, Kazuhiko, additional, Kurahashi, Toshifumi, additional, Miyake, Hideaki, additional, Fujisawa, Masato, additional, Sasano, Hironobu, additional, and Takahashi, Yutaka, additional

Published
2011
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