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1. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination: Results of the UCARE COVAC-CU study

Author

Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al-Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael, Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Meshkova, Raisa Y., Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young-Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, and Maurer, Marcus

Published
2023
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2. Mepolizumab Reduces Hypereosinophilic Syndrome Flares Irrespective of Blood Eosinophil Count and Interleukin-5

Author

García, Gabriel Ricardo, Sosso, Adriana, Wehbe, Luis, Yañez, Anahí, Blockmans, Daniël, Roufosse, Florence, Antila, Martti Anton, Blanco, Daniela, Grava, Sergio, Lima, Marina Andrade, Francisco Pez, Andreia Luisa, Faguer, Stanislas, Hamidou, Mohamed A., Kahn, Jean-Emmanuel, Lefévre, Guillaume, Brockow, Knut, Kern, Peter M., Reiter, Andreas J., Walz, Bastian, Welte, Tobias, Pane, Fabrizio, Vannucchi, Alessandro M., Cerino-Javier, Ruth, Gazca-Aguilar, Alfredo, Hernández-Colín, Dante D., Valdéz-López, Héctor Glenn, Kupryś-Lipińska, Izabela R., Musial, Jacek, Prejzner, Witold, Mihaly, Eniko, Popov, Viola, Zdrenghea, Mihnea Tudor, Gritsaev, Sergey V., Ivanov, Vladimir, Tsyba, Nikolay, Alonso, Aránzazu, Cid Xutgla, Maria Cinta, Fox, Maria Laura, Delgado, Regina Garcia, Hernández Rivas, Jesús María, Santillana, Guillermo Sanz, González, Ana Isabel, Wardlaw, Andrew J., Akuthota, Praveen, Butterfield, Joseph H., Chupp, Geoffrey L., Cox, John B., Gleich, Gerald J., Jhaveri, Devi, Rothenberg, Marc E., Steinfeld, Jonathan, Yancey, Steven W., Mavropoulou, Eleni, and Kwon, Namhee

Published
2022
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3. Usage prevalence of angioedema patient-reported outcome measures: results from the UCARE and ACARE PROMUSE study

Author

Cherrez-Ojeda, Ivan, primary, Bousquet, Jean, additional, Giménez-Arnau, Ana, additional, Godse, Kiran, additional, Krasowska, Dorota, additional, Bartosińska, Joanna, additional, Szczepanik-Kułak, Paulina, additional, Wawrzycki, Bartłomiej, additional, Kolkhir, Pavel, additional, Allenova, Anastasiia, additional, Allenov, Andrey, additional, Tkachenko, Sergey, additional, Teovska Mitrevska, Natasa, additional, Mijakoski, Dragan, additional, Stoleski, Sasho, additional, Kolacinska-Flont, Marta, additional, Kuprys-Lipinska, Izabela, additional, Molinska, Joanna, additional, Kasperska-Zając, Alicja, additional, Zajac, Magdalena, additional, Zamlynski, Mateusz, additional, Mihaltan, Florin, additional, Ulmeanu, Ruxandra, additional, Zalewska-Janowska, Anna, additional, Tomaszewska, Katarzyna, additional, Al-Ahmad, Mona, additional, Al-Nesf, Maryam Ali, additional, Ibrahim, Tayseer, additional, Aqel, Sami, additional, Pesqué, David, additional, Rodríguez-González, Mónica, additional, Wakida-Kuzunoki, Guillermo Hideo, additional, Ramon, German D., additional, Ramon, Gonzalo N., additional, Neisinger, Sophia, additional, Bonnekoh, Hanna, additional, Rukhadze, Maia, additional, Khoshkhui, Maryam, additional, Fomina, Daria, additional, Larenas-Linnemann, Désirée, additional, Košnik, Mitja, additional, Oztas Kara, Rabia, additional, Caballero López, Chrystopherson Gengyny, additional, Liu, Qiang, additional, Ivancevich, Juan Carlos, additional, Ensina, Luis Felipe, additional, Rosario, Nelson, additional, Kvedariene, Violeta, additional, Ben-Shoshan, Moshe, additional, Criado, Roberta Fachini Jardim, additional, Bauer, Andrea, additional, Cherrez, Annia, additional, Cherrez, Sofia, additional, Chong-Neto, Herberto, additional, Rojo-Gutierrez, Maria Isabel, additional, Rudenko, Michael, additional, Larco Sousa, José Ignacio, additional, Lesiak, Aleksandra, additional, Matos, Edgar, additional, Tinoco, Ivan, additional, Crespo Shijin, Carolina, additional, Hinostroza Logroño, Romina, additional, Sagñay, Juan C., additional, Faytong-Haro, Marco, additional, Robles-Velasco, Karla, additional, Zuberbier, Torsten, additional, and Maurer, Marcus, additional

Published
2024
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4. Safety and Efficacy of Mepolizumab in Hypereosinophilic Syndrome: An Open-Label Extension Study

Author

García, Gabriel Ricardo, Pascale, Pablo, Wehbe, Luis, Blockmans, Daniël, Roufosse, Florence, Antila, Martti Anton, Blanco, Daniela, Francisco Pez, Andreia Luisa, Faguer, Stanislas, Kahn, Jean-Emmanuel, Lefévre, Guillaume, Neel, Antoine, Kern, Peter M., Reiter, Andreas J., Walz, Bastian, Welte, Tobias, Pane, Fabrizio, Vannucchi, Alessandro M., Cerino-Javier, Ruth, Hernández-Colín, Dante D., Valdéz-López, Héctor Glenn, Kupryś-Lipińska, Izabela R., Musial, Jacek, Mihaly, Eniko, Popov, Viola Maria, Ivanov, Vladimir, Tsyba, Nikolay, Cid, Maria C., Fox, Maria Laura, Santillana, Guillermo Sanz, Wardlaw, Andrew J., Akuthota, Praveen, Butterfield, Joseph H., Chupp, Geoffrey L., Gleich, Gerald J., Jhaveri, Devi, Rothenberg, Marc E., Chupp, Geoffrey, Reiter, Andreas, Yancey, Steven W., Bentley, Jane H., and Steinfeld, Jonathan

Published
2021
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5. Enhancing Angioedema Patient Care: Unveiling Underutilization and Barriers in the Implementation of Patient-Reported Outcome Measurements

Author

Ojeda, Ivan Cherrez, primary, Maurer, Marcus, additional, Bousquet, Jean, additional, Gimenez-Arnau, Ana, additional, Godse, Kiran, additional, Krasowska, Dorota, additional, Robles-Velasco, Karla, additional, Kolkhir, Pavel, additional, Tkachenko, Sergey, additional, Mitrevska, Natasa Teovska, additional, Kolacinska-Flont, Marta, additional, Kuprys-Lipinska, Izabela, additional, Molinska, Joanna, additional, Kasperska-Zajac, Alicja, additional, Zajac, Magdalena, additional, Zamlynski, Mateusz, additional, Mihaltan, Florin, additional, Zalewska-Janowska, Anna, additional, Tomaszewska, Katarzyna, additional, Al-Ahmad, Mona, additional, Al-Nesf, Maryam Ali, additional, Ibrahim, Tayseer, additional, Pesqué, David, additional, Rodriguez-Gonzalez, Monica, additional, Wakida-Kuzunoki, Guillermo Hideo, additional, Ramon, German, additional, Ramon, Gonzalo, additional, Neisinger, Sophia, additional, Bonnekoh, Hanna, additional, Rukhadze, Maia, additional, Ulmeanu, Ruxandra, additional, Khoshkhui, Maryam, additional, Faytong-Haro, Marco, additional, Fomina, Daria, additional, Rudenko, Michael, additional, Ben-shoshan, Moshe, additional, Linnemann, Desiree Larenas, additional, Kvedariene, Violeta, additional, Košnik, Mitja, additional, Zuberbier, Torsten, additional, Kara, Rabia Oztas, additional, Caballero López, Chrystopherson Gengyny, additional, Criado, Roberta, additional, Liu, Qiang, additional, and Rosario, Nelson, additional

Published
2024
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9. Urticaria exacerbations and adverse reactions in patients with chronic urticaria receiving COVID-19 vaccination:Results of the UCARE COVAC-CU study

Author

Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, Maurer, Marcus, Kocatürk, Emek, Salameh, Pascale, Sarac, Esra, Vera Ayala, Carolina E., Thomsen, Simon Francis, Zuberbier, Torsten, Ensina, Luis Felipe, Popov, Todor A., van Doorn, Martijn B.A., Giménez-Arnau, Ana Maria, Asero, Riccardo, Criado, Paulo Ricardo, Aarestrup, Fernando M., AbdulHameed Ansari, Zainab, Al Abri, Salma, Al Ahmad, Mona, Al Hinai, Bushra, Allenova, Anastasiia, Al-Nesf, Maryam, Altrichter, Sabine, Arnaout, Rand, Bartosińska, Joanna, Bauer, Andrea, Bernstein, Jonathan A., Bizjak, Mojca, Bonnekoh, Hanna, Bouillet, Laurence, Brzoza, Zenon, Calvalcanti Dela Bianca Melo, Ana Caroline, Campinhos, Fernanda L., Carne, Emily, Purayil, Saleema Cherichi, Cherrez-Ojeda, Ivan, Chong-Neto, Herberto Jose, Christoff, George, Conlon, Niall, Jardim Criado, Roberta Fachini, Cvenkel, Klara, Damadoglu, Ebru, Danilycheva, Inna, Day, Cascia, de Montjoye, Laurence, Demir, Semra, Ferucci, Silvia Mariel, Fomina, Daria, Fukunaga, Atsushi, Garcia, Elizabeth, Gelincik, Asli, Göbel, Joe Hannah, Godse, Kiran, Gonçalo, Margarida, Gotua, Maia, Grattan, Clive, Gugala, Agata, Guillet, Carole, Kalyoncu, Ali Fuat, Karakaya, Gul, Kasperska-Zając, Alicja, Katelaris, Constance H., Khoshkhui, Maryam, Kleinheinz, Andreas, Kolacinska-Flont, Marta, Kolkhir, Pavel, Košnik, Mitja, Krasowska, Dorota, Kumaran, Muthu Sendhil, Kuprys-Lipinska, Izabela, Kurowski, Marcin, Kuznetsova, Elizaveta V., Larenas-Linnemann, Désirée, Lebedkina, Marina S., Lee, Youngsoo, Makris, Michael P., Gómez, René Maximiliano, Nasr, Iman, Neisinger, Sophia, Oda, Yoshiko, Kara, Rabia Öztaş, Palitot, Esther Bastos, Papapostolou, Niki, Salvador Parisi, Claudio Alberto, Pesque, David, Peter, Jonathan, Petkova, Elena, Ridge, Katie, Rudenko, Michael, Rutkowski, Krzysztof, Saini, Sarbjit S., Salman, Andac, Sanchez, Jorge, Şekerel, Bülent, Serdotetskova, Sofia A., Serpa, Faradiba S., Dikicier, Bahar Sevimli, Sidiropoulos, Nikitas, Sikora, Agnieszka, Sørensen, Jennifer Astrup, Soria, Angele, Kucuk, Ozlem Su, Thalappil, Sherin Rahim, Tomaszewska, Katarzyna, Tuncay, Gulseren, Unal, Derya, Valle, Solange, van Lindonk, Esmee, Vestergaard, Christian, Vitchuk, Aleksandr, Xepapadaki, Paraskevi, Ye, Young Min, Zalewska-Janowska, Anna, Zamlynski, Mateusz, and Maurer, Marcus

Abstract

Background: Concern about disease exacerbations and fear of reactions after coronavirus disease 2019 (COVID-19) vaccinations are common in chronic urticaria (CU) patients and may lead to vaccine hesitancy. Objective: We assessed the frequency and risk factors of CU exacerbation and adverse reactions in CU patients after COVID-19 vaccination. Methods: COVAC-CU is an international multicenter study of Urticaria Centers of Reference and Excellence (UCAREs) that retrospectively evaluated the effects of COVID-19 vaccination in CU patients aged ≥18 years and vaccinated with ≥1 dose of any COVID-19 vaccine. We evaluated CU exacerbations and severe allergic reactions as well as other adverse events associated with COVID-19 vaccinations and their association with various CU parameters. Results: Across 2769 COVID-19–vaccinated CU patients, most (90%) received at least 2 COVID-19 vaccine doses, and most patients received CU treatment and had well-controlled disease. The rate of COVID-19 vaccination–induced CU exacerbation was 9%. Of 223 patients with CU exacerbation after the first dose, 53.4% experienced recurrence of CU exacerbation after the second dose. CU exacerbation most often started <48 hours after vaccination (59.2%), lasted for a few weeks or less (70%), and was treated mainly with antihistamines (70.3%). Factors that increased the risk for COVID-19 vaccination–induced CU exacerbation included female sex, disease duration shorter than 24 months, having chronic spontaneous versus inducible urticaria, receipt of adenovirus viral vector vaccine, having nonsteroidal anti-inflammatory drug/aspirin intolerance, and having concerns about getting vaccinated; receiving omalizumab treatment and Latino/Hispanic ethnicity lowered the risk. First-dose vaccine–related adverse effects, most commonly local reactions, fever, fatigue, and muscle pain, were reported by 43.5% of CU patients. Seven patients reported severe allergic reactions. Conclusions: COVID-19 vaccination lead

Published
2023

14. Patient-Reported Outcome Measures in Atopic Dermatitis and Chronic Urticaria Are Underused in Clinical Practice

Author

Cherrez-Ojeda, Ivan, Bousquet, Jean, Giménez-Arnau, Ana, Godse, Kiran, Krasowska, Dorota, Bartosińska, Joanna, Szczepanik-Kułak, Paulina, Wawrzycki, Bartłomiej, Kolkhir, Pavel, Allenova, Anastasiia, Allenova, Andrey, Tkachenko, Sergey, Teovska Mitrevska, Natasa, Mijakoski, Dragan, Stoleski, Sasho, Kolacinska-Flont, Marta, Kuprys-Lipinska, Izabela, Molinska, Joanna, Kasperska-Zając, Alicja, Zajac, Magdalena, Zamlynski, Mateusz, Mihaltan, Florin, Ulmeanu, Ruxandra, Zalewska-Janowska, Anna, Tomaszewska, Katarzyna, Al-Ahmad, Mona, Al-Nesf, Maryam Ali, Ibrahim, Tayseer, Aqel, Sami, Pesqué, David, Rodríguez-González, Mónica, Wakida-Kuzunoki, Guillermo Hideo, Ramon, German, Ramon, Gonzalo, Neisinger, Sophia, Bonnekoh, Hanna, Rukhadze, Maia, Khoshkhui, Maryam, Fomina, Daria, Larenas-Linnemann, Désirée, Košnik, Mitja, Oztas Kara, Rabia, Caballero López, Chrystopherson Gengyny, Liu, Qiang, Ivancevich, Juan Carlos, Ensina, Luis Felipe, Rosario, Nelson, Kvedariene, Violeta, Ben-Shoshan, Moshe, Criado, Roberta Fachini Jardim, Bauer, Andrea, Cherrez, Annia, Chong-Neto, Herberto, Rojo-Gutierrez, Maria Isabel, Rudenko, Michael, Larco Sousa, José Ignacio, Lesiak, Aleksandra, Matos, Edgar, Muñoz, Nelson, Tinoco, Ivan, Moreno, Jaime, Crespo Shijin, Carolina, Hinostroza Logroño, Romina, Sagñay, Juan, Faytong-Haro, Marco, Robles-Velasco, Karla, Zuberbier, Torsten, and Maurer, Marcus

Abstract

Patient-reported outcome measures (PROMs) are validated and standardized tools that complement physician evaluations and guide treatment decisions. They are crucial for monitoring atopic dermatitis (AD) and chronic urticaria (CU) in clinical practice, but there are unmet needs and knowledge gaps regarding their use in clinical practice.

Published
2024
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15. The whole-genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge

Author

Wieczfinska, Joanna, Kacprzak, Dorota, Pospiech, Karolina, Sokolowska, Milena, Nowakowska, Magdalena, Pniewska, Ewa, Bednarek, Andrzej, Kuprys-Lipinska, Izabela, Kuna, Piotr, Pawliczak, Rafal, University of Zurich, and Pawliczak, Rafal

Subjects
10183 Swiss Institute of Allergy and Asthma Research, 2740 Pulmonary and Respiratory Medicine, 610 Medicine & health
Published
2015
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18. The whole - genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge

Author

Wieczfinska, Joanna, primary, Kacprzak, Dorota, additional, Pospiech, Karolina, additional, Sokolowska, Milena, additional, Nowakowska, Magdalena, additional, Pniewska, Ewa, additional, Bednarek, Andrzej, additional, Kuprys–Lipinska, Izabela, additional, Kuna, Piotr, additional, and Pawliczak, Rafal, additional

Published
2015
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31. The prevalence of asthma work relatedness: Preliminary data.

Author

Dudek, Wojciech, Kuprys-Lipinska, Izabela, Wittczak, Tomasz, Swierczynska-Machura, Dominika, Kupczyk, Maciej, Walusiak-Skorupa, Jolanta, Kuna, Piotr, Palczynski, Cezary, Kupryś-Lipińska, Izabela, Świerczyńska-Machura, Dominika, and Pałczyński, Cezary

Abstract

Objectives: About 5-10% of asthmatics do not respond well to standard treatment plan. Occupational exposure may be one of the factors that can be linked with treatment failure. The aim of the study was to assess the prevalence of work-related asthma (WRA) among adult asthmatics under follow up in an outpatient allergy clinic and to create a useful tool for detecting individuals with possible WRA.Material and Methods: Preliminary 5-question questionnaire designed to recognize WRA was presented to 300 asthmatics. All patients with positive preliminary verification along with 50 subjects from control group were asked to fill up a detailed questionnaire. The WRA was diagnosed by positive match for asthma symptoms in combination with workplace exposure indicated in the detailed WRA questionnaire followed by confirmation of each WRA case by detailed exposure analysis.Results: Work-related asthma was recognized in 63 subjects (21% of study group). The preliminary questionnaire has 76.9% sensitivity and 94% specificity in recognition of WRA. Occupational exposure to irritants is a risk factor of WRA recognition (relative risk (RR) = 2.09 (1.44:3.03)). Working in exposure-free environment is a factor against WRA recognition (RR = 0.38 (0.24:0.61)). Among subjects with work-related asthma, the uncontrolled course of the disease is significantly more frequent (p = 0.012). Subjects with WRA more often report sickness absenteeism due to asthma than those without WRA (9.6% vs. 3.2%, respectively), but the observed differences did not reach the statistical significance.Conclusions: Short 5-question questionnaire seems to be a promising tool to detect individuals with possible work-related asthma in the outpatient setting for further evaluation and additional attention. [ABSTRACT FROM AUTHOR]

Published
2015
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34. Frequencies of Bcl I, E22E, and N363S of h-GR/NR3C1 restriction fragment length polymorphisms of glucocorticoid receptor gene in Polish adult population.

Author

Pietras T, Panek M, Kuprys-Lipinska I, Oszajca K, Wujcik R, Kuna P, Gorski P, and Szemraj J

Subjects
Adult, Base Sequence, Drug Resistance drug effects, Female, Genotype, Humans, Male, Poland, Gene Frequency, Genetics, Population, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length genetics, Receptors, Glucocorticoid genetics
Abstract

Background: Polymorphism of the gene encoding the glucocorticoid receptor - h-GR/NR3C1 demonstrates close genetic and biochemical correlation with etiopathogenesis of metabolic, cardiovascular, hematologic, and mental disorders. The natural variability of DNA sequence within the h-GR gene affects both the conformation and the activity of glucocorticoid receptors. Modifications of the amino acid receptor structure give rise to disturbances of the receptor-hormone complex interaction with many genes responsible for normal cellular function. Transactivation, or transrepression, of the genes encoding proteins synthesized within the framework of cellular response to glucocorticosteroids is 1 among many molecular pathways leading to the development of resistance to anti-inflammatory drugs., Material/methods: A group of 70 healthy participants, with no history of asthma or atopic conditions, qualified for the study. Genotyping was accomplished using PCR-RFLP method., Results: In healthy, nonatopic population, within the h-GR gene promoter, a polymorphism of Bcl I: GG, GC, and CC occurring with 0.129/0.471/0.40 frequency, were identified. Two polymorphisms were identified in exon 2 at 1220 and 198 position in the h-GR gene: N363S (AA, AG occurring with 0.9/0.1 frequency) and ER22/23EK (GG, GC occurring with 0.843/0.157 frequency)., Conclusions: The frequency of polymorphisms occurring within the h-GR gene has not been assessed to date in the Polish population. The present study is the first attempt of such estimation. The study is an introduction to more-detailed analysis of the correlation between the occurrence of h-GR gene polymorphisms, and the development of severe, steroid-resistant bronchial asthma.

Published
2010

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