712 results on '"Kupcinskas, Juozas"'
Search Results
2. Prolonged culturing of colonic epithelial organoids derived from healthy individuals and ulcerative colitis patients results in the decrease of LINE-1 methylation level
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Inciuraite, Ruta, Steponaitiene, Ruta, Raudze, Odeta, Kulokiene, Ugne, Kiudelis, Vytautas, Lukosevicius, Rokas, Ugenskiene, Rasa, Adamonis, Kestutis, Kiudelis, Gediminas, Jonaitis, Laimas Virginijus, Kupcinskas, Juozas, and Skieceviciene, Jurgita
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- 2024
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3. Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk
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Ünal, Pelin, Lu, Ye, Bueno-de-Mesquita, Bas, van Eijck, Casper H. J., Talar-Wojnarowska, Renata, Szentesi, Andrea, Gazouli, Maria, Kreivenaite, Edita, Tavano, Francesca, Małecka-Wojciesko, Ewa, Erőss, Bálint, Oliverius, Martin, Bunduc, Stefania, Nóbrega Aoki, Mateus, Vodickova, Ludmila, Boggi, Ugo, Giaccherini, Matteo, Kondrackiene, Jurate, Chammas, Roger, Palmieri, Orazio, Theodoropoulos, George E., Bijlsma, Maarten F., Basso, Daniela, Mohelnikova-Duchonova, Beatrice, Soucek, Pavel, Izbicki, Jakob R., Kiudelis, Vytautas, Vanella, Giuseppe, Arcidiacono, Paolo Giorgio, Włodarczyk, Barbara, Hackert, Thilo, Schöttker, Ben, Uzunoglu, Faik G., Bambi, Franco, Goetz, Mara, Hlavac, Viktor, Brenner, Hermann, Perri, Francesco, Carrara, Silvia, Landi, Stefano, Hegyi, Péter, Dijk, Frederike, Maiello, Evaristo, Capretti, Giovanni, Testoni, Sabrina Gloria Giulia, Petrone, Maria Chiara, Stocker, Hannah, Ermini, Stefano, Archibugi, Livia, Gentiluomo, Manuel, Cavestro, Giulia Martina, Pezzilli, Raffaele, Di Franco, Gregorio, Milanetto, Anna Caterina, Sperti, Cosimo, Neoptolemos, John P., Morelli, Luca, Vokacova, Klara, Pasquali, Claudio, Lawlor, Rita T., Bazzocchi, Francesca, Kupcinskas, Juozas, Capurso, Gabriele, Campa, Daniele, and Canzian, Federico
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- 2024
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4. Helicobacter pylori Eradication Treatment in Older Patients
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Jonaitis, Paulius, Kupcinskas, Juozas, Gisbert, Javier P., and Jonaitis, Laimas
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- 2024
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5. Clinical management of liver cyst infections: an international, modified Delphi-based clinical decision framework
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Duijzer, Renée, Bernts, Lucas H P, Geerts, Anja, van Hoek, Bart, Coenraad, Minneke J, Rovers, Chantal, Alvaro, Domenico, Kuijper, Ed J, Nevens, Frederik, Halbritter, Jan, Colmenero, Jordi, Kupcinskas, Juozas, Salih, Mahdi, Hogan, Marie C, Ronot, Maxime, Vilgrain, Valerie, Hanemaaijer, Nicolien M, Kamath, Patrick S, Strnad, Pavel, Taubert, Richard, Gansevoort, Ron T, Torra, Roser, Nadalin, Silvio, Suwabe, Tatsuya, Gevers, Tom J G, Cardinale, Vincenzo, Drenth, Joost P H, and Lantinga, Marten A
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- 2024
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6. Author Correction: Comparison of the management of Helicobacter pylori infection between the older and younger European populations
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Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas
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- 2023
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7. Comparison of the management of Helicobacter pylori infection between the older and younger European populations
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Jonaitis, Paulius, Nyssen, Olga P., Saracino, Ilaria Maria, Fiorini, Giulia, Vaira, Dino, Pérez-Aísa, Ángeles, Tepes, Bojan, Castro-Fernandez, Manuel, Pabón-Carrasco, Manuel, Keco-Huerga, Alma, Voynovan, Irina, Lucendo, Alfredo J., Lanas, Ángel, Martínez-Domínguez, Samuel J., Almajano, Enrique Alfaro, Rodrigo, Luis, Vologzanina, Ludmila, Brglez Jurecic, Natasa, Denkovski, Maja, Bujanda, Luis, Mahmudov, Umud, Leja, Mārcis, Lerang, Frode, Babayeva, Gülüstan, Bordin, Dmitry S., Gasbarrini, Antonio, Kupcinskas, Juozas, Gridnyev, Oleksiy, Rokkas, Theodore, Marcos-Pinto, Ricardo, Phull, Perminder S., Smith, Sinead M., Tonkić, Ante, Boltin, Doron, Buzás, György Miklós, Šembera, Štěpán, Şimşek, Halis, Matysiak-Budnik, Tamara, Milivojevic, Vladimir, Marlicz, Wojciech, Venerito, Marino, Boyanova, Lyudmila, Doulberis, Michael, Capelle, Lisette G., Cano-Català, Anna, Moreira, Leticia, Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., and Jonaitis, Laimas
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- 2023
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8. Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians
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Piccardi, Margherita, Gentiluomo, Manuel, Bertoncini, Stefania, Pezzilli, Raffaele, Erőss, Bálint, Bunduc, Stefania, Uzunoglu, Faik G., Talar-Wojnarowska, Renata, Vanagas, Tomas, Sperti, Cosimo, Oliverius, Martin, Aoki, Mateus Nóbrega, Ermini, Stefano, Hussein, Tamás, Boggi, Ugo, Jamroziak, Krzysztof, Maiello, Evaristo, Morelli, Luca, Vodickova, Ludmila, Di Franco, Gregorio, Landi, Stefano, Szentesi, Andrea, Lovecek, Martin, Puzzono, Marta, Tavano, Francesca, van Laarhoven, Hanneke W. M., Zerbi, Alessandro, Mohelnikova-Duchonova, Beatrice, Stocker, Hannah, Costello, Eithne, Capurso, Gabriele, Ginocchi, Laura, Lawlor, Rita T., Vanella, Giuseppe, Bazzocchi, Francesca, Izbicki, Jakob R., Latiano, Anna, Bueno-de-Mesquita, Bas, Ponz de Leon Pisani, Ruggero, Schöttker, Ben, Soucek, Pavel, Hegyi, Péter, Gazouli, Maria, Hackert, Thilo, Kupcinskas, Juozas, Poskiene, Lina, Tacelli, Matteo, Roth, Susanne, Carrara, Silvia, Perri, Francesco, Hlavac, Viktor, Theodoropoulos, George E., Busch, Olivier R., Mambrini, Andrea, van Eijck, Casper H. J., Arcidiacono, Paolo, Scarpa, Aldo, Pasquali, Claudio, Basso, Daniela, Lucchesi, Maurizio, Milanetto, Anna Caterina, Neoptolemos, John P., Cavestro, Giulia Martina, Janciauskas, Dainius, Chen, Xuechen, Chammas, Roger, Goetz, Mara, Brenner, Hermann, Archibugi, Livia, Dannemann, Michael, Canzian, Federico, Tofanelli, Sergio, and Campa, Daniele
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- 2023
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9. Mucin-microbiome signatures shape the tumor microenvironment in gastric cancer
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Oosterlinck, Baptiste, Ceuleers, Hannah, Arras, Wout, De Man, Joris G., Geboes, Karen, De Schepper, Heiko, Peeters, Marc, Lebeer, Sarah, Skieceviciene, Jurgita, Hold, Georgina L., Kupcinskas, Juozas, Link, Alexander, De Winter, Benedicte Y., and Smet, Annemieke
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- 2023
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10. Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer
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Lehr, Konrad, Nikitina, Darja, Vilchez-Vargas, Ramiro, Steponaitiene, Ruta, Thon, Cosima, Skieceviciene, Jurgita, Schanze, Denny, Zenker, Martin, Malfertheiner, Peter, Kupcinskas, Juozas, and Link, Alexander
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- 2023
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11. Genetic and non-genetic risk factors for early-onset pancreatic cancer
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Nodari, Ylenia, Gentiluomo, Manuel, Mohelnikova-Duchonova, Beatrice, Kreivenaite, Edita, Milanetto, Anna Caterina, Skieceviciene, Jurgita, Landi, Stefano, Lawlor, Rita T, Petrone, Maria Chiara, Arcidiacono, Paolo Giorgio, Lovecek, Martin, Gazouli, Maria, Bijlsma, Maarten F., Morelli, Luca, Kiudelis, Vytautas, Tacelli, Matteo, Zanette, Dalila Lucíola, Soucek, Pavel, Uzunoglu, Faik, Kaaks, Rudolf, Izbicki, Jakob, Boggi, Ugo, Pezzilli, Raffaele, Mambrini, Andrea, Pasquali, Claudio, van Laarhoven, Hanneke W., Katzke, Verena, Cavestro, Giulia Martina, Sperti, Cosimo, Loos, Martin, Latiano, Anna, Erőss, Bálint, Oliverius, Martin, Johnson, Theron, Basso, Daniela, Neoptolemos, John P., Aoki, Mateus Nóbrega, Greenhalf, William, Vodicka, Pavel, Archibugi, Livia, Vanella, Giuseppe, Lucchesi, Maurizio, Talar-Wojnarowska, Renata, Jamroziak, Krzysztof, Saeedi, Mohammed Al, van Eijck, Casper H.J., Kupcinskas, Juozas, Hussein, Tamás, Puzzono, Marta, Bunduc, Stefania, Götz, Mara, Carrara, Silvia, Szentesi, Andrea, Tavano, Francesca, Moz, Stefania, Hegyi, Péter, Luchini, Claudio, Capurso, Gabriele, Perri, Francesco, Ermini, Stefano, Theodoropoulos, George, Capretti, Giovanni, Palmieri, Orazio, Ginocchi, Laura, Furbetta, Niccolò, Canzian, Federico, and Campa, Daniele
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- 2023
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12. The PANcreatic Disease ReseArch (PANDoRA) consortium: Ten years’ experience of association studies to understand the genetic architecture of pancreatic cancer
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Campa, Daniele, Gentiluomo, Manuel, Stein, Angelika, Aoki, Mateus Nóbrega, Oliverius, Martin, Vodičková, Ludmila, Jamroziak, Krzysztof, Theodoropoulos, George, Pasquali, Claudio, Greenhalf, William, Arcidiacono, Paolo Giorgio, Uzunoglu, Faik, Pezzilli, Raffaele, Luchini, Claudio, Puzzono, Marta, Loos, Martin, Giaccherini, Matteo, Katzke, Verena, Mambrini, Andrea, Kiudeliene, Edita, Federico, Kauffmann Emanuele, Johansen, Julia, Hussein, Tamás, Mohelnikova-Duchonova, Beatrice, van Eijck, Casper H.J., Brenner, Hermann, Farinella, Riccardo, Pérez, Juan Sainz, Lovecek, Martin, Büchler, Markus W., Hlavac, Viktor, Izbicki, Jakob R., Hackert, Thilo, Chammas, Roger, Zerbi, Alessandro, Lawlor, Rita, Felici, Alessio, Götz, Mara, Capurso, Gabriele, Ginocchi, Laura, Gazouli, Maria, Kupcinskas, Juozas, Cavestro, Giulia Martina, Vodicka, Pavel, Moz, Stefania, Neoptolemos, John P., Kunovsky, Lumir, Bojesen, Stig E., Carrara, Silvia, Gioffreda, Domenica, Morkunas, Egidijus, Abian, Olga, Bunduc, Stefania, Basso, Daniela, Boggi, Ugo, Wlodarczyk, Barbara, Szentesi, Andrea, Vanella, Giuseppe, Chen, Inna, Bijlsma, Maarten F., Kiudelis, Vytautas, Landi, Stefano, Schöttker, Ben, Corradi, Chiara, Giese, Nathalia, Kaaks, Rudolf, Peduzzi, Giulia, Hegyi, Péter, Morelli, Luca, Furbetta, Niccolò, Soucek, Pavel, Latiano, Anna, Talar-Wojnarowska, Renata, Lindgaard, Sidsel C., Dijk, Frederike, Milanetto, Anna Caterina, Tavano, Francesca, Cervena, Klara, Erőss, Bálint, Testoni, Sabrina G., Verhagen-Oldenampsen, Judith H.E., Małecka-Wojciesko, Ewa, Costello, Eithne, Salvia, Roberto, Maiello, Evaristo, Ermini, Stefano, Sperti, Cosimo, Holleczek, Bernd, Perri, Francesco, Skieceviciene, Jurgita, Archibugi, Livia, Lucchesi, Maurizio, Rizzato, Cosmeri, and Canzian, Federico
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- 2023
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13. Genetics
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Lukosiene, Jaune Ieva, Kupcinskas, Juozas, Tursi, Antonio, editor, Bafutto, Mauro, editor, Brandimarte, Giovanni, editor, and Chaves de Oliveira, Enio, editor
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- 2022
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14. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility
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Sazonovs, Aleksejs, Stevens, Christine R., Venkataraman, Guhan R., Yuan, Kai, Avila, Brandon, Abreu, Maria T., Ahmad, Tariq, Allez, Matthieu, Ananthakrishnan, Ashwin N., Atzmon, Gil, Baras, Aris, Barrett, Jeffrey C., Barzilai, Nir, Beaugerie, Laurent, Beecham, Ashley, Bernstein, Charles N., Bitton, Alain, Bokemeyer, Bernd, Chan, Andrew, Chung, Daniel, Cleynen, Isabelle, Cosnes, Jacques, Cutler, David J., Daly, Allan, Damas, Oriana M., Datta, Lisa W., Dawany, Noor, Devoto, Marcella, Dodge, Sheila, Ellinghaus, Eva, Fachal, Laura, Farkkila, Martti, Faubion, William, Ferreira, Manuel, Franchimont, Denis, Gabriel, Stacey B., Ge, Tian, Georges, Michel, Gettler, Kyle, Giri, Mamta, Glaser, Benjamin, Goerg, Siegfried, Goyette, Philippe, Graham, Daniel, Hämäläinen, Eija, Haritunians, Talin, Heap, Graham A., Hiltunen, Mikko, Hoeppner, Marc, Horowitz, Julie E., Irving, Peter, Iyer, Vivek, Jalas, Chaim, Kelsen, Judith, Khalili, Hamed, Kirschner, Barbara S., Kontula, Kimmo, Koskela, Jukka T., Kugathasan, Subra, Kupcinskas, Juozas, Lamb, Christopher A., Laudes, Matthias, Lévesque, Chloé, Levine, Adam P., Lewis, James D., Liefferinckx, Claire, Loescher, Britt-Sabina, Louis, Edouard, Mansfield, John, May, Sandra, McCauley, Jacob L., Mengesha, Emebet, Mni, Myriam, Moayyedi, Paul, Moran, Christopher J., Newberry, Rodney D., O’Charoen, Sirimon, Okou, David T., Oldenburg, Bas, Ostrer, Harry, Palotie, Aarno, Paquette, Jean, Pekow, Joel, Peter, Inga, Pierik, Marieke J., Ponsioen, Cyriel Y., Pontikos, Nikolas, Prescott, Natalie, Pulver, Ann E., Rahmouni, Souad, Rice, Daniel L., Saavalainen, Päivi, Sands, Bruce, Sartor, R. Balfour, Schiff, Elena R., Schreiber, Stefan, Schumm, L. Philip, Segal, Anthony W., Seksik, Philippe, Shawky, Rasha, Sheikh, Shehzad Z., Silverberg, Mark S., Simmons, Alison, Skeiceviciene, Jurgita, Sokol, Harry, Solomonson, Matthew, Somineni, Hari, Sun, Dylan, Targan, Stephan, Turner, Dan, Uhlig, Holm H., van der Meulen, Andrea E., Vermeire, Séverine, Verstockt, Sare, Voskuil, Michiel D., Winter, Harland S., Young, Justine, Duerr, Richard H., Franke, Andre, Brant, Steven R., Cho, Judy, Weersma, Rinse K., Parkes, Miles, Xavier, Ramnik J., Rivas, Manuel A., Rioux, John D., McGovern, Dermot P. B., Huang, Hailiang, Anderson, Carl A., and Daly, Mark J.
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- 2022
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15. Diurnal variation of clock genes expression and other sleep-wake rhythm biomarkers among acute ischemic stroke patients
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Pajediene, Evelina, Paulekas, Erlandas, Salteniene, Violeta, Skieceviciene, Jurgita, Arstikyte, Justina, Petrikonis, Kestutis, Kupcinskas, Juozas, Bassetti, Claudio L., and Daiva, Rastenyte
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- 2022
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16. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)
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Fiorinni, Giulia, Saracino, Ilaria Maria, Carrasco, Manuel Pabon, Huerga, Alma Keco, Almajano, Enrique Alfaro, Martinez Dominguez, Samuel Jesus, Galan, Horacio Alonso, Velayos, Benito, Sadornil, Carmen Dueñas, Botargues Bote, Jose Maria, Gonzalez-Cordero, Pedro Luis, Areia, Miguel, Gomez Rodriguez, Blas Jose, Pellicano, Rinaldo, Nuñez, Óscar, Franceschi, Francesco, Alekseenko, Sergey, Perona, Monica, Abdulkhakov, Rustam, Dominguez-Cajal, Manuel, Notari, Pedro Almela, Camarero, Judith Gomez, Moreno, Manuel Jimenez, Algaba, Alicia, Bermejo, Fernando, Tejada, Javier Tejedor, Susanibar, Elida Oblitas, Boltin, Doron, Georgopoulos, Sotirios, OMorain, Colm, Qasim, Asghar, Beales, Ian, Bakulina, Natalia, Fadeenko, Galina, Malfertheiner, Peter, Rosania, Rosa, Ilchishina, Tatiana, Bogomolov, Pavel, Bakulin, Igor, Zaytsev, Oleg, Gravina, Antonietta Gerarda, Romano, Marco, Di Leo, Alfredo, Losurdo, Giuseppe, Grigorieva, Ludmila, Guillena, Pedro Delgado, Marusic, Marinko, Jurcic, Dragan, Dekhnich, Natalia Nikolaevna, Iyo, Eduardo, de la Peña Negro, Luisa Carmen, Baryshnikova, Natalia, Bakanova, Natalia, Simsek, Halis, Simsek, Cem, Gridnyev, Oleksiy, Fernandez-Bermejo, Miguel, Angueira, Teresa, Ruiz-Zorrilla Lopez, Rafael, Gomez, Barbara, Kovacheva-Slavova, Mila, Lahat, Adi, Alcedo, Javier, Campillo, Ana, Belousova, Liya Nikolaevna, Villarroya, Ramon Pajares, Ljubicic, Neven, Nikolic, Marko, González-Santiago, Jesús M., Santamaría, Diego Burgos, Pakhomova, Anna, Sekulic-Spasic, Izabela, Ghisa, Matteo, Farinati, Fabio, Sagdati, Sabir Irfan, Panic, Nikola, Heluwaert, Frederic, Amorena, Edurne, Moreira, Leticia, Esparrach, Gloria Fernandez, Plotnikova, Ekaterina Yuryevna, Kukla, Michal, Kamburov, Victor, Lamuela Calvo, Luis Javier, Rankovic, Ivan, Lavín, Antonio Cuadrado, Lazaro, Yolanda Arguedas, Carrera Agnieszka Dobrowolska, Victor Gonzalez, Eder, Piotr, Kononova, Alla, Nyssen, Olga P., Vaira, Dino, Pérez Aísa, Ángeles, Rodrigo, Luis, Castro-Fernandez, Manuel, Jonaitis, Laimas, Tepes, Bojan, Vologzhanina, Liudmila, Caldas, María, Lanas, Angel, Lucendo, Alfredo J., Bujanda, Luis, Ortuño, Juan, Barrio, Jesús, Huguet, Jose M., Voynovan, Irina, Lasala, Jorge Perez, Sarsenbaeva, Aiman Silkanovna, Fernandez-Salazar, Luis, Molina-Infante, Javier, Jurecic, Natasa Brglez, Gasbarrini, Antonio, Kupčinskas, Juozas, Bordin, Dmitry, Marcos-Pinto, Ricardo, Lerang, Frode, Leja, Marcis, Buzas, Gyorgy M., Niv, Yaron, Rokkas, Theodore, Phull, Perminder, Smith, Sinead, Shvets, Oleg, Venerito, Marino, Milivojevic, Vladimir, Simsek, Ilkay, Lamy, Vincent, Bytzer, Peter, Boyanova, Lyudmila, Kunovský, Lumír, Beglinger, Christoph, Doulberis, Michael, Marlicz, Wojciech, Goldis, Adrian, Tonkić, Ante, Capelle, Lisette, Puig, Ignasi, Megraud, Francis, Morain, Colm O’, and Gisbert, Javier P.
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- 2022
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17. The Role of Microbiota in Gastrointestinal Cancer and Cancer Treatment: Chance or Curse?
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Smet, Annemieke, Kupcinskas, Juozas, Link, Alexander, Hold, Georgina L., and Bornschein, Jan
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- 2022
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18. Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women
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Peduzzi, Giulia, Archibugi, Livia, Katzke, Verena, Gentiluomo, Manuel, Capurso, Gabriele, Milanetto, Anna Caterina, Gazouli, Maria, Goetz, Mara, Brenner, Hermann, Vermeulen, Roel C. H., Talar-Wojnarowska, Renata, Vanella, Giuseppe, Tavano, Francesca, Lucchesi, Maurizio, Mohelnikova-Duchonova, Beatrice, Chen, Xuechen, Kiudelis, Vytautas, Hegyi, Péter, Oliverius, Martin, Stocker, Hannah, Stornello, Caterina, Vodickova, Ludmila, Souček, Pavel, Neoptolemos, John P., Testoni, Sabrina Gloria Giulia, Morelli, Luca, Lawlor, Rita T., Basso, Daniela, Izbicki, Jakob R., Ermini, Stefano, Kupcinskas, Juozas, Pezzilli, Raffaele, Boggi, Ugo, van Laarhoven, Hanneke W. M., Szentesi, Andrea, Erőss, Bálint, Capretti, Giovanni, Schöttker, Ben, Skieceviciene, Jurgita, Aoki, Mateus Nóbrega, van Eijck, Casper H. J., Cavestro, Giulia Martina, Canzian, Federico, and Campa, Daniele
- Published
- 2022
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19. Reduction of gastrointestinal tract colonization by Klebsiella quasipneumoniae using antimicrobial protein KvarIa
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Karaliute, Indre, Ramonaite, Rima, Bernatoniene, Jurga, Petrikaite, Vilma, Misiunas, Audrius, Denkovskiene, Erna, Razanskiene, Ausra, Gleba, Yuri, Kupcinskas, Juozas, and Skieceviciene, Jurgita
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- 2022
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20. miRNome profiling analysis reveals novel hepatocellular carcinoma diagnostic, prognostic and treatment-related candidate biomarkers: post-hoc analysis of SORAMIC trial
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Morkunas, Egidijus, primary, Vaitkeviciute, Evelina, additional, Inciuraite, Ruta, additional, Kupcinskas, Juozas, additional, Link, Alexander, additional, Skieceviciene, Jurgita, additional, Alunni-Fabbroni, Marianna, additional, Schütte, Kerstin, additional, Malfertheiner, Peter, additional, Varkalaite, Greta, additional, and Ricke, Jens, additional
- Published
- 2024
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21. Comparison of Fecal MicroRNA Isolation Using Various Total RNA Isolation Kits
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Lederer, Theresa, primary, Hipler, Noam M., additional, Thon, Cosima, additional, Kupcinskas, Juozas, additional, and Link, Alexander, additional
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- 2024
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22. The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey
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Baunwall, Simon Mark Dahl, Terveer, Elisabeth M, Dahlerup, Jens Frederik, Erikstrup, Christian, Arkkila, Perttu, Vehreschild, Maria JGT, Ianiro, Gianluca, Gasbarrini, Antonio, Sokol, Harry, Kump, Patrizia K, Satokari, Reetta, De Looze, Danny, Vermeire, Séverine, Nakov, Radislav, Brezina, Jan, Helms, Morten, Kjeldsen, Jens, Rode, Anne A, Kousgaard, Sabrina Just, Alric, Laurent, Trang-Poisson, Caroline, Scanzi, Julien, Link, Alexander, Stallmach, Andreas, Kupcinskas, Juozas, Johnsen, Peter Holger, Garborg, Kjetil, Rodríguez, Eugenia Sánchez, Serrander, Lena, Brummer, Robert J, Galpérine, Katerina Tatiana, Goldenberg, Simon D, Mullish, Benjamin H, Williams, Horace RT, Iqbal, Tariq H, Ponsioen, Cyriel, Kuijper, Ed J, Cammarota, Giovanni, Keller, Josbert J, and Hvas, Christian Lodberg
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- 2021
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23. Cell-Free Microbial DNA Analysis: Effects of Blood Plasma and Serum Quantity, Biobanking Protocols, and Isolation Kits.
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Nikitina, Darja, Lukosevicius, Rokas, Tilinde, Deimante, Muskieta, Tomas, Hov, Johannes Roksund, Melum, Espen, Klovins, Janis, Org, Elin, Kiudelis, Gediminas, Kupcinskas, Juozas, and Skieceviciene, Jurgita
- Published
- 2024
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24. The impact of modulating the gastrointestinal microbiota in cancer patients
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Morkūnas, Egidijus, Skiecevičienė, Jurgita, and Kupčinskas, Juozas
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- 2020
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25. Health-care costs of inflammatory bowel disease in a pan-European, community-based, inception cohort during 5 years of follow-up: a population-based study
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Turk, Niksa, Cukovic-Cavka, Silvija, Nicolaou, Anastasia, Lukas, Milan, Shonová, Olga, Blichfeldt, Birgitte, Marker, Dorte, Carlsen, Katrine, Weimers, Petra, Aalykke, Clays, Kudsk, Karen, Vind, Ida, Thorsgaard, Niels, Skamnelos, Alexandros, Politis, Dimitrios, Vegh, Zsuzsanna, Demenyi, Peterne, Nemethne Kramli, Szabina, Dal Piaz, Giualia, Santini, Alessia, Girardin, Giulia, Kupcinskas, Limas, Jonaitis, Laimas, Valantiene, Irena, Zykus, Romanas, Kucinskiene, Ruta, Lazar, Daniela, Nikulina, Inna, de Castro, Luisa, Pineda, Juan-Ramon, Pereira, Santos, Martinez-Cadilla, Jesus, Sanroman, Luciano, Figueira, Montserrat, Ares, David Martinez, Rodriguez-Prada, Jose-Ignacio, Carmona, Amalia, Gonzalez-Portela, Carlos, Widen, Ulla-Britt, Myers, Sally, Ashton, Katherine, Whitehead, Emma, Burisch, Johan, Vardi, Hillel, Schwartz, Doron, Friger, Michael, Kiudelis, Gediminas, Kupčinskas, Juozas, Fumery, Mathurin, Gower-Rousseau, Corinne, Lakatos, Laszlo, Lakatos, Peter L, D'Incà, Renata, Sartini, Alessandro, Valpiani, Daniela, Giannotta, Martina, Arebi, Naila, Duricova, Dana, Bortlik, Martin, Chetcuti Zammit, Stefania, Ellul, Pierre, Pedersen, Natalia, Kjeldsen, Jens, Midjord, Jóngerð Maria Miné, Nielsen, Kári Rubek, Winther Andersen, Karina, Andersen, Vibeke, Katsanos, Konstantinos H, Christodoulou, Dimitrios K, Domislovic, Viktor, Krznaric, Zeljko, Sebastian, Shaji, Oksanen, Pia, Collin, Pekka, Barros, Luisa, Magro, Fernando, Salupere, Riina, Kievit, Hendrika Adriana Linda, Goldis, Adrian, Kaimakliotis, Ioannis P, Dahlerup, Jens F, Eriksson, Carl, Halfvarson, Jonas, Fernandez, Alberto, Hernandez, Vicent, Turcan, Svetlana, Belousova, Elena, Langholz, Ebbe, Munkholm, Pia, and Odes, Selwyn
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- 2020
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26. Lyophilized fecal microbiome transfer for primary Clostridioides difficile infection: a multicenter randomized controlled trial (DONATE Study)
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Pitashny, Milena, primary, Kao, Dina, additional, Ianiro, Gianluca, additional, Mullish, Benjamin, additional, Nagy, Gergely, additional, Urbonas, Tadas, additional, Kesten, Inbar, additional, Stabholz, Yoav, additional, Kupcinskas, Juozas, additional, Franz, Rose, additional, Rondinella, Debora, additional, Tamburini, Sabrina, additional, Tudlik, Zsuzsa, additional, Masucci, Luca, additional, Quaranta, Gianluca, additional, Fusco, William, additional, Cammarota, Giovanni, additional, Skieceviciene, Jurgita, additional, Wong, Karen, additional, Segata, Nicola, additional, Paul, Mical, additional, and Bar-Yoseph, Haggai, additional
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- 2024
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27. 5′-Isoforms of miR-1246 Have Distinct Targets and Stronger Functional Impact Compared with Canonical miR-1246 in Colorectal Cancer Cells In Vitro
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Lukosevicius, Rokas, primary, Alzbutas, Gediminas, additional, Varkalaite, Greta, additional, Salteniene, Violeta, additional, Tilinde, Deimante, additional, Juzenas, Simonas, additional, Kulokiene, Ugne, additional, Janciauskas, Dainius, additional, Poskiene, Lina, additional, Adamonis, Kestutis, additional, Kiudelis, Gediminas, additional, Kupcinskas, Juozas, additional, and Skieceviciene, Jurgita, additional
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- 2024
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28. Patient-Physician Relationship in Irritable Bowel Syndrome: Review on Empathy and Stigma
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Kuliaviene, Irma, primary, Gelman, Sigita, primary, and Kupcinskas, Juozas, primary
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- 2024
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29. Detailed Characterization of the Lung–Gut Microbiome Axis Reveals the Link between PD-L1 and the Microbiome in Non-Small-Cell Lung Cancer Patients
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Ankudavicius, Vytautas, primary, Nikitina, Darja, additional, Lukosevicius, Rokas, additional, Tilinde, Deimante, additional, Salteniene, Violeta, additional, Poskiene, Lina, additional, Miliauskas, Skaidrius, additional, Skieceviciene, Jurgita, additional, Zemaitis, Marius, additional, and Kupcinskas, Juozas, additional
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- 2024
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30. Effectiveness of Helicobacter pylori Treatments According to Antibiotic Resistance
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Bujanda, Luis, primary, Nyssen, Olga P., additional, Ramos, June, additional, Bordin, Dmitry S., additional, Tepes, Bojan, additional, Perez-Aisa, Angeles, additional, Pavoni, Matteo, additional, Castro-Fernandez, Manuel, additional, Lerang, Frode, additional, Leja, Mārcis, additional, Rodrigo, Luis, additional, Rokkas, Theodore, additional, Kupcinskas, Juozas, additional, Jonaitis, Laimas, additional, Shvets, Oleg, additional, Gasbarrini, Antonio, additional, Simsek, Halis, additional, Phull, Perminder S., additional, Buzás, György Miklós, additional, Machado, Jose C., additional, Boltin, Doron, additional, Boyanova, Lyudmila, additional, Tonkić, Ante, additional, Marlicz, Wojciech, additional, Venerito, Marino, additional, Vologzanina, Ludmila, additional, Fadieienko, Galina D., additional, Fiorini, Giulia, additional, Resina, Elena, additional, Muñoz, Raquel, additional, Cano-Català, Anna, additional, Puig, Ignasi, additional, García-Morales, Natalia, additional, Hernández, Luis, additional, Moreira, Leticia, additional, Megraud, Francis, additional, Morain, Colm O., additional, Montes, Milagrosa, additional, and Gisbert, Javier P., additional
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- 2024
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31. Distribution of histopathological features along the colon in microscopic colitis
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Fiehn, Anne-Marie Kanstrup, Miehlke, Stephan, Aust, Daniela, Vieth, Michael, Bonderup, Ole, Fernández-Bañares, Fernando, Mihaly, Emese, Kupcinskas, Juozas, Madisch, Ahmed, Munck, Lars Kristian, Nacak, Tanju, Mohrbacher, Ralf, Mueller, Ralph, Greinwald, Roland, and Münch, Andreas
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- 2021
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32. HFE Gene Variants' Impact on Anthracycline-Based Chemotherapy-Induced Subclinical Cardiotoxicity
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Vaitiekus, Domas, Muckiene, Gintare, Vaitiekiene, Audrone, Sereikaite, Liveta, Inciuraite, Ruta, Insodaite, Ruta, Cepuliene, Daiva, Kupcinskas, Juozas, Ugenskiene, Rasa, Jurkevicius, Renaldas, and Juozaityte, Elona
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- 2021
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33. Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival
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Gentiluomo, Manuel, Corradi, Chiara, Vanella, Giuseppe, Johansen, Astrid Z., Strobel, Oliver, Szentesi, Andrea, Milanetto, Anna Caterina, Hegyi, Péter, Kupcinskas, Juozas, Tavano, Francesca, Neoptolemos, John P., Bozzato, Dania, Hackert, Thilo, Pezzilli, Raffaele, Johansen, Julia S., Costello, Eithne, Mohelnikova-Duchonova, Beatrice, van Eijck, Casper H. J., Talar-Wojnarowska, Renata, Hansen, Carsten Palnæs, Darvasi, Erika, Chen, Inna M., Cavestro, Giulia Martina, Soucek, Pavel, Piredda, Liliana, Vodicka, Pavel, Gazouli, Maria, Arcidiacono, Paolo Giorgio, Canzian, Federico, Campa, Daniele, and Capurso, Gabriele
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- 2021
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34. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
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Wolpin, Brian M, Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M, Wang, Zhaoming, Arslan, Alan A, Beane-Freeman, Laura, Bracci, Paige M, Buring, Julie, Canzian, Federico, Duell, Eric J, Gallinger, Steven, Giles, Graham G, Goodman, Gary E, Goodman, Phyllis J, Jacobs, Eric J, Kamineni, Aruna, Klein, Alison P, Kolonel, Laurence N, Kulke, Matthew H, Li, Donghui, Malats, Núria, Olson, Sara H, Risch, Harvey A, Sesso, Howard D, Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C, Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A, Barfield, Richard, Basso, Daniela, Berndt, Sonja I, Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Büchler, Markus W, Bueno-de-Mesquita, H Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E, Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J Michael, Giese, Nathalia A, Giovannucci, Edward L, Goggins, Michael, Gorman, Megan J, Gross, Myron, Haiman, Christopher A, Hassan, Manal, Helzlsouer, Kathy J, Henderson, Brian E, Holly, Elizabeth A, Hu, Nan, Hunter, David J, Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J, Khaw, Kay-Tee, Klein, Eric A, Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C, LaCroix, Andrea, Landi, Maria T, Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L, Nakamura, Yusuke, Oberg, Ann L, Owzar, Kouros, Patel, Alpa V, Peeters, Petra HM, Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X, Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T, Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R, and Theodoropoulos, George E
- Subjects
Cancer ,Aged ,Case-Control Studies ,Female ,Genetic Loci ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genotype ,Humans ,Male ,Middle Aged ,Pancreatic Neoplasms ,Polymorphism ,Single Nucleotide ,White People ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
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- 2014
35. The PSCA-rs2976395 functional variant is associated with pancreatic cancer development
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Corradi, Chiara, primary, Lencioni, Giulia, additional, Felici, Alessio, additional, Rizzato, Cosmeri, additional, Gentiluomo, Manuel, additional, Ermini, Stefano, additional, Archibugi, Livia, additional, Mickevicius, Antanas, additional, Lucchesi, Maurizio, additional, Malecka-Wojciesko, Ewa, additional, Basso, Daniela, additional, Arcidiacono, Paolo Giorgio, additional, Petrone, Maria Chiara, additional, Carrara, Silvia, additional, Götz, Mara, additional, Bunduc, Stefania, additional, Holleczek, Bernd, additional, Aoki, Mateus Nóbrega, additional, Uzunoglu, Faik G., additional, Zanette, Dalila Lucíola, additional, Mambrini, Andrea, additional, Jamroziak, Krzysztof, additional, Oliverius, Martin, additional, Lovecek, Martin, additional, Cavestro, Giulia Martina, additional, Milanetto, Anna Caterina, additional, Duchonova, Beatrice Mohelnikova, additional, Izbicki, Jacob R., additional, Zalinkevicius, Rimantas, additional, Hlavac, Viktor, additional, van Eijck, Casper H.J., additional, Brenner, Hermann, additional, Vanella, Giuseppe, additional, Cervena, Klara, additional, Soucek, Pavel, additional, Tavano, Francesca, additional, Perri, Francesco, additional, Capurso, Gabriele, additional, Hussein, Tamas, additional, Kiudelis, Mindaugas, additional, Kupcinskas, Juozas, additional, Busch, Olivier R., additional, Morelli, Luca, additional, Theodoropoulos, George E., additional, Testoni, Sabrina G.G., additional, Adamonis, Kestutis, additional, Neoptolemos, John P., additional, Gazouli, Maria, additional, Pasquali, Claudio, additional, Kormos, Zita, additional, Skalicky, Pavel, additional, Pezzilli, Raffaele, additional, Sperti, Cosimo, additional, Kauffmann, Emanuele, additional, Büchler, Markus W., additional, Schöttker, Ben, additional, Hegyi, Peter, additional, Capretti, Giovanni, additional, Lawlor, Rita T., additional, Canzian, Federico, additional, and Campa, Daniele, additional
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- 2023
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36. Efficacy and Safety of Budesonide, vs Mesalazine or Placebo, as Induction Therapy for Lymphocytic Colitis
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Stehlk, Jiri, Bonderup, Ole, Munck, Lars Kristian, Rannem, Terje, Armerding, Peter, Bläker, Michael, Böhm, Günter, Hoesl, Mark, Kirsch, Christian, Madisch, Ahmed, Meier, Eberhard, Miehlke, Stephan, Rehbehn, Kai-Uwe, Kiss, Gyula G., Nagy, Ferenc, Tulassay, Zsolt, Zsigmond, Ferenc, Kupcinskas, Limas, Bouma, Gerd, Pierik, Marieke, Fernández-Bañares, Fernando, Lucendo, Alfredo J., Bohr, Johan, Hellström, Per, Lebrun, Barbro, Lindberg, Greger, Münch, Andreas, Vigren, Lina, Wielondek, Miroslav, Krauss, Martin, Dignass, Axel, Kruis, Wolfgang, Aust, Daniela, Mihaly, Emese, Böhm, Günther, Kupcinskas, Juozas, Nacak, Tanju, and Greinwald, Roland
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- 2018
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37. Liquid Biopsy in Gastric Cancer: Analysis of Somatic Cancer Tissue Mutations in Plasma Cell-Free DNA for Predicting Disease State and Patient Survival
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Varkalaite, Greta, Forster, Michael, Franke, Andre, Kupcinskas, Juozas, and Skieceviciene, Jurgita
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- 2021
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38. Recommendations for the diagnosis and management of transthyretin amyloidosis with gastrointestinal manifestations
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Nakov, Radislav, Suhr, Ole B., Ianiro, Gianluca, Kupcinskas, Juozas, Segal, Jonathon P., Dumitrascu, Dan L., Heinrich, Henriette, Mikolasevic, Ivana, Stojkovic-Lalosevic, Milica, Barbov, Ivan, Sarafov, Stayko, Tournev, Ivailo, Nakov, Ventsislav, and Wixner, Jonas
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- 2020
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39. Sterile Fecal Filtrate From A Healthy Donor Improves Microbial Diversity In Patients With Hepatic Encephalopathy
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Gedgaudas, Rolandas, primary, Bajaj, Jasmohan S, primary, Skieceviciene, Jurgita, primary, Valantiene, Irena, primary, Kiudeliene, Edita, primary, Bang, Corinna, primary, Franke, Andre, primary, Schreiber, Stefan, primary, and Kupcinskas, Juozas, primary
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- 2023
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40. Changes of lung microbiota composition in patients with non-small cell lung cancer
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Ankudavicius, Vytautas, primary, Nikitina, Darja, additional, Lukosevicius, Rokas, additional, Skieceviciene, Jurgita, additional, Kupcinskas, Juozas, additional, Miliauskas, Skaidrius, additional, and Zemaitis, Marius, additional
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- 2023
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41. The Translational Impact of Plant-Derived Xeno-miRNA miR-168 in Gastrointestinal Cancers and Preneoplastic Conditions
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Link, Jastin, primary, Thon, Cosima, additional, Petkevicius, Vytenis, additional, Steponaitiene, Ruta, additional, Malfertheiner, Peter, additional, Kupcinskas, Juozas, additional, and Link, Alexander, additional
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- 2023
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42. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”
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Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Glehen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional
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- 2023
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43. A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma
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Giaccherini, Matteo, primary, Gori, Leonardo, additional, Gentiluomo, Manuel, additional, Farinella, Riccardo, additional, Cervena, Klara, additional, Skieceviciene, Jurgita, additional, Dijk, Frederike, additional, Capurso, Gabriele, additional, Vezakis, Antonis, additional, Archibugi, Livia, additional, Chammas, Roger, additional, Hussein, Tamás, additional, Tavano, Francesca, additional, Hegyi, Péter, additional, Lovecek, Martin, additional, Izbicki, Jakob R, additional, Brenner, Hermann, additional, Mohelnikova-Duchonova, Beatrice, additional, Dell’Anna, Giuseppe, additional, Kupcinskas, Juozas, additional, Ermini, Stefano, additional, Aoki, Mateus Nóbrega, additional, Neoptolemos, John P, additional, Gazouli, Maria, additional, Pasquali, Claudio, additional, Pezzilli, Raffaele, additional, Talar-Wojnarowska, Renata, additional, Oliverius, Martin, additional, Al-Saeedi, Mohammed, additional, Lucchesi, Maurizio, additional, Furbetta, Niccolò, additional, Carrara, Silvia, additional, van Eijck, Casper H J, additional, Maleckas, Almantas, additional, Milanetto, Anna Caterina, additional, Lawlor, Rita T, additional, Schöttker, Ben, additional, Boggi, Ugo, additional, Morelli, Luca, additional, Ginocchi, Laura, additional, Ponz de Leon Pisani, Ruggero, additional, Sperti, Cosimo, additional, Zerbi, Alessandro, additional, Arcidiacono, Paolo Giorgio, additional, Uzunoglu, Faik G, additional, Bunduc, Stefania, additional, Holleczek, Bernd, additional, Gioffreda, Domenica, additional, Małecka-Wojciesko, Ewa, additional, Kiudelis, Mindaugas, additional, Szentesi, Andrea, additional, van Laarhoven, Hanneke W M, additional, Soucek, Pavel, additional, Götz, Mara, additional, Erőss, Bálint, additional, Cavestro, Giulia Martina, additional, Basso, Daniela, additional, Perri, Francesco, additional, Landi, Stefano, additional, Canzian, Federico, additional, and Campa, Daniele, additional
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- 2023
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44. Fusobacterium nucleatum is associated with worse prognosis in Lauren’s diffuse type gastric cancer patients
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Boehm, Ellen Teresa, Thon, Cosima, Kupcinskas, Juozas, Steponaitiene, Ruta, Skieceviciene, Jurgita, Canbay, Ali, Malfertheiner, Peter, and Link, Alexander
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- 2020
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45. Common variation in FAM155A is associated with diverticulitis but not diverticulosis
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Reichert, Matthias C., Kupcinskas, Juozas, Schulz, Antje, Schramm, Christoph, Weber, Susanne N., Krawczyk, Marcin, Jüngst, Christoph, Casper, Markus, Grünhage, Frank, Appenrodt, Beate, Zimmer, Vincent, Tamelis, Algimantas, Lukosiene, Jaune I., Pauziene, Neringa, Kiudelis, Gediminas, Jonaitis, Laimas, Goeser, Tobias, Malinowski, Maciej, Glanemann, Matthias, Kupcinskas, Limas, and Lammert, Frank
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- 2020
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46. Dissecting the genetic heterogeneity of gastric cancer
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Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Gehlen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional
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- 2023
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47. Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma
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Corradi, Chiara, primary, Lencioni, Giulia, additional, Gentiluomo, Manuel, additional, Felici, Alessio, additional, Latiano, Anna, additional, Kiudelis, Gediminas, additional, van Eijck, Casper H J, additional, Marta, Katalin, additional, Lawlor, Rita T, additional, Tavano, Francesca, additional, Boggi, Ugo, additional, Dijk, Frederike, additional, Cavestro, Giulia Martina, additional, Vermeulen, Roel C H, additional, Hackert, Thilo, additional, Petrone, Maria Chiara, additional, Uzunoğlu, Faik Güntac, additional, Archibugi, Livia, additional, Izbicki, Jakob R, additional, Morelli, Luca, additional, Zerbi, Alessandro, additional, Landi, Stefano, additional, Stocker, Hannah, additional, Talar-Wojnarowska, Renata, additional, Di Franco, Gregorio, additional, Hegyi, Péter, additional, Sperti, Cosimo, additional, Carrara, Silvia, additional, Capurso, Gabriele, additional, Gazouli, Maria, additional, Brenner, Hermann, additional, Bunduc, Stefania, additional, Busch, Olivier, additional, Perri, Francesco, additional, Oliverius, Martin, additional, Hegyi, Péter Jeno, additional, Goetz, Mara, additional, Scognamiglio, Pasquale, additional, Mambrini, Andrea, additional, Arcidiacono, Paolo Giorgio, additional, Kreivenaite, Edita, additional, Kupcinskas, Juozas, additional, Hussein, Tamas, additional, Ermini, Stefano, additional, Milanetto, Anna Caterina, additional, Vodicka, Pavel, additional, Kiudelis, Vytautas, additional, Hlaváč, Viktor, additional, Soucek, Pavel, additional, Theodoropoulos, George E, additional, Basso, Daniela, additional, Neoptolemos, John P, additional, Nóbrega Aoki, Mateus, additional, Pezzilli, Raffaele, additional, Pasquali, Claudio, additional, Chammas, Roger, additional, Testoni, Sabrina Gloria Giulia, additional, Mohelnikova-Duchonova, Beatrice, additional, Lucchesi, Maurizio, additional, Rizzato, Cosmeri, additional, Canzian, Federico, additional, and Campa, Daniele, additional
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- 2023
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48. Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma
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Corradi, Chiara, Lencioni, Giulia, Gentiluomo, Manuel, Felici, Alessio, Latiano, Anna, Kiudelis, Gediminas, van Eijck, Casper H J, Marta, Katalin, Lawlor, Rita T, Tavano, Francesca, Boggi, Ugo, Dijk, Frederike, Cavestro, Giulia Martina, Vermeulen, Roel C H, Hackert, Thilo, Petrone, Maria Chiara, Uzunoğlu, Faik Güntac, Archibugi, Livia, Izbicki, Jakob R, Morelli, Luca, Zerbi, Alessandro, Landi, Stefano, Stocker, Hannah, Talar-Wojnarowska, Renata, Di Franco, Gregorio, Hegyi, Péter, Sperti, Cosimo, Carrara, Silvia, Capurso, Gabriele, Gazouli, Maria, Brenner, Hermann, Bunduc, Stefania, Busch, Olivier, Perri, Francesco, Oliverius, Martin, Hegyi, Péter Jeno, Goetz, Mara, Scognamiglio, Pasquale, Mambrini, Andrea, Arcidiacono, Paolo Giorgio, Kreivenaite, Edita, Kupcinskas, Juozas, Hussein, Tamas, Ermini, Stefano, Milanetto, Anna Caterina, Vodicka, Pavel, Kiudelis, Vytautas, Hlaváč, Viktor, Soucek, Pavel, Theodoropoulos, George E, Basso, Daniela, Neoptolemos, John P, Nóbrega Aoki, Mateus, Pezzilli, Raffaele, Pasquali, Claudio, Chammas, Roger, Testoni, Sabrina Gloria Giulia, Mohelnikova-Duchonova, Beatrice, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico, Campa, Daniele, Corradi, Chiara, Lencioni, Giulia, Gentiluomo, Manuel, Felici, Alessio, Latiano, Anna, Kiudelis, Gediminas, van Eijck, Casper H J, Marta, Katalin, Lawlor, Rita T, Tavano, Francesca, Boggi, Ugo, Dijk, Frederike, Cavestro, Giulia Martina, Vermeulen, Roel C H, Hackert, Thilo, Petrone, Maria Chiara, Uzunoğlu, Faik Güntac, Archibugi, Livia, Izbicki, Jakob R, Morelli, Luca, Zerbi, Alessandro, Landi, Stefano, Stocker, Hannah, Talar-Wojnarowska, Renata, Di Franco, Gregorio, Hegyi, Péter, Sperti, Cosimo, Carrara, Silvia, Capurso, Gabriele, Gazouli, Maria, Brenner, Hermann, Bunduc, Stefania, Busch, Olivier, Perri, Francesco, Oliverius, Martin, Hegyi, Péter Jeno, Goetz, Mara, Scognamiglio, Pasquale, Mambrini, Andrea, Arcidiacono, Paolo Giorgio, Kreivenaite, Edita, Kupcinskas, Juozas, Hussein, Tamas, Ermini, Stefano, Milanetto, Anna Caterina, Vodicka, Pavel, Kiudelis, Vytautas, Hlaváč, Viktor, Soucek, Pavel, Theodoropoulos, George E, Basso, Daniela, Neoptolemos, John P, Nóbrega Aoki, Mateus, Pezzilli, Raffaele, Pasquali, Claudio, Chammas, Roger, Testoni, Sabrina Gloria Giulia, Mohelnikova-Duchonova, Beatrice, Lucchesi, Maurizio, Rizzato, Cosmeri, Canzian, Federico, and Campa, Daniele
- Abstract
INTRODUCTION: Only a small number of risk factors for pancreatic ductal adenocarcinoma (PDAC) has been established. Several studies identified a role of epigenetics and of deregulation of DNA methylation. DNA methylation is variable across a lifetime and in different tissues; nevertheless, its levels can be regulated by genetic variants like methylation quantitative trait loci (mQTLs), which can be used as a surrogate.MATERIALS AND METHODS: We scanned the whole genome for mQTLs and performed an association study in 14 705 PDAC cases and 246 921 controls. The methylation data were obtained from whole blood and pancreatic cancer tissue through online databases. We used the Pancreatic Cancer Cohort Consortium and the Pancreatic Cancer Case-Control Consortium genome-wide association study (GWAS) data as discovery phase and the Pancreatic Disease Research consortium, the FinnGen project and the Japan Pancreatic Cancer Research consortium GWAS as replication phase.RESULTS: The C allele of 15q26.1-rs12905855 showed an association with a decreased risk of PDAC (OR=0.90, 95% CI 0.87 to 0.94, p=4.93×10 -8 in the overall meta-analysis), reaching genome-level statistical significance. 15q26.1-rs12905855 decreases the methylation of a 'C-phosphate-G' (CpG) site located in the promoter region of the RCCD1 antisense ( RCCD1-AS1) gene which, when expressed, decreases the expression of the RCC1 domain-containing ( RCCD1) gene (part of a histone demethylase complex). Thus, it is possible that the rs12905855 C-allele has a protective role in PDAC development through an increase of RCCD1 gene expression, made possible by the inactivity of RCCD1-AS1. CONCLUSION: We identified a novel PDAC risk locus which modulates cancer risk by controlling gene expression through DNA methylation.
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- 2023
49. Association between a polymorphic variant in the CDKN2B-AS1/ANRIL gene and pancreatic cancer risk
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Giaccherini, Matteo, Farinella, Riccardo, Gentiluomo, Manuel, Mohelnikova-Duchonova, Beatrice, Kauffmann, Emanuele Federico, Palmeri, Matteo, Uzunoglu, Faik, Soucek, Pavel, Petrauskas, Dalius, Cavestro, Giulia Martina, Zykus, Romanas, Carrara, Silvia, Pezzilli, Raffaele, Puzzono, Marta, Szentesi, Andrea, Neoptolemos, John, Archibugi, Livia, Palmieri, Orazio, Milanetto, Anna Caterina, Capurso, Gabriele, van Eijck, Casper H.J., Stocker, Hannah, Lawlor, Rita T., Vodicka, Pavel, Lovecek, Martin, Izbicki, Jakob R., Perri, Francesco, Kupcinskaite-Noreikiene, Rita, Götz, Mara, Kupcinskas, Juozas, Hussein, Tamás, Hegyi, Péter, Busch, Olivier R., Hackert, Thilo, Mambrini, Andrea, Brenner, Hermann, Lucchesi, Maurizio, Basso, Daniela, Tavano, Francesca, Schöttker, Ben, Vanella, Giuseppe, Bunduc, Stefania, Petrányi, Ágota, Landi, Stefano, Morelli, Luca, Canzian, Federico, Campa, Daniele, Giaccherini, Matteo, Farinella, Riccardo, Gentiluomo, Manuel, Mohelnikova-Duchonova, Beatrice, Kauffmann, Emanuele Federico, Palmeri, Matteo, Uzunoglu, Faik, Soucek, Pavel, Petrauskas, Dalius, Cavestro, Giulia Martina, Zykus, Romanas, Carrara, Silvia, Pezzilli, Raffaele, Puzzono, Marta, Szentesi, Andrea, Neoptolemos, John, Archibugi, Livia, Palmieri, Orazio, Milanetto, Anna Caterina, Capurso, Gabriele, van Eijck, Casper H.J., Stocker, Hannah, Lawlor, Rita T., Vodicka, Pavel, Lovecek, Martin, Izbicki, Jakob R., Perri, Francesco, Kupcinskaite-Noreikiene, Rita, Götz, Mara, Kupcinskas, Juozas, Hussein, Tamás, Hegyi, Péter, Busch, Olivier R., Hackert, Thilo, Mambrini, Andrea, Brenner, Hermann, Lucchesi, Maurizio, Basso, Daniela, Tavano, Francesca, Schöttker, Ben, Vanella, Giuseppe, Bunduc, Stefania, Petrányi, Ágota, Landi, Stefano, Morelli, Luca, Canzian, Federico, and Campa, Daniele
- Abstract
Genes carrying high-penetrance germline mutations may also be associated with cancer susceptibility through common low-penetrance genetic variants. To increase the knowledge on genetic pancreatic ductal adenocarcinoma (PDAC) aetiology, the common genetic variability of PDAC familial genes was analysed in our study. We conducted a multiphase study analysing 7745 single nucleotide polymorphisms (SNPs) from 29 genes reported to harbour a high-penetrance PDAC-associated mutation in at least one published study. To assess the effect of the SNPs on PDAC risk, a total of 14 666 PDAC cases and 221 897 controls across five different studies were analysed. The T allele of the rs1412832 polymorphism, that is situated in the CDKN2B-AS1/ANRIL, showed a genome-wide significant association with increased risk of developing PDAC (OR = 1.11, 95% CI = 1.07-1.15, P = 5.25 × 10−9). CDKN2B-AS1/ANRIL is a long noncoding RNA, situated in 9p21.3, and regulates many target genes, among which CDKN2A (p16) that frequently shows deleterious somatic and germline mutations and deregulation in PDAC. Our results strongly support the role of the genetic variability of the 9p21.3 region in PDAC aetiopathogenesis and highlight the importance of secondary analysis as a tool for discovering new risk loci in complex human diseases.
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- 2023
50. Dissecting the genetic heterogeneity of gastric cancer
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Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, Schumacher, Johannes, Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, and Schumacher, Johannes
- Abstract
Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture. Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO. Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level. Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular me, Errata: Hess, T., Maj, C., Gehlen, J. et. al. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”. eBioMedicine. 2023:94:104709. DOI: 10.1016/j.ebiom.2023.104709
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- 2023
- Full Text
- View/download PDF
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