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1. Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author

Brusselle, Guy, Corhay, Jean-Louis, Janssens, Eduard, Janssens, Wim, Leys, Mathias, Ferguson, Murdo, Fitzgerald, Mark, Maltais, François, Mayers, Irvin, McNeil, Shelly, Pek, Bonavuth, Bourdin, Arnaud, Boyer, Laurent, Couturaud, Francis, Dussart, Luc, Andreas, Stefan, Illies, Gabriele, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Blasi, Francesco, Centanni, Stefano, Papi, Alberto, Pomari, Carlo, Echave-Sustaeta, José Maria, Llorca Martínez, Eleuterio, Narejos Pérez, Silvia, Pascual-Guardia, Sergi, Pérez Vera, Mercè, Puente-Maestu, Luis, Terns Riera, Manuel, Anderson, William, Choudhury, Gourab, De-Soyza, Anthony, Saralaya, Dinesh, Wilkinson, Tom MA, Boscia III, Joseph, Chinsky, Kenneth, Dunn, Leonard, Erb, David, Fogarty, Charles, Downey, Herman Jackson, Kerwin, Edward, Kunz, Craig, Poling, Terry, Sellman, Richard, Sigal, Barry, Southard, John, Spangenthal, Selwyn, Tannous, Ziad, Testa, Marco, Casula, Daniela, Di Maro, Gennaro, Lattanzi, Maria, Moraschini, Luca, Schoonbroodt, Sonia, Tasciotti, Annaelisa, Arora, Ashwani K, and Wilkinson, Tom M A

Published
2022
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2. NAME GAME

Author

Kunz, Craig and Wheat, Brent T.

Subjects
Firearms, Sports, sporting goods and toys industry
Abstract

I found the GUNS Magazine Podcast a while ago and have been binge listening, trying to catch up! I just finished episode 110 about Hardware Store Guns. While my question [...]

Published
2022

3. Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author

Andreas, Stefan, primary, Testa, Marco, additional, Boyer, Laurent, additional, Brusselle, Guy, additional, Janssens, Wim, additional, Kerwin, Edward, additional, Papi, Alberto, additional, Pek, Bonavuth, additional, Puente-Maestu, Luis, additional, Saralaya, Dinesh, additional, Watz, Henrik, additional, Wilkinson, Tom M A, additional, Casula, Daniela, additional, Di Maro, Gennaro, additional, Lattanzi, Maria, additional, Moraschini, Luca, additional, Schoonbroodt, Sonia, additional, Tasciotti, Annaelisa, additional, Arora, Ashwani K, additional, Maltais, François, additional, Corhay, Jean-Louis, additional, Janssens, Eduard, additional, Leys, Mathias, additional, Ferguson, Murdo, additional, Fitzgerald, Mark, additional, Mayers, Irvin, additional, McNeil, Shelly, additional, Bourdin, Arnaud, additional, Couturaud, Francis, additional, Dussart, Luc, additional, Andreas, Stefan, additional, Illies, Gabriele, additional, Eich, Andreas, additional, Ludwig-Sengpiel, Andrea, additional, Blasi, Francesco, additional, Centanni, Stefano, additional, Pomari, Carlo, additional, Echave-Sustaeta, José Maria, additional, Llorca Martínez, Eleuterio, additional, Narejos Pérez, Silvia, additional, Pascual-Guardia, Sergi, additional, Pérez Vera, Mercè, additional, Terns Riera, Manuel, additional, Anderson, William, additional, Choudhury, Gourab, additional, De-Soyza, Anthony, additional, Wilkinson, Tom MA, additional, Boscia III, Joseph, additional, Chinsky, Kenneth, additional, Dunn, Leonard, additional, Erb, David, additional, Fogarty, Charles, additional, Downey, Herman Jackson, additional, Kunz, Craig, additional, Poling, Terry, additional, Sellman, Richard, additional, Sigal, Barry, additional, Southard, John, additional, Spangenthal, Selwyn, additional, and Tannous, Ziad, additional

Published
2022
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5. Non-typeable Haemophilus influenzae–Moraxella catarrhalisvaccine for the prevention of exacerbations in chronic obstructive pulmonary disease: a multicentre, randomised, placebo-controlled, observer-blinded, proof-of-concept, phase 2b trial

Author

Andreas, Stefan, Testa, Marco, Boyer, Laurent, Brusselle, Guy, Janssens, Wim, Kerwin, Edward, Papi, Alberto, Pek, Bonavuth, Puente-Maestu, Luis, Saralaya, Dinesh, Watz, Henrik, Wilkinson, Tom M A, Casula, Daniela, Di Maro, Gennaro, Lattanzi, Maria, Moraschini, Luca, Schoonbroodt, Sonia, Tasciotti, Annaelisa, Arora, Ashwani K, Maltais, François, Brusselle, Guy, Corhay, Jean-Louis, Janssens, Eduard, Janssens, Wim, Leys, Mathias, Ferguson, Murdo, Fitzgerald, Mark, Maltais, François, Mayers, Irvin, McNeil, Shelly, Pek, Bonavuth, Bourdin, Arnaud, Boyer, Laurent, Couturaud, Francis, Dussart, Luc, Andreas, Stefan, Illies, Gabriele, Eich, Andreas, Ludwig-Sengpiel, Andrea, Watz, Henrik, Blasi, Francesco, Centanni, Stefano, Papi, Alberto, Pomari, Carlo, Echave-Sustaeta, José Maria, Llorca Martínez, Eleuterio, Narejos Pérez, Silvia, Pascual-Guardia, Sergi, Pérez Vera, Mercè, Puente-Maestu, Luis, Terns Riera, Manuel, Anderson, William, Choudhury, Gourab, De-Soyza, Anthony, Saralaya, Dinesh, Wilkinson, Tom MA, Boscia III, Joseph, Chinsky, Kenneth, Dunn, Leonard, Erb, David, Fogarty, Charles, Downey, Herman Jackson, Kerwin, Edward, Kunz, Craig, Poling, Terry, Sellman, Richard, Sigal, Barry, Southard, John, Spangenthal, Selwyn, Tannous, Ziad, Testa, Marco, Casula, Daniela, Di Maro, Gennaro, Lattanzi, Maria, Moraschini, Luca, Schoonbroodt, Sonia, Tasciotti, Annaelisa, and Arora, Ashwani K

Abstract

Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are associated with changes in the sputum microbiome, including an increased prevalence of pathogenic bacteria. Vaccination against the most frequent bacteria identified in AECOPD might reduce exacerbation frequency. We assessed the efficacy, safety, and immunogenicity of a candidate vaccine containing surface proteins from non-typeable Haemophilus influenzae(NTHi) and Moraxella catarrhalis(Mcat) in patients with COPD.

Published
2022
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7. Relationship Between Opinions Toward Fluoridation and Socioeconomic Status of Salt Lake City Residents

Author

Kunz, Craig D.

Subjects
socioeconomic, opinion, relationship, flouridation, Medicine and Health Sciences, resident, salt lake city, status
Abstract

The purpose of the study was to determine if a relationship exists among opinions toward fluoridation of public water supplies, income, and level of education of the people of Salt Lake City, Utah. There were also two secondary concerns. One was to determine if a relationship exists between opinions toward fluoridation and other controversial social issues. The issues identified for investigations were: (1) the Supreme Court decision on abortion, (2) the Equal Rights Amendment, and (3) capital punishment. The second was to determine the factors on which opinions regarding fluoridation were based. The results of the data that was collected indicated that the higher the education level of the population the higher the probability of a favorable opinion about fluoridation. The lower the education level of the population the higher the probability of an opinion of opposition to fluoridation. (2) If the subjects yearly income was $20,000 or more there was an increased likelihood of a favorable opinion of fluoridation. If the subjects yearly income was less than $20,000, there was a greater likelihood that the opinions would be in opposition to fluoridation. (3) A majority of the subjects opposed the Supreme Court ruling on abortion and the Equal Rights Amendment. A majority favored reinstatement of capital punishment. Interpreted, this was felt to reveal a tendency of the subjects to adopt a conservative stand on controversial social issues.

Published
1974

8. Intrapleural injection of transforming growth factor-beta antibody inhibits pleural fibrosis in empyema.

Author

Kunz CR, Jadus MR, Kukes GD, Kramer F, Nguyen VN, and Sasse SA

Subjects
Animals, Fibrosis, Injections, Intralesional, Male, Pleural Diseases etiology, Pleural Diseases pathology, Prospective Studies, Rabbits, Random Allocation, Empyema, Pleural complications, Pleura pathology, Pleural Diseases prevention & control, Transforming Growth Factor beta administration & dosage
Abstract

Study Objectives: Transforming growth factor (TGF)-beta is a cytokine that has been demonstrated to be an important modulator of inflammation and angiogenesis, as well as a potent stimulator of pleural fluid production and fibrosis. We previously demonstrated that rising levels of pleural fluid TGF-beta(1) correlate with pleural fibrosis in experimental empyema in rabbits. In this study, our hypothesis is that neutralization of TGF-beta with an intrapleural injection of a monoclonal antibody to TGF-beta will decrease pleural fibrosis in empyema., Design: Prospective, randomized, blinded study., Setting: Animal research laboratory., Subjects: Nineteen rabbits., Interventions: An empyema was induced in 19 rabbits by intrapleural injection of Pasteurella multocida. A panspecific monoclonal antibody to TGF-beta was injected into the pleural space on 2 subsequent concurrent days in nine rabbits. Ten rabbits received intrapleural injections of bacteria alone and served as controls. All animals were then killed on day 6. Immunohistochemistry, using the antibody to TGF-beta, was performed on pleural tissue specimens from the control rabbits., Measurements and Results: Immunohistochemistry revealed localization of TGF-beta to macrophages in the exudative material and the visceral pleura. After injection of the antibody to TGF-beta, the amount of purulent, exudative material in the pleural space of the nine experimental animals was markedly decreased at autopsy on day 6, relative to control animals. All markers of empyema and pleural fibrosis were also significantly decreased in the rabbits receiving intrapleural anti-TGF-beta., Conclusions: TGF-beta localizes to macrophages in experimental empyema. Early intrapleural injection of an antibody to TGF-beta inhibits empyema formation and significantly decreases pleural fibrosis in experimental empyema.

Published
2004
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