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12. Rheumatic disorders developed after hepatitis B vaccination

Author

Wendling, D., Kuntz, J.L., Sibilia, J., Toussirot, E., Gaudin, P., Vignon, E., Eschard, J.P., Lorcerie, B., Juvin, R., Parchin-Geneste, N., Maillefert, J.F., Piroth, C., and Tavernier, C.

Abstract

Objective. To obtain an overview of rheumatic disorders occurring after hepatitis B vaccination.
Methods. A questionnaire was sent to rheumatology departments in nine French hospitals. Criteria for entry were rheumatic complaints of 1 week's duration or more, occurrence during the 2 months following hepatitis B vaccination, no previously diagnosed rheumatic disease and no other explanation for the complaints.
Results. Twenty-two patients were included. The observed disorders were as follows: rheumatoid arthritis for six patients; exacerbation of a previously non-diagnosed systemic lupus erythematosus for two; post-vaccinal arthritis for five; polyarthralgia-myalgia for four; suspected or biopsy-proved vasculitis for three; miscellaneous for two.
Conclusions. Hepatitis B vaccine might be followed by various rheumatic conditions and might trigger the onset of underlying inflammatory or autoimmune rheumatic diseases. However, a causal relationship between hepatitis B vaccination and the observed rheumatic manifestations cannot be easily established. Further epidemiological studies are needed to establish whether hepatitis B vaccination is associated or not with an incidence of rheumatic disorders higher than normal.

Published
1999

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