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Your search keyword '"Kunkel, Miriam"' showing total 13 results
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13 results on '"Kunkel, Miriam"'

3. A phase ib trial to evaluate the safety and efficacy of quinacrine plus capecitabine in patients with refractory metastatic colorectal cancer.

Author

Winer, Arthur, primary, Vijayvergia, Namrata, additional, Cohen, Steven J., additional, Denlinger, Crystal S., additional, Astsaturov, Igor A., additional, Dotan, Efrat, additional, Gallant, Jean-Nicolas, additional, Wang, Edward W, additional, Kunkel, Miriam, additional, Lim, Bora, additional, Harvey, Harold A., additional, Sivik, Jeffrey Michael, additional, Zhou, Lanlan, additional, Korzekwa, Kenneth, additional, Ruth, Karen, additional, Ross, Eric A., additional, and El-Deiry, Wafik S., additional

Published
2019
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4. Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients

Author

Schachner Melitta, Bockhorn Maximilian, Wolters Gerrit, Kunkel Miriam, Tachezy Michael, von Wedemeyer Max, Rawnaq Tamina, Zander Hilke, Izbicki Jakob R, and Kaifi Jussuf

Subjects
Gastrointestinal stromal tumor (GIST), L1, Enzyme-linked Immunosorbent assay (ELISA), progression marker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background L1 cell adhesion molecule (CD171) is expressed in many malignant tumors and its expression correlates with unfavourable outcome. It thus represents a target for tumor diagnosis and therapy. An earlier study conducted by our group identified L1 expression levels in primary gastrointestinal stromal tumors (GIST) as a prognostic marker. The aim of the current study was to compare L1 serum levels of GIST patients with those of healthy controls and to determine whether levels of soluble L1 in sera could serve as a prognostic marker. Methods Using a sensitive enzyme-linked immunosorbent assay (ELISA), soluble L1 was measured in sera of 93 GIST patients und 151 healthy controls. Soluble L1 levels were then correlated with clinicopathological data. Results Median levels of soluble L1 were significantly higher (p < 0.001; Mann-Whitney U test) in sera of GIST patients compared to healthy individuals. Median soluble L1 levels were particularly elevated in patients with recurrence and relapse (p < 0.05; Mann Whitney U test). Conclusion These results suggest that high soluble L1 levels predict poor prognosis and may thus be a promising tumor marker that can contribute to individualise therapy.

Published
2011
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5. Clinico-pathological correlation of serial measurement of circulating tumor cells in 24 metastatic colorectal cancer patients receiving chemotherapy reveals interpatient heterogeneity correlated with CEA levels but independent of KRAS and BRAF mutation

Author

Das, Avisnata, primary, Kunkel, Miriam, additional, Joudeh, Jamal, additional, Dicker, David T, additional, Scicchitano, Angelique, additional, Allen, Joshua E, additional, Sarwani, Nabeel, additional, Yang, Zhaohai, additional, Kaifi, Jussuf, additional, Zhu, Junjia, additional, Liao, Jason, additional, and El-Deiry, Wafik S, additional

Published
2015
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6. Circulating tumor cell isolation during resection of colorectal cancer lung and liver metastases: a prospective trial with different detection techniques

Author

Kaifi, Jussuf T, primary, Kunkel, Miriam, additional, Das, Avisnata, additional, Harouaka, Ramdane A, additional, Dicker, David T, additional, Li, Guangfu, additional, Zhu, Junjia, additional, Clawson, Gary A, additional, Yang, Zhaohai, additional, Reed, Michael F, additional, Gusani, Niraj J, additional, Kimchi, Eric T, additional, Staveley-O'Carroll, Kevin F, additional, Zheng, Si-Yang, additional, and El-Deiry, Wafik S, additional

Published
2015
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7. Circulating tumor cell levels are elevated in colorectal cancer patients with high tumor burden in the liver

Author

Kaifi, Jussuf T, primary, Kunkel, Miriam, additional, Dicker, David T, additional, Joude, Jamal, additional, Allen, Joshua E, additional, Das, Avisnata, additional, Zhu, Junjia, additional, Yang, Zhaohai, additional, Sarwani, Nabeel E, additional, Li, Guangfu, additional, Staveley-O'Carroll, Kevin F, additional, and El-Deiry, Wafik S, additional

Published
2015
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10. Predicting therapy response in live tumor cells isolated with the flexible micro spring array device

Author

Gallant, Jean-Nicolas, primary, Matthew, Elizabeth M., additional, Harouaka, Ramdane, additional, Lamparella, Nicholas, additional, Kunkel, Miriam, additional, Yang, Zhaohai, additional, Cream, Leah V., additional, Kumar, Suresh M., additional, Robertson, Gavin P., additional, Zheng, Siyang, additional, Drabick, Joseph J., additional, Truica, Cristina I., additional, and El-Deiry, Wafik S., additional

Published
2013
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13. Apoptotic circulating tumor cells (CTCs) in the peripheral blood of metastatic colorectal cancer patients are associated with liver metastasis but not CTCs.

Author

Allen JE, Saroya BS, Kunkel M, Dicker DT, Das A, Peters KL, Joudeh J, Zhu J, and El-Deiry WS

Subjects
Adult, Aged, Aged, 80 and over, Apoptosis, Carcinoembryonic Antigen blood, Cell Count, Female, Humans, Liver Neoplasms blood, Liver Neoplasms pathology, Lung Neoplasms secondary, Lymphatic Metastasis, Male, Middle Aged, Colorectal Neoplasms blood, Colorectal Neoplasms pathology, Liver Neoplasms secondary, Lung Neoplasms blood, Neoplastic Cells, Circulating pathology
Abstract

Enumeration of circulating tumor cells (CTCs) by the CellSearch system provides prognostic information in metastatic colorectal cancer, regardless of metastatic site. We found that CTCs generally represent <1% of observed events with CellSearch analysis and adapted scoring criteria to classify other peripheral blood events. Examination of twenty two metastatic colorectal cancer patients' blood revealed that patients with high CEA or liver metastases, but not lung or distant lymph node metastases, possessed significant numbers of apoptotic CTCs prior to treatment initiation by Fischer's exact test. Six out of eleven patients with liver metastasis possessed apoptotic CTCs whereas one of nine patients with other metastases had measurable apoptotic CTCs. An elevated CTC number was not necessarily associated with apoptotic CTCs or CTC debris by Spearman's correlation, suggesting the metastatic site rather than CTCs per se as contributing to the origin of these events.

Published
2014
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