20 results on '"Kunkel, Angelika"'
Search Results
2. Placeboeffekte in der Schmerztherapie: Einfluss der Erwartung auf die Wirksamkeit und Verträglichkeit schmerzmedizinischer Behandlungen
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Kunkel, Angelika and Bingel, Ulrike
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- 2023
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3. Neurobiologische und neurochemische Mechanismen der Placeboanalgesie
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Asan, Livia, Bingel, Ulrike, and Kunkel, Angelika
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- 2022
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4. Dopamine has no direct causal role in the formation of treatment expectations and placebo analgesia in humans.
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Kunkel, Angelika, Asan, Livia, Krüger, Isabel, Erfurt, Clara, Ruhnau, Laura, Caliskan, Elif Buse, Hackert, Jana, Wiech, Katja, Schmidt, Katharina, and Bingel, Ulrike
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TREATMENT effectiveness , *ANALGESIA , *DOPA , *DOPAMINE , *CLINICAL trials , *DOPAMINE antagonists , *PLACEBOS - Abstract
Dopamine-based reward and learning mechanisms have been suggested to contribute to placebo effects. However, the exact role of dopaminergic neurotransmission in their generation and maintenance is still unclear. This study aimed to shed light on the causal role of dopamine in establishing positive treatment expectations, as well as on the magnitude and duration of their effect on pain. To this end, we used an established placebo analgesia paradigm in combination with 2 opposing pharmacological modulations of dopaminergic tone, i.e., the dopamine antagonist sulpiride and the dopamine precursor L-dopa which were both applied in an experimental, double-blind, randomized, placebo-controlled trial with a between-subject design in N = 168 healthy volunteers. The study medication successfully altered dopaminergic tone during the conditioning procedure. Contrary to our hypotheses, the medication did not modulate the formation of positive treatment expectation and placebo analgesia tested 1 day later. Placebo analgesia was no longer detectable on day 8 after conditioning. Using a combined frequentist and Bayesian approach, our data provide strong evidence against a direct dopaminergic influence on the generation and maintenance of placebo effects. Further exploration of the neurochemical mechanisms underlying placebo analgesia remains paramount in the quest to exploit these effects for optimal treatment outcomes. Trial registration: ClinicalTrials.gov German Clinical Trials Register, ID: DRKS00029366, https://drks.de/search/en/trial/DRKS00029366. Dopamine signalling has been linked to pain analgesia and placebo effects but whether there is causal relationship remains unclear. This pre-registered study shows that enhancing dopaminergic tone does not alter the generation of positive treatment expectations or placebo analgesia. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Translating knowledge on placebo and nocebo effects into clinical practice
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Caliskan, Elif Buse, primary, Bingel, Ulrike, additional, and Kunkel, Angelika, additional
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- 2024
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6. Learning by observing: a systematic exploration of modulatory factors and the impact of observationally induced placebo and nocebo effects on treatment outcomes.
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Klauß, Helena, Kunkel, Angelika, Müßgens, Diana, Haaker, Jan, and Bingel, Ulrike
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TREATMENT effectiveness ,PLACEBOS ,ITCHING ,DRUG side effects ,OBSERVATIONAL learning ,NOCEBOS - Abstract
Introduction: Observational learning (OL) refers to learning through observing other people’s behavior. OL has been suggested as an effective and simple tool to evoke treatment expectations and corresponding placebo and nocebo effects. However, the exact mechanisms by which OL shapes treatment outcomes, its moderating factors and possible areas of application remain unclear. We thus reviewed the existing literature with two different literature searches to answer the following questions: Which influencing factors contribute to OL-induced placebo and nocebo effects (in healthy volunteers and patients) and how large are these effects (search 1)? In which medical fields has OL been used so far to modulate treatment expectancy and treatment outcomes in patients, their caregivers, and at-risk groups (search 2)? We also aimed to explore whether and how the assessment of treatment expectations has been incorporated. Methods: We conducted two independent and comprehensive systematic literature searches, both carried out on September 20, 2022. Results: We identified 21 studies that investigated OL-mediated placebo and nocebo effects for pain and itch, the (placebo) efficacy of sham treatment on anxiety, and the (nocebo) induction of medication side effects (search 1). Studies showed that OL can efficiently induce placebo and nocebo effects across different presentation modes, with medium effect sizes on average: placebo effects, d = 0.79 (range: d = −0.36–1.58), nocebo effects, d = 0.61 (range: d = 0.04–1.5). Although several moderating factors have been investigated, their contribution to OL-induced effects remains unclear because of inconsistent results. Treatment expectation was assessed in only four studies. Regarding medical applications of OL (search 2), we found 12 studies. They showed that OL was effectively applied in preventive, therapeutic and rehabilitative interventions and that it was mainly used in the field of psychosomatics. Discussion: OL effects on treatment outcomes can be both positive and negative. Future research should investigate which individuals would benefit most from OL and how OL can be implemented most effectively to induce placebo and avoid nocebo effects in clinical settings. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Task-dependent evaluative processing of moral and emotional content during comprehension: An ERP study
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Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, and Leuthold, Hartmut
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- 2018
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8. Acquiring treatment expectation by Observational Learning: A Systematic Review
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Klauss, Helena, Kunkel, Angelika, and Bingel, Ulrike
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Social Learning Theory ,Nocebo ,Observational Learning ,Treatment Expectation ,Medicine and Health Sciences ,Placebo - Abstract
Research indicates that Observational Learning offers the chance to induce positive treatment expectations that may lead to symptom alleviation and increased treatment success. By actively modifying patients’ expectations, the occurrence of negative side effects can be reduced. In this work, studies investigating observationally induced placebo and nocebo responses and expectation acquisition will be reviewed systematically and research methods will be presented. This project is conducted at the University Duisburg-Essen, Germany. For detailed information, please find the pdf attached.
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- 2022
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9. The role of dopamine for positive treatment expectations and placebo analgesia
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Kunkel, Angelika, Asan, Livia, Schmidt, Katharina, and Bingel, Ulrike
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Medical Sciences ,Neuroscience and Neurobiology ,FOS: Clinical medicine ,sulpiride ,Neurosciences ,Life Sciences ,Psychiatry and Psychology ,l-dopa ,placebo analgesia ,Behavior and Behavior Mechanisms ,conditioning ,mesolimbic system ,Medical Neurobiology ,Medicine and Health Sciences ,placebo ,pain ,dopamine ,levodopa ,expectation - Abstract
Stage 1 Registered Report Protocol, in-principle accepted by the journal PLOS Biology, for a study investigating the role of dopamine for positive treatment expectations and placebo analgesia.
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- 2022
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10. Online processing of moral transgressions: ERP evidence for spontaneous evaluation
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Leuthold, Hartmut, Kunkel, Angelika, Mackenzie, Ian G., and Filik, Ruth
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- 2015
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11. The Processing of Moral Transgressions: Investigating the Role of Affective Evaluations
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Kunkel, Angelika Ellen and Leuthold, Hartmut (Prof. Dr.)
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Emotion ,Anterior Negativity ,Moral , Gefühl , Ereigniskorreliertes Potenzial , Textverstehen ,Affective Evaluation ,LPP ,Embodied Cognition ,ERPs - Abstract
Every day we are confronted with other’s actions which clash with our understanding about what is right and what is wrong. This understanding is summarised here by the concept of morality. For many decades, scientists have been investigating how we evaluate the morality of actions and which brain processes underlie such evaluations. For instance, recently it has been suggested that affective as compared to cognitive processes might play a more fundamental role in moral judgement than previously assumed. So far, however, it is still unclear what the underlying mechanisms exactly are. This dissertation, which is based on three studies, intends to contribute to answering this question. By using a language comprehension approach, moral information processing is taken as a special case of emotional information processing. All three studies are based on the assumption that affective processes play an important role in the processing of moral transgressions. Therefore, in addition to moral texts, the processing of emotional texts was also considered in all studies. In study 1, event-related brain potentials (ERPs) were used to investigate how moral transgressions are processed in the brain during discourse comprehension of everyday scenarios and whether affective pro- cessing is task-dependent. The focus was on the time course of mental mechanisms during a morality and an emotional judgement task. Study 2 aimed at examining whether moral transgressions during reading of the same everyday scenarios trigger embodied responses. By using peripheral psychophysiological measures, we investigated whether embodied pro- cessing takes place when participants perform an emotional judgement task. Finally, Study 3 analysed both, ERPs and peripheral psychophysiological measures to investigate the type of processes involved in moral information processing when participants merely read for comprehension. In summary, the results of the studies reported in this thesis point towards the involve- ment of affective processes in the processing of moral content. This is reflected by ERP correlates indicating affective processing and by peripheral psychophysiological measures suggesting the embodiment of moral content. Moreover, the results suggest a task de- pendency of involved processes. This means that the goals with which one reads a text influence whether moral information is emotionally salient or not. As a result, cognitive processes dominate over affective processes when moral judgements are demanded and vice versa when affective judgements are required or participants merely read for comprehen- sion., Im Alltag passiert es uns oft, dass wir Menschen begegnen, die entgegen unseres Verst ̈andnisses darüber, was richtig und was falsch ist, handeln. Dieses Verständnis soll hier unter dem Begriff der Moralität zusammengefasst werden. Seit vielen Jahrzehnten beschäftigen sich Wissenschaftler mit der Frage, wie wir unsere eigenen und die Handlungen anderer hinsichtlich ihres moralischen Gehalts bewerten, und welche Verarbeitungsprozesse dabei im Gehirn ablaufen. In jüngster Zeit wurde vorgeschlagen, dass affektiven im Vergleich zu kognitiven Prozessen eine wichtige Rolle bei moralischen Entscheidungen zukommt. Bisher fehlt es jedoch an einem tieferen Verständnis über die zugrundeliegenden Verarbeitungsmechanismen. Die vorliegende Dissertationsschrift, welche sich dreier Studien bedient, soll einen Beitrag zur Klärung dieser Frage leisten. Hierfür werden bereits bekannte Paradigmen herangezogen und moralisches Sprachverstehen als Spezialfall des emotionalen Sprachverständnisses betrachtet. Alle drei Studien bauen auf der Vorstellung auf, dass die Verarbeitung moralischer Verletzungen eine wichtige affektive Komponente besitzt. Deshalb wurde in allen Studien neben moralischen Texten zusätzlich die Verarbeitung emotionaler Texte betrachtet. In Studie 1 wurde mittels ereigniskorrelierter Potentiale (EKPs) der Frage nachgegangen, wie während des Lesens kurzer Alltagsszenarien die Verarbeitung moralischer Verletzungen im Gehirn abläuft und ob diese Verarbeitung von der Art der Aufgabe abhängt. Dabei lag der Fokus auf dem zeitlichen Verlauf mentaler Mechanismen bei moralischen und bei affektiven Urteilen. In Studie 2 wurde die Frage untersucht, ob moralische Verletzungen verkörperlicht verarbeitet werden. Mittels der Messung peripherer psychophysiologischer Methoden wurde untersucht, ob beim Lesen konkrete emotionale Zustände simuliert werden. Studie 3 untersuchte sowohl für EKPs, als auch für periphere psychophysiologische Maße die Art der beteiligten Prozesse bei der Verarbeitung moralischer Information beim reinen Lesen. Zusammenfassend weisen die Ergebnisse der vorliegenden Studien auf eine maßgebliche Beteiligung affektiver Prozesse bei der Verarbeitung moralischer Information hin. Dies spiegelt sich sowohl im EKP, als auch in der verkörperten Verarbeitung moralischer In- halte wider. Des Weiteren legen die Ergebnisse eine Aufgabenabhängigkeit der beteiligten Prozesse nahe. Beim Lesen und beim emotionalen Urteil wird moralische Information af- fektiv verarbeitet, wohingegen beim moralischen Urteil kognitive Verarbeitung dominiert.
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- 2018
12. Online Processing of Moral Transgressions: ERP Evidence for Spontaneous Evaluation
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Kunkel, Angelika, primary, Mackenzie, Ian Grant, additional, Filik, Ruth, additional, and Leuthold, Hartmut, additional
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- 2014
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13. Task-dependent evaluative processing of moral and emotional content during comprehension: an ERP study
- Author
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Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, Leuthold, Hartmut, Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, and Leuthold, Hartmut
- Abstract
Recently, we showed that when participants passively read about moral transgressions (e.g., adultery) they implicitly engage in the evaluative (good–bad) categorization of incoming information, as indicated by a larger event-related brain potential (ERP) positivity to immoral than moral scenarios (Leuthold, Kunkel, Mackenzie, & Filik, 2015). Behavioral and neuroimaging studies indicated that explicit moral tasks prioritize the semantic-cognitive analysis of incoming information but that implicit tasks, as used in Leuthold et al. (2015), favor their affective processing. Therefore, it is unclear whether an affective categorization process is also involved when participants perform explicit moral judgments. Thus, in two experiments, we used similarly constructed morality and emotion materials for which their moral and emotional content had to be inferred from the context. Target sentences from negative vs. neutral emotional scenarios and from moral vs. immoral scenarios were presented using rapid serial visual presentation. In Experiment 1, participants made moral judgments for moral materials and emotional judgments for emotion materials. Negative compared to neutral emotional scenarios elicited a larger posterior ERP positivity (LPP) about 200 ms after critical word onset, whereas immoral compared to moral scenarios elicited a larger anterior negativity (500-700 ms). In Experiment 2, where the same emotional judgment to both types of materials was required, a larger LPP was triggered for both types of materials. These results accord with the view that morality scenarios trigger a semantic-cognitive analysis when participants explicitly judge the moral content of incoming linguistic information but an affective evaluation when judging their emotional content.
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14. Task-dependent evaluative processing of moral and emotional content during comprehension: an ERP study
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Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, Leuthold, Hartmut, Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, and Leuthold, Hartmut
- Abstract
Recently, we showed that when participants passively read about moral transgressions (e.g., adultery) they implicitly engage in the evaluative (good–bad) categorization of incoming information, as indicated by a larger event-related brain potential (ERP) positivity to immoral than moral scenarios (Leuthold, Kunkel, Mackenzie, & Filik, 2015). Behavioral and neuroimaging studies indicated that explicit moral tasks prioritize the semantic-cognitive analysis of incoming information but that implicit tasks, as used in Leuthold et al. (2015), favor their affective processing. Therefore, it is unclear whether an affective categorization process is also involved when participants perform explicit moral judgments. Thus, in two experiments, we used similarly constructed morality and emotion materials for which their moral and emotional content had to be inferred from the context. Target sentences from negative vs. neutral emotional scenarios and from moral vs. immoral scenarios were presented using rapid serial visual presentation. In Experiment 1, participants made moral judgments for moral materials and emotional judgments for emotion materials. Negative compared to neutral emotional scenarios elicited a larger posterior ERP positivity (LPP) about 200 ms after critical word onset, whereas immoral compared to moral scenarios elicited a larger anterior negativity (500-700 ms). In Experiment 2, where the same emotional judgment to both types of materials was required, a larger LPP was triggered for both types of materials. These results accord with the view that morality scenarios trigger a semantic-cognitive analysis when participants explicitly judge the moral content of incoming linguistic information but an affective evaluation when judging their emotional content.
- Full Text
- View/download PDF
15. Task-dependent evaluative processing of moral and emotional content during comprehension: an ERP study
- Author
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Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, Leuthold, Hartmut, Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, and Leuthold, Hartmut
- Abstract
Recently, we showed that when participants passively read about moral transgressions (e.g., adultery) they implicitly engage in the evaluative (good–bad) categorization of incoming information, as indicated by a larger event-related brain potential (ERP) positivity to immoral than moral scenarios (Leuthold, Kunkel, Mackenzie, & Filik, 2015). Behavioral and neuroimaging studies indicated that explicit moral tasks prioritize the semantic-cognitive analysis of incoming information but that implicit tasks, as used in Leuthold et al. (2015), favor their affective processing. Therefore, it is unclear whether an affective categorization process is also involved when participants perform explicit moral judgments. Thus, in two experiments, we used similarly constructed morality and emotion materials for which their moral and emotional content had to be inferred from the context. Target sentences from negative vs. neutral emotional scenarios and from moral vs. immoral scenarios were presented using rapid serial visual presentation. In Experiment 1, participants made moral judgments for moral materials and emotional judgments for emotion materials. Negative compared to neutral emotional scenarios elicited a larger posterior ERP positivity (LPP) about 200 ms after critical word onset, whereas immoral compared to moral scenarios elicited a larger anterior negativity (500-700 ms). In Experiment 2, where the same emotional judgment to both types of materials was required, a larger LPP was triggered for both types of materials. These results accord with the view that morality scenarios trigger a semantic-cognitive analysis when participants explicitly judge the moral content of incoming linguistic information but an affective evaluation when judging their emotional content.
- Full Text
- View/download PDF
16. Task-dependent evaluative processing of moral and emotional content during comprehension: an ERP study
- Author
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Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, Leuthold, Hartmut, Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, and Leuthold, Hartmut
- Abstract
Recently, we showed that when participants passively read about moral transgressions (e.g., adultery) they implicitly engage in the evaluative (good–bad) categorization of incoming information, as indicated by a larger event-related brain potential (ERP) positivity to immoral than moral scenarios (Leuthold, Kunkel, Mackenzie, & Filik, 2015). Behavioral and neuroimaging studies indicated that explicit moral tasks prioritize the semantic-cognitive analysis of incoming information but that implicit tasks, as used in Leuthold et al. (2015), favor their affective processing. Therefore, it is unclear whether an affective categorization process is also involved when participants perform explicit moral judgments. Thus, in two experiments, we used similarly constructed morality and emotion materials for which their moral and emotional content had to be inferred from the context. Target sentences from negative vs. neutral emotional scenarios and from moral vs. immoral scenarios were presented using rapid serial visual presentation. In Experiment 1, participants made moral judgments for moral materials and emotional judgments for emotion materials. Negative compared to neutral emotional scenarios elicited a larger posterior ERP positivity (LPP) about 200 ms after critical word onset, whereas immoral compared to moral scenarios elicited a larger anterior negativity (500-700 ms). In Experiment 2, where the same emotional judgment to both types of materials was required, a larger LPP was triggered for both types of materials. These results accord with the view that morality scenarios trigger a semantic-cognitive analysis when participants explicitly judge the moral content of incoming linguistic information but an affective evaluation when judging their emotional content.
- Full Text
- View/download PDF
17. Task-dependent evaluative processing of moral and emotional content during comprehension: an ERP study
- Author
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Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, Leuthold, Hartmut, Kunkel, Angelika, Filik, Ruth, Mackenzie, Ian Grant, and Leuthold, Hartmut
- Abstract
Recently, we showed that when participants passively read about moral transgressions (e.g., adultery) they implicitly engage in the evaluative (good–bad) categorization of incoming information, as indicated by a larger event-related brain potential (ERP) positivity to immoral than moral scenarios (Leuthold, Kunkel, Mackenzie, & Filik, 2015). Behavioral and neuroimaging studies indicated that explicit moral tasks prioritize the semantic-cognitive analysis of incoming information but that implicit tasks, as used in Leuthold et al. (2015), favor their affective processing. Therefore, it is unclear whether an affective categorization process is also involved when participants perform explicit moral judgments. Thus, in two experiments, we used similarly constructed morality and emotion materials for which their moral and emotional content had to be inferred from the context. Target sentences from negative vs. neutral emotional scenarios and from moral vs. immoral scenarios were presented using rapid serial visual presentation. In Experiment 1, participants made moral judgments for moral materials and emotional judgments for emotion materials. Negative compared to neutral emotional scenarios elicited a larger posterior ERP positivity (LPP) about 200 ms after critical word onset, whereas immoral compared to moral scenarios elicited a larger anterior negativity (500-700 ms). In Experiment 2, where the same emotional judgment to both types of materials was required, a larger LPP was triggered for both types of materials. These results accord with the view that morality scenarios trigger a semantic-cognitive analysis when participants explicitly judge the moral content of incoming linguistic information but an affective evaluation when judging their emotional content.
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18. Professor Dr. Lili Kaufmann: 17. April 1918 - 23. April 2016.
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Dronowa, Nina and Kunkel, Angelika
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- 2016
19. Laudatio auf Frau Professor Dr. Lili Kaufmann (Tambow/Rußland).
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Kunkel, Angelika
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- 2007
20. Bericht über die Partnerschaft zwischen der Goethe-Gesellschaft Wetzlar und der Goethe-Gesellschaft Tambow/Rußland.
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Kunkel, Angelika
- Published
- 1998
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