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49 results on '"Kunimoto, Kayo"'

3. Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency

Author

Kanazawa, Nobuo, Hemmi, Hiroaki, Kinjo, Noriko, Ohnishi, Hidenori, Hamazaki, Jun, Mishima, Hiroyuki, Kinoshita, Akira, Mizushima, Tsunehiro, Hamada, Satoru, Hamada, Kazuya, Kawamoto, Norio, Kadowaki, Saori, Honda, Yoshitaka, Izawa, Kazushi, Nishikomori, Ryuta, Tsumura, Miyuki, Yamashita, Yusuke, Tamura, Shinobu, Orimo, Takashi, Ozasa, Toshiya, Kato, Takashi, Sasaki, Izumi, Fukuda-Ohta, Yuri, Wakaki-Nishiyama, Naoko, Inaba, Yutaka, Kunimoto, Kayo, Okada, Satoshi, Taketani, Takeshi, Nakanishi, Koichi, Murata, Shigeo, Yoshiura, Koh-ichiro, and Kaisho, Tsuneyasu

Published
2021
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7. Glycoprotein M6A upregulation detected by transcriptome analysis controls the proliferation of keloidal fibroblasts.

Author

Kurimoto‐Nishiguchi, Mana, Muraoka, Kyoko, Inaba, Yutaka, Kunimoto, Kayo, Yamamoto, Yuki, Kumegawa, Shinji, Ueno, Kazuki, Asamura, Shinichi, Nakatani, Yumi, Sawamura, Soichiro, Makino, Katsunari, and Jinnin, Masatoshi

Abstract

Hypertrophic scars and keloids are fibroproliferative disorders caused by abnormal wound healing. Their exact cause has not been found, but abnormalities during the wound healing process including inflammatory, immune, genetic, and other factors are thought to predispose an individual to excessive scarring. In the present study, we performed transcriptome analysis of established keloid cell lines (KEL FIB), focusing on gene expression analysis and fusion gene detection for the first time. For gene expression analysis, fragments per kilobase per million map read values were calculated, which were validated by real‐time PCR and immunohistochemistry. Fusion genes were predicted by transcriptome sequence, and validated by Sanger sequence and G‐banding. As a result, GPM6A was shown in the expression analysis to be upregulated in KEL FIB compared with normal fibroblasts. The GPM6A upregulation in KEL FIB was confirmed by real‐time PCR, and GPM6A messenger ribonucleic acid expression was consistently significantly elevated in the tissues of hypertrophic scar and keloid compared to normal skin. Immunohistochemistry also revealed that the number of fibroblast‐like spindle‐shaped cells positive for GPM6A was significantly increased in keloidal tissues. GPM6A inhibition by small interfering ribonucleic acid significantly reduced the number of KEL FIB. On the other hand, although we hypothesized that fusion genes are involved in the pathogenesis of keloids, the transcriptome analysis could not prove the presence of fusion genes in KEL FIB. Taken together, GPM6A upregulation may have an inducible effect on cell proliferation in keloidal fibroblasts. GPM6A can be a novel therapeutic target in hypertrophic scars and keloids. The inflammatory nature may be more prominent in the pathogenesis of keloids, rather than being skin tumors, as proposed by Ogawa et al. Future studies using several cell lines will be required. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Dupilumab Improves Pruritus in Netherton Syndrome: A Case Study

Author

Inaba, Yutaka, primary, Kanazawa, Nobuo, additional, Muraoka, Kyoko, additional, Yariyama, Azusa, additional, Kawaguchi, Ami, additional, Kunimoto, Kayo, additional, Kaminaka, Chikako, additional, Yamamoto, Yuki, additional, Tsujioka, Kaoru, additional, Yoshida, Akira, additional, Yanagi, Teruki, additional, and Jinnin, Masatoshi, additional

Published
2022
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13. Neonatal-onset autoinflammation and immunodeficiency caused by heterozygous missense mutation of the proteasome subunit β-type 9

Author

Kanazawa, Nobuo, primary, Hemmi, Hiroaki, additional, Kinjo, Noriko, additional, Ohnishi, Hidenori, additional, Hamazaki, Jun, additional, Mishima, Hiroyuki, additional, Kinoshita, Akira, additional, Mizushima, Tsunehiro, additional, Hamada, Satoru, additional, Hamada, Kazuya, additional, Kawamoto, Norio, additional, Kadowaki, Saori, additional, Honda, Yoshitaka, additional, Izawa, Kazushi, additional, Nishikomori, Ryuta, additional, Tsumura, Miyuki, additional, Yamashita, Yusuke, additional, Tamura, Shinobu, additional, Orimo, Takashi, additional, Ozasa, Toshiya, additional, Kato, Takashi, additional, Sasaki, Izumi, additional, Fukuda-Ohta, Yuri, additional, Wakaki-Nishiyama, Naoko, additional, Inaba, Yutaka, additional, Kunimoto, Kayo, additional, Okada, Satoshi, additional, Taketani, Takeshi, additional, Nakanishi, Koichi, additional, Murata, Shigeo, additional, Yoshiura, Koh-ichiro, additional, and Kaisho, Tsuneyasu, additional

Published
2021
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16. Case series of BRAF ‐mutated advanced melanoma treated with encorafenib plus binimetinib combination therapy

Author

Fujimura, Taku, primary, Yoshino, Koji, additional, Kato, Hiroshi, additional, Fujisawa, Yasuhiro, additional, Nakamura, Yoshiyuki, additional, Yamamoto, Yuki, additional, Kunimoto, Kayo, additional, Ito, Takamichi, additional, Matsushita, Shigeto, additional, Maekawa, Takeo, additional, Ohuchi, Kentaro, additional, Amagai, Ryo, additional, Muto, Yusuke, additional, Furudate, Sadanori, additional, Kambayashi, Yumi, additional, Hashimoto, Akira, additional, and Aiba, Setsuya, additional

Published
2020
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17. Bilateral Eyebrow Sclerosis

Author

Ueno, Kazuki, primary, Kunimoto, Kayo, additional, Iwahashi, Yoshifumi, additional, Murata, Shin-ichi, additional, Yamamoto, Yuki, additional, Jinnin, Masatoshi, additional, and Asamura, Shinichi, additional

Published
2020
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18. Change of serum cytokine profiles by propranolol treatment in patients with infantile hemangioma

Author

Tani, Sayaka, primary, Kunimoto, Kayo, additional, Inaba, Yutaka, additional, Mikita, Naoya, additional, Kaminaka, Chikako, additional, Kanazawa, Nobuo, additional, Yamamoto, Yuki, additional, Kakimoto, Nobuyuki, additional, Suenaga, Tomohiro, additional, Takeuchi, Takashi, additional, Suzuki, Hiroyuki, additional, and Jinnin, Masatoshi, additional

Published
2020
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21. Distribution analysis of infantile hemangioma or capillary malformation on the head and face in Japanese patients

Author

Kawaguchi, Ami, primary, Kunimoto, Kayo, additional, Inaba, Yutaka, additional, Mikita, Naoya, additional, Kaminaka, Chikako, additional, Kanazawa, Nobuo, additional, Yamamoto, Yuki, additional, Kakimoto, Nobuyuki, additional, Suenaga, Tomohiro, additional, Takeuchi, Takashi, additional, Suzuki, Hiroyuki, additional, Baba, Naoko, additional, and Jinnin, Masatoshi, additional

Published
2019
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24. Clinical and histological evaluation of a single high energy microwave treatment for primary axillary hyperhidrosis in Asians: A prospective, randomized, controlled, split‐area comparative trial

Author

Kaminaka, Chikako, primary, Mikita, Naoya, additional, Inaba, Yutaka, additional, Kunimoto, Kayo, additional, Okuhira, Hisako, additional, Jinnin, Masatoshi, additional, Kao, Bunsho, additional, Tanino, Ryuzaburo, additional, Tanioka, Kensuke, additional, Shimokawa, Toshio, additional, and Yamamoto, Yuki, additional

Published
2019
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26. A case of slowly progressing angiosarcoma

Author

KUNIMOTO, Kayo, primary, KAWAGUCHI, Ami, additional, OKUHIRA, Hisako, additional, YAMAMOTO, Yuki, additional, FUJIMOTO, Masakazu, additional, MURATA, Shinichi, additional, and JINNIN, Masatoshi, additional

Published
2019
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27. Case series of BRAF‐mutated advanced melanoma treated with encorafenib plus binimetinib combination therapy.

Author

Fujimura, Taku, Yoshino, Koji, Kato, Hiroshi, Fujisawa, Yasuhiro, Nakamura, Yoshiyuki, Yamamoto, Yuki, Kunimoto, Kayo, Ito, Takamichi, Matsushita, Shigeto, Maekawa, Takeo, Ohuchi, Kentaro, Amagai, Ryo, Muto, Yusuke, Furudate, Sadanori, Kambayashi, Yumi, Hashimoto, Akira, and Aiba, Setsuya

Abstract

The efficacy of encorafenib plus binimetinib (E + B) combination therapy for BRAF‐mutated advanced melanoma as second‐line therapy and beyond is still unknown. In this report, we investigated 22 cases of BRAF‐mutated advanced melanoma treated with E + B combination therapy. The objective response rate (ORR) for the total cohort was 68.4%. Notably, the ORR for the second‐line and beyond cohort was 73.3%, suggesting that the therapeutic effect of E + B combination therapy is comparable with that of first‐line targeted therapy. In contrast, overall survival and progress‐free survival in our present cohort was worse than that in a previous clinical trial. Notably, although the incidence rate of severe adverse events was higher than that in a previous report, our present study suggested that E + B combination therapy is a well‐tolerated antimelanoma regimen. Our present study suggested that the efficacy and safety profile of E + B combination therapy as a second‐line therapy and beyond is comparable with that of first‐line targeted therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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30. Comparative study of cutaneous adverse reactions induced by a proteasome inhibitor with skin eruptions in Nakajo-Nishimura syndrome

Author

Kunimoto, Kayo, primary, Kanazawa, Nobuo, additional, Furukawa, Fukumi, additional, Manabe, Keiko, additional, Asagoe, Kenji, additional, Yamasaki, Osamu, additional, Kabahara, Takeshi, additional, Kanaoka, Miwa, additional, Aihara, Michiko, additional, Teraki, Yuichi, additional, Izaki, Seiichi, additional, Okuyama, Ryuhei, additional, Yamamoto, Toshiyuki, additional, and Hanna, John, additional

Published
2017
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33. CO2 narcosis as a notable cause of premature death in Nakajo-Nishimura syndrome.

Author

Kanazawa, Nobuo, Hara, Mariko, Hara, Tomoyuki, Kunimoto, Kayo, Mikita, Naoya, and Furukawa, Fukumi

Subjects
EARLY death, GENETIC mutation, CAUSES of death, INERT gas narcosis, CLINICAL trials
Abstract

Nakajo-Nishimura syndrome (NNS) is an inherited inflammatory and wasting disease caused by a distinct homozygous mutation of the PSMB8 gene, which encodes the β5i subunit of the immunoproteasome. Although NNS was originally reported in Japan more than 70 years ago, related diseases with an overlapping entity, namely joint contractures, muscular atrophy, microcytic anemia and panniculitis-associated lipodystrophy (JMP) syndrome and chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome, have recently been reported and these three diseases are now collectively referred to as proteasome-associated autoinflammatory syndromes (PRAAS). Although some distinct characteristics can be pointed out in each disease, most patients with these diseases commonly start to show inflammatory attacks in infancy and, after growing-up, clinically resemble progeria with marked emaciation especially in the upper body. Notably, some NNS cases with premature or sudden death have been reported and cardiac failure was considered to be a major cause of death. Here we report a Japanese male case with NNS, who had received no continuous medication and died of CO2 narcosis (respiratory acidosis) triggered by an acute septic infection in the absence of cardiac failure at 47 years of age. Due to a remarkable lipomuscular atrophy and contracture of the chest wall, CO2 narcosis should be noted as an important complication of NNS/PRAAS, which can develop into premature death. [ABSTRACT FROM AUTHOR]

Published
2019
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34. The effects of continuous application of sunscreen on photoaged skin in Japanese elderly people – the relationship with the usage

Author

Mizuno,Makoto, Kunimoto,Kayo, Naru,Eiji, Kameyama,Koichi, Furukawa,Fukumi, Yamamoto,Yuki, Mizuno,Makoto, Kunimoto,Kayo, Naru,Eiji, Kameyama,Koichi, Furukawa,Fukumi, and Yamamoto,Yuki

Abstract

Makoto Mizuno,1,2 Kayo Kunimoto,1 Eiji Naru,2 Koichi Kameyama,2 Fukumi Furukawa,1 Yuki Yamamoto1,3 1Department of Dermatology, Wakayama Medical University, Wakayama, Japan; 2Fundamental Research Laboratories, KOSÉ Corporation, Tokyo, Japan; 3Department of Cosmetic Dermatology and Photomedicine, Wakayama Medical University, Wakayama, Japan Abstract: Since photoaging of skin is caused by chronic sun exposure, it is well-recognized that regular sunscreen use can help prevent photoaging of skin in fair-skinned people. Therefore, application of sunscreen is recommended for the prevention of photoaging in many countries. However, the relationship between UV exposure and photoaging has rarely been investigated in clinical studies in Japan. In addition, there have been almost no long-term interventional studies in Japanese people. We have previously conducted a study where Japanese actinic keratosis patients were instructed to continuously apply sunscreen. The results indicated that long-term application of sunscreen is effective in suppressing actinic keratosis progression and generation. In the present study, we investigated the effects of sunscreen on photoaged skin in 14 elderly Japanese people. Skin conditions such as water content, transepidermal water loss, the number of spots, wrinkles, and skin color tone uniformity were measured and compared before and after the study. A statistically significant difference was observed only in skin surface hydration. There were large inter-individual differences in amount of sunscreen used throughout the study. The changes in the number of spots and skin color tone uniformity during the 18 months showed good correlation with amount of sunscreen being used. These results suggest an increase in the number of spots and deterioration in skin color tone uniformity in the 18-month non-sunscreen application period, and that such skin conditions improved with increasing use of sunscreen. In this study, we suggested an inhibito

Published
2016

49. The effects of continuous application of sunscreen on photoaged skin in Japanese elderly people - the relationship with the usage.

Author

Mizuno M, Kunimoto K, Naru E, Kameyama K, Furukawa F, and Yamamoto Y

Abstract

Since photoaging of skin is caused by chronic sun exposure, it is well-recognized that regular sunscreen use can help prevent photoaging of skin in fair-skinned people. Therefore, application of sunscreen is recommended for the prevention of photoaging in many countries. However, the relationship between UV exposure and photoaging has rarely been investigated in clinical studies in Japan. In addition, there have been almost no long-term interventional studies in Japanese people. We have previously conducted a study where Japanese actinic keratosis patients were instructed to continuously apply sunscreen. The results indicated that long-term application of sunscreen is effective in suppressing actinic keratosis progression and generation. In the present study, we investigated the effects of sunscreen on photoaged skin in 14 elderly Japanese people. Skin conditions such as water content, transepidermal water loss, the number of spots, wrinkles, and skin color tone uniformity were measured and compared before and after the study. A statistically significant difference was observed only in skin surface hydration. There were large inter-individual differences in amount of sunscreen used throughout the study. The changes in the number of spots and skin color tone uniformity during the 18 months showed good correlation with amount of sunscreen being used. These results suggest an increase in the number of spots and deterioration in skin color tone uniformity in the 18-month non-sunscreen application period, and that such skin conditions improved with increasing use of sunscreen. In this study, we suggested an inhibitory effect on photoaging symptoms such as spots and skin color tone non-uniformity, by application of the appropriate amount of sunscreen over a long period of time in Japanese people, similar to Caucasians.

Published
2016
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