1. A Chronic Progressive Case of Enteroviral Limbic Encephalitis Associated with Autoantibody to Glutamate Receptor ε2
- Author
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Kuniko Matsuyama, Toshiaki Hanafusa, Fumiharu Kimura, Keiichi Shinoda, Yukitoshi Takahashi, Masakazu Sugino, Hideto Nakajima, Daisuke Furutama, Muneyoshi Tagami, Mitsuaki Hosoya, and Simon Ishida
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Limbic encephalitis ,Autoantibody ,Glutamate receptor ,Amnesia ,Fluid-attenuated inversion recovery ,Hippocampal formation ,medicine.disease_cause ,medicine.disease ,Herpes simplex virus ,Neurology ,medicine ,Betamethasone ,Neurology (clinical) ,medicine.symptom ,business ,medicine.drug - Abstract
(mononuclear), pro-tein concentration 54 mg/dl and glucose 63 mg/dl. PCR for herpes simplex virus (HSV) DNA was negative. He was treated with acyclovir (30 mg/kg/day for 14 days) and betamethasone (16 mg/day for 7 days) based on the diagnosis of limbic encepha-litis. His symptoms and MRI abnormali-ties gradually disappeared by the second hospital month, and he was discharged without any sequelae. In November 1995, the patient again experienced a week of fever, headache and disorientation. At second admission, the patient was disoriented with memory im-pairment, including anterograde and ret-rograde amnesia. His Mini-Mental State Examination score was 17/30. FLAIR MRI again revealed hyperintense lesions in the bilateral hippocampal structures (f ig. 1B ). CSF examination showed 6 cells/mm
- Published
- 2007
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