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1. Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996–2012

Author

Martin C.W. Chan, Maggie H. Wang, Zigui Chen, David S.C. Hui, Angela K. Kwok, Apple C.M. Yeung, Kun M. Liu, Yun Kit Yeoh, Nelson Lee, and Paul K.S. Chan

Subjects
Molecular epidemiology, hemagglutinin, genetic drift, antigenic drift, subtropics, China, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

The World Health Organization selects influenza vaccine compositions biannually to cater to peaks in temperate regions. In tropical and subtropical regions, where influenza seasonality varies and epidemics can occur year-round, the choice of vaccine remains uncertain. Our 17-year molecular epidemiologic survey showed that most influenza A(H3N2) (9/11) and B (6/7) vaccine strains had circulated in East Asia >1 year before inclusion into vaccines. Northern Hemisphere vaccine strains and circulating strains in East Asia were closely matched in 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for B. Southern Hemisphere vaccines also had a low probability of matching (H3N2, 14.7%; B, 11.1%). Strain drift among seasons was common (H3N2, 41.2%; B, 35.3%), and biannual vaccination strategy (Northern Hemisphere vaccines in November followed by Southern Hemisphere vaccines in May) did not improve matching. East Asia is an important contributor to influenza surveillance but often has mismatch between vaccine and contemporarily circulating strains.

Published
2018
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2. Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996–2012

Author

David S.C. Hui, Yun Kit Yeoh, Kun M. Liu, Nelson Lee, Martin C.W. Chan, Paul K.S. Chan, Angela K. Kwok, Maggie Haitian Wang, Apple C.M. Yeung, and Zigui Chen

Subjects
0301 basic medicine, Microbiology (medical), Influenzavirus A, Veterinary medicine, China, Frequent Genetic Mismatch between Vaccine Strains and Circulating Seasonal Influenza Viruses, Hong Kong, China, 1996–2012, Influenzavirus B, Epidemiology, Influenza vaccine, lcsh:Medicine, Hemagglutinin Glycoproteins, Influenza Virus, Subtropics, Biology, History, 21st Century, Antigenic drift, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Influenza, Human, Temperate climate, Humans, viruses, lcsh:RC109-216, hemagglutinin, Southern Hemisphere, Phylogeny, Retrospective Studies, antigenic drift, Molecular epidemiology, Research, lcsh:R, Genetic Variation, virus diseases, History, 20th Century, vaccines, vaccination, Vaccination, 030104 developmental biology, Infectious Diseases, Influenza Vaccines, Hong Kong, RNA, Viral, Seasons, genetic drift, influenza, subtropics
Abstract

The World Health Organization selects influenza vaccine compositions biannually to cater to peaks in temperate regions. In tropical and subtropical regions, where influenza seasonality varies and epidemics can occur year-round, the choice of vaccine remains uncertain. Our 17-year molecular epidemiologic survey showed that most influenza A(H3N2) (9/11) and B (6/7) vaccine strains had circulated in East Asia >1 year before inclusion into vaccines. Northern Hemisphere vaccine strains and circulating strains in East Asia were closely matched in 7 (20.6%) of 34 seasons for H3N2 and 5 (14.7%) of 34 seasons for B. Southern Hemisphere vaccines also had a low probability of matching (H3N2, 14.7%; B, 11.1%). Strain drift among seasons was common (H3N2, 41.2%; B, 35.3%), and biannual vaccination strategy (Northern Hemisphere vaccines in November followed by Southern Hemisphere vaccines in May) did not improve matching. East Asia is an important contributor to influenza surveillance but often has mismatch between vaccine and contemporarily circulating strains.

Published
2018

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