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Your search keyword '"Kumariya, Sanjana"' showing total 11 results
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11 results on '"Kumariya, Sanjana"'

8. Spontaneous vascular dysfunction in Dahl salt‐sensitive male rats raised without a high‐salt diet.

Author

Grano de Oro, Arturo, Kumariya, Sanjana, Mell, Blair, Zubcevic, Jasenka, Joe, Bina, and Osman, Islam

Subjects
*HIGH-salt diet, *SALT-free diet, *NITRIC-oxide synthases, *RATS, *ENDOTHELIUM diseases
Abstract

Dahl salt‐sensitive (SS) rats fed a high‐salt diet, but not low‐salt, exhibit vascular dysfunction. Several substrains of SS rats exist that differ in their blood pressure phenotypes and salt sensitivity. The goal of this study was to investigate whether the John‐Rapp‐derived SS rat (SS/Jr), which exhibits spontaneous hypertension on a low‐salt diet, presents with hallmarks of vascular dysfunction observed in another experimental model of hypertension independent of dietary salt, the spontaneously hypertensive rat (SHR). Endothelium‐intact aortic rings and mesenteric resistance arteries were isolated from low‐salt fed adult male SS/Jr rats and SHRs, or their respective controls, for isometric wire myography. Vessels were challenged with cumulative concentrations of various vasoactive substances, in the absence or presence of nitric oxide synthase or cyclooxygenase inhibitors. Despite showing some differences in their responses to various vasoactive substances, both SS/Jr rats and SHRs exhibited key features of vascular dysfunction, including endothelial dysfunction and hyperresponsiveness to vasocontractile agonists. In conclusion, this study provides evidence to support the utility of the SS/Jr rat strain maintained on a low‐salt diet as a valid experimental model for vascular dysfunction, a key feature of human hypertension. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Cissus quadrangularisextract mitigates diabetic cardiomyopathy by inhibiting RAAS activation, inflammation and oxidative stress

Author

Syed, Anees Ahmed, Reza, Mohammad Irshad, Shafiq, Mohammad, Kumariya, Sanjana, Katekar, Roshan, Hanif, Kashif, and Gayen, Jiaur R.

Abstract

ABSTRACTBackgroundDiabetic cardiomyopathy (DCM) is an age-related disease, and its progression is accompanied by hyperglycaemia, cardiac dysfunction, and myocardial structural and functional abnormalities. Cissus quadrangularis, a traditional medicinal plant, contains polyphenols, flavonoids, phytosterols, carbohydrates and ascorbic acid. It is used to treat osteoporosis, asthma, haemorrhoids and menstrual disorders.Objective:In the current research, we have investigated the effect of ethanolic extract of C. quadrangularis(EECQ) against a high-fat diet (HFD)/streptozotocin-induced DCM by estimating cardiac biomarkers, inflammatory markers and Reactive oxygen species (ROS) production.Material and methodsRats were fed with an HFD for 12 weeks, followed by single-shot low-dose streptozotocin (35 mg/kg; i.p.). The treatment was performed by EECQ (200 mg/kg/day, orally) for six weeks.ResultsThe extract EECQ improves glucose, insulin tolerance tests and hypercholesteremia. DCM is characterized by cardiac dysfunction, cardiac biomarkers CKMB and LDH, which were attenuated by the EECQ treatment. The hypertrophic biomarker ANP, BNP expression and cardiomyocyte surface area were decreased by EECQ. Moreover, EECQ also alleviated the biomarkers Angiotensin II and renin level. EECQ also reduced oxidative stress, ROS production and cardiac inflammation.ConclusionsThus, these findings suggested that EECQ could be used as a possible therapeutic regiment to treat DCM.

Published
2022
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