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405 results on '"Kumari, Kanchan"'

3. The scaffolding function of LSD1 controls DNA methylation in mouse ESCs

Author

Malla, Sandhya, Kumari, Kanchan, García-Prieto, Carlos A., Caroli, Jonatan, Nordin, Anna, Phan, Trinh T. T., Bhattarai, Devi Prasad, Martinez-Gamero, Carlos, Dorafshan, Eshagh, Stransky, Stephanie, Álvarez-Errico, Damiana, Saiki, Paulina Avovome, Lai, Weiyi, Lyu, Cong, Lizana, Ludvig, Gilthorpe, Jonathan D., Wang, Hailin, Sidoli, Simone, Mateus, Andre, Lee, Dung-Fang, Cantù, Claudio, Esteller, Manel, Mattevi, Andrea, Roman, Angel-Carlos, and Aguilo, Francesca

Published
2024
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4. Hexachlorobenzene

Author

Kumari, Kanchan, Swamy, Senerita, Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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5. Aldrin

Author

Kumari, Kanchan, Akhtar, Shaheen, Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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7. Toxaphene

Author

Kumari, Kanchan, Akhtar, Shaheen, Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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8. Mirex

Author

Kumari, Kanchan, Marathe, Deepak, Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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9. Endrin

Author

Kumari, Kanchan, Akhtar, Shaheen, Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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12. Dieldrin

Author

Kumari, Kanchan, Akhtar, Shaheen, Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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15. Chlordane

Author

Kumari, Kanchan, Swamy, Senerita, Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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17. Penta-Chlorobenzene (PeCB)

Author

Kumari, Kanchan, Marathe, Deepak, Shahbaz, Md., Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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19. Dioxins and Furans

Author

Kumari, Kanchan, Akhtar, Shaheen, Prathish, K. P., Hashmi, Muhammad Zaffar, Series Editor, Strezov, Vladimir, Series Editor, and Kumari, Kanchan

Published
2024
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25. Automated Identification and Classification of Polymeric Waste Wrappers Using Convolutional Neural Networks and IoT-Based GSM Communication

Author

Kumari, Kanchan, Barua, Abhishek, Patra, Aman, Ghosh, Arindam, Series Editor, Chua, Daniel, Series Editor, de Souza, Flavio Leandro, Series Editor, Aktas, Oral Cenk, Series Editor, Han, Yafang, Series Editor, Gong, Jianghong, Series Editor, Jawaid, Mohammad, Series Editor, Suar, Mrutyunjay, editor, Mohanty, Smita, editor, Misra, Namrata, editor, and Ranjan Mohanty, Smruti, editor

Published
2024
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26. Parameters Appraisal of Resistance Spot Welded SS304 Sheets Using WASPAS Method

Author

Kumari, Kanchan, Patra, Abhijeet, Behera, Basanti, Pattanaik, Ajit Kumar, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Sahoo, Seshadev, editor, and Yedla, Natraj, editor

Published
2024
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32. Parametric Appraisal of Mahua Biodiesel-Powered Compression Ignition Engine to Improve Performance Characteristics by RSM Coupled WASPAS Simulated Annealing and Genetic Algorithm

Author

Sahoo, Bibhuti Bhusan, Jena, Shakti Prakash, Barua, Abhishek, Jeet, Siddharth, Kumari, Kanchan, Bagal, Dilip Kumar, Saran, Madhumanjari, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Tripathy, Sasmeeta, editor, Samantaray, Sikata, editor, Ramkumar, J., editor, and Mahapatra, S. S., editor

Published
2023
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33. Parametric Optimization of Resistance Spot Welded Dissimilar Metals Utilizing Advanced Hybrid Taguchi-MARCOS Method

Author

Kamilla, Bhabani Shankar, Sahoo, Bibhuti Bhusan, Barua, Abhishek, Jeet, Siddharth, Kumari, Kanchan, Bagal, Dilip Kumar, Panda, Bibhu Prasad, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Haddar, Mohamed, Editorial Board Member, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Tripathy, Sasmeeta, editor, Samantaray, Sikata, editor, Ramkumar, J., editor, and Mahapatra, S. S., editor

Published
2023
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34. Numerical Modeling of Explosive Welded Ti/Al7075-T6 Bimetal Composite Plate Using Smoothed Particle Hydrodynamics

Author

Barua, Abhishek, Pradhan, Swastik, Jeet, Siddharth, Bagal, Dilip Kumar, Kumari, Kanchan, Sahu, Saujanya Kumar, Rath, Arati, Cavas-Martínez, Francisco, Editorial Board Member, Chaari, Fakher, Series Editor, di Mare, Francesca, Editorial Board Member, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Editorial Board Member, Ivanov, Vitalii, Series Editor, Kwon, Young W., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Prakash, Chander, editor, Singh, Sunpreet, editor, and Krolczyk, Grzegorz, editor

Published
2023
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36. MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis

Author

Parvez Khan, Jawed Akhtar Siddiqui, Prakash G. Kshirsagar, Ramakanth Chirravuri Venkata, Shailendra Kumar Maurya, Tamara Mirzapoiazova, Naveenkumar Perumal, Sanjib Chaudhary, Ranjana Kumari Kanchan, Mahek Fatima, Md Arafat Khan, Asad Ur Rehman, Imayavaramban Lakshmanan, Sidharth Mahapatra, Geoffrey A. Talmon, Prakash Kulkarni, Apar K. Ganti, Maneesh Jain, Ravi Salgia, Surinder Kumar Batra, and Mohd Wasim Nasser

Subjects
Small cell lung cancer, microRNAs, CXCR4, FOXM1, RRM2, Neuroendocrine carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Small cell lung cancer (SCLC) is an aggressive lung cancer subtype that is associated with high recurrence and poor prognosis. Due to lack of potential drug targets, SCLC patients have few therapeutic options. MicroRNAs (miRNAs) provide an interesting repertoire of therapeutic molecules; however, the identification of miRNAs regulating SCLC growth and metastasis and their precise regulatory mechanisms are not well understood. Methods To identify novel miRNAs regulating SCLC, we performed miRNA-sequencing from donor/patient serum samples and analyzed the bulk RNA-sequencing data from the tumors of SCLC patients. Further, we developed a nanotechnology-based, highly sensitive method to detect microRNA-1 (miR-1, identified miRNA) in patient serum samples and SCLC cell lines. To assess the therapeutic potential of miR-1, we developed various in vitro models, including miR-1 sponge (miR-1Zip) and DOX-On-miR-1 (Tet-ON) inducible stable overexpression systems. Mouse models derived from intracardiac injection of SCLC cells (miR-1Zip and DOX-On-miR-1) were established to delineate the role of miR-1 in SCLC metastasis. In situ hybridization and immunohistochemistry were used to analyze the expression of miR-1 and target proteins (mouse and human tumor specimens), respectively. Dual-luciferase assay was used to validate the target of miR-1, and chromatin immunoprecipitation assay was used to investigate the protein-gene interactions. Results A consistent downregulation of miR-1 was observed in tumor tissues and serum samples of SCLC patients compared to their matched normal controls, and these results were recapitulated in SCLC cell lines. Gain of function studies of miR-1 in SCLC cell lines showed decreased cell growth and oncogenic signaling, whereas loss of function studies of miR-1 rescued this effect. Intracardiac injection of gain of function of miR-1 SCLC cell lines in the mouse models showed a decrease in distant organ metastasis, whereas loss of function of miR-1 potentiated growth and metastasis. Mechanistic studies revealed that CXCR4 is a direct target of miR-1 in SCLC. Using unbiased transcriptomic analysis, we identified CXCR4/FOXM1/RRM2 as a unique axis that regulates SCLC growth and metastasis. Our results further showed that FOXM1 directly binds to the RRM2 promoter and regulates its activity in SCLC. Conclusions Our findings revealed that miR-1 is a critical regulator for decreasing SCLC growth and metastasis. It targets the CXCR4/FOXM1/RRM2 axis and has a high potential for the development of novel SCLC therapies. Graphical Abstract MicroRNA-1 (miR-1) downregulation in the tumor tissues and serum samples of SCLC patients is an important hallmark of tumor growth and metastasis. The introduction of miR-1 in SCLC cell lines decreases cell growth and metastasis. Mechanistically, miR-1 directly targets CXCR4, which further prevents FOXM1 binding to the RRM2 promoter and decreases SCLC growth and metastasis.

Published
2023
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47. WELD QUALITY APPRAISAL OF AA1050/Cu FSWed JOINTS: A NOVEL HYBRID TAGUCHI–WASPAS–ALIBABA AND THE FORTY THIEVES ALGORITHM.

Author

KUMARI, KANCHAN, PRADHAN, SWASTIK, PRIYADARSHINI, MANISHA, and BARUA, ABHISHEK

Subjects
*FRICTION stir welding, *TENSILE strength, *TAGUCHI methods, *WELDING, *COPPER
Abstract

Several studies using Friction Stir Welding (FSW) on dissimilar Aluminium and Copper weld configurations and the mechanical and microstructure characteristics, as well as the identification of intermetallic phases that appear in the weld region, have been conducted. Indeed, earlier several studies had been conducted in both lap and butt FSW joint designs. Even so, Al–Cu lap welding has received further attention than butt–welding, which has attracted only a few studies thus far. The studies ended with varying findings and were unable to reach high strengths despite the fact that very few studies addressed tool placement factors. The present investigation starts with butt–welding of AA1050 and pure Cu sheet by employing the FSW procedure. Experimental trails were designed using the L16 array (Taguchi’s technique) with distinct combinations of tool spinning speed, tool offset, welding speed, and plunge depth. Weld parameters such as compressive strength (CS), ultimate tensile strength (UTS), and average hardness at nugget zone (AHNZ) were evaluated using three different optimization methodologies, i.e. the WASPAS method, Alibaba and the Forty Thieves algorithm, and the Taguchi–WASPAS method, to find out the best weld constraint arrangement for maximizing the welded joint mechanical characteristics. ANOVA test was also conducted, which revealed that welding speed is the most significant and influential FSW factor for Al–Cu butt–welding using FSW. Finally, confirmatory tests were piloted to check the consistency of the predicted FSW parameters. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Thickness Dependent Morphological, Structural, and Magnetic Studies of Nickel Ferrite Films

Author

Kumari, Kanchan, Kumar, Rajesh, Barman, Partha Bir, Cavas-Martínez, Francisco, Series Editor, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Haddar, Mohamed, Series Editor, Ivanov, Vitalii, Series Editor, Kwon, Young W., Series Editor, Trojanowska, Justyna, Series Editor, di Mare, Francesca, Series Editor, Manik, Gaurav, editor, Kalia, Susheel, editor, Sahoo, Sushanta Kumar, editor, Sharma, Tarun K., editor, and Verma, Om Prakash, editor

Published
2021
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