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A comparison was made between Mg alloy and A3 steel on weight, bending, sound absorption, and vibration conditions. In this study, a swivel plate, which is used in rotating car seats, is to be taken into consideration for finding bending, natural frequency, and frequency under static loading conditions. The swivel plate is generally made up of A3 steel plate; instead, we have replaced that with Mg alloy (AZ91D) plate. Stiffness, flexural strength, natural frequency, frequency under different static loading conditions, and sound absorption capacity were obtained through experimental methods. Finally, it was concluded that the damping capacity of Mg alloy of swivel plate is higher, has better stiffness, and incurred weight reduction by 26.58% less than that of the A3 steel. Also, the Mg alloy material exhibits better specific flexural strength, and specific flexural modulus and sound absorption coefficient are 11.76% and 25% higher than those of A3 steel at higher frequency level (2000 Hz) and at lower frequency level (100 Hz).

Background: Workers laboring in steel industries in tropical settings with high ambient temperatures are subjected to thermally stressful environments that can create well-known risks of heat-related illnesses and limit workers’ productivity. Methods: A cross-sectional study undertaken in a steel industry in a city nicknamed “Steel City” in Southern India assessed thermal stress by wet bulb globe temperature (WBGT) and level of dehydration from urine color and urine specific gravity. A structured questionnaire captured self-reported heat-related health symptoms of workers. Results: Some 90% WBGT measurements were higher than recommended threshold limit values (27.2–41.7°C) for heavy and moderate workloads and radiational heat from processes were very high in blooming-mill/coke-oven (67.6°C globe temperature). Widespread heat-related health concerns were prevalent among workers, including excessive sweating, fatigue, and tiredness reported by 50% workers. Productivity loss was significantly reported high in workers with direct heat exposures compared to those with indirect heat exposures (χ2 = 26.1258, degrees of freedom = 1, p

Abstract The pearlspot, Etroplus suratensis is a climate resilient cichlid fish that exhibits unusual adaptation to salinity. The fish is able to complete full life cycle in diverse salinity habitats ranging from fresh water to marine environments. High-quality primary and phased genome assemblies were generated for pearlspot fish using PacBio HiFi and Arima HiC sequencing technologies, for the first time. The primary assembly is highly contiguous with contig N50 length of 36 Mb. The final assembly is of 1.247 Gb with N50 length of 51.57 Mb and 98% of the genome length anchored to 24 chromosomes. The genome was assessed to be 99.9% complete based on BUSCO evaluation and was predicted to contain 52.96% repeat elements. We have predicted 27,192 protein encoding genes, of which 21,580 were functionally annotated. The genome offers an invaluable resource to understand adaptation of pearlspot fish to diverse salinity habitats.

Abstract Background Enteric infections are hypothesized to be associated with intussusception in children. A small increase in intussusception following rotavirus vaccination has been seen in some settings. We conducted post-marketing surveillance for intussusception following rotavirus vaccine, Rotavac introduction in India and evaluated association of intussusception with enteric pathogens. Methods In a case-control study nested within a large sentinel hospital-based surveillance program in India, stool samples from 272 children aged less than 2 years admitted for intussusception and 272 age-, gender- and location-matched controls were evaluated with Taqman array card based molecular assays to detect enteric viruses, bacterial enteropathogens and parasites. Matched case-control analysis with conditional logistic regression evaluated association of enteropathogens with intussusception. Population attributable fractions (PAF) were calculated for enteropathogens significantly associated with intussusception. Results The most prevalent enteropathogens in cases and controls were enteroaggregative Escherichia coli, adenovirus 40/41, adenovirus C serotypes and enteroviruses. Children with intussusception were more likely to harbor adenovirus C serotypes (adjusted odds-ratio (aOR) = 1.74; 95% confidence interval (CI) 1.06–2.87) and enteroviruses (aOR = 1.77; 95% CI 1.05–2.97) than controls. Rotavirus was not associated with increased intussusception risk. Adenovirus C (PAF = 16.9%; 95% CI 4.7% − 27.6%) and enteroviruses (PAF = 14.7%; 95% CI 4.2% − 24.1%) had the highest population attributable fraction for intussusception. Conclusion Adenovirus C serotypes and enteroviruses were significantly associated with intussusception in Indian children. Rotavirus was not associated with risk of intussusception.

Aquatic ecosystems that are subject to urbanization and environmental changes, such as the Kapaleeswarar and Chitrakulam tanks, depend on evaluating water quality. Their complicated data present challenges for conventional approaches. The usefulness of the Mamdani fuzzy inference system in determining the water quality in these tanks is investigated in this work. It creates a comprehensive assessment based on subject-matter expertise by handling ambiguous descriptors with linguistic variables and fuzzy sets. The system’s procedures for implementation are described in detail, with an emphasis on how well they can manage interrelated variables. The study shows how well the system measures the water quality in tanks and suggests ways to improve it. Tank evaluation that incorporates the Mamdani system encourages comprehensive resource management and cultural preservation.

Objective: The purpose of this study was to investigate the association of mental health, subjective well-being, and the impact of COVID-19 on quality of life with PA intensity among college students. Participants: The sample included 1262 college students from a large Midwestern research university (mean age = 21.5 ± 3.6 years). Methods: Participants voluntarily and anonymously completed the Qualtrics questionnaires which included the "Patient Health Questionnaire--Anxiety and Depression Scale," the "Satisfaction with Life Scale," the "Impact of COVID-19 on Quality of Life (QoL) Scale," and the "International Physical Activity Questionnaire." Results: Multiple linear regression models indicated that COVID-19 QoL and life satisfaction were significant predictors of the total, vigorous, and moderate PA (p's < 0.05). Life satisfaction was also a significant predictor of walking. Conclusion: Higher level satisfaction and lower impact of COVID-19 on quality of life were related to higher total, vigorous, and moderate PA levels.

Current paper reports the findings of a content analysis of Open Educational Resources. Twenty three studies were collected for the analysis. The studies were collected from different journals depending on open access policy. Every study was categorised by author, year of publication, title of the study, author characteristics and analysis. The analysis refers to the information about Open Educational Resources variables. Therefore the investigators categorize the research papers based on OER. An analysis of research papers was formed in conclusion and finalizing the common dimensions of content analysis of OER studies.

Alzheimer's disease (AD) is a progressive neurodegeneration. Oligomers of amyloid-β peptides (Aβ) are thought to play a pivotal role in AD pathogenesis, yet the mechanisms involved remain unclear. Two major isoforms of Aβ associated with AD are Aβ40 and Aβ42, the latter being more toxic and prone to form oligomers. Here, we took a systems biology approach to study two humanized yeast AD models which expressed either Aβ40 or Aβ42 in bioreactor cultures. Strict control of oxygen availability and culture pH, strongly affected chronological lifespan and reduced variations during cell growth. Reduced growth rates and biomass yields were observed upon Aβ42 expression, indicating a redirection of energy from growth to maintenance. Quantitative physiology analyses furthermore revealed reduced mitochondrial functionality and ATP generation in Aβ42 expressing cells, which matched with observed aberrant mitochondrial structures. Genome-wide expression level analysis showed that Aβ42 expression triggered strong ER stress and unfolded protein responses. Equivalent expression of Aβ40, however, induced only mild ER stress, which resulted in hardly affected physiology. Using AD yeast models in well-controlled cultures strengthened our understanding on how cells translate different Aβ toxicity signals into particular cell fate programs, and further enhance their potential as a discovery platform to identify possible therapies.

Objective: To aim at the preparation and characterization of a chitosan and betel leaf extract biopolymer followed by an assessment of mechanical and antibacterial properties. Material and Methods: A chitosan-betel leaf stock solution was prepared and dip-coated on thermoformed aligner cubes. The groups (five samples per group) involved were one control (only chitosan coating) and three test groups based on the duration of coating (coating with chitosan and betel extract coated for 5, 10, and 15 minutes, named B5, B10, and B15 respectively). The coating of the samples was confirmed by an FTIR test and anti-microbial properties were assessed by the disc diffusion method. Wear resistance assessment of the coating was carried out by scratch test. Results: Coating of the aligners with the extract was confirmed with FTIR. The zone of inhibition against S. mutans was noted to be the widest for aligners coated for 15 minutes (7± 0.5mm), and the intergroup difference was statistically significant (p

In tumors with WT p53, alternate mechanisms of p53 inactivation are reported. Here, we have identified a long noncoding RNA, PITAR (p53 Inactivating TRIM28 Associated RNA), as an inhibitor of p53. PITAR is an oncogenic Cancer/testis lncRNA and is highly expressed in glioblastoma (GBM) and glioma stem-like cells (GSC). We establish that TRIM28 mRNA, which encodes a p53-specific E3 ubiquitin ligase, is a direct target of PITAR. PITAR interaction with TRIM28 RNA stabilized TRIM28 mRNA, which resulted in increased TRIM28 protein levels and reduced p53 steady-state levels due to enhanced p53 ubiquitination. DNA damage activated PITAR, in addition to p53, in a p53-independent manner, thus creating an incoherent feedforward loop to inhibit the DNA damage response by p53. While PITAR silencing inhibited the growth of WT p53 containing GSCs in vitro and reduced glioma tumor growth in vivo, its overexpression enhanced the tumor growth in a TRIM28-dependent manner and promoted resistance to Temozolomide. Thus, we establish an alternate way of p53 inactivation by PITAR, which maintains low p53 levels in normal cells and attenuates the DNA damage response by p53. Finally, we propose PITAR as a potential GBM therapeutic target.

Advanced industrialization requires an enormous amount of water, dyes, and chemicals, and it continuously releases toxic effluents into the environment and water bodies. In textile, paper, leather, and other industries, dyes are the compounds being used to provide color to the substances. Among all of the dyes utilized in the dyeing sector, azo dyes contribute about 60 % of all dyestuffs used globally. Synthetic dyes harm the aesthetic qualities of water resources by elevating COD (Chemical oxygen demand) and BOD (Biological oxygen demand), toxic substances, turbidity, hindering photosynthesis, stifling plant development, contaminating the food chain, inducing recalcitrance, and accumulation, and effectively stimulating toxicity, carcinogenicity, as well as mutagenicity. To minimize negative impacts on the surroundings, people, and natural water bodies, wastewater comprising dye pollutants must be removed effectively through eco-friendly technology. As a result, treatment of these textile effluents is required before they are eliminated into the surroundings. Physical, chemical, physio-chemical, and biological methods are among those used for treating textile wastewater. Biological methods, such as treatment with bacteria, bacterial enzymes, fungi, and plants, were used due to their environment-friendly and cost-effective method. The classification of dyes and their degradation mechanism by bacteria are addressed in this paper.

Background: The management of Aneurysmal Bone Cyst of Talus (ABC) has been long debated. Being a benign tumour of the foot and ankle, the goals of therapy for ABC include symptomatic relief, prevention of recurrence and pathological fractures. There is a need to ascertain a pattern of presentation and disease progression to diagnose and administer appropriate care. Case report: A 23-year-old male with insidious onset atraumatic ankle pain. On preliminary clinical examination of the ankle, fullness was felt over the posteromedial aspect and tenderness was elicited on deep palpation with a normal range of movements. Initially, it was suspected to be Giant Cell Tumour (GCT). On fine needle aspiration cytology, it showed multinucleated giant cells. The patient underwent excision and curettage. Postoperatively, diagnosed as ABC.A 19-year-old boy with a posttraumatic swelling of the ankle. On initial radiographs, it was clear that the trauma was not the inciting factor for the swelling and after magnetic resonance imaging, it was suspected to be a haemorrhagic cyst. The patient was taken up for excision and curettage.Both patients had an excellent return to normal activities. Conclusion: An extended intralesional curettage with autologous bone grafting is an excellent management option for ABC Talus, with hydrogen peroxide as an adjuvant.