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637 results on '"Kumar, Sudhesh"'

6. Impact of Drain Placement on Postoperative Complications after Thyroidectomy for Substernal Goiter

Author

Waqar, Usama, additional, Hameed, Ayesha Nasir, additional, Angez, Meher, additional, Kumar, Sudhesh, additional, Arshad, Hajra, additional, Siddiqui, Marium Tariq, additional, Khan, Hira, additional, Viquar, Werdah, additional, Abbas, Aiza, additional, Javid, Arsalan, additional, Iftikhar, Haissan, additional, Abbas, Syed Akbar, additional, Naz, Huma, additional, and Saleem, Sarah, additional

Published
2024
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27. Additional file 1 of The impact of metabolic endotoxaemia on the browning process in human adipocytes

Author

Omran, Farah, Murphy, Alice M., Younis, Awais Z., Kyrou, Ioannis, Vrbikova, Jana, Hainer, Vojtech, Sramkova, Petra, Fried, Martin, Ball, Graham, Tripathi, Gyanendra, Kumar, Sudhesh, McTernan, Philip G., and Christian, Mark

Abstract

Additional file 1: Table S1. Primer sequences. Sequences of primers used during qRT-PCR. Figure S1. Artificial neural network inference of brown and inflammatory genes pre- and post-bariatric surgery. A network map showing the strength and direction of interactions between genes measured before and after bariatric surgery. Figure S2. UCP1 expression in lean and obese subcutaneous and omental adipose tissue. Gene expression of UCP1 in subcutaneous and omental adipose tissue from lean participants and participants with obesity. Figure S3. Inflammatory markers are increased with BMI. Bar graphs showing the expression of inflammatory genes across participants divided into lean, overweight and obese cohorts. Figure S4. Artificial neural network inference of brown and inflammatory genes in subcutaneous adipose tissue. A network map showing the strength and direction of interactions between genes in subcutaneous adipose tissue. Figure S5. Artificial neural network inference of brown and inflammatory genes in omental adipose tissue. A network map showing the strength and direction of interactions between genes in omental adipose tissue. Figure S6. AP2 gene expression during differentiation with LPS treatment. Gene expression of AP2 demonstrating that differentiation of adipocytes is not affected by cellular treatments. Figure S7. Effect of LPS on inflammation in primary human adipocytes. Expression of inflammatory genes in primary human adipocytes following LPS treatment.

Published
2023
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34. Establishing abdominal height cut-offs and their association with conventional indices of obesity among Arab children and adolescents

Author

Al-Daghri Nasser, Alokail Majed, Al-Attas Omar, Sabico Shaun, and Kumar Sudhesh

Subjects
Medicine
Abstract

Background and Objectives: Obesity, particularly childhood obesity is common in the Middle East, but no studies have examined the relationship of sagittal abdominal diameter (SAD) or abdominal height to conventional markers of obesity in this region. This is the first study to document the association of SAD with measures of obesity among Arab children and adolescents. Methods : Nine hundred sixty-four Saudi children aged 5-17 years (365 prepubertal, including 146 boys and 219 girls; 249 pubertal, including 125 boys and 124 girls; and 350 postpubertal, including 198 boys and 152 girls) were included in this cross-sectional study. Results : SAD was significantly correlated with indices of obesity regardless of gender, but was strongest among pubertal boys. The cut-off values were as follows: for prepubertal children, 14 cm (equivalent to 50th percentile among girls and 60th percentile among boys); for pubertal children, 15 cm for girls (30th percentile) and 16 cm for boys (50th percentile), and for postpubertal, 21.5 cm for girls (70th percentile) and 22 cm for boys (80th percentile). Conclusion : SAD is a reliable indicator of visceral obesity among Arab children and adolescents in particular. Prospective studies should be done to determine whether such an association translates to a promising risk factor for hard endpoints such as diabetes mellitus and coronary heart disease.

Published
2010

36. Additional file 1 of The mid-term and long-term effects of tourniquet use in total knee arthroplasty: systematic review

Author

Rafaqat, Wardah, Kumar, Sudhesh, Ahmad, Tashfeen, Qarnain, Zul, Khan, Khalid Saeed, and Lakdawala, Riaz Hussain

Subjects
body regions, surgical procedures, operative, equipment and supplies, digestive system, digestive system diseases
Abstract

Additional file 1: Appendix 1. Search strategy for studies on long-term effects of tourniquet use in total knee arthroplasty. Appendix 2. Population demographics of studies included in the systematic review on long-term complications of tourniquet use. Appendix 3. Quality assessment of RCTs using Risk of Bias Assessment tool for review assessing the long-term effects of tourniquet use in TKA. Appendix 4. Quality assessment of cohort studies using Newcastle-Ottawa scale for review assessing the long-term effects of tourniquet use in TKA.

Published
2022
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47. Association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19 including clinical course, morbidity and mortality outcomes? A systematic review

Author

Grove, Amy, primary, Osokogu, Osemeke, additional, Al-Khudairy, Lena, additional, Mehrabian, Amin, additional, Zanganeh, Mandana, additional, Brown, Anna, additional, Court, Rachel, additional, Taylor-Phillips, Sian, additional, Uthman, Olalekan A, additional, McCarthy, Noel, additional, Kumar, Sudhesh, additional, and Clarke, Aileen, additional

Published
2021
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48. Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass

Author

Kos, Katarina, Harte, Alison L., James, Sean, Snead, David R., O'Hare, Joseph P., McTernan, Philip G., and Kumar, Sudhesh

Subjects
Neuropeptide Y -- Influence, Adipose tissues -- Research, Insulin -- Properties, Rosiglitazone maleate -- Properties, Leptin -- Properties, Biological sciences
Abstract

NPY is an important central orexigenic hormone, but little is known about its peripheral actions in human adipose tissue (AT) or its potential paracrine effects. Our objective was to examine NPY's role in AT, specifically addressing NPY protein expression, the effect of NPY on adipokine secretion, and the influence of insulin and rosiglitazone (RSG) on adipocytederived NPY in vitro. Ex vivo human AT was obtained from women undergoing elective surgery [age: 42.7 [+ or -] 1.5 yr (mean [+ or -] SE), BMI: 26.2 [+ or -] 0.7 kg/[m.sup.2]; n = 38]. Western blot analysis was used to determine NPY protein expression in AT depots. Abdominal subcutaneous (AbSc) adipocytes were isolated and treated with recombinant (rh) NPY, insulin, and RSG. NPY and adipokine levels were measured by ELISA. Our results were that NPY was localized in human AT and adipocytes and confirmed by immunohistochemistry. Depot-specific NPY expression was noted as highest in AbSc AT (1.87 [+ or -] 0.23 ODU) compared with omental (Om; 1.03 [+ or -] 0.15 ODU, P = 0.029) or thigh AT (Th; 1.0 [+ or -] 0.29 ODU, P = 0.035). Insulin increased NPY secretion (control: 0.22 [+ or -] 0.024 ng/ml; 1 nM insulin: 0.26 [+ or -] 0.05 ng/ml; 100 nM insulin: 0.29 [+ or -] 0.04 ng/ml; 1,000 nM insulin: 0.3 [+ or -] 0.04 ng/ml; P < 0.05, n = 13), but cotreatment of RSG (10 nM) with insulin (100 nM) had no effect on NPY secretion. Furthermore, adipocyte treatment with rh-NPY downregulated leptin secretion (control: 6.99 [+ or -] 0.89 ng/ml; 1 nmol/l rh-NPY: 4.4 [+ or -] 0.64 ng/ml; 10 nmol/l rh-NPY: 4.3 [+ or -] 0.61 ng/ml, 100 nmol/l rh-NPY: 4.2 [+ or -] 0.67 ng/ml; P < 0.05, n = 10) but had no effect on adiponectin or TNF-[alpha] secretion. We conclude that NPY is expressed and secreted by human adipocytes. NPY secretion is stimulated by insulin, but this increment was limited by cotreatment with RSG. NPY's antilipolytic action may promote an increase in adipocyte size in hyperinsulinemic conditions. Adipose-derived NPY mediates reduction of leptin secretion and may have implications for central feedback of adiposity signals. adipokines; insulin; rosiglitazone; leptin

Published
2007

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