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28 results on '"Kumar, Shiva Senthil"'

1. Overcoming barriers to establishing autopsy procurement programs in pediatric patients with central nervous system tumors: a call to develop regional centers

Author

DeWire, Mariko, Erker, Craig, Hummel, Trent R., Chow, Lionel M. L, de Blank, Peter, Salloum, Ralph, Pillay-Smiley, Natasha, Hoffman, Lindsey, Gilger, Elizabeth, Gallagher, Maureen, Driver, Lori, Meister, Dinah, Ward, Heather, Drissi, Rachid, Kumar, Shiva Senthil, Sengupta, Satarupa, Kikta, Bridget, Meriwether, Wanda, Jelinek, Susan, Asher, Anthony, Jones, Blaise, Leach, James, Miles, Lili, Fuller, Christine, and Fouladi, Maryam

Published
2021
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2. A phase I/II study of ribociclib following radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG)

Author

DeWire, Mariko, Fuller, Christine, Hummel, Trent R., Chow, Lionel M. L., Salloum, Ralph, de Blank, Peter, Pater, Luke, Lawson, Sarah, Zhu, Xiaoting, Dexheimer, Phil, Carle, Adam C., Kumar, Shiva Senthil, Drissi, Rachid, Stevenson, Charles B., Lane, Adam, Breneman, John, Witte, David, Jones, Blaise V., Leach, James L., and Fouladi, Maryam

Published
2020
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3. Vorinostat, temozolomide or bevacizumab with irradiation and maintenance BEV/TMZ in pediatric high-grade glioma: A Children’s Oncology Group Study

Author

Lulla, Rishi R, primary, Buxton, Allen, additional, Krailo, Mark D, additional, Lazow, Margot A, additional, Boue, Daniel R, additional, Leach, James L, additional, Lin, Tong, additional, Geller, James I, additional, Kumar, Shiva Senthil, additional, Nikiforova, Marina N, additional, Chandran, Uma, additional, Jogal, Sachin S, additional, Nelson, Marvin D, additional, Onar-Thomas, Arzu, additional, Haas-Kogan, Daphne A, additional, Cohen, Kenneth J, additional, Kieran, Mark W, additional, Gajjar, Amar, additional, Drissi, Rachid, additional, Pollack, Ian F, additional, and Fouladi, Maryam, additional

Published
2024
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7. A molecular biology and phase II study of imetelstat (GRN163L) in children with recurrent or refractory central nervous system malignancies: a pediatric brain tumor consortium study

Author

Salloum, Ralph, Hummel, Trent R., Kumar, Shiva Senthil, Dorris, Kathleen, Li, Shaoyu, Lin, Tong, Daryani, Vinay M., Stewart, Clinton F., Miles, Lili, Poussaint, Tina Young, Stevenson, Charles, Goldman, Stewart, Dhall, Girish, Packer, Roger, Fisher, Paul, Pollack, Ian F., Fouladi, Maryam, Boyett, James, and Drissi, Rachid

Published
2016
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10. EPCT-06. Phase I study of ribociclib and everolimus post-radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG): Updated report from the COllaborative Network for NEuro-Oncology Clinical Trials (CONNECT)

Author

Lazow, Margot A, primary, DeWire, Mariko, additional, Campagne, Olivia, additional, Leach, James L, additional, Fuller, Christine, additional, Kumar, Shiva Senthil, additional, Stanek, Joseph, additional, de Blank, Peter, additional, Hummel, Trent R, additional, Pillay-Smiley, Natasha, additional, Salloum, Ralph, additional, Stevenson, Charles B, additional, Baxter, Patricia, additional, Gass, David, additional, Goldman, Stewart, additional, Leary, Sarah E S, additional, Carle, Adam, additional, Lane, Adam, additional, Drissi, Rachid, additional, Stewart, Clinton, additional, and Fouladi, Maryam, additional

Published
2022
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13. EPCT-05. Phase Ib study of unesbulin (PTC596) in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) and high-grade glioma (HGG): A report from the COllaborative Network for NEuro-Oncology Clinical Trials (CONNECT)

Author

Lazow, Margot A, primary, Baxter, Patricia, additional, Stanek, Joseph, additional, Lane, Adam, additional, Rodriguez, Diana P, additional, Kumar, Shiva Senthil, additional, Leach, James L, additional, Mikael, Leonie, additional, Fuller, Christine, additional, Boué, Daniel R, additional, Pierson, Christopher R, additional, Thomas, Diana, additional, Breneman, John, additional, Palmer, Joshua, additional, Li, Xiao-Nan, additional, Salloum, Ralph, additional, Ashley, David, additional, de Blank, Peter, additional, Hwang, Eugene, additional, Leary, Sarah E S, additional, Plant, Ashley, additional, Crabtree, Dorothy, additional, Wahba, Mona, additional, Weetall, Marla, additional, Baird, John, additional, Leonard, Jeffrey, additional, Stewart, Clinton F, additional, Mardis, Elaine, additional, Fouladi, Maryam, additional, and Drissi, Rachid, additional

Published
2022
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14. Limitations of radiosensitization by direct telomerase inhibition to treat high-risk medulloblastoma.

Author

Sengupta, Satarupa, Kumar, Shiva Senthil, Bondra, Kathryn, Sobo, Matthew, Xiaokui Mo, and Drissi, Rachid

Subjects
TELOMERASE, CEREBELLAR tumors, MEDULLOBLASTOMA, RADIATION-sensitizing agents, IONIZING radiation, CANCER relapse
Abstract

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. Previous studies have elucidated the genomic landscape of MB leading to the recognition of four core molecular subgroups (WNT, SHH, group 3 and group 4) with distinct clinical outcomes. Group 3 has the worst prognosis of all MB. Radiotherapy (RT) remains a major component in the treatment of poor prognosis MB but is rarely curative alone and is associated with acute and longterm toxicities. A hallmark of cancer cells is their unlimited proliferative potential which correlates closely with telomere length. The vast majority of malignant tumors activate telomerase to maintain telomere length, whereas this activity is barely detectable in most normal human somatic tissues, making telomerase inhibition a rational therapeutic target in the setting of cancer recurrence and therapy resistance. We and others have previously shown that short telomeres confer sensitivity to ionizing radiation (IR) suggesting that telomerase inhibition mediated telomere shortening will improve the efficacy of RT while minimizing its side effects. Here, we investigated the efficacy of the combination of IR with IMT, a potent telomerase inhibitor, in an in vivo model of group 3 MB. Our results indicate that although IMT inhibited MB telomerase activity resulting in telomere shortening and delayed tumor growth, the combination with IR did not prevent tumor recurrence and did not improve survival compared to the treatment with IR alone. Together, these findings suggest that the radiosensitization by direct telomerase inhibition is not an effective approach to treat high-risk pediatric brain tumors. [ABSTRACT FROM AUTHOR]

Published
2023
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15. OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes

Author

Liao, Yunfei, primary, Luo, Zaili, additional, Deng, Yaqi, additional, Zhang, Feng, additional, Rao, Rohit, additional, Wang, Jiajia, additional, Xu, Lingli, additional, Kumar, Shiva Senthil, additional, Sengupta, Satarupa, additional, DeWire-Schottmiller, Mariko, additional, Berry, Kalen, additional, Garrett, Matthew, additional, Fouladi, Maryam, additional, Drissi, Rachid, additional, and Lu, Qing Richard, additional

Published
2021
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17. EPCT-19. A PHASE I STUDY OF RIBOCICLIB AND EVEROLIMUS FOLLOWING RADIATION THERAPY IN CHILDREN WITH NEWLY DIAGNOSED NON-BIOPSIED DIFFUSE PONTINE GLIOMAS (DIPG) AND RB+ BIOPSIED DIPG AND HIGH GRADE GLIOMAS (HGG)

Author

DeWire, Mariko, primary, Leach, James, additional, Fuller, Christine, additional, de Blank, Peter, additional, Hummel, Trent, additional, Pillay-Smiley, Natasha, additional, Salloum, Ralph, additional, Stevenson, Charles, additional, Drissi, Rachid, additional, Kumar, Shiva Senthil, additional, Baxter, Patricia, additional, Gass, David, additional, Goldman, Stewart, additional, Leary, Sarah, additional, Lane, Adam, additional, Campagne, Olivia, additional, Stewart, Clinton, additional, and Fouladi, Maryam, additional

Published
2020
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18. Phase I study of ribociclib and everolimus in children with newly diagnosed DIPG and high-grade glioma: A CONNECT pediatric neuro-oncology consortium report.

Author

DeWire, Mariko, Lazow, Margot, Campagne, Olivia, Leach, James, Fuller, Christine, Kumar, Shiva Senthil, Stanek, Joseph, de Blank, Peter, Hummel, Trent R., Pillay-Smiley, Natasha, Salloum, Ralph, Stevenson, Charles B., Baxter, Patricia, Gass, David, Goldman, Stewart, Leary, Sarah E. S., Carle, Adam, Mikael, Leonie, Crabtree, Dorothy, and Chaney, Brooklyn

Published
2022
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24. TMOD-10. INTRACRANIAL PATIENT-DERIVED XENOGRAFT FROM A PEDIATRIC GLIOBLASTOMA RETAINS MOLECULAR CHARACTERISTICS AND GROWTH PATHWAYS

Author

White, Angela R., primary, Kumar, Shiva Senthil, additional, Smith, Amanda R., additional, Ramkissoon, Annmarie, additional, Oatman, Nicole, additional, Dasgupta, Biplab, additional, Breese, Erin H., additional, Stevenson, Charles, additional, Fuller, Christine, additional, Fouladi, Maryam, additional, DeWire, Mariko D., additional, Drissi, Rachid, additional, and Chow, Lionel M.L., additional

Published
2017
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27. Erratum: Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

Author

Hoffman, Lindsey M., primary, DeWire, Mariko, additional, Ryall, Scott, additional, Buczkowicz, Pawel, additional, Leach, James, additional, Miles, Lili, additional, Ramani, Arun K., additional, Brudno, Michael, additional, Kumar, Shiva Senthil, additional, Drissi, Rachid, additional, Dexheimer, Phillip, additional, Salloum, Ralph, additional, Chow, Lionel, additional, Hummel, Trent, additional, Stevenson, Charles, additional, Lu, Q. Richard, additional, Jones, Blaise, additional, Witte, David, additional, Aronow, Bruce, additional, Hawkins, Cynthia E., additional, and Fouladi, Maryam, additional

Published
2016
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28. Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics

Author

Hoffman, Lindsey M., primary, DeWire, Mariko, additional, Ryall, Scott, additional, Buczkowicz, Pawel, additional, Leach, James, additional, Miles, Lili, additional, Ramani, Arun, additional, Brudno, Michael, additional, Kumar, Shiva Senthil, additional, Drissi, Rachid, additional, Dexheimer, Phillip, additional, Salloum, Ralph, additional, Chow, Lionel, additional, Hummel, Trent, additional, Stevenson, Charles, additional, Lu, Q. Richard, additional, Jones, Blaise, additional, Witte, David, additional, Aronow, Bruce, additional, Hawkins, Cynthia E., additional, and Fouladi, Maryam, additional

Published
2016
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