Search

Recent studies have shown that the present limited antifungal arsenal and the high toxicity of the chemicals toward the high rates of morbidity and death driven on by fungal infections. Furthermore, because human and fungal cells have many similarities, it might be difficult to find new therapeutic targets. Mycoses are fungal illnesses that can affect the skin, nails, body hair, internal organs including the lungs, and bodily systems like the neurological system. In the current investigation, a molecule called 4-aminobenzoic acid 4-nitroaniline that was identified through certain FT-IR and UV spectral studies. Suitable basis sets were used to study the molecular geometry. Based on the PED results, vibrational assignments have been created for all vibrational modes. The NBO analysis was used to investigate the molecular stability and bond strength, which are relevant for bioactivities. Through NCI and IRI investigations, the chemical interactions inside the molecule were examined. Molecular docking research was carried out using the anti-fungal proteins after NABA was screened for its anti-fungal activity to validate the substance's powerful anti-fungal action against pathogenic fungi. The pharmokinetic properties were expected to be determined by drug likeness and the ADMET parameters. Accordingly, the NABA molecule is recommended for the anti-fungal medications. [ABSTRACT FROM AUTHOR]

Background: Empirical studies in competence are lacking in the field of Drug dose calculation. Objective:To construct a clinical guideline for drug dose calculation and to enhance the comprehension of the forthcoming nursing students. Methods: Two rounds of the Delphi method were used. Data were analyzed by content analysis and with descriptive statistics. Results: After two sequential sessions of discussion by the Delphi method, a clinical guideline for Drug dose Calculation was constructed. This guideline includes the formulas for Drug dose Calculations. The reliability was achieved by Median and Consensus percentage. Conclusions:We constructed a clinical guideline for palliative sedation therapy using the Delphi technique. The clinical efficacy of this guideline should be tested in the future. [ABSTRACT FROM AUTHOR]

The defect classification of knitted fabrics is a challenging area of research. Most of the defect detection works in India; Bangladesh is being carried by manually trained inspectors. The long working hours and the working environment at the company induces the fatigue, lack of concentration, and triteness to the workers due to this they may not able to detect the defects on the clothes after it is manufactured. To overcome this problem, a computer-aided defect detection system is being developed using digital image processing and artificial neural Network methods. The two types of artificial neural networks were applied to compare the results obtained. The networks were: a back propagation based feed forward neural network and the other was Levenberg–Marquardt (LM) algorithm based back propagation network. Experimental results predicted detection of a high degree of variety of fabric defects. [ABSTRACT FROM AUTHOR]

Purpose: This systematic review was undertaken to establish the most favourable protocol to treat an edentulous mandible with a single implant‐retained overdenture. The formulated PICO question was: "Which surgical and prosthetic protocols result in the highest survival and complication rates of implants and prostheses employed in a single implant retained overdenture for the rehabilitation of a completely edentulous mandibular ridge?" Materials and Methods: A structured literature search was conducted using the following databases; PubMed, ScienceDirect, COCHRANE, LILACS, IndeMED, OVID, EMBASE, NIH Clinical Trials for reports related to the single implant‐retained overdenture treatment. Only English articles were included. Publications with a minimum follow up time of 1 year and above were included for meta‐analysis. A Poisson regression model was applied to estimate the survival rates of the implant and prosthesis employed. Results: The electronic database search yielded 2083 titles and abstracts; and a total of 17 were selected for the systematic review, of which 11 studies were subjected to meta‐analysis. The implants showed high estimated five and 10‐year survival rates of 91.93% and 84.62%, respectively. Implants that were delayed loaded showed the greatest survival rates, while immediately loaded implants presented with higher survival rates at five (p = 0.849) and 10 years (p = 0.464) when compared to early loaded implants. The greatest number of fractures were associated with ball abutments with an event rate of 10.8 (95% CI: 10.5‐11.09) per 100 prosthesis years, while locator abutments showed a greater number of maintenance events with an event rate of 16.84(95% CI:16.01‐17.66) per 100 prosthesis years. Conclusion: Single implant‐retained overdenture treatment is a cost‐effective, minimally invasive and simple treatment that can be used to restore function and aesthetics to edentulous patients, with relatively high implant and prosthesis success rates and minimal complications. [ABSTRACT FROM AUTHOR]

Background: The physiologically mobile natural tooth and rigidly fixed dental implant causes different distribution of stress when connected in prosthesis and nonrigid connector compensates this. Understanding of biomechanical behavior is necessary for an adequate choice and construction of this type of rehabilitation. However, there has been insufficient research focusing on different location and type of the nonrigid connector related with the prognosis of both implant and the tooth.Aim of the Study: The purpose of this finite element (FE) analysis was to evaluate the stress distribution around bone, implant, and tooth in tooth implant fixed prosthesis under static load with variations in design and location of nonrigid connectors under simulated functional loads.Materials and Method: Three, 3-dimensional FE models connecting tooth and implant were constructed with different location and type of nonrigid connector. Simulated occlusal load was applied on the restorations and stresses developed in the supporting structures were monitored.Results: The highest stresses were found around the implant in model with nonrigid connector placed between the tooth and implant and model with modified nonrigid connector. On the other hand, less stress was noted around the implant where nonrigid connector was placed between the implant and pontic.Conclusion: It is advisable to place the nonrigid connector between the implant and the pontic to protect the implant from torque effects in a tooth implant fixed prosthesis. [ABSTRACT FROM AUTHOR]