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According to molecular docking results (in silico calculations), main protease Mpro of SARS-CoV-2 coronavirus can be blocked by 2-formyl-8-methyl-3-carbethoxy quinoline. The calculations as well as estimation of ADME profile (absorption, distribution, metabolism, and excretion) of this compound provide grounds to consider it as active ingredient against COVID-19 coronavirus, its efficiency is comparable with known inhibitors of SARS-CoV-2. The structure of 2-formyl-8-methyl-3-carbethoxy quinoline is determined by X-ray structure analysis. [ABSTRACT FROM AUTHOR]

Estimation of stature plays a major role in the field of Forensic Medicine and anthropometry especially helps in establishing the identity of an individual from mutilated, decomposed and amputated body parts. In our study, stature was estimated from the percutaneous length of ulna. Study sample consisted of 96 adult males and 66 adult females between the age group of 18 - 22 years, born and brought up in Chennai. The length of the of the right and left ulna was measured with a vernier caliper from the tip of the olecranon to the styloid process and the height of the individual was measured with a calibrated stadiometer. The measurements were noted in the proforma. The data was statistically analyzed and linear regression formulae were derived. [ABSTRACT FROM AUTHOR]

This study demonstrates the design, synthesis and sensing applications of a simple and efficient chemosensor, 2-(1,3-dioxo-1H-inden-2(3H)-ylidene)hydrazinecarbothioamide (R) for quick detection of Hg2+ and F− in aqueous media using a colorimetric test, UV–Vis spectral analysis, and silica gel support. Sensor R showed the typical absorption peak at 305 nm for Hg2+ which is responsible for color change from yellow to colorless, while in the case of F−, R exhibits a major peak at 415 nm and a color change from yellow to red. The limit of detection (LOD) of R for the analysis of Hg2+ was calculated as 1×10−6 M while for F−, it was found to be 3.4×10−7 M. The binding modes of R with Hg2+ and F− have been investigated by the Job’s plot, Benesi–Hildebrand (BH) method, 1H NMR, FTIR and theoretical studies. The sensor R was reversible after treating it with reagents such as EDTA and calcium nitrate solution after contacting with Hg2+ and F−, respectively. The performance of R can be successfully applied for the analysis of F− contents present in toothpastes. A simple and efficient receptor ninhydrin-based Schiff’s base (R) for quick detection of Hg2+ and F− in aqueous medium using colorimetric and UV–Vis spectral analyses. [ABSTRACT FROM AUTHOR]

A new dibutyl(2-oxo-2-(quinolin-8-ylamino)ethyl)phosphinate (L) was designed, synthesised and developed as a light activated optode for Th4+ determination. The sensing performance of L was studied in solution and in the polymeric membrane phase using absorbance and emission techniques. The neutral ion carrier L exhibits weak fluorescence at 400 nm in CH3CN : H2O (9 : 1, v/v). Upon complexation of L with Th4+, the emission intensity at 486 nm was increased 100-fold due to chelation induced enhanced fluorescence. The L–Th4+ binding interaction was studied using both Hill's and Job's plots. They indicate the formation of complex species in a 2 : 1 ratio with an estimated binding constant of 2.66 × 104 M−2. Complex formation between L and Th4+ was studied by NMR (1H, 31P), FTIR and LC-MS analyses. In order to synthesize a probe for the sensing of Th4+ in 100% aqueous medium, the optode was prepared by immobilizing L as a neutral ion carrier in a PVC support using dioctyl phthalate (DOP) as a membrane solvent. The best performance of the optode was observed with a membrane composition of PVC : L : NaTPB : DOP in proportions of 35 : 5 : 3 : 57 (%, w/w) in the pH range of 4.0–8.0. The optode can detect Th4+ concentrations down to 1.1 nM with a fast response time of 15 s and the optical response remains unaltered even after 3 months; the optode sensor can be regenerated using Na2EDTA solution. Finally, the optode was used for the quantification of Th4+ in various water samples, monazite sand, and gas mantle samples. [ABSTRACT FROM AUTHOR]

The suggestion is prepared for Particle Swarm Optimization (PSO) Recurrent Neural Network (RNN) based Z-Source Inverter Fed Induction Motor Drive in this document. The proposed method is employed to develop the presentation of the induction motor while decreasing the Total Harmonic Distortion (THD), eliminating the oscillation period of the stator current, torque and speed. Currently, as the input parameters, the PSO technique uses the induction motor speed and reference speed. It optimizes the raise of the PI controller and produces the reference quadrature axis current from the input parameters. By employing the RNN the reference three phase current for accurate control pulses of the voltage source inverter is predicted. The RNN is trained by the input motor actual quadrature axis current and the reference quadrature axis current with the associated target reference three phase current. The training process used the supervised learning process. Next the proposed technique is implemented in the MATLAB/simulink platform and the competence is scrutinized by comparing with the other techniques such as PSO-Radial Biased Neural Network (RBNN) and PSO-Artificial Neural Network (ANN). The comparison results show the superiority of the proposed approach and confirm its potential to effort out the problem. [ABSTRACT FROM AUTHOR]

A new dibutyl(2-oxo-2-(quinolin-8-ylamino)ethyl)phosphinate (L) was designed, synthesised and developed as a light activated optode for Th 4+ determination. The sensing performance of L was studied in solution and in the polymeric membrane phase using absorbance and emission techniques. The neutral ion carrier L exhibits weak fluorescence at 400 nm in CH 3 CN : H 2 O (9 : 1, v/v). Upon complexation of L with Th 4+ , the emission intensity at 486 nm was increased 100-fold due to chelation induced enhanced fluorescence. The L-Th 4+ binding interaction was studied using both Hill's and Job's plots. They indicate the formation of complex species in a 2 : 1 ratio with an estimated binding constant of 2.66 × 10 4 M -2 . Complex formation between L and Th 4+ was studied by NMR ( 1 H, 31 P), FTIR and LC-MS analyses. In order to synthesize a probe for the sensing of Th 4+ in 100% aqueous medium, the optode was prepared by immobilizing L as a neutral ion carrier in a PVC support using dioctyl phthalate (DOP) as a membrane solvent. The best performance of the optode was observed with a membrane composition of PVC : L : NaTPB : DOP in proportions of 35 : 5 : 3 : 57 (%, w/w) in the pH range of 4.0-8.0. The optode can detect Th 4+ concentrations down to 1.1 nM with a fast response time of 15 s and the optical response remains unaltered even after 3 months; the optode sensor can be regenerated using Na 2 EDTA solution. Finally, the optode was used for the quantification of Th 4+ in various water samples, monazite sand, and gas mantle samples.

Background and Objectives: Glycated hemoglobin (HbA1c) provides an accurate and reliable method to assess the glycemic control in patients with Diabetes. Its measurement is limited by the inconvenience of sample collection that requires venipuncture, sample handling and storage factors. The aim of this study was to assess the feasibility of using a dried capillary blood spot on a filter paper to estimate HbA1c, to check its stability at room temperature and to compare these values with the venous sample HbA1c by Turbidimetric Inhibition Immunoassay (TINA, Tina-quant HbA1c II)., Methods: Venous blood samples of seventy eight patients with Type 1 or type 2 diabetes, were collected in EDTA containing vacutainers. Stability of HbA1c was studied in capillary blood samples blotted on to Whatman number 1 filter paper and stored at room temperature, for the first 20 patients enrolled in the study. After establishing the stability over a ten day period, HbA1c values obtained on the capillary blood spots were compared with those obtained from the venous blood samples of the remaining 58 patients., Results: Glycated hemoglobin is found to be stable in dried capillary blood spots on filter paper till the 10th day, stored at room temperature. It however, shows an inherent variability of +/- 15%, which falls within the permissible variability (18%) of the quality control material. Seventy nine percent of the capillary HbA1c values were found to fall within this range. With linear regression, we derived the relationship between filter paper and venous HbA1c values. The regression equation was as follows: Cap.HbA1c = 0.95 (Ven.HbA1c) + 1.4. The filter paper results were highly correlated with the venous sample values (r = 0.889, p < 0.01)., Conclusion: Measurement of glycated hemoglobin in dried blood spots on filter paper gives reliable and reproducible results. In our study, the mean capillary sample HbA1c value was 12% higher compared to the venous sample HbA1c values. Therefore a higher normal range may have to be used for interpreting the dried blood spot capillary blood HbA1c values.