Search

This article discusses the illness and death of President William Henry Harrison in 1841. After taking office, Harrison fell ill with a severe chill and was treated for what was believed to be pneumonia. However, his condition worsened, and he eventually passed away. The exact cause of his illness has been a subject of debate, with some suggesting that he may have had enteric (typhoid) fever. Regardless of the diagnosis, Harrison's death led to a constitutional crisis. [Extracted from the article]

Dr. Thomas E. Starzl, known as the "Father of Transplantation," was a renowned surgeon whose career spanned four decades. He achieved the first successful human liver transplant and made significant contributions to the understanding of immunosuppressants. Despite facing criticism and doubt, Dr. Starzl persevered and performed groundbreaking surgeries, including the first successful pediatric liver transplant and the world's first heart-liver transplant. He authored numerous publications and books throughout his career. Dr. Starzl's work has had a profound impact on the field of transplantation, and his legacy continues to influence transplant surgeons worldwide. [Extracted from the article]

Background: New or worsened mitral regurgitation (MR) is an uncommon yet serious complication after surgical aortic valve replacement (SAVR). While there have been numerous reports of its occurrence, there is little consensus regarding its presentation and management. This systematic review summarizes the evidence in the current literature surrounding new or worsened MR after SAVR and analyzes its potential implications. Methods: Databases were examined for all articles and abstracts reporting on new or worsened MR after SAVR. Data collected included number of patients studied; patient characteristics; incidences of new or worsened MR; timing of diagnosis; and treatment. Results: Thirty-six full-text citations were included in this review. The prevalence of new or worsened MR after SAVR was 8.4%. Sixteen percent of new MR occurrences were from an organic etiology, and 83% of new MR occurrences were that of a functional etiology. Most diagnoses were made in the late or unspecified postoperative period using echocardiography (range: 0 minutes to 18 years postoperatively). While no patients died from this complication, 7.7% of patients (16 out of 207) required emergent procedural re-intervention. Conclusions: This systematic review underscores the importance of identifying new or worsened MR following SAVR and accurate scoring of MR severity to guide treatment. It also outlines the associated clinical measures commonly documented following this complication, and the usefulness of transesophageal echocardiography for the detection of significant MR. These results reflect the current, limited state of the literature on this topic and warrant further investigation into MR detection and management strategies in SAVR patients. [ABSTRACT FROM AUTHOR]

Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.