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Peritoneal carcinomatosis is a common evolution in ovarian cancers. Although majority of patients have option of cytoreductive surgery and HIPEC, a few with recurrent cancers who are not eligible for curative approach can undergo pressurized intraperitoneal aerosol chemotherapy (PIPAC) which is an emerging field of research with major therapeutic potential. It is a safe and innovative approach, which enhances the effect of chemotherapy without major toxicity. Between June 2017 and December 2017, 9 PIPAC applications in 3 patients with pressurized aerosol solution of cisplatin and doxorubicin every 6 weeks at 37 °C and 12 mmHg for 30 min were performed. The patient demographics, perioperative findings, adverse events, and outcomes were prospectively recorded. Nine PIPAC administrations were performed in 3 patients with peritoneal carcinomatosis secondary to ovarian cancer. The median hospital stay was 1 day. There were no major perioperative complications. CTCAE grade 2 was observed in 1 patient, for abdominal pain and nausea. Renal and hepatic functions were not impaired. Of the 3 patients, two patients had partial response, and one had stable disease. Our results show the feasibility and safety of PIPAC in Indian patients with advanced ovarian cancer. The procedure has low morbidity with no mortality with short learning curve. It can be easily adopted as a palliative option apart from systemic chemotherapy.

An investigation was undertaken by the Indiana Division of Reclamation (DOR) on behalf of the Indiana Department of Insurance (DOI) to determine if mine subsidence due to old underground works was resulting in structural damage to a residential structure in Alfordsville, Indiana. The owner had alleged that subsidence was causing damage to the structure and had filed a claim under the Indiana Mine Subsidence Insurance Fund. Previous reports that addressed the damage to the owner`s house and their possible causes are summarized. Core drilling, gamma logs, borehole TV camera observations, and elevation surveys indicated no evidence of mine workings in the two coal seams present below the owner`s house. The rock cores showed no signs of disturbance that would be expected if a mine collapse had occurred at shallow depth and progressed to the surface. The gamma logs were in agreement with core descriptions. Elevation measurements of points on the house indicated a continuing differential settlement of the house; surface elevation measurements in the vicinity of the house did not exhibit such a consistent trend. It is the authors` opinion that the observed indications of continuing differential settlement are due to local soil conditions and non-engineered construction modifications without regardmore » to subsoil conditions.« less