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In response to the enhancing utilization of technologies and the present state of the field, this study aims to explore the E-learning revolution in Higher Educational institutes in India. Through a systematic review using bibliometric methods, data mining, and analytics, a total of 293 publications were examined. The study reveals a consistent growth in research on E-learning, particularly in recent years, with the USA, China, and India in this field. The primary contributors to this research area are Education and Information Technology, followed by an International review of research in open and distance. This study employs the Scopus database to identify trends in publications, influential papers, key themes, and keywords. It also explores futuristic themes and target concepts. The average citation value over three years stands at 6.768. Issues In Information Systems, T and D and Developments In Marketing Science: Proceedings Of The Academy Of Marketing Science. Research has shown that it is effective in increasing the effectiveness of e-learning in educational settings, especially in the areas of organizational behavior, corporate professionals, training and development, and finance, among others. It makes significant contributions to topics like financial crises, sustainability, COVID-19 issues, team challenges, organizational conflicts, and digital transformation. The study recognizes its limitations and explores possible directions for future investigation.The findings also highlight crucial research gaps, underscoring the need for further investigations. This knowledge can inform the development of strategic approaches to tackle challenges and leverage opportunities related to E-learning in higher educational institutes. Ultimately, the study aims to provide insights for strategies that support the advancement of E-Learning

The cobalt-based full Heusler alloy Co2MnGa (CMG) is well known for exhibiting an exotic phenomenon such as magnetic Weyl semimetallic nature with a high Curie temperature of ∼700 K and a giant anomalous Hall effect. Here, we report a detailed study of structural, electrical, and magnetic properties of Co2MnGa thin films (thickness in the 40–10 nm range) grown on Si(100) by the direct-current magnetron co-sputtering technique using Co and MnGa targets. Structural analysis of the samples revealed the polycrystalline nature of these films with B2 type structural ordering. The damping parameter decreases with the increase in film thickness and reaches the minimum value of 6.1 × 10−3 for a 40 nm thin CMG film. These CMG films are magnetically isotropic and soft ferromagnetic in nature. A remarkably high value of anomalous Hall conductivity (AHC) of 1920 S/cm (2 K) is found for the 40 nm thin film, which is comparable to earlier reported values on highly ordered CMG films. Nearly 73% of this AHC value originates from the intrinsic contribution. The AHC and longitudinal conductivity both increase with the film thickness. Different scaling mechanisms are used to compute the intrinsic and extrinsic contributions playing a role in AHC. The analysis of advanced scaling [by Tian et al., Phys. Rev. Lett. 103, 1–4 (2009)] performed on these CMG films suggests the consistency in the enhanced intrinsic AHC value irrespective of the thickness and a decrease in skew scattering contribution with thickness. These results will enhance the understanding about the magnetic and transport properties of Co2MnGa thin films of different thicknesses and suggest it to be a promising material for topospintronic applications. [ABSTRACT FROM AUTHOR]

Introduction. Chronic persistent device-related infections (DRIs) often give culture-negative results in a microbiological investigation. In such cases, investigations on the device metagenome might have a diagnostic value. Materials and Methods. The 16SrRNA gene sequence analysis and next-generation sequencing (NGS) of clinical metagenome were performed to detect bacterial diversity on invasive medical devices possibly involved in culture-negative DRIs. Device samples were first subjected to microbiological investigation followed by metagenome analysis. Environmental DNA (e-DNA) isolated from device samples was subjected to 16SrRNA gene amplification followed by Sanger sequencing (n=14). In addition, NGS of the device metagenome was also performed (n=12). Five samples were only common in both methods. Results. Microbial growth was observed in only nine cases; among these, five cases were considered significant growth, and in the remaining four cases, growth was considered either insignificant or contaminated. Culture and sequencing analysis yielded identical results only in six cases. In culture-negative cases, Sanger sequencing of 16SrRNA gene and NGS of 16SrDNA microbiome was able to identify the presence of rarely described human pathogens, namely Streptococcus infantis, Gemella haemolysans, Meiothermus silvanus, Schlegelella aquatica, Rothia mucilaginosa, Serratia nematodiphila, and Enterobacter asburiae, along with some known common nosocomial pathogens. Bacterial species such as M. silvanus and S. nematodiphila that are never reported in human infection were also identified. Conclusions. Results of a small number of diverse samples of this pilot study might lead to a path to study a large number of device samples that may validate the diversity witnessed. The study shows that a culture free, a holistic metagenomic approach using NGS could help identify the pathogens in culture-negative chronic DRIs.

Identification of disease and therapeutic biomarkers remains a significant challenge in the early diagnosis and effective treatment of juvenile idiopathic arthritis (JIA). In this study, plasma metabolomic profiling was conducted to identify disease-related metabolic biomarkers associated with JIA. Plasma samples from treatment-naïve JIA patients and non-JIA reference patients underwent global metabolomic profiling across discovery (60 JIA, 60 non-JIA) and replication (49 JIA, 38 non-JIA) cohorts. Univariate analysis identified significant metabolites (q-value ≤ 0.05), followed by enrichment analysis using ChemRICH and metabolic network mapping with MetaMapp and Cytoscape. Receiver operating characteristic (ROC) analysis determined the top discriminating biomarkers based on area under the curve (AUC) values. A total of over 800 metabolites were measured, consisting of 714 known and 155 unknown compounds. In the discovery cohort, 587 metabolites were significantly altered in JIA patients compared with the reference population (q < 0.05). In the replication cohort, 288 metabolites were significantly altered, with 78 overlapping metabolites demonstrating the same directional change in both cohorts. JIA was associated with a notable increase in plasma levels of sphingosine metabolites and fatty acid ethanolamides and decreased plasma levels of sarcosine, iminodiacetate, and the unknown metabolite X-12462. Chemical enrichment analysis identified cycloparaffins in the form of naproxen and its metabolites, unsaturated lysophospholipids, saturated phosphatidylcholines, sphingomyelins, ethanolamines, and saturated ceramides as the top discriminating biochemical clusters. ROC curve analysis identified 11 metabolites classified as highly discriminatory based on an AUC > 0.90, with the top discriminating metabolite being sphinganine-1-phosphate (AUC = 0.98). This study identifies specific metabolic changes in JIA, particularly within sphingosine metabolism, through both discovery and replication cohorts. Plasma metabolomic profiling shows promise in pinpointing JIA-specific biomarkers, differentiating them from those in healthy controls and Crohn's disease, which may improve diagnosis and treatment. [ABSTRACT FROM AUTHOR]

Simple Summary: Aphids are phloem feeders and are one of the most destructive pests of crop plants. Lipaphis erysimi is a specialist aphid that infests members of the Brassicaceae family and has detrimental impacts on the yield of oilseed and vegetable Brassicas in the Indian subcontinent. Recognising the critical need for developing aphid control strategies, we aimed to enhance the pool of gene targets for RNAi for developing resistance in Brassica crop plants against L. erysimi infestation. To understand the variations in expression profiles of genes while the aphid is feeding upon the host plant, as well as between two developmental stages (adults and nymphs), we conducted a two-way transcriptome-based differential expression analysis between feeding and non-feeding adults and between adults and nymphs. This led to the identification of important transcripts involved in detoxification, feeding, metabolism and aphid development. Our study provides valuable insights into the molecular mechanisms underlying feeding and development in aphids. It also generated an important resource for further research on aphid biology and for developing effective RNAi-based strategies for pest management and control. Lipaphis erysimi is a specialist aphid of the Indian subcontinent that causes significant yield losses in oilseed Brassicas. Several aphid genes have been used as preferred targets in RNAi-based transgenic plants for aphid resistance. In order to enhance the repertoire of potential target genes for aphid control and to identify the genes associated with aphid feeding and development, we performed a two-way comparative study of differential gene expression profiles between (i) feeding and non-feeding adults and (ii) adult and nymph developmental stages of L. erysimi. De novo RNA-seq of aphids using Illumina technology generated a final transcriptome comprising 52,652 transcripts. Potential transcripts for host selection, detoxification, salivary proteins and effectors, molecular chaperones and developmental genes were identified. Differential gene expression studies identified variations in the expression of 1502 transcripts between feeding and non-feeding adults and 906 transcripts between nymphs and adults. These data were used to identify novel target genes for RNAi-based aphid control and facilitate further studies on the molecular basis of aphid feeding and development. [ABSTRACT FROM AUTHOR]

The spin-pumping behavior in the as-deposited and post-deposition annealed (at 400 °C) Co60Fe20B20/Molybdenum (CoFeB/Mo) heterostructures is investigated. It is found that while in both the as-deposited and annealed CoFeB/Mo heterostructures, Mo crystallizes in the form of mixed phases, i.e., body centered cubic (bcc) and face centered cubic (fcc), the dominance, however, changes from fcc to bcc on annealing. The ferromagnetic resonance measurements reveal that despite relatively low spin orbit coupling of Mo, the spin-pumping efficiency and magnetic properties in both the as-deposited as well as in the annealed heterostructures was comparable with those reported in similar CoFeB based heterostructures comprising of other nonmagnetic metals such as W and Ta. The spin efficiency parameters are, however, slightly better when the Mo film is predominantly in the fcc phase as compared to the case when the Mo film dominantly comprises of the bcc phase. The different spin-pumping efficiencies in the two different combinations of phases of Mo are attributed to the different band structures and the density of states in different phases of Mo, as confirmed by density functional theory calculations. The slight changes observed in the spin-pumping response are possibly attributed to the structural manifestations that result at the interface that the two phases of Mo share with CoFeB. Importantly, despite the weak spin–orbit interaction, the 4d transition metal Mo could be a suitable choice of non-magnetic material for spin pumping when the thermal stability of different layers in the CoFeB based spintronic devices is of paramount concern. [ABSTRACT FROM AUTHOR]

India has implemented the Goods and Services Tax, an indirect tax, to help and promote the nation's economic expansion. The Goods and Services Tax Bill has been enacted in the majority of developed nations. In India, GST was established in 1999. A committee was set up to design the model of GST. But GST was re-launched on 1 July 2017 by the Indian government. There was a lot of uproar in favor of its introduction. All of the different taxes levied by the federal and state governments were replaced with the GST. The phrase "One Nation, One Tax" refers to the fact that all taxes must be paid in one location nationwide. The report thoroughly examines the effects of GST in India. The study offers sentiment analysis and bibliometric visualization of GST. It was discovered that the government implemented the GST in order to tax everyone in the nation and stop the flow of illicit money. However, it was noted that many Indian residents' feelings were conflicted. Therefore, it is advised to review the structure and maintain a focus on ongoing development. [ABSTRACT FROM AUTHOR]