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15 results on '"Kulyova, S. A."'

6. Geographical Distribution, Incidence, Malignancies, and Outcome of 136 Eastern Slavic Patients With Nijmegen Breakage Syndrome and NBN Founder Variant c.657_661del5

Author

Sharapova, S. O., Pashchenko, O. E., Bondarenko, A. V., Vakhlyarskaya, S. S., Prokofjeva, T., Fedorova, A. S., Savchak, I., Mareika, Y., Valiev, T. T., Popa, A., Tuzankina, I. A., Vlasova, E. V., Sakovich, I. S., Polyakova, E. A., Rumiantseva, N. V., Naumchik, I. V., Kulyova, S. A., Aleshkevich, S. N., Golovataya, E. I., Minakovskaya, N. V., Belevtsev, M. V., Latysheva, E. A., Latysheva, T. V., Beznoshchenko, A. G., Akopyan, H., Makukh, H., Kozlova, O., Varabyou, D. S., Ballow, M., Ong, M. -S., Walter, J. E., Kondratenko, I. V., Kostyuchenko, L. V., Aleinikova, O. V., Sharapova, S. O., Pashchenko, O. E., Bondarenko, A. V., Vakhlyarskaya, S. S., Prokofjeva, T., Fedorova, A. S., Savchak, I., Mareika, Y., Valiev, T. T., Popa, A., Tuzankina, I. A., Vlasova, E. V., Sakovich, I. S., Polyakova, E. A., Rumiantseva, N. V., Naumchik, I. V., Kulyova, S. A., Aleshkevich, S. N., Golovataya, E. I., Minakovskaya, N. V., Belevtsev, M. V., Latysheva, E. A., Latysheva, T. V., Beznoshchenko, A. G., Akopyan, H., Makukh, H., Kozlova, O., Varabyou, D. S., Ballow, M., Ong, M. -S., Walter, J. E., Kondratenko, I. V., Kostyuchenko, L. V., and Aleinikova, O. V.

Abstract

Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and a high predisposition to lymphoid malignancies. The majority of NBS patients are identified with a homozygous five base pair deletion in the Nibrin (NBN) gene (c.657_661del5, p.K219fsX19) with a founder effect observed in Caucasian European populations, especially of Slavic origin. We present here an analysis of a cohort of 136 NBS patients of Eastern Slav origin across Belarus, Ukraine, Russia, and Latvia with a focus on understanding the geographic distribution, incidence of malignancy, and treatment outcomes of this cohort. Our analysis shows that Belarus had the highest prevalence of NBS (2.3 per 1,000,000), followed by Ukraine (1.3 per 1,000,000), and Russia (0.7 per 1,000,000). Of note, the highest concentration of NBS cases was observed in the western regions of Belarus and Ukraine, where NBS prevalence exceeds 20 cases per 1,000,000 people, suggesting the presence of an “Eastern Slavic NBS hot spot.” The median age at diagnosis of this cohort ranged from 4 to 5 years, and delay in diagnosis was more pervasive in smaller cities and rural regions. A total of 62 (45%) patients developed malignancies, more commonly in males than females (55.2 vs. 34.2%; p=0.017). In 27 patients, NBS was diagnosed following the onset of malignancies (mean age: 8 years). Malignancies were mostly of lymphoid origin and predominantly non-Hodgkin lymphoma (NHL) (n=42, 68%); 38% of patients had diffuse large B-cell lymphoma. The 20-year overall survival rate of patients with malignancy was 24%. However, females with cancer experienced poorer event-free survival rates than males (16.6% vs. 46.8%, p=0.036). Of 136 NBS patients, 13 underwent hematopoietic stem cell transplantation (HSCT) with an overall survival of 3.5 years following treatment (range: 1 to 14 years). Indications for HSCT included malignancy (n=7) and immunodeficiency (n=6). Overall, 9% of patients in this cohort reac

Published
2021

13. Combustion of Carbon Black Catalyzed by Transition Metal-Promoted Y2O3–CeO2–ZrO2 Solid Solutions1.

Author

Lamonier, J. F., Kulyova, S. P., Zhilinskaya, E. A., Kostyuk, B. G., Lunin, V. V., and Aboukaïs, A.

Subjects
*COMBUSTION, *CARBON, *TRANSITION metals, *SOLID solutions, *CATALYSIS, *SPECTRUM analysis
Abstract

The activity of M-free and M-loaded 10YO1.5–10CeO2–80ZrO2 solid solution (M = Cu, V, or W) towards carbon black combustion was studied using TG/DTA and TPO techniques. It was demonstrated that all studied catalysts lower the temperature of carbon black combustion. The selectivity of the catalytic reaction in CO2 formation was 100%. It was evidenced that the fast oxidation of carbon at lower temperatures, observed only in the TG/DTA apparatus, was due to heat- and mass-transfer limitations, resulting in a runaway reaction. Using TPR technique, it was shown that, in the temperature range of DTA curve, oxygen on the catalyst surface was rather reactive (and, therefore, it could be easily released by support for the oxidation of carbon), whereas the reactivity of bulk oxygen was negligible. The activity of the metal-loaded 10YO1.5–10CeO2–80ZrO2 (Y-10) samples varied according to the following sequence: Cu/Y-10 > V/Y-10 > W/Y-10. For Cu- and V-containing catalysts, a contribution of a surface redox mechanism in reaction was proposed by comparing EPR spectra of pure catalysts with those of the samples (catalysts mixed with carbon black) after catalysis. [ABSTRACT FROM AUTHOR]

Published
2004
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14. Combustion of Carbon Black Catalyzed by Transition Metal-Promoted Y2O3–CeO2–ZrO2 Solid Solutions1.

Author

Lamonier, J. F., Kulyova, S. P., Zhilinskaya, E. A., Kostyuk, B. G., Lunin, V. V., and Aboukaïs, A.

Subjects
COMBUSTION, CARBON, TRANSITION metals, SOLID solutions, CATALYSIS, SPECTRUM analysis
Abstract

The activity of M-free and M-loaded 10YO1.5–10CeO2–80ZrO2 solid solution (M = Cu, V, or W) towards carbon black combustion was studied using TG/DTA and TPO techniques. It was demonstrated that all studied catalysts lower the temperature of carbon black combustion. The selectivity of the catalytic reaction in CO2 formation was 100%. It was evidenced that the fast oxidation of carbon at lower temperatures, observed only in the TG/DTA apparatus, was due to heat- and mass-transfer limitations, resulting in a runaway reaction. Using TPR technique, it was shown that, in the temperature range of DTA curve, oxygen on the catalyst surface was rather reactive (and, therefore, it could be easily released by support for the oxidation of carbon), whereas the reactivity of bulk oxygen was negligible. The activity of the metal-loaded 10YO1.5–10CeO2–80ZrO2 (Y-10) samples varied according to the following sequence: Cu/Y-10 > V/Y-10 > W/Y-10. For Cu- and V-containing catalysts, a contribution of a surface redox mechanism in reaction was proposed by comparing EPR spectra of pure catalysts with those of the samples (catalysts mixed with carbon black) after catalysis. [ABSTRACT FROM AUTHOR]

Published
2004
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15. [Predictive value of Hodgkin's lymphoma tumor burden in present].

Author

Kulyova SA and Karitsky AP

Subjects
Adolescent, Child, Combined Modality Therapy, Drug Resistance, Neoplasm, Humans, Positron-Emission Tomography, Predictive Value of Tests, Prognosis, Risk Assessment, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hodgkin Disease pathology, Hodgkin Disease therapy, Tumor Burden
Abstract

Today approximately 70% of patients with Hodgkin lymphoma can be cured with the combined-modality therapy. Tumor burden, the importance of which was demonstrated 15 years ago for the first time, is a powerful prognostic factor. Data of literature of representations on predictive value of Hodgkin's lymphoma tumor burden are shown in the article. The difficult immunological relations between tumor cells and reactive ones lead to development of the main symptoms. Nevertheless, the collective sign of tumor burden shows the greatest influence on survival and on probability of resistance, which relative risk can be predicted on this variable and treatment program. Patients with bulky disease need escalated therapy with high-dose chemotherapy. Integration into predictive models of the variable will change an expected contribution of clinical and laboratory parameters in the regression analyses constructed on patients with Hodgkin's lymphoma. Today the role of diagnostic functional methods, in particular a positron emission tomography, for metabolic active measurement is conducted which allows excluding a reactive component.

Published
2014

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