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The present investigation entitled “Effect of shoot pruning intensity and sowing direction on growth and yield of green gram (Vigna radiata L.) under bael (Aegle marmelos L.) based Agri-horti system in Vindhyan region” was conducted during the Kharif season of 2015-2016 at Agricultural Research Farm, R.G.S.C. (BHU), Barakachha, Mirzapur (U. P.).The experiment was conducted in 9 year old bael orchard planted in 7x7 meter spacing. The experiment was laid out in randomized complete block design with agri- horti system (fruit based Agroforestry system) i.e bael agri-horti system. Factorial experiment was laid out in randomized complete block design having four different intensity of pruning (i.e. control, 25%, 50% and 75%) and two different level of sowing direction (North-South and East-West). Treatments were replicated thrice. Results revealed that all the growth, yield attributes, yields were increased significantly with the increasing intensity of pruning 75% pruning significantly higher growth characters like plant height (cm), dry matter accumulation (g plant-1) trifoliate leaves, branches plant-1 and root nodules plant-1as well as yield and yield attributes like pods plant-1, number of grains pod-1, 1000-grains weight and yield of grain kg ha-1and stover with North South (NS) sowing direction. The maximum gross return, net return and benefit: cost ratio was obtained from the combined intensity of pruning 75% with NS sowing direction. Application of phosphorus at 40 kg P2O5 ha-1, to green gram was found optimum to realize the high yield and profit under stone apple based agri-horti system. The 75% pruning intensity with North South (NS) sowing direction under agro climatic conditions of Vindhyan region of Mirzapur was markedly enhanced the yield and net return of green gram as compared to control under bael based agri-horti system.

Isocyanides-based multicomponent strategy for the construction of highly functionalized quinolones derivatives has been developed under mild conditions, in which few derivatives obtained in moderate to good yield. This is a mechanistic study of the carbonyl group of quinolone. A simple and convenient isocyanide-based multicomponent reaction for the construction of highly functionalized quinolones derivatives has been developed under mild conditions.

Purpose: Falls are an emerging public health problem causing a cascade of medical, functional, and socio-economic consequences. Apart from other widely explored risk factors affecting balance, anthropometric factors are also known to have an impact on balance. However, this relationship hasn’t been studied extensively in older adults. This study aimed to evaluate the relationship between the anthropometric factors such as Body Mass Index (BMI), Body Fat Mass (BFM), Waist-Hip Ratio (WHR), Lower Limb Length (LLL), Foot Length (FL) and balance in the elderly among fallers and non-fallers. Method: This cross-sectional study was performed on 100 fallers and 100 non-fallers, aged 60 years and above. These participants were recruited by a stratified random sampling technique from Navi Mumbai region. All the above anthropometric factors were measured and recorded. Each participant’s balance was assessed using the Mini-BESTest scale. Obtained scores were analysed in SPSS software; descriptive statistics, Spearman correlation coefficient, and Z scores were applied. Results: A sample size of 100 non-fallers, 50% male and 50% females, participated in this study. Among those participants classified as “fallers,” 56% were males and 44% were females. The mean age of the non-fallers was 66±5.01 and the mean age of the fallers was 67.72±6.73. In fallers, WHR showed good negative correlation (r= -.807), BFM as moderate (r= -.577) and BMI as fair (r= -.426) whereas in non-fallers, BMI showed moderate (r= -.546) and fair negative correlation for both WHR (r= -.303) and BFM (r= -.441). However, LLL and FL in both groups show little or no correlation. The Association of all anthropometric factors with the balance between fallers and non-fallers showed no-significant difference. It may be inter-group variance for age, gender and BMI, as participants were not matched for these variables during the recruiting phase. Additionally, the reason for the fall was not explored, thus adding to the limitations of our study. Conclusion: This study demonstrated the impact of increased WHR, BFM and BMI on balance in the elderly fallers and non-fallers. Thus, it is important to screen these factors while assessing biological risk factors for predicting falls. This study further recommends exploring the normative value for anthropometric factors in a healthy elderly population.

Additive manufacturing (AM) refers to manufacturing of products or prototypes using layer by layer addition of material. It is quite different from traditional manufacturing which is essentially classified as subtractive manufacturing. AM technology has tremendous versatile applications in the healthcare sector, thus making it a popular choice of the sector. AM technology is not only used for training and simulation products but also for producing medical tools and equipment. This paper discusses the current status of various healthcare applications of AM and the factors affecting implementation of AM in Indian Healthcare Sector.

The primary target of this paper is to give an away from of powerful business choices. This investigation makes a focus on the connection of the present business framework and artificial knowledge. As we enter in the period of PCs in mid 1950s, we named that this will change our method of working. Yet, as it develops, it has changed the perspective too. The customary business chiefs for settling on any dynamic utilize their data sources from the market, now and then they give the proper data and some of the time not due to the HR blunders. Now, many decision-making tools (like MIS, EIS, DSS, etc.) prove as a boon to businesses for making sensible and right decisions. By using the current and past data about any situation, these systems predict the future trend of the market. Now we enter in the age of man-made intelligence since last decade. The artificial intelligence in the processing of business data proves itself as a major base for decision making. It will give better outcomes as the suitable data ship off it. The most proper approach to convey a privilege and fast data in the association, the knowledge-based information systems, can be utilized, thus named as business insight frameworks.

In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, four compounds (10, 14, 20 and 33) exhibited more potent activity (MIC = 3.08, 3.01, 2.62 and 2.51 μM) than ethambutol (MIC = 9.78 μM) and pyrazinamide (MIC = 101.53 μM) against Mycobacterium tuberculosis. Furthermore, they displayed no toxicity against Vero cells (C1008) and mouse bone marrow derived macrophages (MBMDMɸ). These investigated analogues have emerged as possible lead molecule to enlarge the scope of the study.

A series of novel 4-aminoquinolinyl and 9-anilinoacridinyl Schiff base hydrazones have been synthesized and evaluated for their antimalarial activity. All compounds were evaluated in vitro for their antimalarial activity against chloroquine-sensitive strain 3D7 and the chloroquine-resistant K1 strain of Plasmodium falciparum and for cytotoxicity toward Vero cells. Compounds 17, 20, and 21 displayed good activity against the 3D7 strain with IC50 values ranging from 19.69 to 25.38 nm. Moreover, compounds 16, 17, 21, 24, 32, and 33 exhibited excellent activities (21.64-54.26 nm) against K1 strain and several compounds displayed β-hematin inhibitory activity, suggesting that they act on the heme crystallization process such as CQ. Compounds were also found to be non-toxic with good selectivity index.

The World Health Organization has classified the leishmaniasis as a major tropical disease. The discovery of new compounds for leishmaniasis is therefore a pressing concern for the anti-infective research program. We have synthesized 19 compounds of triazine dimers as novel antileishmanial agents. Most of the synthesized derivatives exhibited better activity against intracellular amastigotes (IC50 ranging from 0.77 to 10.32 μM) than the control, pentamidine (IC50 = 13.68 μM), and are not toxic to Vero cells. Compounds 14 and 15 showed significant in vivo inhibition of 74.41% and 62.64%, respectively, in L. donovani/hamster model. Moreover, expansion of Th1-type and suppression of Th2-type immune responses proved that compound 14 stimulates mouse macrophages to prevent the progression of leishmania parasite. The molecular docking studies involving PTR1 protein PDB further validated the concepts involved in the design of these compounds. Among the investigated analogues, compound 14 has emerged as the potential one to enlarge the scope of the study.

The high potential of quinazolinone containing natural products and their derivatives in medicinal chemistry led us to discover four novel series of 53 compounds of quinazolinone based on the concept of molecular hybridization. Most of the synthesized analogues exhibited potent leishmanicidal activity against intracellular amastigotes (IC50 from 0.65 ± 0.2 to 7.76 ± 2.1 μM) as compared to miltefosine (IC50 = 8.4 ± 2.1 μM) and nontoxic toward the J-774A.1 cell line and Vero cells. Moreover, activation of Th1 type and suppression of Th2 type immune responses and induction in nitric oxide generation proved that 8a and 8g induce murine macrophages to prevent survival of parasites. Compounds 8a and 8g exhibited significant in vivo inhibition of parasite 73.15 ± 12.69% and 80.93 ± 10.50% against Leishmania donovani /hamster model. Our results indicate that compounds 8a, 8g, and 9f represent a new structural lead for this serious and neglected disease.

Analogues of a novel class of hybrid 4-anilinoquinoline triazines have been synthesized with the aim of identifying the compounds with improved antimalarial activity preserving the potency of parent drug chloroquine (CQ). All the synthesized molecules were evaluated in vitro for their antimalarial activity against chloroquine-sensitive 3D7 and chloroquine-resistant K1 strains of P. falciparum. Molecules were also screened for their cytotoxicity towards VERO cell line. Sixteen compounds (17, 19, 26, 27, 29, 31, 32, 33, 35, 36, 37, 39, 40, 49, 50, and 52) exhibited excellent antimalarial activity with IC50 values ranging from 1.36–4.63 ng ml−1 and were also found to be nontoxic with good selectivity index. In silico activity prediction as well as enzyme inhibitory activity against P. falciparumtransketolase reveals that the molecules are also good inhibitors of the enzymeP. falciparumtransketolase. The compound 52 showed good in vivo activity by oral route and resulted in survival of 3 out of 5 mice till day 28.

A series of novel 8-fluoro Norfloxacin derivatives and the hybrids of its piperazinyl derivatives incorporated with 1,3,5-triazine and pyrimidine were synthesized. All the above compounds were evaluated for their antibacterial activity against Klebsiella pneumoniae, methicillin-resistant Staphylococcus aureus and methicillin & vancomycin-resistant S. aureus. Among all, compounds having Morpholine, N-methyl/phenyl/benzyl/pyrimidinyl piperazines and n-butylamine substitution at C-7 position, have shown increased potency in comparison to norfloxacin and ciprofloxacin.

Novel series of 7-piperazinylquinolones with tetrazole derivatives were synthesized and evaluated for their antibacterial activity against various strains of Staphylococcus aureus. All the synthesized compounds showed significant in vitro antibacterial activity against Gram-positive bacteria whereas some compounds displayed moderate activity against Gram-negative bacteria. Among all the synthesized compounds, compounds (6a-c, 6e-g, 6i-k, 6m, 6'f and 6'm) were found to be more effective with MIC ranging from (0.78-3.12 μg/mL) against S. aureus (ATCC-29213) than the control; ciprofloxacin (MIC = 25 μg/mL). Moreover, these analogues displayed no toxicity up to MIC = 0.39 μg/mL against mammalian cell line L-929. Furthermore, to correlate the biological activities of synthesized compounds with their 3D conformation, we attempted 3D-QSAR study.

Novel series of 7-piperazinylquinolones with tetrazole derivatives were synthesized and evaluated for their antibacterial activity against various strains of Staphylococcus aureus. All the synthesized compounds showed significant in vitro antibacterial activity against Gram-positive bacteria whereas some compounds displayed moderate activity against Gram-negative bacteria. Among all the synthesized compounds, compounds (6a-c, 6e-g, 6i-k, 6m, 6'f and 6'm) were found to be more effective with MIC ranging from (0.78-3.12 μg/mL) against S. aureus (ATCC-29213) than the control; ciprofloxacin (MIC = 25 μg/mL). Moreover, these analogues displayed no toxicity up to MIC = 0.39 μg/mL against mammalian cell line L-929. Furthermore, to correlate the biological activities of synthesized compounds with their 3D conformation, we attempted 3D-QSAR study.

Synthesis of novel 4-aminoquinoline-rhodanine hybrid using inexpensive starting materials via easy to operate methodology, and their biological activity is reported. All the compounds were screened for their in vitro antimalarial activity against chloroquine-resistant (K1) and chloroquine-sensitive (3D7) strains of Plasmodium falciparum, and their cytotoxicity toward VERO cell line. Compounds 9, 19, 21 and 23 exhibited excellent antimalarial activity with IC50 value ranging from 13.2 to 45.5 nM against chloroquine-resistant (K1) strain. Biochemical studies revealed that inhibition of hemozoin formation is the primary mechanism of action of these analogs for their antimalarial activity. Additionally, some derivatives (14, 18 and 26) of this series also exhibited the antimycobacterial activity against H37Rv strain of Mycobacterium tuberculosis with MIC value of 6.25 μM.

We have developed an efficient cyanuric chloride (2,4,6-trichloro-1,3,5-triazine, TCT) catalyzed approach for the synthesis of 2,3-dihydroquinazolin-4(1H)-one (3a–3x), 2-spiroquinazolinone (5, 7), and glycoconjugates of 2,3-dihydroquinazolin-4(1H)-one (10a, 10b) derivatives. The reaction allows rapid cyclization (8–20 min) with 10 mol % cyanuric chloride to give skeletal complexity in good to excellent yield. We believe that this novel procedure may open the door for the easy generation of new and bioactive quinazolinones.

Novel fluoroquinolones (I) are synthesized and evaluated for their antibacterial activity against K.

Drug resistance to established antifungals such as azole derivatives (fluconazole and ketoconazole) is driving the rise in global mortality due to fungal infection. Identification of new molecular entities structurally unrelated to these may represent a valid strategy to overcome resistance to currently available drugs. In an effort to develop highly potent antifungal agents, we report herein a series of 27 compounds of dithiocarbamate and the rhodanine molecules containing pyridine moiety and their antifungal activity. Among the synthesized compounds, several analogues have shown potent antifungal activity. The potent compounds against Candida albicans strain were further tested for in vitro anticandidal activity and amphotericin B-resistant strain of Candida albicans. Several derivatives 4a–f, 6, and 7k–n were found to be more effective (MIC = 0.39 – 3.12 μg mL−1) against Candida albicans MTCC183 and further these compounds, except 4e, 4f, and 7m, showed significant activity against amphotericin B-resistant strain of Candida albicans than that of fluconazole. Moreover, these analogues did not exhibit any toxicity up to MIC 3.12 μg mL−1 against mammalian cell line L929. A molecular docking study was undertaken to understand the mode of action of the active compounds towards prospective target lanosterol 14α-demethylase (CYP-51).