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4. Addition of danicopan to ravulizumab or eculizumab in patients with paroxysmal nocturnal haemoglobinuria and clinically significant extravascular haemolysis (ALPHA): a double-blind, randomised, phase 3 trial

Author

Barcellini, Wilma, Barraco, Fiorenza, Beneitez Pastor, David, Capra, Marcelo, Chew, Lee Ping, Chrysavgi, Lalayanni, De Castro, Carlos, de la Tour, Régis Peffault, De Oliveira, Michel Michels, Di Bona, Eros, Forcade, Edouard, Fu, Chieh-Lin, Furha, Cossor, Gaya Valls, Anna, Giannouli, Stavroula, Gonzalez-Fernandez, Ataulfo, Griffin, Morag, Gural, Alexander, Gutierrez, Emilio Ojeda, Hernández-Rodríguez, Inés, Ibrahim, Ibrahim, Iori, Anna Paola, Ishida, Tadao, Jang, Jun Ho, Kim, Jeong-A, Kim, Jin Seok, Kitano, Toshiyuki, Kosugi, Hiroshi, Kreiniz, Natalia, Kulasekararaj, Austin, Lee, Jong Wook, Lee Lee, Lily Wong, Mayer, Jiri, Mitchell, Lindsay, Mori, Yasuo, Nishiwaki, Kaichi, Notaro, Rosario, Nunez, Ramiro, Obara, Naoshi, Oliva, Esther Natalie, Patriquin, Christopher, Pessoa, Viviani, Piatek, Caroline, Piekarska, Agnieszka, Raza, Shahzad, Risitano, Antonio Maria, Rojnuckarin, Ponlapat, Samuel, Desmond, Shammo, Jamile, Tadmor, Tamar, Takami, Akiyoshi, Tamari, Roni, Terriou, Louis, Uchiyama, Hitoji, Vannucchi, Alessandro Maria, Yamaguchi, Hiroki, Nishimura, Jun-ichi, Carrillo Infante, Cynthia, Jain, Deepak, Liu, Peng, Filippov, Gleb, Sicre de Fontbrune, Flore, Risitano, Antonio, and Kulasekararaj, Austin G

Published
2023
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7. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Author

Makishima, Hideki, Saiki, Ryunosuke, Nannya, Yasuhito, Korotev, Sophia, Gurnari, Carmelo, Takeda, June, Momozawa, Yukihide, Best, Steve, Krishnamurthy, Pramila, Yoshizato, Tetsuichi, Atsuta, Yoshiko, Shiozawa, Yusuke, Iijima-Yamashita, Yuka, Yoshida, Kenichi, Shiraishi, Yuichi, Nagata, Yasunobu, Kakiuchi, Nobuyuki, Onizuka, Makoto, Chiba, Kenichi, Tanaka, Hiroko, Kon, Ayana, Ochi, Yotaro, Nakagawa, Masahiro M., Okuda, Rurika, Mori, Takuto, Yoda, Akinori, Itonaga, Hidehiro, Miyazaki, Yasushi, Sanada, Masashi, Ishikawa, Takayuki, Chiba, Shigeru, Tsurumi, Hisashi, Kasahara, Senji, Müller-Tidow, Carsten, Takaori-Kondo, Akifumi, Ohyashiki, Kazuma, Kiguchi, Toru, Matsuda, Fumihiko, Jansen, Joop H., Polprasert, Chantana, Blombery, Piers, Kamatani, Yoichiro, Miyano, Satoru, Malcovati, Luca, Haferlach, Torsten, Kubo, Michiaki, Cazzola, Mario, Kulasekararaj, Austin G., Godley, Lucy A., Maciejewski, Jaroslaw P., and Ogawa, Seishi

Published
2023
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11. Allogeneic hematopoietic cell transplantation for VEXAS syndrome: results of a multicenter study of the EBMT

Author

Gurnari, Carmelo, primary, Koster, Linda, additional, Baaij, Laurien, additional, Heiblig, Mael, additional, Yakoub-Agha, Ibrahim, additional, Collin, Matthew, additional, Passweg, Jakob, additional, Bulabois, Claude E., additional, Khan, Anjum, additional, Loschi, Michael, additional, Carnevale-Schianca, Fabrizio, additional, Crisà, Elena, additional, Caravelli, Daniela, additional, Kuball, Jürgen, additional, Saraceni, Francesco, additional, Olivieri, Attilio, additional, Rambaldi, Alessandro, additional, Kulasekararaj, Austin G., additional, Hayden, Patrick J., additional, Badoglio, Manuela, additional, Onida, Francesco, additional, Scheid, Christof, additional, Franceschini, Franco, additional, Mekinian, Arsène, additional, Savic, Sinisa, additional, Voso, Maria Teresa, additional, Drozd-Sokolowska, Joanna, additional, Snowden, John A, additional, Raj, Kavita, additional, Alexander, Tobias, additional, Robin, Marie, additional, Greco, Raffaella, additional, and McLornan, Donal P., additional

Published
2024
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12. Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria

Author

Peffault de Latour, Régis, primary, Röth, Alexander, additional, Kulasekararaj, Austin G., additional, Han, Bing, additional, Scheinberg, Phillip, additional, Maciejewski, Jaroslaw P., additional, Ueda, Yasutaka, additional, de Castro, Carlos M., additional, Di Bona, Eros, additional, Fu, Rong, additional, Zhang, Li, additional, Griffin, Morag, additional, Langemeijer, Saskia M.C., additional, Panse, Jens, additional, Schrezenmeier, Hubert, additional, Barcellini, Wilma, additional, Mauad, Vitor A.Q., additional, Schafhausen, Philippe, additional, Tavitian, Suzanne, additional, Beggiato, Eloise, additional, Chew, Lee Ping, additional, Gaya, Anna, additional, Huang, Wei-Han, additional, Jang, Jun Ho, additional, Kitawaki, Toshio, additional, Kutlar, Abdullah, additional, Notaro, Rosario, additional, Pullarkat, Vinod, additional, Schubert, Jörg, additional, Terriou, Louis, additional, Uchiyama, Michihiro, additional, Wong Lee Lee, Lily, additional, Yap, Eng-Soo, additional, Sicre de Fontbrune, Flore, additional, Marano, Luana, additional, Alashkar, Ferras, additional, Gandhi, Shreyans, additional, Trikha, Roochi, additional, Yang, Chen, additional, Liu, Hui, additional, Kelly, Richard J., additional, Höchsmann, Britta, additional, Kerloeguen, Cécile, additional, Banerjee, Partha, additional, Levitch, Rafael, additional, Kumar, Rakesh, additional, Wang, Zhixin, additional, Thorburn, Christine, additional, Maitra, Samopriyo, additional, Li, Shujie, additional, Verles, Aurelie, additional, Dahlke, Marion, additional, and Risitano, Antonio M., additional

Published
2024
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13. Pharmacokinetics, pharmacodynamics, efficacy, and safety of ravulizumab in pediatric paroxysmal nocturnal hemoglobinuria

Author

Haematologie patientenzorg, Poli Van Creveldkliniek Medisch, Child Health, Chonat, Satheesh, Kulagin, Alexander, Maschan, Alexey, Bartels, Marije, Buechner, Jochen, Punzalan, Rowena, Richards, Michael, Ogawa, Masayo, Hicks, Eden, Yu, Ji, Baruchel, André, Kulasekararaj, Austin G, Haematologie patientenzorg, Poli Van Creveldkliniek Medisch, Child Health, Chonat, Satheesh, Kulagin, Alexander, Maschan, Alexey, Bartels, Marije, Buechner, Jochen, Punzalan, Rowena, Richards, Michael, Ogawa, Masayo, Hicks, Eden, Yu, Ji, Baruchel, André, and Kulasekararaj, Austin G

Published
2024

14. Allogeneic Hematopoietic Cell Transplantation for VEXAS Syndrome: Results of a Multicenter Study of the EBMT

Author

CTI Kuball, MS Hematologie, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, Gurnari, Carmelo, Koster, Linda, Baaij, Laurien Greetje Antoinette, Heiblig, Mael, Yakoub-Agha, Ibrahim, Collin, Matthew, Passweg, Jakob R, Bulabois, Claude-Eric, Khan, Anjum Bashir, Loschi, Michael, Carnevale-Schianca, Fabrizio, Crisà, Elena, Caravelli, Daniela, Kuball, Jürgen, Saraceni, Francesco, Olivieri, Attilio, Rambaldi, Alessandro, Kulasekararaj, Austin G, Hayden, Patrick, Badoglio, Manuela, Onida, Francesco, Scheid, Christof, Franceschini, Franco, Mékinian, Arsene, Savic, Sinisa, Voso, Maria Teresa, Drozd-Sokolowska, Joanna, Snowden, John, Raj, Kavita, Alexander, Tobias, Robin, Marie, Greco, Raffaela, McLornan, Donal P, CTI Kuball, MS Hematologie, Cancer, Infection & Immunity, Regenerative Medicine and Stem Cells, Gurnari, Carmelo, Koster, Linda, Baaij, Laurien Greetje Antoinette, Heiblig, Mael, Yakoub-Agha, Ibrahim, Collin, Matthew, Passweg, Jakob R, Bulabois, Claude-Eric, Khan, Anjum Bashir, Loschi, Michael, Carnevale-Schianca, Fabrizio, Crisà, Elena, Caravelli, Daniela, Kuball, Jürgen, Saraceni, Francesco, Olivieri, Attilio, Rambaldi, Alessandro, Kulasekararaj, Austin G, Hayden, Patrick, Badoglio, Manuela, Onida, Francesco, Scheid, Christof, Franceschini, Franco, Mékinian, Arsene, Savic, Sinisa, Voso, Maria Teresa, Drozd-Sokolowska, Joanna, Snowden, John, Raj, Kavita, Alexander, Tobias, Robin, Marie, Greco, Raffaela, and McLornan, Donal P

Published
2024

15. Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7

Author

Crisà, Elena, Kulasekararaj, Austin G., Adema, Vera, Such, Esperanza, Schanz, Julie, Haase, Detlef, Shirneshan, Katayoon, Best, Steven, Mian, Syed A, Kizilors, Aytug, Cervera, José, Lea, Nicholas, Ferrero, Dario, Germing, Ulrich, Hildebrandt, Barbara, Martínez, Ana Belén Valencia, Santini, Valeria, Sanz, Guillermo F., Solé, Francesc, and Mufti, Ghulam J.

Published
2020
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17. Ravulizumab (ALXN1210) vs eculizumab in C5-inhibitor–experienced adult patients with PNH: the 302 study

Author

Kulasekararaj, Austin G., Hill, Anita, Rottinghaus, Scott T., Langemeijer, Saskia, Wells, Richard, Gonzalez-Fernandez, F. Ataulfo, Gaya, Anna, Lee, Jong Wook, Gutierrez, Emilio Ojeda, Piatek, Caroline I., Szer, Jeff, Risitano, Antonio, Nakao, Shinji, Bachman, Eric, Shafner, Lori, Damokosh, Andrew I., Ortiz, Stephan, Röth, Alexander, and Peffault de Latour, Regis

Published
2019
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19. Treatment Outcomes of Complement Protein C5 Inhibition in 509 UK Patients with Paroxysmal Nocturnal Hemoglobinuria

Author

Kelly, Richard J, primary, Holt, Matthew, additional, Vidler, Jenniner, additional, Arnold, Louise M, additional, Large, Joanna, additional, Forrest, Briony, additional, Barnfield, Catherine, additional, Pike, Alexandra, additional, Griffin, Morag, additional, Munir, Talha, additional, Muus, Petra, additional, Nagumantry, Sateesh, additional, Mullasseril Varghese, Abraham, additional, Davies, John R, additional, Trikha, Roochi, additional, Kulasekararaj, Austin G, additional, Mitchell, Lindsay, additional, and Gandhi, Shreyans A, additional

Published
2023
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20. Addition of danicopan to ravulizumab or eculizumab in patients with paroxysmal nocturnal haemoglobinuria and clinically significant extravascular haemolysis (ALPHA): a double-blind, randomised, phase 3 trial

Author

Lee, Jong Wook, primary, Griffin, Morag, additional, Kim, Jin Seok, additional, Lee Lee, Lily Wong, additional, Piatek, Caroline, additional, Nishimura, Jun-ichi, additional, Carrillo Infante, Cynthia, additional, Jain, Deepak, additional, Liu, Peng, additional, Filippov, Gleb, additional, Sicre de Fontbrune, Flore, additional, Risitano, Antonio, additional, Kulasekararaj, Austin G, additional, Barcellini, Wilma, additional, Barraco, Fiorenza, additional, Beneitez Pastor, David, additional, Capra, Marcelo, additional, Chew, Lee Ping, additional, Chrysavgi, Lalayanni, additional, De Castro, Carlos, additional, de la Tour, Régis Peffault, additional, De Oliveira, Michel Michels, additional, Di Bona, Eros, additional, Forcade, Edouard, additional, Fu, Chieh-Lin, additional, Furha, Cossor, additional, Gaya Valls, Anna, additional, Giannouli, Stavroula, additional, Gonzalez-Fernandez, Ataulfo, additional, Gural, Alexander, additional, Gutierrez, Emilio Ojeda, additional, Hernández-Rodríguez, Inés, additional, Ibrahim, Ibrahim, additional, Iori, Anna Paola, additional, Ishida, Tadao, additional, Jang, Jun Ho, additional, Kim, Jeong-A, additional, Kitano, Toshiyuki, additional, Kosugi, Hiroshi, additional, Kreiniz, Natalia, additional, Kulasekararaj, Austin, additional, Lee, Jong Wook, additional, Mayer, Jiri, additional, Mitchell, Lindsay, additional, Mori, Yasuo, additional, Nishiwaki, Kaichi, additional, Notaro, Rosario, additional, Nunez, Ramiro, additional, Obara, Naoshi, additional, Oliva, Esther Natalie, additional, Patriquin, Christopher, additional, Pessoa, Viviani, additional, Piekarska, Agnieszka, additional, Raza, Shahzad, additional, Risitano, Antonio Maria, additional, Rojnuckarin, Ponlapat, additional, Samuel, Desmond, additional, Shammo, Jamile, additional, Tadmor, Tamar, additional, Takami, Akiyoshi, additional, Tamari, Roni, additional, Terriou, Louis, additional, Uchiyama, Hitoji, additional, Vannucchi, Alessandro Maria, additional, and Yamaguchi, Hiroki, additional

Published
2023
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23. Clinical, histopathological and molecular characterization of hypoplastic myelodysplastic syndrome

Author

Bono, Elisa, McLornan, Donal, Travaglino, Erica, Gandhi, Shreyans, Gallì, Anna, Khan, Alesia Abigael, Kulasekararaj, Austin G., Boveri, Emanuela, Raj, Kavita, Elena, Chiara, Ireland, Robin M., Bianchessi, Antonio, Jiang, Jie, Todisco, Gabriele, Ferretti, Virginia Valeria, Cazzola, Mario, Marsh, Judith. C. W., Malcovati, Luca, and Mufti, Ghulam J.

Published
2019
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24. Heterozygous RTEL1 variants in bone marrow failure and myeloid neoplasms

Author

Marsh, Judith C.W., Gutierrez-Rodrigues, Fernanda, Cooper, James, Jiang, Jie, Gandhi, Shreyans, Kajigaya, Sachiko, Feng, Xingmin, Ibanez, Maria del Pilar F., Donaires, Flávia S., Lopes da Silva, João P., Li, Zejuan, Das, Soma, Ibanez, Maria, Smith, Alexander E., Lea, Nicholas, Best, Steven, Ireland, Robin, Kulasekararaj, Austin G., McLornan, Donal P., Pagliuca, Anthony, Callebaut, Isabelle, Young, Neal S., Calado, Rodrigo T., Townsley, Danielle M., and Mufti, Ghulam J

Published
2018
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26. Phase II trials of zilucoplan in paroxysmal nocturnal hemoglobinuria

Author

Kulasekararaj, Austin G., primary, Lehtinen, Anna-Elina, additional, Forsyth, Cecily, additional, Gandhi, Shreyans, additional, Griffin, Morag, additional, Körper, Sixten, additional, Mikala, Gabor, additional, Muus, Petra, additional, Overgaard, Ulrik, additional, Patriquin, Christopher J., additional, Pullon, Humphrey, additional, Shen, Yu-Min, additional, Spearing, Ruth, additional, Szer, Jeff, additional, De la Borderie, Guillemette, additional, Duda, Petra W., additional, Farzaneh-Far, Ramin, additional, Ragunathan, Sharan, additional, Sayegh, Camil E., additional, Vadysirisack, Douangsone D., additional, and Schrezenmeier, Hubert, additional

Published
2023
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27. Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes

Author

Unnikrishnan, Ashwin, Papaemmanuil, Elli, Beck, Dominik, Deshpande, Nandan P., Verma, Arjun, Kumari, Ashu, Woll, Petter S., Richards, Laura A., Knezevic, Kathy, Chandrakanthan, Vashe, Thoms, Julie A.I., Tursky, Melinda L., Huang, Yizhou, Ali, Zara, Olivier, Jake, Galbraith, Sally, Kulasekararaj, Austin G., Tobiasson, Magnus, Karimi, Mohsen, Pellagatti, Andrea, Wilson, Susan R., Lindeman, Robert, Young, Boris, Ramakrishna, Raj, Arthur, Christopher, Stark, Richard, Crispin, Philip, Curnow, Jennifer, Warburton, Pauline, Roncolato, Fernando, Boultwood, Jacqueline, Lynch, Kevin, Jacobsen, Sten Eirik W., Mufti, Ghulam J., Hellstrom-Lindberg, Eva, Wilkins, Marc R., MacKenzie, Karen L., Wong, Jason W.H., Campbell, Peter J., and Pimanda, John E.

Published
2017
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29. Consensus proposal for revised International Working Group 2023 response criteria for higher-risk myelodysplastic syndromes

Author

Zeidan, Amer M., Platzbecker, Uwe, Bewersdorf, Jan Philipp, Stahl, Maximilian, Adès, Lionel, Borate, Uma, Bowen, David, Buckstein, Rena, Brunner, Andrew, Carraway, Hetty E., Daver, Naval, Díez-Campelo, Maria, de Witte, Theo, DeZern, Amy E., Efficace, Fabio, Garcia-Manero, Guillermo, Garcia, Jacqueline S., Germing, Ulrich, Giagounidis, Aristoteles, Griffiths, Elizabeth A., Hasserjian, Robert P., Hellström-Lindberg, Eva, Iastrebner, Marcelo, Komrokji, Rami, Kulasekararaj, Austin G., Malcovati, Luca, Miyazaki, Yasushi, Odenike, Olatoyosi, Santini, Valeria, Sanz, Guillermo, Scheinberg, Phillip, Stauder, Reinhard, van de Loosdrecht, Arjan A., Wei, Andrew H., Sekeres, Mikkael A., Fenaux, Pierre, Hematology, AII - Cancer immunology, AII - Inflammatory diseases, and CCA - Cancer biology and immunology

Subjects
All institutes and research themes of the Radboud University Medical Center, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]
Abstract

Contains fulltext : 292382.pdf (Publisher’s version ) (Closed access) Myelodysplastic syndromes/myelodysplastic neoplasms (MDS) are associated with variable clinical presentations and outcomes. The initial response criteria developed by the International Working Group (IWG) in 2000 have been used in clinical practice, clinical trials, regulatory reviews, and drug labels. Although the IWG criteria were revised in 2006 and 2018 (the latter focusing on lower-risk disease), limitations persist in their application to higher-risk MDS (HR-MDS) and their ability to fully capture the clinical benefits of novel investigational drugs or serve as valid surrogates for longer-term clinical end points (eg, overall survival). Further, issues related to the ambiguity and practicality of some criteria lead to variability in interpretation and interobserver inconsistency in reporting results from the same sets of data. Thus, we convened an international panel of 36 MDS experts and used an established modified Delphi process to develop consensus recommendations for updated response criteria that would be more reflective of patient-centered and clinically relevant outcomes in HR-MDS. Among others, the IWG 2023 criteria include changes in the hemoglobin threshold for complete remission (CR), the introduction of CR with limited count recovery and CR with partial hematologic recovery as provisional response criteria, the elimination of marrow CR, and specific recommendations for the standardization of time-to-event end points and the derivation and reporting of responses. The updated criteria should lead to a better correlation between patient-centered outcomes and clinical trial results in an era of multiple emerging new agents with novel mechanisms of action.

Published
2023
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31. Current use of androgens in bone marrow failure disorders: a report from the Severe Aplastic Anemia Working Party of the European Society of Blood and Marrow Transplantation

Author

Pagliuca, Simona, primary, Kulasekararaj, Austin G., additional, Eikema, Dirk-Jan, additional, Piepenbroek, Brian, additional, Iftikhar, Raheel, additional, Satti, Tariq Mahmood, additional, Griffin, Morag, additional, Laurino, Marica, additional, Kupesiz, Alphan, additional, Bertrand, Yves, additional, Fattizzo, Bruno, additional, Yakoub-Agha, Ibrahim, additional, Aljurf, Mahmoud, additional, Corti, Paola, additional, Massaccesi, Erika, additional, Lioure, Bruno, additional, Calabuig, Marisa, additional, Klammer, Matthias, additional, Unal, Emel, additional, Wu, Depei, additional, Chevallier, Patrice, additional, Forcade, Edouard, additional, Snowden, John A., additional, Ozdogu, Hakan, additional, Risitano, Antonio, additional, and De Latour, Régis Peffault, additional

Published
2023
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32. Ravulizumab is a suitable long-term treatment option for patients with paroxysmal nocturnal hemoglobinuria

Author

Kulasekararaj, Austin G., primary, Griffin, Morag, additional, Langemeijer, Saskia, additional, Usuki, Kensuke, additional, Kulagin, Alexander, additional, Ogawa, Masayo, additional, Yu, Ji, additional, Mujeebuddin, Arshad, additional, Nishimura, Jun-ichi, additional, Lee, Jong Wook, additional, and de Latour, Régis Peffault, additional

Published
2023
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33. COVID-19 in adult acute myeloid leukemia patients: a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)

Author

Gilead Sciences, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Gomes-Silva, Maria, Fracchiolla, Nicola S., Jonge, Nick de, Collins, Graham P., Marchetti, Monia, Magliano, Gabriel, García-Vidal, Carolina, Biernat, Monika, Doesum, Jaap van, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamin, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Príncipe, María Ilaria del, Cabirta, Alba, Ormazabal-Vélez, Irati, Jakšić, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Praet, Jens van, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin G., Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, Ramón, Cristina de, Cattaneo, Chiara, Calbacho, María, Bahr, Nathan C., El-Ashwah, Shaimaa, Córdoba, Raúl, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Nunes-Rodrigues, Raquel, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., Pagano, Livio, Gilead Sciences, Marchesi, Francesco, Salmanton-García, Jon, Emarah, Ziad, Piukovics, Klára, Nucci, Marcio, López-García, Alberto, Ráčil, Zdeněk, Farina, Francesca, Popova, Marina, Zompi, Sofia, Audisio, Ernesta, Ledoux, Marie-Pierre, Verga, Luisa, Weinbergerová, Barbora, Szotkovski, Tomas, Gomes-Silva, Maria, Fracchiolla, Nicola S., Jonge, Nick de, Collins, Graham P., Marchetti, Monia, Magliano, Gabriel, García-Vidal, Carolina, Biernat, Monika, Doesum, Jaap van, Machado, Marina, Demirkan, Fatih, Al-Khabori, Murtadha, Žák, Pavel, Víšek, Benjamin, Stoma, Igor, Méndez, Gustavo-Adolfo, Maertens, Johan, Khanna, Nina, Espigado, Ildefonso, Dragonetti, Giulia, Fianchi, Luana, Príncipe, María Ilaria del, Cabirta, Alba, Ormazabal-Vélez, Irati, Jakšić, Ozren, Buquicchio, Caterina, Bonuomo, Valentina, Batinić, Josip, Omrani, Ali S., Lamure, Sylvain, Finizio, Olimpia, Fernández, Noemí, Falces-Romero, Iker, Blennow, Ola, Bergantim, Rui, Ali, Natasha, Win, Sein, Praet, Jens van, Tisi, Maria Chiara, Shirinova, Ayten, Schönlein, Martin, Prattes, Juergen, Piedimonte, Monica, Petzer, Verena, Navrátil, Milan, Kulasekararaj, Austin G., Jindra, Pavel, Sramek, Jiří, Glenthøj, Andrea, Fazzi, Rita, Ramón, Cristina de, Cattaneo, Chiara, Calbacho, María, Bahr, Nathan C., El-Ashwah, Shaimaa, Córdoba, Raúl, Hanakova, Michaela, Zambrotta, Giovanni, Sciumè, Mariarita, Booth, Stephen, Nunes-Rodrigues, Raquel, Sacchi, Maria Vittoria, García-Poutón, Nicole, Martín-González, Juan-Alberto, Khostelidi, Sofya, Gräfe, Stefanie, Rahimli, Laman, Ammatuna, Emanuele, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Cornely, Oliver A., and Pagano, Livio

Abstract

Patients with acute myeloid leukemia (AML) are at high risk of mortality from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients with COVID-19 diagnosis between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the prior 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with an improved survival when AML treatment could be delayed (80%; p<0.001). Overall survival in patients with COVID-19 diagnosis between January 2020 and August 2020 was significantly lower than those who were diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs 60% vs 61.9%, respectively; p=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.

Published
2023

34. Impact of SARS-CoV-2 vaccination and monoclonal antibodies on outcome post–CD19-directed CAR T-cell therapy: an EPICOVIDEHA survey

Author

Doesum, Jaap van, Salmanton-García, Jon, Marchesi, Francesco, Blasi, Roberta di, Falces-Romero, Iker, Cabirta, Alba, Farina, Francesca, Besson, Caroline, Weinbergerová, Barbora, Praet, Jens van, Schönlein, Martin, López-García, Alberto, Lamure, Sylvain, Guidetti, Anna, Ramón, Cristina de, Batinić, Josip, Gavriilaki, Eleni, Tragiannidis, Athanasios, Tisi, Maria Chiara, Plantefeve, Gaëtan, Petzer, Verena, Ormazabal-Vélez, Irati, Marques de Almedia, Joyce, Marchetti, Monia, Maertens, Johan, Machado, Marina, Kulasekararaj, Austin G., Hernández-Rivas, José Ángel, Gomes Da Silva, María, Fernández, Noemí, Espigado, Ildefonso, Drgona, Lubos, Dragonetti, Giulia, Metafuni, Elisabetta, Calbacho, María, Blennow, Ola, Wolf, Dominik, Anrooij, Bjorn van, Nunes-Rodrigues, Raquel, Nordlander, Anna, Martín-González, Juan-Alberto, Lievin, Raphaël, Jiménez, Moraima, Gräfe, Stefanie, García-Sanz, Ramón, Córdoba, Raúl, Rahimli, Laman, Meerten, Tom van, Cornely, Oliver A., Pagano, Livio, Doesum, Jaap van, Salmanton-García, Jon, Marchesi, Francesco, Blasi, Roberta di, Falces-Romero, Iker, Cabirta, Alba, Farina, Francesca, Besson, Caroline, Weinbergerová, Barbora, Praet, Jens van, Schönlein, Martin, López-García, Alberto, Lamure, Sylvain, Guidetti, Anna, Ramón, Cristina de, Batinić, Josip, Gavriilaki, Eleni, Tragiannidis, Athanasios, Tisi, Maria Chiara, Plantefeve, Gaëtan, Petzer, Verena, Ormazabal-Vélez, Irati, Marques de Almedia, Joyce, Marchetti, Monia, Maertens, Johan, Machado, Marina, Kulasekararaj, Austin G., Hernández-Rivas, José Ángel, Gomes Da Silva, María, Fernández, Noemí, Espigado, Ildefonso, Drgona, Lubos, Dragonetti, Giulia, Metafuni, Elisabetta, Calbacho, María, Blennow, Ola, Wolf, Dominik, Anrooij, Bjorn van, Nunes-Rodrigues, Raquel, Nordlander, Anna, Martín-González, Juan-Alberto, Lievin, Raphaël, Jiménez, Moraima, Gräfe, Stefanie, García-Sanz, Ramón, Córdoba, Raúl, Rahimli, Laman, Meerten, Tom van, Cornely, Oliver A., and Pagano, Livio

Abstract

Patients with previous CD19-directed chimeric antigen receptor (CAR) T-cell therapy have a prolonged vulnerability to viral infections. Coronavirus disease 2019 (COVID-19) has a great impact and has previously been shown to cause high mortality in this population. Until now, real-world data on the impact of vaccination and treatment on patients with COVID-19 after CD19-directed CAR T-cell therapy are lacking. Therefore, this multicenter, retrospective study was conducted with data from the EPICOVIDEHA survey. Sixty-four patients were identified. The overall mortality caused by COVID-19 was 31%. Patients infected with the Omicron variant had a significantly lower risk of death due to COVID-19 compared with patients infected with previous variants (7% vs 58% [P = .012]). Twenty-six patients were vaccinated at the time of the COVID-19 diagnosis. Two vaccinations showed a marked but unsignificant reduction in the risk of COVID-19–caused mortality (33.3% vs 14.2% [P = .379]). In addition, the course of the disease appears milder with less frequent intensive care unit admissions (39% vs 14% [P = .054]) and a shorter duration of hospitalization (7 vs 27.5 days [P = .022]). Of the available treatment options, only monoclonal antibodies seemed to be effective at reducing mortality from 32% to 0% (P = .036). We conclude that survival rates of CAR T-cell recipients with COVID-19 improved over time and that the combination of prior vaccination and monoclonal antibody treatment significantly reduces their risk of death. This trial was registered at www.clinicaltrials.gov as #NCT04733729.

Published
2023

37. Consensus proposal for revised International Working Group response criteria for higher risk myelodysplastic syndromes

Author

Zeidan, Amer M., primary, Platzbecker, Uwe, additional, Bewersdorf, Jan Philipp, additional, Stahl, Maximilian, additional, Adès, Lionel, additional, Borate, Uma, additional, Bowen, David T, additional, Buckstein, Rena J., additional, Brunner, Andrew M., additional, Carraway, Hetty E, additional, Daver, Naval G., additional, Díez-Campelo, Maria, additional, de Witte, Theo M, additional, DeZern, Amy E., additional, Efficace, Fabio, additional, Garcia-Manero, Guillermo, additional, Garcia, Jacqueline S., additional, Germing, Ulrich, additional, Giagounidis, Aristoteles, additional, Griffiths, Elizabeth A, additional, Hasserjian, Robert P, additional, Hellström-Lindberg, Eva, additional, Iastrebner, Marcelo C, additional, Komrokji, Rami S., additional, Kulasekararaj, Austin G, additional, Malcovati, Luca, additional, Miyazaki, Yasushi, additional, Odenike, Olatoyosi, additional, Santini, Valeria, additional, Sanz, Guillermo F., additional, Scheinberg, Phillip, additional, Stauder, Reinhard, additional, Van de Loosdrecht, Arjan A, additional, Wei, Andrew H, additional, Sekeres, Mikkael A., additional, and Fenaux, Pierre, additional

Published
2023
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43. COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Author

Gilead Sciences, Pagano, Livio [0000-0001-8287-928X], Salmanton-García, Jon [0000-0002-6766-8297], Marchesi, Francesco [0000-0001-6353-2272], Busca, Alessandro [0000-0001-5361-5613], Corradini, Paolo [0000-0002-9186-1353], Hoenigl, Martin [0000-0002-1653-2824], Klimko, Nikolay [0000-0001-6095-7531], Koehler, Philipp [0000-0002-7386-7495], Pagliuca, Antonio [0000-0003-2519-0333], Passamonti, Francesco [0000-0001-8068-5289], Verga, Luisa [0000-0003-1142-8435], Víšek, Benjamin [0000-0001-8268-452X], Ilhan, Osman [0000-0003-1665-372X], Weinbergerová, Barbora [0000-0001-6460-2471], Córdoba, Raúl [0000-0002-7654-8836], Marchetti, Monia [0000-0001-7615-0572], Farina, Francesca [0000-0002-5124-6970], Cattaneo, Chiara [0000-0003-0031-3237], Cabirta, Alba [0000-0001-7198-8894], Gomes-Silva, Maria [0000-0002-6993-2450], Itri, Federico [0000-0002-3532-5281], Doesum, Jaap van [0000-0003-0214-3219], Ledoux, Marie-Pierre [0000-0002-3261-3616], Čerňan, Martin [0000-0003-2345-1229], Jakšić, Ozren [0000-0003-4026-285X], Magliano, Gabriel [0000-0002-9129-1530], Omrani, Ali S. [0000-0001-5309-6358], Fracchiolla, Nicola S. [0000-0002-8982-8079], Kulasekararaj, Austin G. [0000-0003-3180-3570], Valković, Toni [0000-0001-6083-8815], Poulsen, Christian Bjørn [0000-0001-9785-1378], Machado, Marina [0000-0002-8370-2248], Glenthøj, Andrea [0000-0003-2082-0738], Stoma, Igor [0000-0003-0483-7329], Ráčil, Zdeněk [0000-0003-3511-4596], Piukovics, Klára [0000-0003-4480-3131], Emarah, Ziad [0000-0003-0622-2598], Sili, Uluhan [0000-0002-9939-9298], Maertens, Johan [0000-0003-4257-5980], Bergantim, Rui [0000-0002-7811-9509], García-Vidal, Carolina [0000-0002-8915-0683], Prezioso, Lucia [0000-0003-1660-4960], Principe, Maria Ilaria del [0000-0002-3958-0669], Popova, Marina [0000-0001-8536-5495], Jonge, Nick de [0000-0002-9901-0887], Ormazabal-Vélez, Irati [0000-0003-1141-5546], Falces-Romero, Iker [0000-0001-5888-7706], Cuccaro, Annarosa [0000-0002-0237-1839], Meers, Stef [0000-0003-1754-2175], Buquicchio, Caterina [0000-0002-3683-5953], Antić, Darko [0000-0002-2608-1342], Al-Khabori, Murtadha [0000-0002-2937-8838], García-Sanz, Ramón [0000-0003-4120-2787], Biernat, Monika [0000-0003-3161-3398], Tisi, Maria Chiara [0000-0001-8231-6700], Sal, Ertan [0000-0003-2761-2675], Rahimli, Laman [0000-0003-2266-445X], Schönlein, Martin [0000-0002-1010-0975], Calbacho, María [0000-0001-8106-4863], Tascini, Carlo [0000-0001-9625-6024], Miranda-Castillo, Carolina [0000-0001-8763-9576], Khanna, Nina [0000-0002-2642-419X], Méndez, Gustavo-Adolfo [0000-0003-0514-7004], Petzer, Verena [0000-0002-9205-1440], Besson, Caroline [0000-0003-4364-7173], Duléry, Rémy [0000-0002-5024-1713], Lamure, Sylvain [0000-0001-5980-305X], Nucci, Marcio [0000-0003-4867-0014], Zambrotta, Giovanni [0000-0002-8612-2994], Žák, Pavel [0000-0003-4465-5343], Cengiz Seval, Guldane [0000-0001-9433-2054], Bonuomo, Valentina [0000-0001-6491-8337], Mayer, Jiří [0000-0003-0567-9887], López-García, Alberto [0000-0002-5354-5261], Sacchi, Maria Vittoria [0000-0001-8133-3357], Booth, Stephen [0000-0003-2687-0234], Ciceri, Fabio [0000-0003-0873-0123], Nunes-Rodrigues, Raquel [0000-0002-8347-4281], Ammatuna, Emanuele [0000-0001-8247-4901], Obr, Aleš [0000-0002-6758-3074], Herbrecht, Raoul [0000-0002-9381-4876], Shwaylia, Hawraa [0000-0002-4098-6092], Sciumè, Mariarita [0000-0001-7958-4966], Essame, Jenna [0000-0003-0926-5577], Batinić, Josip [0000-0001-5595-9911], Gonzaga, Yung [0000-0003-1416-2118], Regalado-Artamendi, Isabel [0000-0002-9673-9015], Karlsson, Linda Katharina [0000-0003-3317-7550], Shapetska, Maryia [0000-0002-1223-9161], El-Ashwah, Shaimaa [0000-0003-2210-1534], Çolak, Gökçe Melis [0000-0002-7662-7454], Dragonetti, Giulia [0000-0003-1775-6333], Rinaldi, Amelia [0000-0002-8211-5076], Ramón, Cristina de [0000-0002-8167-6410], Cornely, Oliver A. [0000-0001-9599-3137], Pagano, Livio, Salmanton-García, Jon, Marchesi, Francesco, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Verga, Luisa, Gonzaga, Yung, Regalado-Artamendi, Isabel, Karlsson, Linda Katharina, Shapetska, Maryia, Hanakova, Michaela, El-Ashwah, Shaimaa, Borbényi, Zita, Çolak, Gökçe Melis, Nordlander, Anna, Dragonetti, Giulia, Víšek, Benjamin, Maraglino, Alessio Maria Edoardo, Rinaldi, Amelia, Ramón, Cristina de, Cornely, Oliver A., Ilhan, Osman, Nadali, Gianpaolo, Weinbergerová, Barbora, Córdoba, Raúl, Marchetti, Monia, Collins, Graham P., Farina, Francesca, Cattaneo, Chiara, Cabirta, Alba, Gomes-Silva, Maria, Itri, Federico, Doesum, Jaap van, Ledoux, Marie-Pierre, Čerňan, Martin, Jakšić, Ozren, Duarte, Rafael F., Magliano, Gabriel, Omrani, Ali S., Fracchiolla, Nicola S., Kulasekararaj, Austin G., Valković, Toni, Poulsen, Christian Bjørn, Machado, Marina, Glenthøj, Andrea, Stoma, Igor, Ráčil, Zdeněk, Piukovics, Klára, Navrátil, Milan, Emarah, Ziad, Sili, Uluhan, Maertens, Johan, Blennow, Ola, Bergantim, Rui, García-Vidal, Carolina, Prezioso, Lucia, Guidetti, Anna, Principe, Maria Ilaria del, Popova, Marina, Jonge, Nick de, Ormazabal-Vélez, Irati, Fernández, Noemí, Falces-Romero, Iker, Cuccaro, Annarosa, Meers, Stef, Buquicchio, Caterina, Antić, Darko, Al-Khabori, Murtadha, García-Sanz, Ramón, Biernat, Monika, Tisi, Maria Chiara, Sal, Ertan, Rahimli, Laman, Čolović, Natasa, Schönlein, Martin, Calbacho, María, Tascini, Carlo, Miranda-Castillo, Carolina, Khanna, Nina, Méndez, Gustavo-Adolfo, Petzer, Verena, Novák, Jan, Besson, Caroline, Duléry, Rémy, Lamure, Sylvain, Nucci, Marcio, Zambrotta, Giovanni, Žák, Pavel, Cengiz Seval, Guldane, Bonuomo, Valentina, Mayer, Jiří, López-García, Alberto, Sacchi, Maria Vittoria, Booth, Stephen, Ciceri, Fabio, Oberti, Margherita, Salvini, Marco, Izuzquiza, Macarena, Nunes-Rodrigues, Raquel, Ammatuna, Emanuele, Obr, Aleš, Herbrecht, Raoul, Núñez-Martín-Buitrago, Lucía, Mancini, Valentina, Shwaylia, Hawraa, Sciumè, Mariarita, Essame, Jenna, Nygaard, Marietta, Batinić, Josip, Gilead Sciences, Pagano, Livio [0000-0001-8287-928X], Salmanton-García, Jon [0000-0002-6766-8297], Marchesi, Francesco [0000-0001-6353-2272], Busca, Alessandro [0000-0001-5361-5613], Corradini, Paolo [0000-0002-9186-1353], Hoenigl, Martin [0000-0002-1653-2824], Klimko, Nikolay [0000-0001-6095-7531], Koehler, Philipp [0000-0002-7386-7495], Pagliuca, Antonio [0000-0003-2519-0333], Passamonti, Francesco [0000-0001-8068-5289], Verga, Luisa [0000-0003-1142-8435], Víšek, Benjamin [0000-0001-8268-452X], Ilhan, Osman [0000-0003-1665-372X], Weinbergerová, Barbora [0000-0001-6460-2471], Córdoba, Raúl [0000-0002-7654-8836], Marchetti, Monia [0000-0001-7615-0572], Farina, Francesca [0000-0002-5124-6970], Cattaneo, Chiara [0000-0003-0031-3237], Cabirta, Alba [0000-0001-7198-8894], Gomes-Silva, Maria [0000-0002-6993-2450], Itri, Federico [0000-0002-3532-5281], Doesum, Jaap van [0000-0003-0214-3219], Ledoux, Marie-Pierre [0000-0002-3261-3616], Čerňan, Martin [0000-0003-2345-1229], Jakšić, Ozren [0000-0003-4026-285X], Magliano, Gabriel [0000-0002-9129-1530], Omrani, Ali S. [0000-0001-5309-6358], Fracchiolla, Nicola S. [0000-0002-8982-8079], Kulasekararaj, Austin G. [0000-0003-3180-3570], Valković, Toni [0000-0001-6083-8815], Poulsen, Christian Bjørn [0000-0001-9785-1378], Machado, Marina [0000-0002-8370-2248], Glenthøj, Andrea [0000-0003-2082-0738], Stoma, Igor [0000-0003-0483-7329], Ráčil, Zdeněk [0000-0003-3511-4596], Piukovics, Klára [0000-0003-4480-3131], Emarah, Ziad [0000-0003-0622-2598], Sili, Uluhan [0000-0002-9939-9298], Maertens, Johan [0000-0003-4257-5980], Bergantim, Rui [0000-0002-7811-9509], García-Vidal, Carolina [0000-0002-8915-0683], Prezioso, Lucia [0000-0003-1660-4960], Principe, Maria Ilaria del [0000-0002-3958-0669], Popova, Marina [0000-0001-8536-5495], Jonge, Nick de [0000-0002-9901-0887], Ormazabal-Vélez, Irati [0000-0003-1141-5546], Falces-Romero, Iker [0000-0001-5888-7706], Cuccaro, Annarosa [0000-0002-0237-1839], Meers, Stef [0000-0003-1754-2175], Buquicchio, Caterina [0000-0002-3683-5953], Antić, Darko [0000-0002-2608-1342], Al-Khabori, Murtadha [0000-0002-2937-8838], García-Sanz, Ramón [0000-0003-4120-2787], Biernat, Monika [0000-0003-3161-3398], Tisi, Maria Chiara [0000-0001-8231-6700], Sal, Ertan [0000-0003-2761-2675], Rahimli, Laman [0000-0003-2266-445X], Schönlein, Martin [0000-0002-1010-0975], Calbacho, María [0000-0001-8106-4863], Tascini, Carlo [0000-0001-9625-6024], Miranda-Castillo, Carolina [0000-0001-8763-9576], Khanna, Nina [0000-0002-2642-419X], Méndez, Gustavo-Adolfo [0000-0003-0514-7004], Petzer, Verena [0000-0002-9205-1440], Besson, Caroline [0000-0003-4364-7173], Duléry, Rémy [0000-0002-5024-1713], Lamure, Sylvain [0000-0001-5980-305X], Nucci, Marcio [0000-0003-4867-0014], Zambrotta, Giovanni [0000-0002-8612-2994], Žák, Pavel [0000-0003-4465-5343], Cengiz Seval, Guldane [0000-0001-9433-2054], Bonuomo, Valentina [0000-0001-6491-8337], Mayer, Jiří [0000-0003-0567-9887], López-García, Alberto [0000-0002-5354-5261], Sacchi, Maria Vittoria [0000-0001-8133-3357], Booth, Stephen [0000-0003-2687-0234], Ciceri, Fabio [0000-0003-0873-0123], Nunes-Rodrigues, Raquel [0000-0002-8347-4281], Ammatuna, Emanuele [0000-0001-8247-4901], Obr, Aleš [0000-0002-6758-3074], Herbrecht, Raoul [0000-0002-9381-4876], Shwaylia, Hawraa [0000-0002-4098-6092], Sciumè, Mariarita [0000-0001-7958-4966], Essame, Jenna [0000-0003-0926-5577], Batinić, Josip [0000-0001-5595-9911], Gonzaga, Yung [0000-0003-1416-2118], Regalado-Artamendi, Isabel [0000-0002-9673-9015], Karlsson, Linda Katharina [0000-0003-3317-7550], Shapetska, Maryia [0000-0002-1223-9161], El-Ashwah, Shaimaa [0000-0003-2210-1534], Çolak, Gökçe Melis [0000-0002-7662-7454], Dragonetti, Giulia [0000-0003-1775-6333], Rinaldi, Amelia [0000-0002-8211-5076], Ramón, Cristina de [0000-0002-8167-6410], Cornely, Oliver A. [0000-0001-9599-3137], Pagano, Livio, Salmanton-García, Jon, Marchesi, Francesco, Busca, Alessandro, Corradini, Paolo, Hoenigl, Martin, Klimko, Nikolay, Koehler, Philipp, Pagliuca, Antonio, Passamonti, Francesco, Verga, Luisa, Gonzaga, Yung, Regalado-Artamendi, Isabel, Karlsson, Linda Katharina, Shapetska, Maryia, Hanakova, Michaela, El-Ashwah, Shaimaa, Borbényi, Zita, Çolak, Gökçe Melis, Nordlander, Anna, Dragonetti, Giulia, Víšek, Benjamin, Maraglino, Alessio Maria Edoardo, Rinaldi, Amelia, Ramón, Cristina de, Cornely, Oliver A., Ilhan, Osman, Nadali, Gianpaolo, Weinbergerová, Barbora, Córdoba, Raúl, Marchetti, Monia, Collins, Graham P., Farina, Francesca, Cattaneo, Chiara, Cabirta, Alba, Gomes-Silva, Maria, Itri, Federico, Doesum, Jaap van, Ledoux, Marie-Pierre, Čerňan, Martin, Jakšić, Ozren, Duarte, Rafael F., Magliano, Gabriel, Omrani, Ali S., Fracchiolla, Nicola S., Kulasekararaj, Austin G., Valković, Toni, Poulsen, Christian Bjørn, Machado, Marina, Glenthøj, Andrea, Stoma, Igor, Ráčil, Zdeněk, Piukovics, Klára, Navrátil, Milan, Emarah, Ziad, Sili, Uluhan, Maertens, Johan, Blennow, Ola, Bergantim, Rui, García-Vidal, Carolina, Prezioso, Lucia, Guidetti, Anna, Principe, Maria Ilaria del, Popova, Marina, Jonge, Nick de, Ormazabal-Vélez, Irati, Fernández, Noemí, Falces-Romero, Iker, Cuccaro, Annarosa, Meers, Stef, Buquicchio, Caterina, Antić, Darko, Al-Khabori, Murtadha, García-Sanz, Ramón, Biernat, Monika, Tisi, Maria Chiara, Sal, Ertan, Rahimli, Laman, Čolović, Natasa, Schönlein, Martin, Calbacho, María, Tascini, Carlo, Miranda-Castillo, Carolina, Khanna, Nina, Méndez, Gustavo-Adolfo, Petzer, Verena, Novák, Jan, Besson, Caroline, Duléry, Rémy, Lamure, Sylvain, Nucci, Marcio, Zambrotta, Giovanni, Žák, Pavel, Cengiz Seval, Guldane, Bonuomo, Valentina, Mayer, Jiří, López-García, Alberto, Sacchi, Maria Vittoria, Booth, Stephen, Ciceri, Fabio, Oberti, Margherita, Salvini, Marco, Izuzquiza, Macarena, Nunes-Rodrigues, Raquel, Ammatuna, Emanuele, Obr, Aleš, Herbrecht, Raoul, Núñez-Martín-Buitrago, Lucía, Mancini, Valentina, Shwaylia, Hawraa, Sciumè, Mariarita, Essame, Jenna, Nygaard, Marietta, and Batinić, Josip

Abstract

Background Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However

Published
2021

44. Concomitant Immunosuppressive Therapy and Eculizumab Use in Patients with Paroxysmal Nocturnal Hemoglobinuria: An International PNH Registry Analysis

Author

Hill, Anita, primary, de Latour, Régis Peffault, additional, Kulasekararaj, Austin G., additional, Griffin, Morag, additional, Brodsky, Robert A., additional, Maciejewski, Jaroslaw P., additional, Marantz, Jing L., additional, Gustovic, Philippe, additional, and Schrezenmeier, Hubert, additional

Published
2022
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50. Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

Author

Jerez, Andres, Sugimoto, Yuka, Makishima, Hideki, Verma, Amit, Jankowska, Anna M., Przychodzen, Bartlomiej, Visconte, Valeria, Tiu, Ramon V., O'Keefe, Christine L., Mohamedali, Azim M., Kulasekararaj, Austin G., Pellagatti, Andrea, McGraw, Kathy, Muramatsu, Hideki, Moliterno, Alison R., Sekeres, Mikkael A., McDevitt, Michael A., Kojima, Seiji, List, Alan, Boultwood, Jacqueline, Mufti, Ghulam J., and Maciejewski, Jaroslaw P.

Published
2012
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